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  1. One of the hallmarks of cancer is the occurrence of high levels of chromosomal rearrangements as a result of inaccurate repair of double-strand breaks (DSB). Germline mutations in BRCA and RAD51 genes, involved i...

    Authors: Ana Paula Carneiro Brandalize, Lavínia Schüler-Faccini, Jean-Sébastien Hoffmann, Maira Caleffi, Christophe Cazaux and Patricia Ashton-Prolla
    Citation: BMC Cancer 2014 14:850
  2. Gefitinib, an EGFR-tyrosine kinase inhibitor, significantly improve prognosis in patients with advanced non-small cell lung cancer (NSCLC). The aim of this study was to evaluate the usefulness of MUC1 and vasc...

    Authors: Jian Li, Yi-Ming Hu, Yong-Jie Du, Li-Rong Zhu, Hai Qian, Yan Wu and Wei-Lin Shi
    Citation: BMC Cancer 2014 14:848
  3. Triple negative breast cancer (TNBC) is a distinct subtype of breast cancer burdened with a dismal prognosis due to the lack of effective therapeutic agents. Receptors for LHRH (luteinizing hormone-releasing h...

    Authors: Stephan Seitz, Stefan Buchholz, Andrew Victor Schally, Florian Weber, Monika Klinkhammer-Schalke, Elisabeth C Inwald, Roberto Perez, Ferenc G Rick, Luca Szalontay, Florian Hohla, Sabine Segerer, Chui Wai Kwok, Olaf Ortmann and Jörg Bernhard Engel
    Citation: BMC Cancer 2014 14:847
  4. The procoagulant state in cancer increases the thrombotic risk, but also supports tumor progression. To investigate the molecular mechanisms controlling cancer and hemostasis, we conducted a case-control study...

    Authors: Mari Tinholt, Marte Kathrine Viken, Anders Erik Dahm, Hans Kristian Moen Vollan, Kristine Kleivi Sahlberg, Øystein Garred, Anne-Lise Børresen-Dale, Anne Flem Jacobsen, Vessela Kristensen, Ida Bukholm, Rolf Kåresen, Ellen Schlichting, Grethe Skretting, Benedicte Alexandra Lie, Per Morten Sandset and Nina Iversen
    Citation: BMC Cancer 2014 14:845
  5. Previous studies have shown that preoperative anemia is correlated with the prognoses of various solid tumors. This study was performed to determine the effect of preoperative anemia on relapse and survival in...

    Authors: YingJun Zhang, YuYang Chen, DongTai Chen, Yu Jiang, Wan Huang, HanDong Ouyang, Wei Xing, MuSheng Zeng, XiaoMing Xie and Weian Zeng
    Citation: BMC Cancer 2014 14:844
  6. We sought to determine the comparative diagnostic performance of standard b-value (800–1000 s/mm2) versus low b-value (400–500 s/mm2) diffusion-weighted magnetic resonance imaging (DW-MRI) in the detection of ren...

    Authors: Yanlong Tang, Yue Zhou, Wei Du, Ning Liu, Chengzhi Zhang, Tianzhao Ouyang and Jinbo Hu
    Citation: BMC Cancer 2014 14:843
  7. The bisdioxopiperazine dexrazoxane (DRZ) prevents anthracycline-induced heart failure, but its clinical use is limited by uncertain cardioprotective mechanism and by concerns of interference with cancer respon...

    Authors: Shiwei Deng, Tiandong Yan, Cathleen Jendrny, Andrea Nemecek, Mladen Vincetic, Ute Gödtel-Armbrust and Leszek Wojnowski
    Citation: BMC Cancer 2014 14:842
  8. Epoxyeicosatrienoic acids (EETs) are derived from arachidonic acid by cytochrome P450 (CYP) and metabolized by soluble epoxide hydrolase (sEH). EETs have been associated with cardiovascular disease, diabetes a...

