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  1. There is extensive evidence for the role of aberrant cell survival signaling mechanisms in cancer progression and metastasis. Akt is a major component of cell survival-signaling mechanisms in several types of ...

    Authors: Ekta Agarwal, Anathbandhu Chaudhuri, Premila D Leiphrakpam, Katie L Haferbier, Michael G Brattain and Sanjib Chowdhury
    Citation: BMC Cancer 2014 14:145
    Content type: Research article Published on:

  2. Maspin, which is classified as a tumor suppressor protein, is downregulated in many types of cancer. Several studies have suggested potential anti-proliferative activity of maspin as well as sensitizing activi...

    Authors: Magdalena Machowska, Katarzyna Wachowicz, Mirosław Sopel and Ryszard Rzepecki
    Citation: BMC Cancer 2014 14:142
    Content type: Research article Published on:

  3. The anticancer properties of aspirin are restricted by its gastrointestinal toxicity and its limited efficacy. Therefore, we synthesized phospho-aspirin (PA-2; MDC-22), a novel derivative of aspirin, and evalu...

    Authors: Liqun Huang, Chi C Wong, Gerardo G Mackenzie, Yu Sun, Ka Wing Cheng, Kvetoslava Vrankova, Ninche Alston, Nengtai Ouyang and Basil Rigas
    Citation: BMC Cancer 2014 14:141
    Content type: Research article Published on:

  4. Small cell cervical carcinoma (SCCC) is a rare, aggressive tumor with a poor prognosis. However, information in relation to its treatment is scarce due to the limited numbers of patients. The aim of this study...

    Authors: Long Huang, Ling-Min Liao, An-Wen Liu, Jian-Bing Wu, Xiao-Ling Cheng, Jia-Xin Lin and Min Zheng
    Citation: BMC Cancer 2014 14:140
    Content type: Research article Published on:

  5. Embryonal Rhabdomyosarcoma (RMS) is a pediatric soft-tissue sarcoma derived from myogenic precursors that is characterized by a good prognosis in patients with localized disease. Conversely, metastatic tumors ...

    Authors: Roberta Ciarapica, Elena Carcarino, Laura Adesso, Maria De Salvo, Giorgia Bracaglia, Pier Paolo Leoncini, Alessandra Dall’Agnese, Federica Verginelli, Giuseppe M Milano, Renata Boldrini, Alessandro Inserra, Stefano Stifani, Isabella Screpanti, Victor E Marquez, Sergio Valente, Antonello Mai…
    Citation: BMC Cancer 2014 14:139
    Content type: Research article Published on:

  6. MicroRNA (miR)-182 is frequently upregulated in cancers, has generally been viewed as an oncogene and is possibly connected to angiogenesis. We aimed to explore what impact miR-182 has in non-small cell lung c...

    Authors: Helge Stenvold, Tom Donnem, Sigve Andersen, Samer Al-Saad, Lill-Tove Busund and Roy M Bremnes
    Citation: BMC Cancer 2014 14:138
    Content type: Research article Published on:

  7. Identification of new drugs against paediatric sarcomas represents an urgent clinical need that mainly relies on public investments due to the rarity of these diseases. In this paper we evaluated the in vitro and...

    Authors: Clara Guerzoni, Stefano Amatori, Luca Giorgi, Maria Cristina Manara, Lorena Landuzzi, Pier-Luigi Lollini, Aurora Tassoni, Mauro Balducci, Marco Manfrini, Loredana Pratelli, Massimo Serra, Piero Picci, Mauro Magnani, Vieri Fusi, Mirco Fanelli and Katia Scotlandi
    Citation: BMC Cancer 2014 14:137
    Content type: Research article Published on:

  8. To observe the primary tumor (PT) regression speed after radiotherapy (RT) in nasopharyngeal carcinoma (NPC) and evaluate its prognostic significance.

    Authors: Ning Zhang, Shao-Bo Liang, Yan-Ming Deng, Rui-Liang Lu, Hai-Yang Chen, Hai Zhao, Zhi-Qian Lv, Shao-Qiang Liang, Lin Yang, Dong-Sheng Liu and Yong Chen
    Citation: BMC Cancer 2014 14:136
    Content type: Research article Published on:

  10. Resistance to humanized monoclonal erbB2/HER2 antibody, trastuzumab (Herceptin), has become a pivotal obstacle for targeted therapy of HER2-positive breast cancers. The activation of alternative growth factor ...

