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  1. 17β-hydroxysteroid dehydrogenase type 10 (HSD10) has been shown to play a protective role in cells undergoing stress. Upregulation of HSD10 under nutrient-limiting conditions leads to recovery of a homeostatic...

    Authors: Emily A Carlson, Rebecca T Marquez, Fang Du, Yongfu Wang, Liang Xu and Shirley ShiDu Yan
    Citation: BMC Cancer 2015 15:166
    Content type: Research article Published on:

  2. Electroporation is a novel treatment technique utilizing electric pulses, traveling between two or more electrodes, to ablate targeted tissue. The first in human studies have proven the safety of IRE for the a...

    Authors: Peter GK Wagstaff, Daniel M de Bruin, Patricia J Zondervan, C Dilara Savci Heijink, Marc RW Engelbrecht, Otto M van Delden, Ton G van Leeuwen, Hessel Wijkstra, Jean JMCH de la Rosette and M Pilar Laguna Pes
    Citation: BMC Cancer 2015 15:165
    Content type: Study protocol Published on:

  3. The EphB4 receptor tyrosine kinase is overexpressed in many cancers including prostate cancer. The molecular mechanisms by which this ephrin receptor influences cancer progression are complex as there are tumo...

    Authors: Inga Mertens-Walker, Bruno C Fernandini, Mohanan SN Maharaj, Anja Rockstroh, Colleen C Nelson, Adrian C Herington and Sally-Anne Stephenson
    Citation: BMC Cancer 2015 15:164
    Content type: Research article Published on:

  4. Hyponatraemia is a common finding in patients with cancer, and has been shown to be associated with poor prognosis in different settings. We have analysed the impact of severe hyponatraemia in patients with ca...

    Authors: Kirsty Balachandran, Alicia Okines, Ranga Gunapala, Daniel Morganstein and Sanjay Popat
    Citation: BMC Cancer 2015 15:163
    Content type: Research article Published on:

  5. The potential benefits of colorectal cancer screening are limited by low uptake. This study tested whether providing narrative accounts of the colorectal cancer (CRC) screening experience positively affected b...

    Authors: Lesley M McGregor, Christian von Wagner, Gemma Vart, Wing Chee Yuen, Rosalind Raine, Jane Wardle and Kathryn A Robb
    Citation: BMC Cancer 2015 15:162
    Content type: Research article Published on:

  7. Metastasis of colorectal cancer (CRC) is directly linked to patient survival. We previously identified the novel gene Metastasis Associated in Colon Cancer 1 (MACC1) in CRC and demonstrated its importance as m...

    Authors: Viktor H Koelzer, Pia Herrmann, Inti Zlobec, Eva Karamitopoulou, Alessandro Lugli and Ulrike Stein
    Citation: BMC Cancer 2015 15:160
    Content type: Research article Published on:

  8. High levels of thymidine kinase 1 (TK1) and thymidine phosphorylase (TYMP) are key molecular targets by thymidine therapeutics in cancer treatment. The dual roles of TYMP as a tumor growth factor and a key act...

    Authors: Qiong Wei, Haijuan Liu, Honghao Zhou, Dejun Zhang, Zhiwei Zhang and Qibing Zhou
    Citation: BMC Cancer 2015 15:159
    Content type: Research article Published on:

  9. Although microRNAs offer great potential as cancer biomarkers, effective clinical dignostics and tumor maker have not been verified to diagnose with colorectal cancer (CRC). The purpose of our study is to syst...

    Authors: Juan Peng, Zhengyong Xie, Liyang Cheng, Yuxin Zhang, Junyong Chen, Hongping Yu, Zehang Li and Huixing Kang
    Citation: BMC Cancer 2015 15:158
    Content type: Research article Published on:

  10. Thyroid neoplasias with oncocytic features represent a specific phenotype in non-medullary thyroid cancer, reflecting the unique biological phenomenon of mitochondrial hyperplasia in the cytoplasm. Oncocytic t...