    Authors: Xiaolong Wei, Donghong Zhang, Xiaowei Dou, Na Niu, Wenhe Huang, Jingwen Bai and Guojun Zhang
    Citation: BMC Cancer 2014 14:841
  9. Segmental genomic copy number alterations, such as loss of 11q or 3p and gain of 17q, are well established markers of poor outcome in neuroblastoma, and have been suggested to comprise tumor suppressor genes o...

    Authors: Sandra Ackermann, Hayriye Kocak, Barbara Hero, Volker Ehemann, Yvonne Kahlert, André Oberthuer, Frederik Roels, Jessica Theißen, Margarete Odenthal, Frank Berthold and Matthias Fischer
    Citation: BMC Cancer 2014 14:840
  10. Indigenous and/or minority ethnic women are known to experience longer delays for treatment of breast cancer, which has been shown to contribute to ethnic inequities in breast cancer mortality. We examined fac...

    Authors: Sanjeewa Seneviratne, Ian Campbell, Nina Scott, Marion Kuper-Hommel, Glenys Round and Ross Lawrenson
    Citation: BMC Cancer 2014 14:839
  11. Percutaneous needle aspiration or biopsy (PCNA or PCNB) is an established diagnostic technique that has a high diagnostic yield. However, its role in the diagnosis of nodular ground-glass opacities (nGGOs) is ...

    Authors: Jaeyoung Cho, Sung-Jun Ko, Se Joong Kim, Yeon Joo Lee, Jong Sun Park, Young-Jae Cho, Ho Il Yoon, Sukki Cho, Kwhanmien Kim, Sanghoon Jheon, Jae Ho Lee and Choon-Taek Lee
    Citation: BMC Cancer 2014 14:838
  12. Primary systemic treatment for ovarian cancer is surgery, followed by platinum based chemotherapy. Platinum resistant cancers progress/recur in approximately 25% of cases within six months. We aimed to identif...

    Authors: Zsófia Pénzváltó, András Lánczky, Julianna Lénárt, Nóra Meggyesházi, Tibor Krenács, Norbert Szoboszlai, Carsten Denkert, Imre Pete and Balázs Győrffy
    Citation: BMC Cancer 2014 14:837
  13. Current knowledge about the molecular properties and prognostic markers of upper tract urothelial carcinoma (UTUC) is sparse and often based on bladder urothelial carcinoma (UC), which is thought to share comm...

    Authors: Song Wu, Jiahao Chen, Pei Dong, Shiqiang Zhang, Yingying He, Liang Sun, Jialou Zhu, Yanbing Cheng, Xianxin Li, Aifa Tang, Yi Huang, Yaoting Gui, Chunxiao Liu, Guosheng Yang, Fangjian Zhou, Zhiming Cai…
    Citation: BMC Cancer 2014 14:836
  14. EBV-encoded latent membrane protein 1 (EBV-LMP1) is an important oncogenic protein for nasopharyngeal carcinoma (NPC) and has been shown to engage a plethora of signaling pathways. Correspondingly, an LMP1-tar...

    Authors: Wei-Hua Liao, Li-Fang Yang, Xiao-Yu Liu, Gao-Feng Zhou, Wu-Zhong Jiang, Bob-Lei Hou, Lun-Quan Sun, Ya Cao and Xiao-Yi Wang
    Citation: BMC Cancer 2014 14:835
  15. The translocations of the anaplastic lymphoma kinase (ALK) gene with the echinoderm microtubule-associated protein-like 4 (EML4) gene on chromosome 2p have been identified in non-small-cell lung cancers (NSCLCs) ...

    Authors: Yongjun Guo, Jie Ma, Xiaodong Lyu, Hai Liu, Bing Wei, Jiuzhou Zhao, Shuang Fu, Lu Ding and Jihong Zhang
    Citation: BMC Cancer 2014 14:834
  16. To appraise the role of volumetric modulated arc (RapidArc, RA) in the treatment of anal canal carcinoma (ACC).