    Authors: Xing-Ming Ye, Hua-Yu Zhu, Wen-Dong Bai, Ting Wang, Lei Wang, Ying Chen, An-Gang Yang and Lin-Tao Jia
    Citation: BMC Cancer 2014 14:134
    Content type: Research article Published on:

  11. Deregulation of the MAPK genes signalling caused by somatic mutations have been implied in leukaemia pathogenesis, including RAS mutation (RAS mut) in acute myeloid leukaemia (AML), which has been associated with...

    Authors: Francianne Gomes Andrade, Juliana Montibeller Furtado-Silva, Bruno Alves de Aguiar Gonçalves, Luiz Claudio Santos Thuler, Thayana Conceição Barbosa, Mariana Emerenciano, André Siqueira and Maria S Pombo-de-Oliveira
    Citation: BMC Cancer 2014 14:133
    Content type: Research article Published on:

  12. Among women, breast cancer (BC) is the leading cancer and the most common cause of cancer-related death between 30 and 69 years. Although lifestyle and diet are considered to have a role in global BC incidence...

    Authors: Catarina Rodrigues dos Santos, Isabel Fonseca, Sérgio Dias and JC Mendes de Almeida
    Citation: BMC Cancer 2014 14:132
    Content type: Research article Published on:

  13. To evaluate the insulin receptor isoform mRNA expression status in non-small cell lung cancer (NSCLC) patients.

    Authors: Liyan Jiang, Wei Zhu, Katie Streicher, Chris Morehouse, Philip Brohawn, Xiaoxiao Ge, Zhengwei Dong, Xiaolu Yin, Guanshan Zhu, Yi Gu, Koustubh Ranade, Brandon W Higgs, Yihong Yao and Jiaqi Huang
    Citation: BMC Cancer 2014 14:131
    Content type: Research article Published on:

  14. Quantification of molecular cell processes is important for prognostication and treatment individualization of head and neck cancer (HNC). However, individual tumor comparison can show discord in upregulation ...

    Authors: Bianca AW Hoeben, Maud HW Starmans, Ralph TH Leijenaar, Ludwig J Dubois, Albert J van der Kogel, Johannes HAM Kaanders, Paul C Boutros, Philippe Lambin and Johan Bussink
    Citation: BMC Cancer 2014 14:130
    Content type: Research article Published on:

  15. Colorectal-cancer is a leading cause of cancer death in the United States, and Latinos have particularly low rates of screening. Strategies and Opportunities to STOP Colon Cancer in Priority Populations (STOP CRC...

    Authors: Gloria D Coronado, William M Vollmer, Amanda Petrik, Josue Aguirre, Tanya Kapka, Jennifer DeVoe, Jon Puro, Tran Miers, Jennifer Lembach, Ann Turner, Jennifer Sanchez, Sally Retecki, Christine Nelson and Beverly Green
    Citation: BMC Cancer 2014 14:55
    Content type: Research article Published on:

  16. To reduce sampling error associated with cancer detection in prostate needle biopsies, we explored the possibility of using fluorescence in situ hybridisation (FISH) to detect chromosomal abnormalities in the ...

    Authors: Ying Zhang, Thomas Perez, Beth Blondin, Jing Du, Ping Liu, Diana Escarzaga, John S Coon, Larry E Morrison and Katerina Pestova
    Citation: BMC Cancer 2014 14:129
    Content type: Research article Published on:

  17. Loss of phosphatase and tensin homologue (PTEN) function evaluated by loss of PTEN protein expression on immunohistochemistry (IHC) has been reported as both prognostic in metastatic colorectal cancer and pred...

    Authors: Christopher Hocking, Jennifer E Hardingham, Vy Broadbridge, Joe Wrin, Amanda R Townsend, Niall Tebbutt, John Cooper, Andrew Ruszkiewicz, Chee Lee and Timothy J Price
    Citation: BMC Cancer 2014 14:128
    Content type: Research article Published on:

  18. Acute leukemia in early age (EAL) is characterized by acquired genetic alterations such as MLL rearrangements (MLL-r). The aim of this case-controlled study was to investigate whether single nucleotide polymorphi...

