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  1. In cancer patients where gastrointestinal function is marginal and malnutrition significant enough to result in the requirement for intensive nutrition support, parenteral nutrition (PN) is indicated. This lon...

    Authors: Pankaj G Vashi, Sadie Dahlk, Brenten Popiel, Carolyn A Lammersfeld, Carol Ireton-Jones and Digant Gupta
    Citation: BMC Cancer 2014 14:593
    Content type: Research article Published on:

  2. Based on improved clinical outcomes in randomized controlled clinical trials (RCTs) the FDA and EMA have approved bevacizumab with interferon, sunitinib, and pazopanib in the first-line treatment of low to int...

    Authors: Benjamin Haaland, Akhil Chopra, Sanchalika Acharyya, André P Fay and Gilberto de Lima Lopes
    Citation: BMC Cancer 2014 14:592
    Content type: Research article Published on:

  3. The cytokine TRAIL (tumor necrotic factor-related apoptosis-inducing ligand) selectively induces apoptosis in cancer cells, but cancer stem cells (CSCs) that contribute to cancer-recurrence are frequently TRAI...

    Authors: Dan Wang, Bijaya Upadhyaya, Yi Liu, David Knudsen and Moul Dey
    Citation: BMC Cancer 2014 14:591
    Content type: Research article Published on:

  4. Neoplastic and bland portal vein thrombi (PVT) are both common in patients with hepatocellular carcinoma (HCC). The correct discrimination of them is essential for therapeutic strategies planning and survival ...

    Authors: Chuanming Li, Jiani Hu, Daiquan Zhou, Jun Zhao, Kuansheng Ma, Xuntao Yin and Jian Wang
    Citation: BMC Cancer 2014 14:590
    Content type: Research article Published on:

  5. This study was performed to develop a validated score predicting ambulatory status after radiotherapy (RT) alone for metastatic spinal cord compression (MSCC) in elderly patients.

    Authors: Dirk Rades, Jasmin N Evers, Volker Rudat, Amira Bajrovic, Johann H Karstens and Steven E Schild
    Citation: BMC Cancer 2014 14:589
    Content type: Research article Published on:

  6. Lung cancer cells have been reported to produce cytokines, resulting in systemic reactions. There have been few reports showing that these cytokines induced the formation of an inflammatory mass around lung ca...

    Authors: Masataka Matsumoto, Takashi Nakayama, Daiki Inoue, Kazufumi Takamatsu, Ryo Itotani, Manabu Ishitoko, Shinko Suzuki, Minoru Sakuramoto, Yoshiaki Yuba, Osamu Yoshie, Masaya Takemura and Motonari Fukui
    Citation: BMC Cancer 2014 14:588
    Content type: Case report Published on:

  7. In the process of epithelial mesenchymal transition EMT, the disassembly of junctional adhesion complexes such as E-cadherin is a remarkable sign during changes in cell morphology and polarity. However, E-cadh...

    Authors: Yuan-Chiang Chung, Wan-Chen Wei, Shin-Han Huang, Chi-Min Shih, Chih-Ping Hsu, King-Jen Chang and Wei-Ting Chao
    Citation: BMC Cancer 2014 14:587
    Content type: Research article Published on:

  8. Current treatment of diffuse-large-B-cell lymphoma (DLBCL) includes rituximab, an expensive drug, combined with cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy. Economic models h...

    Authors: Sara Khor, Jaclyn Beca, Murray Krahn, David Hodgson, Linda Lee, Michael Crump, Karen E Bremner, Jin Luo, Muhammad Mamdani, Chaim M Bell, Carol Sawka, Scott Gavura, Terrence Sullivan, Maureen Trudeau, Stuart Peacock and Jeffrey S Hoch
    Citation: BMC Cancer 2014 14:586
    Content type: Research article Published on:

  9. The purpose of this study was to evaluate the prognostic implication of findings of intratumoral metabolic heterogeneity on pretreatment 18F-FDG PET/CT scans in patients with invasive ductal carcinoma (IDC) of th...