    Authors: Angelo Tozzi, Luca Cozzi, Cristina Iftode, Annamaria Ascolese, Maria Concetta Campisi, Elena Clerici, Tiziana Comito, Fiorenza De Rose, Antonella Fogliata, Ciro Franzese, Pietro Mancosu, Piera Navarria, Stefano Tomatis, Elisa Villa and Marta Scorsetti
    Citation: BMC Cancer 2014 14:833
  17. To evaluate the prognostic significance of paranasal sinus invasion for patients with NPC and to provide empirical proofs for the T-staging category of paranasal sinus invasion according to the AJCC staging sy...

    Authors: Li Tian, Yi-Zhuo Li, Yun-Xian Mo, Li-Zhi Liu, Chuan-Miao Xie, Xue-Xia Liang, Xiao Gong and Wei Fan
    Citation: BMC Cancer 2014 14:832
  18. Epidemiological evidence of relationships between endometriosis and epithelial ovarian cancer (EOC) has been obtained mainly from Western countries. Our goal was to determine the risk of EOC due to endometrios...

    Authors: Kuan-Chin Wang, Wen-Hsun Chang, Wen-Ling Lee, Nicole Huang, Hsin-Yi Huang, Ming-Shyen Yen, Chao-Yu Guo and Peng-Hui Wang
    Citation: BMC Cancer 2014 14:831
  19. BRCA1 promoter methylation has been detected in DNA from peripheral blood cells of both breast cancer patients and cancer-free females. However, the pathological significance of this epigenetic change in white b...

    Authors: Nisreen Al-Moghrabi, Asmaa Nofel, Nujoud Al-Yousef, Safia Madkhali, Suad M Bin Amer, Ayodele Alaiya, Zakia Shinwari, Taher Al-Tweigeri, Bedri Karakas, Asma Tulbah and Abdelilah Aboussekhra
    Citation: BMC Cancer 2014 14:830
  20. To characterize prognostic and risk factors of central nervous system (CNS) metastases in patients with epithelial ovarian cancer (EOC).

    Authors: Bo-lin Liu, Shu-juan Liu, Andrius Baskys, Hong Cheng, Ying Han, Chao Xie, Hui Song, Jia Li and Xiao-yan Xin
    Citation: BMC Cancer 2014 14:829
  21. Cachexia may occur in 40% of cancer patients, representing the major cause of death in more than 20% of them. The aim of this study was to investigate the role of leptin, ghrelin and obestatin as diagnostic an...

    Authors: Patrizia Mondello, Antonio Lacquaniti, Stefania Mondello, Davide Bolignano, Vincenzo Pitini, Carmela Aloisi and Michele Buemi
    Citation: BMC Cancer 2014 14:828
  22. Gender-based differences in disease onset in murine models of malignant peripheral nerve sheath tumor (MPNST) and in patients with Neurofibromatosis type-1-(NF-1)-associated or spontaneous MPNST has not been w...

    Authors: Elizabeth Shurell, Linh M Tran, Jonathan Nakashima, Kathleen B Smith, Brenna M Tam, Yunfeng Li, Sarah M Dry, Noah Federman, William D Tap, Hong Wu and Fritz C Eilber
    Citation: BMC Cancer 2014 14:827
  23. Although invasive lobular carcinoma (ILC) of the breast differs from invasive ductal carcinoma (IDC) in numerous respects - including its genetics, clinical phenotype, metastatic pattern, and chemosensitivity ...

    Authors: Hilda Wong, Silvia Lau, Polly Cheung, Ting Ting Wong, Andrew Parker, Thomas Yau and Richard J Epstein
    Citation: BMC Cancer 2014 14:826
  24. Aggressive metastatic breast cancer cells seemingly evade surgical resection and current therapies, leading to colonization in distant organs and tissues and poor patient prognosis. Therefore, high-throughput in ...

    Authors: Mark Tyler Nelson, Aaron Short, Sara L Cole, Amy C Gross, Jessica Winter, Tim D Eubank and John J Lannutti
    Citation: BMC Cancer 2014 14:825
  25. Oropharyngeal cancer (OPC) associated with human papilloma virus (HPV OPC) shows better treatment outcomes than non-HPV OPC. We investigated the expression of p53, β-tubulin, bcl-2 and ERCC 1, which are well-k...