    Authors: Mariana Emerenciano, Thayana Conceição Barbosa, Bruno Almeida Lopes, Caroline Barbieri Blunck, Alessandra Faro, Camilla Andrade, Claus Meyer, Rolf Marschalek and Maria S Pombo-de-Oliveira
    Citation: BMC Cancer 2014 14:127
    Content type: Research article Published on:

  19. Breast cancer is the second most lethal cancer in women. Understanding biological mechanisms that cause progression of this disease could yield new targets for prevention and treatment. Recent experimental stu...

    Authors: Qi Cao, Jerome Hersl, Hongloan La, Mark Smith, Jason Jenkins, Olga Goloubeva, Vasken Dilsizian, Katherine Tkaczuk, Wengen Chen and Laundette Jones
    Citation: BMC Cancer 2014 14:126
    Content type: Research article Published on:

  20. The wnt/β-catenin signaling pathway is known to affect in cancer oncogenesis and progression by interacting with the tumor microenvironment. However, the roles of wnt3a and wnt5a in colorectal cancer (CRC) hav...

    Authors: Myung Ah Lee, Jin-Hee Park, Si Young Rhyu, Seong-Taek Oh, Won-Kyoung Kang and Hee-Na Kim
    Citation: BMC Cancer 2014 14:125
    Content type: Research article Published on:

  21. Triple negative breast cancer (TNBC) has higher rates of recurrence and distant metastasis, and poorer outcome as compared to non-TNBC. Aberrant activation of WNT signaling has been detected in TNBC, which mig...

    Authors: Lixin Yang, Aldwin Apollo Perez, Sayuri Fujie, Charles Warden, Jie Li, Yafan Wang, Bryan Yung, Yun-Ru Chen, Xiyong Liu, Hang Zhang, Shu Zheng, Zheng Liu, David Ann and Yun Yen
    Citation: BMC Cancer 2014 14:124
    Content type: Research article Published on:

  22. In Germany, about 20% of the total population have a migration background. Differences exist between migrants and non-migrants in terms of health care access and utilisation. Colorectal cancer is the second mo...

    Authors: Anne Dahlhaus, Corina Guethlin, Arthur Schall, Maja Taubenroth, Reyn van Ewijk, Hajo Zeeb, Zeycan Albay, Sylvia Schulz-Rothe, Martin Beyer, Ferdinand M Gerlach, Maria Blettner and Andrea Siebenhofer
    Citation: BMC Cancer 2014 14:123
    Content type: Study protocol Published on:

  23. Bmi1 has been identified as an important regulator in breast cancer, but its relationship with other signaling molecules such as ERα and HER2 is undetermined.

    Authors: Huali Wang, Haijing Liu, Xin Li, Jing Zhao, Hong Zhang, Jingzhuo Mao, Yongxin Zou, Hong Zhang, Shuang Zhang, Wei Hou, Lin Hou, Michael A McNutt and Bo Zhang
    Citation: BMC Cancer 2014 14:122
    Content type: Research article Published on:

  24. It remains presently unclear whether disease progression in colorectal carcinoma (CRC), from early, to invasive and metastatic forms, is associated to a gradual increase in genetic instability and to a scheme ...

    Authors: Béatrice Orsetti, Janick Selves, Caroline Bascoul-Mollevi, Laurence Lasorsa, Karine Gordien, Frédéric Bibeau, Blandine Massemin, François Paraf, Isabelle Soubeyran, Isabelle Hostein, Valérie Dapremont, Rosine Guimbaud, Christophe Cazaux, Michel Longy and Charles Theillet
    Citation: BMC Cancer 2014 14:121
    Content type: Research article Published on:

  25. Ovarian cancer is now recognized as a number of distinct diseases primarily defined by histological subtype. Both clear cell ovarian carcinomas (CCC) and ovarian endometrioid carcinomas (EC) may arise from end...