    Authors: Cecilia Evangelisti, Dario de Biase, Ivana Kurelac, Claudio Ceccarelli, Holger Prokisch, Thomas Meitinger, Paola Caria, Roberta Vanni, Giovanni Romeo, Giovanni Tallini, Giuseppe Gasparre and Elena Bonora
    Citation: BMC Cancer 2015 15:157
    Content type: Research article Published on:

  11. We systematically reviewed the evidence for the interaction of microsatellite instability status (MSI) and treatment with 5FU in colorectal cancer to determine how well MSI status predicts health outcomes in p...

    Authors: Elizabeth M Webber, Tia L Kauffman, Elizabeth O’Connor and Katrina AB Goddard
    Citation: BMC Cancer 2015 15:156
    Content type: Research article Published on:

  12. The role of urine markers in the surveillance of patients with non-muscle invasive bladder cancer (NMIBC) is discussed extensively. In case of negative cystoscopy the additional prognostic value of these marke...

    Authors: Tilman Todenhöfer, Jörg Hennenlotter, Philipp Guttenberg, Sarah Mohrhardt, Ursula Kuehs, Michael Esser, Stefan Aufderklamm, Simone Bier, Niklas Harland, Steffen Rausch, Georgios Gakis, Arnulf Stenzl and Christian Schwentner
    Citation: BMC Cancer 2015 15:155
    Content type: Research article Published on:

  13. We retrospectively reviewed outcomes of treatment with pazopanib, an oral multi-tyrosine kinase angiogenesis inhibitor, in patients with advanced soft tissue sarcoma, a rare and heterogeneous tumor group with ...

    Authors: Kwai Han Yoo, Hyo Song Kim, Su Jin Lee, Se Hoon Park, Sung Joo Kim, Soo Hee Kim, Yoon La Choi, Kyoo-Ho Shin, Yong Jin Cho, Jeeyun Lee and Sun Young Rha
    Citation: BMC Cancer 2015 15:154
    Content type: Research article Published on:

  15. One of the major controversies of contemporary medicine is created by an increased consumption of nicotine and growing evidence of its connection to cancer, which urges elucidation of the molecular mechanisms ...

    Authors: Alex I Chernyavsky, Igor B Shchepotin, Valentin Galitovkiy and Sergei A Grando
    Citation: BMC Cancer 2015 15:152
    Content type: Research article Published on:

  16. Cancers of unknown primary (CUPs) constitute ~5% of all cancers. The tumors have an aggressive biological and clinical behavior. The aim of the present study has been to uncover whether CUPs exhibit distinct m...

    Authors: Jonas Vikeså, Anne Kirstine H Møller, Bogumil Kaczkowski, Rehannah Borup, Ole Winther, Ricardo Henao, Anders Krogh, Katharina Perell, Flemming Jensen, Gedske Daugaard and Finn C Nielsen
    Citation: BMC Cancer 2015 15:151
    Content type: Research article Published on:

  17. Tobacco smoking and red meat consumption are some of the known risk factors associated with the development of oesophageal cancer. N-acetytransferases (NAT1 and NAT2) play a key role in metabolism of carcinogenic...

    Authors: Marco Matejcic, Matjaz Vogelsang, Yabing Wang and Iqbal M Parker
    Citation: BMC Cancer 2015 15:150
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2015 15:658

  18. To compare the prognosis of upper urinary tract (UUT)-urothelial carcinoma (UC) and UC of the bladder (UCB) by pathological staging in patients treated with radical surgeries.

    Authors: Myong Kim, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim and Ja Hyeon Ku
    Citation: BMC Cancer 2015 15:149
    Content type: Research article Published on:

  19. Mutations in the TP53 (Tumour Protein 53) gene can lead to expression of mutant p53 proteins that accumulate in cancer cells and can induce circulating p53 antibodies in cancer patients. Our aim was to evaluate t...