    Authors: Min-Jee Kim, Myung-Seo Ki, Karham Kim, Hyun-Jeong Shim, Jun-Eul Hwang, Woo-Kyun Bae, Ik-Joo Chung, Dong-Hoon Lee, Joon-Kyoo Lee, Tae-Mi Yoon, Sang-Chul Lim, Woong-Ki Chung, Jae-Uk Jeong, Hoi-Soon Lim, Yoo-Duk Choi and Sang-Hee Cho
    Citation: BMC Cancer 2014 14:824
  26. Lauren-classification and human epidermal growth factor receptor 2 (HER2) status are two important pathological features of gastric cancer patients. The prognostic value of HER2 in gastric cancer remains contr...

    Authors: Miaozhen Qiu, Yixin Zhou, Xinke Zhang, Zixian Wang, Fang Wang, Jianyong Shao, Jiabin Lu, Ying Jin, Xiaoli Wei, Dongsheng Zhang, Fenghua Wang, Yuhong Li, Dajun Yang and Ruihua Xu
    Citation: BMC Cancer 2014 14:823
  27. Vulvar carcinoma is an infrequent tumour, accounting for fewer than 3% of all malignant tumours that affect women, but its incidence is rising in the past few decades. In young women, the manifestation of the ...

    Authors: Erica M Akagi, André M Lavorato-Rocha, Beatriz de Melo Maia, Iara S Rodrigues, Kátia C Carvalho, Monica M Stiepcich, Glauco Baiocchi, Yukie Sato-Kuwabara, Silvia R Rogatto, Fernando A Soares and Rafael M Rocha
    Citation: BMC Cancer 2014 14:822
  28. Comorbidity has an adverse impact on cancer survival partly through its negative impact on receipt of curative treatment. Comorbidity is unevenly distributed within populations, with some ethnic and socioecono...

    Authors: Diana Sarfati, Jason Gurney, James Stanley and Jonathan Koea
    Citation: BMC Cancer 2014 14:821
  29. Apatinib is a tyrosine kinase inhibitor targeting vascular endothelial growth factor receptor 2(VEGFR-2). This study was conducted to assess the efficacy and safety of apatinib in patients with non-triple-nega...

    Authors: Xichun Hu, Jun Cao, Wenwei Hu, Changping Wu, Yueyin Pan, Li Cai, Zhongsheng Tong, Shusen Wang, Jin Li, Zhonghua Wang, Biyun Wang, Xiaoyu Chen and Hao Yu
    Citation: BMC Cancer 2014 14:820
  30. MicroRNA-21 (miR-21) has been suggested to play a significant role in the prognosis of carcinoma. The recognition of novel biomarkers for the prediction of cancer outcomes is urgently required. However, the po...

    Authors: Wenjia Wang, Jinhui Li, Wei Zhu, Chen Gao, RuiJingfang Jiang, Wenxue Li, Qiansheng Hu and Bo Zhang
    Citation: BMC Cancer 2014 14:819
  31. The management of liver metastases from nasopharyngeal carcinoma (NPC) has not been extensively investigated. This study aimed to compare the long-term outcome of patients with liver metastases from NPC who we...

    Authors: Jun Huang, Qijiong Li, Yun Zheng, Jingxian Shen, Binkui Li, Ruhai Zou, Jianping Wang and Yunfei Yuan
    Citation: BMC Cancer 2014 14:818
  32. Evidence has accumulated which suggests that sex steroids influence colorectal cancer development and progression. We therefore assessed the association of repeat polymorphisms in the estrogen receptor β gene (ES...

    Authors: Anja Rudolph, Hong Shi, Asta Försti, Michael Hoffmeister, Juan Sainz, Lina Jansen, Kari Hemminki, Hermann Brenner and Jenny Chang-Claude
    Citation: BMC Cancer 2014 14:817
  33. The management of rectal cancer (RC) has substantially changed over the last decades with the implementation of neoadjuvant chemoradiotherapy, adjuvant therapy and improved surgery such as total mesorectal exc...