    Authors: Kimberly C Wiegand, Bryan T Hennessy, Samuel Leung, Yemin Wang, Zhenlin Ju, Mollianne McGahren, Steve E Kalloger, Sarah Finlayson, Katherine Stemke-Hale, Yiling Lu, Fan Zhang, Michael S Anglesio, Blake Gilks, Gordon B Mills, David G Huntsman and Mark S Carey
    Citation: BMC Cancer 2014 14:120
    Content type: Research article Published on:

  26. Yes-associated protein (YAP1) is frequently reported to function as an oncogene in many types of cancer, but in breast cancer results remain controversial. We set out to clarify the role of YAP1 in breast canc...

    Authors: Sophie Lehn, Nicholas P Tobin, Andrew H Sims, Olle Stål, Karin Jirström, Håkan Axelson and Göran Landberg
    Citation: BMC Cancer 2014 14:119
    Content type: Research article Published on:

  27. Chemokines have been implicated in tumor progression and metastasis. In melanoma, chemokine receptors have been implicated in organ selective metastasis by regulating processes such as chemoattraction, adhesio...

    Authors: Sandra Pinto, Alicia Martínez-Romero, José-Enrique O’Connor, Rosario Gil-Benso, Teresa San-Miguel, Liria Terrádez, Carlos Monteagudo and Robert C Callaghan
    Citation: BMC Cancer 2014 14:118
    Content type: Research article Published on:

  28. Neutrophil-lymphocyte ratio (NLR) has recently been reported as a predictor of Hepatocellular carcinoma (HCC). However, its prognostic value in HCC still remains controversial. In this study, we aimed to evalu...

    Authors: Wei-Kai Xiao, Dong Chen, Shao-Qiang Li, Shun-Jun Fu, Bao-Gang Peng and Li-Jian Liang
    Citation: BMC Cancer 2014 14:117
    Content type: Research article Published on:

  29. Cervical cancer ranks second among all cancers reported in Sri Lankan women. This study assessed the prevalence and type-distribution of human papillomavirus (HPV) among Sri Lankan women with invasive cervical...

    Authors: Kanishka Karunaratne, Himali Ihalagama, Saman Rohitha, Anco Molijn, Kusuma Gopala, Johannes E Schmidt, Jing Chen, Sanjoy Datta and Shailesh Mehta
    Citation: BMC Cancer 2014 14:116
    Content type: Research article Published on:

  30. Adult brainstem gliomas are rare primary brain tumors (<2% of gliomas). The goal of this study was to analyze clinical, prognostic and therapeutic factors in a large series of histologically proven brainstem g...

    Authors: Thomas Reithmeier, Aanyo Kuzeawu, Bettina Hentschel, Markus Loeffler, Michael Trippel and Guido Nikkhah
    Citation: BMC Cancer 2014 14:115
    Content type: Research article Published on:

  31. Hepatocellular carcinoma (HCC) is a primary liver tumor and is the most difficult human malignancy to treat. In this study, we sought to develop an integrative approach in which real-time tumor monitoring, gen...

    Authors: Jing Chen, Shu Zhu, Liangqian Tong, Jiansha Li, Fei Chen, Yunfeng Han, Ming Zhao and Wei Xiong
    Citation: BMC Cancer 2014 14:114
    Content type: Research article Published on:

  32. CD248 is a cell surface glycoprotein, highly expressed by stromal cells and fibroblasts of tumors and inflammatory lesions, but virtually undetectable in healthy adult tissues. CD248 promotes tumorigenesis, wh...

    Authors: Sahana Suresh Babu, Yanet Valdez, Andrea Xu, Alice M O’Byrne, Fernando Calvo, Victor Lei and Edward M Conway
    Citation: BMC Cancer 2014 14:113
    Content type: Research article Published on:

  33. Resistin, adipocyte-secreting adipokine, may play critical role in modulating cancer pathogenesis. The aim of this study was to investigate the effects of resistin on HCC adhesion to the endothelium, and the m...

    Authors: Chen-Chieh Yang, Shun-Fu Chang, Jian-Kang Chao, Yi-Liang Lai, Wei-En Chang, Wen-Hsiu Hsu and Wu-Hsien Kuo
    Citation: BMC Cancer 2014 14:112
    Content type: Research article Published on:

  34. Bevacizumab, an antibody neutralizing Vascular Endothelial Growth Factor (VEGF), is licensed for the management of patients with advanced colon cancer. However, tumor biomarkers identifying the molecular tumor...