    Authors: Seung Hyun Son, Do-Hoon Kim, Chae Moon Hong, Choon-Young Kim, Shin Young Jeong, Sang-Woo Lee, Jaetae Lee and Byeong-Cheol Ahn
    Citation: BMC Cancer 2014 14:585
    Content type: Research article Published on:

  10. Increasing focus on potentially unnecessary diagnosis and treatment of certain breast cancers prompted our investigation of whether clinical and mammographic features predictive of invasive breast cancer versu...

    Authors: Mehmet US Ayvaci, Oguzhan Alagoz, Jagpreet Chhatwal, Alejandro Munoz del Rio, Edward A Sickles, Houssam Nassif, Karla Kerlikowske and Elizabeth S Burnside
    Citation: BMC Cancer 2014 14:584
    Content type: Research article Published on:

  11. Hemostatic alterations occur during the development of cancer. Plasma D-dimer is a hypercoagulability and fibrinolytic system marker that is increased in patients with various solid tumours. The aim of this st...

    Authors: Wen-Hui Chen, Lin-Quan Tang, Feng-Wei Wang, Chang-Peng Li, Xiao-Peng Tian, Xiao-Xia Huang, Shi-Juan Mai, Yi-Ji Liao, Hai-Xia Deng, Qiu-Yan Chen, Huai Liu, Lu Zhang, Shan-Shan Guo, Li-Ting Liu, Shu-Mei Yan, Chao-Feng Li…
    Citation: BMC Cancer 2014 14:583
    Content type: Research article Published on:

  12. A specific targeting modality for hepatocellular carcinoma (HCC) could ideally encompass a liver cell specific delivery system of a transcriptional unit that is active only in neoplastic cells. Sendai virosome...

    Authors: Mohammad Khalid Zakaria, Imran Khan, Prashant Mani, Parthaprasad Chattopadhyay, Debi P Sarkar and Subrata Sinha
    Citation: BMC Cancer 2014 14:582
    Content type: Research article Published on:

  13. Differences in cancer awareness between individuals may explain variations in healthcare seeking behaviour and ultimately also variations in cancer survival. It is therefore important to examine cancer awarene...

    Authors: Line Hvidberg, Anette Fischer Pedersen, Christian Nielsen Wulff and Peter Vedsted
    Citation: BMC Cancer 2014 14:581
    Content type: Research article Published on:

  14. Transforming growth factor (TGF)-β plays a pivotal role in cancer progression through regulating cancer cell proliferation, invasion, and remodeling of the tumor microenvironment. Cancer-associated fibroblasts...

    Authors: Masafumi Horie, Akira Saito, Satoshi Noguchi, Yoko Yamaguchi, Mitsuhiro Ohshima, Yasuyuki Morishita, Hiroshi I Suzuki, Tadashi Kohyama and Takahide Nagase
    Citation: BMC Cancer 2014 14:580
    Content type: Research article Published on:

  15. Seroepidemiological studies have reported associations between exposure to sexually transmitted organisms and prostate cancer risk. This study sought DNA evidence of candidate organisms in archival prostate ca...

    Authors: Melissa A Yow, Sepehr N Tabrizi, Gianluca Severi, Damien M Bolton, John Pedersen, Anthony Longano, Suzanne M Garland, Melissa C Southey and Graham G Giles
    Citation: BMC Cancer 2014 14:579
    Content type: Research article Published on:

  16. Macrophage inhibitory cytokine 1 (MIC-1/GDF15) has been identified as a potential novel biomarker for detection of pancreatic cancer (PCa). However, the diagnostic value of serum MIC-1 for pancreatic ductal ad...