    Authors: Armin Wiegering, Christoph Isbert, Ulrich A Dietz, Volker Kunzmann, Sabine Ackermann, Alexander Kerscher, Uwe Maeder, Michael Flentje, Nicolas Schlegel, Joachim Reibetanz, Christoph-Thomas Germer and Ingo Klein
    Citation: BMC Cancer 2014 14:816
  34. Hepatocellular carcinoma (HCC) is a malignancy with poor survival outcome. New treatment options for the disease are needed. In this study, we identified and evaluated tumor vascular PLVAP as a therapeutic tar...

    Authors: Yun-Hsin Wang, Tsung-Yen Cheng, Ta-Yuan Chen, Kai-Ming Chang, Vincent P Chuang and Kuo-Jang Kao
    Citation: BMC Cancer 2014 14:815
  35. Pancreatic adenocarcinoma is one of the most lethal cancers, yet it remains understudied and poorly understood. Hyperinsulinemia has been reported to be a risk factor of pancreatic cancer, and the rapid rise o...

    Authors: Michelle T Chan, Gareth E Lim, Søs Skovsø, Yu Hsuan Carol Yang, Tobias Albrecht, Emilyn U Alejandro, Corinne A Hoesli, James M Piret, Garth L Warnock and James D Johnson
    Citation: BMC Cancer 2014 14:814
  36. Preclinical studies have documented antitumor activity of PARP inhibition both in vitro and in vivo, against Ewing sarcoma cells. This study aimed to translate that observation into a clinical trial to assess the...

    Authors: Edwin Choy, James E Butrynski, David C Harmon, Jeffrey A Morgan, Suzanne George, Andrew J Wagner, David D’Adamo, Gregory M Cote, Yael Flamand, Cyril H Benes, Daniel A Haber, Jose M Baselga and George D Demetri
    Citation: BMC Cancer 2014 14:813
  37. Prostate cancer (PC) incidence and progression may be influenced by dietary factors, but little is known about the acceptability of dietary modification to men at increased risk of PC. Qualitative interviews w...

    Authors: Jeremy P Horwood, Kerry NL Avery, Chris Metcalfe, Jenny L Donovan, Freddie C Hamdy, David E Neal and J Athene Lane
    Citation: BMC Cancer 2014 14:812
  38. Although altered levels of adiponectin have been reported as a potential risk factor in colorectal cancer (CRC), the importance of the role played by adiponectin in colorectal carcinogenesis has not been estab...

    Authors: Chung Hyun Tae, Seong-Eun Kim, Sung-Ae Jung, Yang-Hee Joo, Ki-Nam Shim, Hye-Kyung Jung, Tae Hun Kim, Min-Sun Cho, Kwang Ho Kim and Joung Sook Kim
    Citation: BMC Cancer 2014 14:811
  39. Purpose of this study was to analyse the surgical management and long-term clinical outcome of patients diagnosed with colorectal liver metastases (CLM) over a period of 10 years using data from a German tumou...

    Authors: Christina Hackl, Peter Neumann, Michael Gerken, Martin Loss, Monika Klinkhammer-Schalke and Hans J Schlitt
    Citation: BMC Cancer 2014 14:810
  40. The pathogenesis of multiple myeloma involves complex genetic and epigenetic events. This study aimed to investigate the role and clinical relevance of the long non-coding RNA (lncRNA), metastasis-associated l...

    Authors: Shih-Feng Cho, Yuli Christine Chang, Chao-Sung Chang, Sheng-Fung Lin, Yi-Chang Liu, Hui-Hua Hsiao, Jan-Gowth Chang and Ta-Chih Liu
    Citation: BMC Cancer 2014 14:809
  41. Radiotherapy is a chosen treatment option for prostate cancer patients and while some tumours respond well, up to 50% of patients may experience tumour recurrence. Identification of functionally relevant predi...

    Authors: Arabella Young, Rachael Berry, Adele F Holloway, Nicholas B Blackburn, Joanne L Dickinson, Marketa Skala, Jessica L Phillips and Kate H Brettingham-Moore
    Citation: BMC Cancer 2014 14:808
  42. Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) provide an effective treatment option for selected patients with colorectal peritoneal metastasis with encouraging survival res...