    Authors: Manlio Mattioni, Silvia Soddu, Andrea Prodosmo, Paolo Visca, Salvatore Conti, Gabriele Alessandrini, Francesco Facciolo and Lidia Strigari
    Citation: BMC Cancer 2015 15:148
    Content type: Research article Published on:

  20. Studies evaluating the presence of viral sequences in breast cancer (BC), including various strains of human papillomavirus and human herpes virus, have yielded conflicting results. Most were based on RT-PCR and

    Authors: Danai Fimereli, David Gacquer, Debora Fumagalli, Roberto Salgado, Françoise Rothé, Denis Larsimont, Christos Sotiriou and Vincent Detours
    Citation: BMC Cancer 2015 15:147
    Content type: Research article Published on:

  21. With advances in hepatocellular carcinoma (HCC) screening and treatment, the incidence of diagnosing a case of extrahepatic primary malignancy (EHPM) in patients with HCC has increased. This study aimed to elu...

    Authors: Sukho Hong, Sook-Hyang Jeong, Sang Soo Lee, Jung Wha Chung, Sung Wook Yang, Seong Min Chung, Eun Sun Jang, Jin-Wook Kim, Jee Hyun Kim, Haeryoung Kim, Jai Young Cho, Yoo-Seok Yoon and Ho-Seong Han
    Citation: BMC Cancer 2015 15:146
    Content type: Research article Published on:

  22. CBX7 is a Polycomb group protein that shows variable expression changes in various cancers that are often contradictive. A mouse knockout experiment has validated the tumor suppressor role in carcinogenesis. T...

    Authors: Xiang Zheng, Jing Zhou, Baozhen Zhang, Jun Zhang, James Wilson, Liankun Gu, Budong Zhu, Jin Gu, Jiafu Ji and Dajun Deng
    Citation: BMC Cancer 2015 15:145
    Content type: Research article Published on:

  23. HIV infection is a known risk factor for cancer but little is known about HIV testing patterns and the burden of HIV infection in cancer patients. We did a cross-sectional analysis to identify predictors of pr...

    Authors: Mazvita Sengayi, Chantal Babb, Matthias Egger and Margaret I Urban
    Citation: BMC Cancer 2015 15:144
    Content type: Research article Published on:

  24. Breast density and single-nucleotide polymorphisms (SNPs) have both been associated with breast cancer risk. To determine the extent to which these two breast cancer risk factors are associated, we investigate...

    Authors: Brad M Keller, Anne Marie McCarthy, Jinbo Chen, Katrina Armstrong, Emily F Conant, Susan M Domchek and Despina Kontos
    Citation: BMC Cancer 2015 15:143
    Content type: Research article Published on:

  25. Preoperative radiochemotherapy improves outcomes in patients with locally advanced rectal carcinoma, and has been used increasingly in patient management. However, there is a strong clinical need to assess tum...

    Authors: Lianhuang Li, Zhifen Chen, Xingfu Wang, Hongsheng Li, Weizhong Jiang, Shuangmu Zhuo, Guoxian Guan and Jianxin Chen
    Citation: BMC Cancer 2015 15:142
    Content type: Research article Published on:

  26. Lactate dehydrogenase A (LDHA) and Pyruvate Kinase M2 (PKM2) are important enzymes of glycolysis. Both of them can be phosphorylated and therefore regulated by Fibroblast growth factor receptor 1 (FGFR1). Whil...

    Authors: Paul Kachel, Bogusz Trojanowicz, Carsten Sekulla, Hanna Prenzel, Henning Dralle and Cuong Hoang-Vu
    Citation: BMC Cancer 2015 15:140
    Content type: Research article Published on:

  27. Annonaceous acetogenins are a family of natural products with antitumor activities. Annonaceous acetogenin mimic AA005 reportedly inhibits mammalian mitochondrial NADH-ubiquinone reductase (Complex I) and indu...