    Authors: George Pentheroudakis, Vassiliki Kotoula, Elena Fountzilas, George Kouvatseas, George Basdanis, Ioannis Xanthakis, Thomas Makatsoris, Elpida Charalambous, Demetris Papamichael, Epaminontas Samantas, Pavlos Papakostas, Dimitrios Bafaloukos, Evangelia Razis, Christos Christodoulou, Ioannis Varthalitis, Nicholas Pavlidis…
    Citation: BMC Cancer 2014 14:111
    Content type: Research article Published on:

  35. In many tumour types serumlactate dehydrogenase (LDH) levels proved to represent an indirect marker of tumour hypoxia, neo-angiogenesis and worse prognosis. As we previously reported LDH is an important predic...

    Authors: Luca Faloppi, Mario Scartozzi, Maristella Bianconi, Gianluca Svegliati Baroni, Pierluigi Toniutto, Riccardo Giampieri, Michela Del Prete, Samuele De Minicis, Davide Bitetto, Cristian Loretelli, Marco D’Anzeo, Antonio Benedetti and Stefano Cascinu
    Citation: BMC Cancer 2014 14:110
    Content type: Research article Published on:

  36. MicroRNAs(miRNAs) are small non-coding RNAs that participate in a variety of biologic processes, and dysregulation of miRNA is always associated with cancer development and progression. Aberrant expression of ...

    Authors: Guang-jun Zhang, He Zhou, Hua-xu Xiao, Yu Li and Tong Zhou
    Citation: BMC Cancer 2014 14:109
    Content type: Research article Published on:

  37. Hepatocellular carcinoma (HCC) is one of the major causes of cancer-related death especially among Asian and African populations. It is urgent that we identify carcinogenesis-related genes to establish an inno...

    Authors: Masamichi Hayashi, Shuji Nomoto, Mitsuhiro Hishida, Yoshikuni Inokawa, Mitsuro Kanda, Yukiyasu Okamura, Yoko Nishikawa, Chie Tanaka, Daisuke Kobayashi, Suguru Yamada, Goro Nakayama, Tsutomu Fujii, Hiroyuki Sugimoto, Masahiko Koike, Michitaka Fujiwara, Shin Takeda…
    Citation: BMC Cancer 2014 14:108
    Content type: Research article Published on:

  38. ATAD2 is associated with many cellular processes, such as cell growth, migration and invasion. However, no studies have been conducted on the molecular biological function of the ATAD2 gene in hepatocellular c...

    Authors: Gang Wu, Haiyang Liu, Hui He, Yawei Wang, Xiaojun Lu, Yanqiu Yu, Shuguan Xia, Xiangyu Meng and Yongfeng Liu
    Citation: BMC Cancer 2014 14:107
    Content type: Research article Published on:

  39. Prostate cancer is the most common cancer in male in most Western countries, including France. Despite a significant morbidity and mortality to a lesser extent, the etiology of prostate cancer remains largely ...

    Authors: Florence Menegaux, Antoinette Anger, Hasina Randrianasolo, Claire Mulot, Pierre Laurent-Puig, François Iborra, Jean-Pierre Bringer, Benoit Leizour, Rodolphe Thuret, Pierre-Jean Lamy, Xavier Rébillard and Brigitte Trétarre
    Citation: BMC Cancer 2014 14:106
    Content type: Study protocol Published on:

  40. Increased ratio of n-3/n-6 polyunsaturated fatty acids (PUFAs) in diet or serum may have a protective effect on the risk of breast cancer (BC); however, the conclusions from prospective studies are still contr...

    Authors: Bo Yang, Xiao-Li Ren, Yuan-Qin Fu, Jin-Long Gao and Duo Li
    Citation: BMC Cancer 2014 14:105
    Content type: Research article Published on:

  41. Glypican-3(GPC3) has been implicated in tumor development and progression for several years. However, the prognostic significance of GPC3 expression in patients with hepatocellular carcinoma (HCC) is controver...

    Authors: Wei-Kai Xiao, Chao-Ying Qi, Dong Chen, Shao-Qiang Li, Shun-Jun Fu, Bao-Gang Peng and Li-Jian Liang
    Citation: BMC Cancer 2014 14:104
    Content type: Research article Published on:

  42. Obesity is associated with an increased risk of esophageal adenocarcinoma (EAC) and a decreased risk of esophageal squamous cell carcinoma (ESCC). However, little is known about the risk of EAC and ESCC relate...