    Authors: Xiaobing Wang, Yanfen Li, Haimei Tian, Jun Qi, Mo Li, Chao Fu, Fan Wu, Yi Wang, Dongwan Cheng, Wenya Zhao, Chao Zhang, Teng Wang, Jianyu Rao and Wei Zhang
    Citation: BMC Cancer 2014 14:578
    Content type: Research article Published on:

  17. CDK11p58, a Ser/Thr kinase that belongs to the cell division cycle 2-like 1 (CDC2L1) subfamily, is associated with cell cycle progression, tumorigenesis and apoptotic signaling. CDK11p58 is also involved in the r...

    Authors: Yayun Chi, Sheng Huang, Lei Wang, Ruoji Zhou, Lisha Wang, Xiuying Xiao, Dali Li, Ying Cai, Xiaoyan Zhou and Jiong Wu
    Citation: BMC Cancer 2014 14:577
    Content type: Research article Published on:

  18. We previously reported that polyploid giant cancer cells (PGCCs) exhibit cancer stem cell properties and express cell cycle-related proteins. HEY PGCCs induced by cobalt chloride generated daughter cells and t...

    Authors: Hongcheng Lv, Yang Shi, Li Zhang, Dan Zhang, Guang Liu, Zhengduo Yang, Yan Li, Fei Fei and Shiwu Zhang
    Citation: BMC Cancer 2014 14:576
    Content type: Research article Published on:

  19. GIST patients often undergo GI-surgery. Previous studies have shown that imatinib and nilotinib exposures were decreased in GIST patients with prior major gastrectomy. We investigated whether major gastrectomy...

    Authors: Djoeke de Wit, Nielka P van Erp, Reza Khosravan, Robin Wiltshire, Randy Allred, George D Demetri, Henk-Jan Guchelaar and Hans Gelderblom
    Citation: BMC Cancer 2014 14:575
    Content type: Research article Published on:

  20. Poor attendance to cervical cancer (CC) screening is a major risk factor for CC. Efforts to capture underscreened women are considerable and once women agree to participate, the provision of longitudinal valid...

    Authors: Raquel Ibáñez, Josefina Autonell, Montserrat Sardà, Nayade Crespo, Pilar Pique, Amparo Pascual, Clara Martí, Montserrat Fibla, Cristina Gutiérrez, Belén Lloveras, Judit Moreno-Crespi, Anna Torrent, Núria Baixeras, María Alejo, Francesc Xavier Bosch and Silvia de Sanjosé
    Citation: BMC Cancer 2014 14:574
    Content type: Research article Published on:

  21. Two studies have reported statistically significant associations between the use of cardiac glycosides (CGs) and an increased risk of lung cancer. However, these studies had a number of methodological limitati...

    Authors: Sébastien Couraud, Laurent Azoulay, Sophie Dell’Aniello and Samy Suissa
    Citation: BMC Cancer 2014 14:573
    Content type: Research article Published on:

  22. Treatment of locally advanced non-small-cell lung cancer is based on a combined approach. To study the impact of trimodal therapy for stage III-N2 NSCLC a single centre retrospective evaluation focusing on sur...

    Authors: Vasileios Askoxylakis, Judith Tanner, Jutta Kappes, Hans Hoffmann, Nils H Nicolay, Harald Rief, Juergen Debus, Michael Thomas and Marc Bischof
    Citation: BMC Cancer 2014 14:572
    Content type: Research article Published on:

  23. Golgi phosphoprotein 3 (GOLPH3) has been identified as an oncoprotein in various human cancers; however, its role in pancreatic ductal adenocarcinoma (PDAC) is unknown. We examined GOLPH3 expression levels and...

    Authors: Luan-Jing Zhang, Ke-Bing Wang, Long-shan Liu, Lian-zhou Chen, Bao-Gang Peng, Li-Jian Liang, Zhi Li, Ling Xue, Wen Li and Jing-Tang Xia
    Citation: BMC Cancer 2014 14:571
    Content type: Research article Published on:

  24. Chk1 inhibitors are currently in clinical trials as putative potentiators of cytotoxic chemotherapy drugs. Chk1 inhibitors may exhibit single agent anti-tumor activity in cancers with underlying DNA repair, DN...