    Authors: Bing Han, Tong-Dan Wang, Shao-Ming Shen, Yun Yu, Chan Mao, Zhu-Jun Yao and Li-Shun Wang
    Citation: BMC Cancer 2015 15:139
    Content type: Research article Published on:

  28. Response to endocrine therapy in breast cancer correlates with estrogen receptor (ER) and progesterone receptor (PR) status. Generally, hormone receptor-positive (HR+) breast cancers have favorable prognosis. ...

    Authors: Soo Youn Bae, Sangmin Kim, Jun Ho Lee, Hyun-chul Lee, Se Kyung Lee, Won Ho Kil, Seok Won Kim, Jeong Eon Lee and Seok Jin Nam
    Citation: BMC Cancer 2015 15:138
    Content type: Research article Published on:

  29. The use of imaging to implement on-treatment adaptation of radiotherapy is a promising paradigm but current data on imaging changes during radiotherapy is limited. This is a hypothesis-generating pilot study t...

    Authors: Manil Subesinghe, Andrew F Scarsbrook, Steven Sourbron, Daniel J Wilson, Garry McDermott, Richard Speight, Neil Roberts, Brendan Carey, Roan Forrester, Sandeep Vijaya Gopal, Jonathan R Sykes and Robin JD Prestwich
    Citation: BMC Cancer 2015 15:137
    Content type: Research article Published on:

  30. Exactly assessing tumor response to different dose of chemotherapy would help to tailor therapy for individual patients. This study was to determine the feasibility of dynamic contrast-enhanced ultrasound (CEU...

    Authors: Yao Chen, Feng Han, Long-hui Cao, Cheng Li, Jian-wei Wang, Qing Li, Wei Zheng, Zhi-xing Guo, An-hua Li and Jian-hua Zhou
    Citation: BMC Cancer 2015 15:136
    Content type: Research article Published on:

  31. Insulin-like growth factor binding protein 7 (IGFBP7) has been suggested to act as a tumour suppressor gene in various human cancers, yet its role in epithelial ovarian cancer (EOC) has not yet been investigated....

    Authors: Karen Gambaro, Michael CJ Quinn, Katia Y Cáceres-Gorriti, Rebecca S Shapiro, Diane Provencher, Kurosh Rahimi, Anne-Marie Mes-Masson and Patricia N Tonin
    Citation: BMC Cancer 2015 15:135
    Content type: Research article Published on:

  32. Hepatocellular carcinoma (HCC) is a major cause of cancer deaths worldwide. However, current chemotherapeutic drugs for HCC are either poorly effective or expensive, and treatment with these drugs has not led ...

    Authors: Yu-Min Feng, Chin-Wen Feng, Syue-Yi Chen, Hsiao-Yen Hsieh, Yu-Hsin Chen and Cheng-Da Hsu
    Citation: BMC Cancer 2015 15:134
    Content type: Research article Published on:

  33. The burden of cancer is likely to increase among the human immunodeficiency virus (HIV)-positive population as it ages due to successful antiretroviral therapy (ART). The purpose of this study was to determine...

    Authors: Chang-Hua Chen, Chih-Yuan Chung, Li-Hsuan Wang, Che Lin, Hsiu-Li Lin and Hsiu-Chen Lin
    Citation: BMC Cancer 2015 15:133
    Content type: Research article Published on:

  34. ETS variant 1 (ETV1) and E3 ubiquitin ligase constitutive photomorphogenetic 1 (COP1) have been proposed to be a pair of oncogene and tumor suppressor. However, the co-existing status of ETV1 and COP1 in tripl...

    Authors: Mao Ouyang, Hua Wang, Jieyi Ma, Weiming Lü, Jie Li, Chen Yao, Guangqi Chang, Jiong Bi, Shenming Wang and Wenjian Wang
    Citation: BMC Cancer 2015 15:132
    Content type: Research article Published on:

  35. Eukaryotic Initiation factor 6 (eIF6) is a peculiar translation initiation factor that binds to the large 60S ribosomal subunits, controlling translation initiation and participating in ribosome biogenesis. In...