    Authors: Björn Lindkvist, Dorthe Johansen, Tanja Stocks, Hans Concin, Tone Bjørge, Martin Almquist, Christel Häggström, Anders Engeland, Göran Hallmans, Gabriele Nagel, Håkan Jonsson, Randi Selmer, Hanno Ulmer, Steinar Tretli, Pär Stattin and Jonas Manjer
    Citation: BMC Cancer 2014 14:103
    Content type: Research article Published on:

  44. GATA-5, a zinc-finger transcription factor and member of the GATA family proteins 1–6, is known to be involved in cellular differentiation. We recently found that tumor-specific hypermethylation of the GATA5 CpG ...

    Authors: Inga Peters, Natalia Dubrowinskaja, Michael Kogosov, Mahmoud Abbas, Jörg Hennenlotter, Christoph von Klot, Axel S Merseburger, Arnulf Stenzl, Ralph Scherer, Markus A Kuczyk and Jürgen Serth
    Citation: BMC Cancer 2014 14:101
    Content type: Research article Published on:

  45. At the present time, there is a lack of data about the involvement of flotillins and stomatin in the development of non-small cell lung cancer (NSCLC) and soft tissue sarcomas (STS). Moreover, changes in expre...

    Authors: Ksenia A Arkhipova, Anastasia N Sheyderman, Konstantin K Laktionov, Valeria V Mochalnikova and Irina B Zborovskaya
    Citation: BMC Cancer 2014 14:100
    Content type: Research article Published on:

  46. Endothelial cells play a complex role in the pathobiology of cancer. This role is not limited to the making of blood vessels to allow for influx of oxygen and nutrients required for the high metabolic demands ...

    Authors: Kathleen G Neiva, Kristy A Warner, Marcia S Campos, Zhaocheng Zhang, Juliana Moren, Theodora E Danciu and Jacques E Nör
    Citation: BMC Cancer 2014 14:99
    Content type: Research article Published on:

  47. Esophageal squamous cell carcinoma (ESCC) is one of the most lethal malignancies with a 5-year survival rate less than 15%. Understanding of the molecular mechanisms involved in the pathogenesis of ESCC become...

    Authors: Haidan Liu, Jinfu Yang, Yunchang Yuan, Zhenkun Xia, Mingjiu Chen, Li Xie, Xiaolong Ma, Jian Wang, Sufeng Ouyang, Qin Wu, Fenglei Yu, Xinmin Zhou, Yifeng Yang, Ya Cao, Jianguo Hu and Bangliang Yin
    Citation: BMC Cancer 2014 14:98
    Content type: Research article Published on:

  48. Accumulating evidence showed that microRNAs are involved in development and progression of multiple tumors. Recent studies have found that miR-181a were dysregulated in several types of cancers, however, the f...

    Authors: Chengcheng Zou, Yongguo Li, Yiyi Cao, Jinnan Zhang, Jingrong Jiang, Yanrui Sheng, Sen Wang, Ailong Huang and Hua Tang
    Citation: BMC Cancer 2014 14:97
    Content type: Research article Published on:

  49. There are a lot of unmet needs in patients with triple-negative breast cancer (TNBC). Fenofibrate, a peroxisome proliferator-activated receptor alpha (PPAR-α) agonist, has been used for decades to treat hypert...

    Authors: Ting Li, Qunling Zhang, Jian Zhang, Gong Yang, Zhimin Shao, Jianmin Luo, Minhao Fan, Chen Ni, Zhenhua Wu and Xichun Hu
    Citation: BMC Cancer 2014 14:96
    Content type: Research article Published on:

  50. Cancer patients with primary tumors showing extensive hypoxia and highly elevated interstitial fluid pressure (IFP) have poor prognosis. The potential of diffusion-weighted magnetic resonance imaging (DW-MRI) ...

    Authors: Tord Hompland, Christine Ellingsen, Kanthi Galappathi and Einar K Rofstad
    Citation: BMC Cancer 2014 14:92
    Content type: Research article Published on:

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