    Authors: Christopher Bryant, Rebecca Rawlinson and Andrew J Massey
    Citation: BMC Cancer 2014 14:570
    Content type: Research article Published on:

  25. Neuroendocrine tumors (NETs) of the esophagus are extremely rare, and few cases have been reported worldwide. Thus, a comprehensive nationwide study is needed to understand the characteristics of and treatment...

    Authors: Chang Geun Lee, Yun Jeong Lim, Seun Ja Park, Byung Ik Jang, Seok Reyol Choi, Jae Kwang Kim, Yong-Tae Kim, Joo Young Cho, Chang Hun Yang, Hoon Jai Chun and Si Young Song
    Citation: BMC Cancer 2014 14:569
    Content type: Research article Published on:

  26. A disintegrin and metalloprotease 8 (ADAM8) has been reported to be associated with various malignancies. However, no studies have examined ADAM8 association in colorectal cancer (CRC). The aim of this study w...

    Authors: Zuli Yang, Yang Bai, Lijun Huo, Hao Chen, Jintuan Huang, Jizheng Li, Xinjuan Fan, Zihuan Yang, Lei Wang and Jianping Wang
    Citation: BMC Cancer 2014 14:568
    Content type: Research article Published on:

  27. Increasingly, the role of chronic inflammation and its mediators in tumor generation and progression is gaining importance in the field of cancer research. In this context, candidature of non steroidal anti-in...

    Authors: Jolly Deb, Joydeb Majumder, Sankar Bhattacharyya and Siddhartha Sankar Jana
    Citation: BMC Cancer 2014 14:567
    Content type: Research article Published on:

  28. Coagulation and fibrinolysis activation is frequently observed in cancer patients, and the tumors in these cases are thought to be associated with a higher risk of invasion, metastasis, and worse long-term out...

    Authors: Yi-Jun Shu, Hao Weng, Run-Fa Bao, Xiang-Song Wu, Qian Ding, Yang Cao, Xu-An Wang, Fei Zhang, Shan-Shan Xiang, Huai-Feng Li, Mao-Lan Li, Jia-Sheng Mu, Wen-Guang Wu and Ying-Bin Liu
    Citation: BMC Cancer 2014 14:566
    Content type: Research article Published on:

  29. The phosphoinositide 3- kinase (PI3K) pathway is involved in the growth of various human cancers, including lymphoid malignancies. However its role in the pathogenesis of follicular lymphoma (FL) has not been ...

    Authors: Ouardia I Yahiaoui, Jacques A Nunès, Céline Castanier, Raynier Devillier, Florence Broussais, Aurélie J Fabre, Dalila Naimi, Réda Bouabdallah, Daniel Olive and Luc Xerri
    Citation: BMC Cancer 2014 14:565
    Content type: Research article Published on:

  31. The incidence of testicular germ cell tumors (TGCT), the most common cancer in men aged 15 to 45 years, has doubled over the last 30 years in developed countries. Reasons remain unclear but a role of environme...

    Authors: Rémi Béranger, Olivia Pérol, Louis Bujan, Elodie Faure, Jeffrey Blain, Charlotte Le Cornet, Aude Flechon, Barbara Charbotel, Thierry Philip, Joachim Schüz and Béatrice Fervers
    Citation: BMC Cancer 2014 14:563
    Content type: Study protocol Published on:

  32. We previously reported that 3'-ethynylcytidine (ECyd, TAS-106), an RNA polymerases inhibitor, enhances the anti-tumor efficacy of platinum in several tumor types in both in vitro and in vivo tumor models. However...

    Authors: Hiroto Fukushima, Tetsuya Abe, Kazuki Sakamoto, Hiroaki Tsujimoto, Shinji Mizuarai and Shinji Oie
    Citation: BMC Cancer 2014 14:562
    Content type: Research article Published on:

  33. Patients with advanced endocrine cancers, such as adrenocortical carcinoma and medullary thyroid carcinoma, have few well-validated therapeutic options. Pre-clinical studies have suggested potential activity o...