    Authors: Michela Pinzaglia, Claudia Montaldo, Dorina Polinari, Mattei Simone, Anna La Teana, Marco Tripodi, Carmine Mancone, Paola Londei and Dario Benelli
    Citation: BMC Cancer 2015 15:131
    Content type: Research article Published on:

  36. Cancer-associated fibroblasts (CAFs) play an important role in breast cancer pathogenesis by paracrine regulation of breast cancer cell biology. Several in vitro and mouse models have characterized the role of ce...

    Authors: Abdel Nasser Hosein, Julie Livingstone, Marguerite Buchanan, James F Reid, Michael Hallett and Mark Basik
    Citation: BMC Cancer 2015 15:130
    Content type: Research article Published on:

  37. Of many specialized blood cells, monocytes are gaining increasing attention for their role in neoplastic disorders. The purpose of the present investigation was to determine the expression of selected peripher...

    Authors: Maciej Jóźwik, Osazee E Okungbowa, Alina Lipska, Marcin Jóźwik, Marzena Smoktunowicz, Andrzej Semczuk, Michał Jóźwik and Piotr Radziwon
    Citation: BMC Cancer 2015 15:129
    Content type: Research article Published on:

  38. Osteopontin (OPN) can recruit macrophages to the site of inflammation and promote tumorigenesis. M2 tumor-associated macrophages (M2-TAMs) also play an important role in cancer progression. This study aimed to...

    Authors: Chang-Ni Lin, Chih-Jung Wang, Ying-Jui Chao, Ming-Derg Lai and Yan-Shen Shan
    Citation: BMC Cancer 2015 15:128
    Content type: Research article Published on:

  39. Angiogenesis, among other signaling pathways, plays a key-role in sarcoma biology. Regorafenib (RE) has recently been shown to be effective in imatinib and sunitinib-refractory GIST in a phase III trial.

    Authors: Thomas Brodowicz, Bernadette Liegl-Atzwager, Emmanuelle Tresch, Sophie Taieb, Andrew Kramar, Viktor Gruenwald, Marie Vanseymortier, Stéphanie Clisant, Jean-Yves Blay, Axel Le Cesne and Nicolas Penel
    Citation: BMC Cancer 2015 15:127
    Content type: Study protocol Published on:

  40. Intrahepatic cholangiocarcinomas (ICC) are relatively rare malignant tumors associated with a poor prognosis. Recent studies using genome-wide sequencing technologies have mainly focused on identifying new dri...

    Authors: Cyril Dalmasso, Wassila Carpentier, Catherine Guettier, Sophie Camilleri-Broët, Wyllians Vendramini Borelli, Cedália Rosane Campos dos Santos, Denis Castaing, Jean-Charles Duclos-Vallée and Philippe Broët
    Citation: BMC Cancer 2015 15:126
    Content type: Research Article Published on:

  41. Molecular alterations are well studied in colon cancer, however there is still need for an improved understanding of their prognostic impact. This study aims to characterize colon cancer with regard to KRAS, B...

    Authors: Helgi Birgisson, Karolina Edlund, Ulrik Wallin, Lars Påhlman, Hanna Göransson Kultima, Markus Mayrhofer, Patrick Micke, Anders Isaksson, Johan Botling, Bengt Glimelius and Magnus Sundström
    Citation: BMC Cancer 2015 15:125
    Content type: Research article Published on:

  42. Alcohol consumption is associated with higher breast cancer risk. While studies suggest a modest association between alcohol intake and mammographic density, few studies have examined the association in racial...