    Authors: Gabriel Glockzin, Michael Gerken, Sven A Lang, Monika Klinkhammer-Schalke, Pompiliu Piso and Hans J Schlitt
    Citation: BMC Cancer 2014 14:807
  43. In this study, we examined patients who had non-progressive disease for at least 2 years after diagnosis of inoperable locoregional recurrent or metastatic breast cancer under continuous trastuzumab treatment....

    Authors: Isabell Witzel, Volkmar Müller, Wolfgang Abenhardt, Manfred Kaufmann, Winfried Schoenegg, Andreas Schneeweis and Fritz Jänicke
    Citation: BMC Cancer 2014 14:806
  44. Cancer is the leading cause of disease-related death in adolescents and young adults (AYA). Annual improvements in AYA cancer survival have been inferior to those observed in children and older adults. Prior s...

    Authors: Nancy N Baxter, Corinne Daly, Sumit Gupta, Jason D Pole, Rinku Sutradhar, Mark L Greenberg and Paul C Nathan
    Citation: BMC Cancer 2014 14:805
  45. Anterior gradient 2 (AGR2) has been implicated in tumor-associated phenotypes such as cell viability, invasion and metastasis in various human cancers. However, the tumor promoting activity of AGR2 has not yet...

    Authors: Su Jin Kim, Suyeon Jun, Hee-Yeon Cho, Dong Chul Lee, Young Il Yeom, Jong Hyeok Kim and Dongchul Kang
    Citation: BMC Cancer 2014 14:804
  46. Mutations in KRAS, BRAF and PIK3CA are the most common somatic alterations found in the colorectal cancer (CRC) patients from Western countries; but their prevalence and prognostic value have not been adequately ...

    Authors: Jing Chen, Fang Guo, Xin Shi, Lihua Zhang, Aifeng Zhang, Hui Jin and Youji He
    Citation: BMC Cancer 2014 14:802
  47. Superparamagnetic poly (lactic-co-glycolic acid) (PLGA)-coated Fe3O4 microcapsules are receiving increased attention as potential diagnostic and therapeutic modalities in the field of oncology. In this study, PLG...

    Authors: Yang Sun, Yuanyi Zheng, Pan Li, Dong Wang, Chengcheng Niu, Yuping Gong, Rongzhong Huang, Zhibiao Wang, Zhigang Wang and Haitao Ran
    Citation: BMC Cancer 2014 14:800
  48. Epithelial ovarian cancer (EOC) is the most common cause of gynecological malignancy-related mortality. Ovarian clear cell carcinoma (CCC) has unique clinical characteristics and behaviors that differ from oth...

    Authors: Yukihiro Hirata, Noriyuki Murai, Nozomu Yanaihara, Misato Saito, Motoaki Saito, Mitsuyoshi Urashima, Yasuko Murakami, Senya Matsufuji and Aikou Okamoto
    Citation: BMC Cancer 2014 14:799
  49. Recurrent T1-2 Nasopharyngeal Carcinoma (rT1-2) may be salvaged by 3D – CRT (3D-Conformal Radiotherapy), IMRT (Intensity Modulated Radiotherapy), Brachytherapy (BT), BT with external radiotherapy. The purpose ...

    Authors: Sufang Qiu, Jun Lu, Wei Zheng, Luying Xu, Shaojun Lin, Chaobin Huang, Yuanji Xu, Lingling Huang and Jianji Pan
    Citation: BMC Cancer 2014 14:797
  50. The aim of this study was to examine the efficacy and safety of everolimus in patients with progressive unresectable adenoid cystic carcinoma (ACC).

    Authors: Dong-Wan Kim, Do-Youn Oh, Seong Hoon Shin, Jin Hyoung Kang, Byoung Chul Cho, Joo-Seop Chung, HyeJin Kim, Keon Uk Park, Jung Hye Kwon, Ji-Youn Han, Mi-Jung Kim and Yung-Jue Bang
    Citation: BMC Cancer 2014 14:795

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