    Authors: Daniel M Halperin, Alexandria T Phan, Ana O Hoff, Marie Aaron, James C Yao and Paulo M Hoff
    Citation: BMC Cancer 2014 14:561
    Content type: Research article Published on:

  34. In addition to alterations concerning the expression of oncogenes and onco-suppressors, melanoma is characterized by the presence of distinctive gangliosides (sialic acid carrying glycosphingolipids). Ganglios...

    Authors: Cristina Tringali, Ilaria Silvestri, Francesca Testa, Paola Baldassari, Luigi Anastasia, Roberta Mortarini, Andrea Anichini, Alejandro López-Requena, Guido Tettamanti and Bruno Venerando
    Citation: BMC Cancer 2014 14:560
    Content type: Research article Published on:

  35. ΔNp63, a splice variant of p63, is overexpressed and exhibits oncogenic activity in many cancers including pancreatic and breast cancer and promotes cell survival by inhibiting apoptosis. Despite its role in t...

    Authors: Ram Mohan Ram Kumar, Michael M Betz, Bernhard Robl, Walter Born and Bruno Fuchs
    Citation: BMC Cancer 2014 14:559
    Content type: Research article Published on:

  36. The main aim of this study is to estimate the rate of false negative and true IC on the Program for the Early Detection of Breast Cancer (PEDBC) run by the Girona Health Region (GHR) and compare the clinicopat...

    Authors: Gemma Renart-Vicens, Montserrat Puig-Vives, Joan Albanell, Francesc Castañer, Joana Ferrer, Miquel Carreras, Joan Tarradas, Maria Sala and Rafael Marcos-Gragera
    Citation: BMC Cancer 2014 14:558
    Content type: Research article Published on:

  37. Although anal cancer is common in HIV positive men who have sex with men, few centres offer systematic screening. Regular digital ano-rectal examination (DARE) is a type of screening that has been recommended ...

    Authors: Jason J Ong, Marcus Chen, Andrew E Grulich and Christopher K Fairley
    Citation: BMC Cancer 2014 14:557
    Content type: Research article Published on:

  38. The widespread use of phthalates as plasticizers has raised public health concerns regarding their adverse effects, including an association with cancer. Although animal investigations have suggested an associ...

    Authors: Cheng-Fang Tsai, Tsung-Hua Hsieh, Jau-Nan Lee, Chia-Yi Hsu, Yu-Chih Wang, Feng-Jie Lai, Kung-Kai Kuo, Hua-Lin Wu, Eing-Mei Tsai and Po-Lin Kuo
    Citation: BMC Cancer 2014 14:556
    Content type: Research article Published on:

  39. Cervical cancer continues to threaten women’s health worldwide, and the incidence of cervical adenocarcinoma (AD) is rising in the developed countries. Previously, we showed that glucose-regulated protein 58 (...

    Authors: Chia-Jung Liao, Tzu-I Wu, Ya-Hui Huang, Ting-Chang Chang, Chyong-Huey Lai, Shih-Ming Jung, Chuen Hsueh and Kwang-Huei Lin
    Citation: BMC Cancer 2014 14:555
    Content type: Research article Published on:

  40. The purpose of this study was to evaluate the survival outcome for middle ear cancer and to construct prognostic models to provide patients and clinicians with more accurate estimates of individual survival pr...

    Authors: Weidong Shen, Naoko Sakamoto and Limin Yang
    Citation: BMC Cancer 2014 14:554
    Content type: Research article Published on:

  41. A rare syndrome of watery diarrhea, hypokalemia and achlorhydria (WDHA) is usually caused by pancreatic endocrine tumors that secrete excessive vasoactive intestinal polypeptide (VIP). Here we report a rare ca...