    Authors: Zoe Quandt, Julie D Flom, Parisa Tehranifar, Diane Reynolds, Mary Beth Terry and Jasmine A McDonald
    Citation: BMC Cancer 2015 15:124
    Content type: Research article Published on:

  43. Inflammatory cytokines in the colonic microenvironment have been shown to increase with advance colorectal cancer disease state. However, the contribution of inflammatory cytokines to pre-malignant disease, su...

    Authors: Curtis J Henry, Rebecca L Sedjo, Andrii Rozhok, Jennifer Salstrom, Dennis Ahnen, Theodore R Levin, Ralph D’Agostino Jr, Steven Haffner, James DeGregori and Tim Byers
    Citation: BMC Cancer 2015 15:123
    Content type: Research article Published on:

  44. We performed a multicenter, double-blind, placebo-controlled, phase II clinical trial of human dsDNA-based preparation Panagen in a tablet form. In total, 80 female patients with stage II-IV breast cancer were...

    Authors: Anastasia S Proskurina, Tatiana S Gvozdeva, Ekaterina A Alyamkina, Evgenia V Dolgova, Konstantin E Orishchenko, Valeriy P Nikolin, Nelly A Popova, Sergey V Sidorov, Elena R Chernykh, Alexandr A Ostanin, Olga Y Leplina, Victoria V Dvornichenko, Dmitriy M Ponomarenko, Galina S Soldatova, Nikolay A Varaksin, Tatiana G Ryabicheva…
    Citation: BMC Cancer 2015 15:122
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:117

  45. Despite multimodal therapy esophageal cancer often presents with poor prognosis. To improve outcome, tumor angiogenesis and anti-angiogenic therapeutic agents have recently gained importance. However, patient ...

    Authors: Lena Dreikhausen, Susanne Blank, Leila Sisic, Ulrike Heger, Wilko Weichert, Dirk Jäger, Thomas Bruckner, Natalia Giese, Lars Grenacher, Christine Falk, Katja Ott and Thomas Schmidt
    Citation: BMC Cancer 2015 15:121
    Content type: Research article Published on:

  46. This study aimed to evaluate the behavior of non-muscle-invasive bladder cancer (NMIBC) in patients submitted to transurethral bladder resection (TURB) comparing subjects in chronic therapy with aspirin, stati...

    Authors: Antonio Luigi Pastore, Giovanni Palleschi, Andrea Fuschi, Luigi Silvestri, Yazan Al Salhi, Elisabetta Costantini, Alessandro Zucchi, Vincenzo Petrozza, Cosimo de Nunzio and Antonio Carbone
    Citation: BMC Cancer 2015 15:120
    Content type: Research article Published on:

  47. Everolimus (RAD001) is an orally administered mTOR inhibitor that is well known for its antitumor efficacy and that has been approved for the treatment of several solid tumors, including renal cell carcinoma. ...

    Authors: Ji Hyun Park, Min-Hee Ryu, Young Soo Park, Sook Ryun Park, Young-Soon Na, Baek-Yeol Rhoo and Yoon-Koo Kang
    Citation: BMC Cancer 2015 15:119
    Content type: Case report Published on:

  48. Malignant glioma is one of the most devastating tumors in adults with poor patient prognosis. Notably, glioma often exhibits resistance to conventional chemotherapeutic approaches, complicating patient treatme...

    Authors: Sangeetha Sukumari-Ramesh, Niyathi Prasad, Cargill H Alleyne Jr, John R Vender and Krishnan M Dhandapani
    Citation: BMC Cancer 2015 15:118
    Content type: Research article Published on:

  50. Capecitabine has activity against several types of cancer. In 10-15% of patients treated with capecitabine, treatment is discontinued because of serious adverse reactions, mostly within the first weeks of trea...

    Authors: Melanie JM van Pelt-Sprangers, Eric CT Geijteman, Jelmer Alsma, Ingrid A Boere, Ron HJ Mathijssen and Stephanie CE Schuit
    Citation: BMC Cancer 2015 15:115
    Content type: Case report Published on:

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