    Authors: Jingjing Jiang, Li Zhang, Zhaodi Wu, Zhilong Ai, Yingyong Hou, Zhiqiang Lu and Xin Gao
    Citation: BMC Cancer 2014 14:553
    Content type: Case report Published on:

  42. E-cadherin is an adherens junction protein that forms homophilic intercellular contacts in epithelial cells while also interacting with the intracellular cytoskeletal networks. It has roles including establish...

    Authors: Augustine Chen, Henry Beetham, Michael A Black, Rashmi Priya, Bryony J Telford, Joanne Guest, George A R Wiggins, Tanis D Godwin, Alpha S Yap and Parry J Guilford
    Citation: BMC Cancer 2014 14:552
    Content type: Research article Published on:

  43. Oncolytic viruses represent a promising therapy against cancers with acquired drug resistance. However, low efficacy limits its clinical application. The objective of this study is to investigate whether pharm...

    Authors: Ke Jiang, Yingchun Li, Qiumin Zhu, Jiansheng Xu, Yupeng Wang, Wuguo Deng, Quentin Liu, Guirong Zhang and Songshu Meng
    Citation: BMC Cancer 2014 14:551
    Content type: Research article Published on:

  44. Patients with luminal HER2-negative tumours have a favourable prognosis. However, there is a subpopulation in which poorer outcomes are obtained with endocrine therapy alone. This subpopulation is considered t...

    Authors: Yoshiya Horimoto, Atsushi Arakawa, Masahiko Tanabe, Hiroshi Sonoue, Fumie Igari, Koji Senuma, Emi Tokuda, Hideo Shimizu, Taijiro Kosaka and Mitsue Saito
    Citation: BMC Cancer 2014 14:550
    Content type: Research article Published on:

  45. One in eight women will be affected by breast cancer in her lifetime. Approximately 75% of breast cancers express estrogen receptor alpha (ERα) and/or progesterone receptor and these receptors are markers for ...

    Authors: Jae Woo Jung, Sun Young Shim, Dong Kun Lee, Witek Kwiatkowski and Senyon Choe
    Citation: BMC Cancer 2014 14:549
    Content type: Research article Published on:

  47. Nine-beta-D-arabinofuranosylguanine (ara-G), an active metabolite of nelarabine, enters leukemic cells through human Equilibrative Nucleoside Transporter 1, and is then phosphorylated to an intracellular activ...

    Authors: Takahiro Yamauchi, Kanako Uzui, Rie Nishi, Hiroko Shigemi and Takanori Ueda
    Citation: BMC Cancer 2014 14:547
    Content type: Research article Published on:

  48. Ectopic TSH-secreting pituitary adenoma (TSH-oma) is a very unusual disorder. To date, there are only four cases reported. It is difficult to distinguish ectopic cases from both regular TSH-omas and resistance...

    Authors: Mingqiang Song, Haijing Wang, Li Song, Haiye Tian, Quanxu Ge, Jun Li, Yan Zhu, Jizhou Li, Runzhen Zhao and Hong-Long Ji
    Citation: BMC Cancer 2014 14:544
    Content type: Case report Published on:

  49. Brain metastasis from epithelial ovarian cancer (EOC) is very rare with a reported incidence of less than 2%. It is usually associated with a poor prognosis that is related to several factors, the most importa...

    Authors: Raffaele Longo, Christian Platini, Nada Eid, Clémence Elias-Matta, Thaar Buda, Denis 'Nguyen and Philippe Quétin
    Citation: BMC Cancer 2014 14:543
    Content type: Case report Published on:

  50. The modified Glasgow Prognostic Score (mGPS) has been reported to be an important prognostic indicator in a number of tumor types, including colorectal cancer (CRC). The features of the inflammatory state thou...

    Authors: Trevor D Hamilton, Derek Leugner, Karen Kopciuk, Elijah Dixon, Francis R Sutherland and Oliver F Bathe
    Citation: BMC Cancer 2014 14:542
    Content type: Research article Published on:

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