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  1. Colorectal cancer patients with unresectable liver-only metastases may be cured after downsizing of metastases by neoadjuvant systemic therapy. However, the optimal neoadjuvant induction regimen has not been d...

    Authors: Joost Huiskens, Thomas M van Gulik, Krijn P van Lienden, Marc RW Engelbrecht, Gerrit A Meijer, Nicole CT van Grieken, Jonne Schriek, Astrid Keijser, Linda Mol, I Quintus Molenaar, Cornelis Verhoef, Koert P de Jong, Kees HC Dejong, Geert Kazemier, Theo M Ruers, Johanus HW de Wilt…
    Citation: BMC Cancer 2015 15:365
    Content type: Study protocol Published on:

  2. Muscle invasive bladder cancer (MIBC) is often lethal and non-MIBC (NMIBC) can recur and progress, yet prognostic markers are currently inadequate. SAM68, a member of RNA-binding proteins, has been reported to...

    Authors: Zhiling Zhang, Chunping Yu, Yonghong Li, Lijuan Jiang and Fangjian Zhou
    Citation: BMC Cancer 2015 15:364
    Content type: Research article Published on:

  3. Outcome of consecutive patients with locally advanced non-small cell lung cancer and histopathologically proven mediastional lymph node metastases treated with induction chemotherapy, neoadjuvant radiochemothe...

    Authors: Christoph Pöttgen, Martin Stuschke, Britta Graupner, Dirk Theegarten, Thomas Gauler, Verena Jendrossek, Lutz Freitag, Jehad Abu Jawad, Eleni Gkika, Jeremias Wohlschlaeger, Stefan Welter, Matthias Hoiczyk, Martin Schuler, Georgios Stamatis and Wilfried Eberhardt
    Citation: BMC Cancer 2015 15:363
    Content type: Research article Published on:

  4. Hepatitis B virus (HBV)-X protein(HBx) is a transactivator of host several cellular genes including alpha-fetoprotein(AFP) and AFP receptor(AFPR) which contributes to HBV-associated tumor development. The expr...

    Authors: Mingyue Zhu, Junli Guo, Wei Li, Hua Xia, Yan Lu, Xu Dong, Yi Chen, Xieju Xie, Shigan Fu and Mengsen Li
    Citation: BMC Cancer 2015 15:362
    Content type: Research article Published on:

  5. Cervical cancer is the third most common cancer in women globally, and despite treatment, distant metastasis and nodal recurrence will still develop in approximately 30% of patients. The ability to predict whi...

    Authors: Christine How, Jeff Bruce, Jonathan So, Melania Pintilie, Benjamin Haibe-Kains, Angela Hui, Blaise A Clarke, David W Hedley, Richard P Hill, Michael Milosevic, Anthony Fyles and Fei-Fei Liu
    Citation: BMC Cancer 2015 15:361
    Content type: Research article Published on:

  6. Circulating tumor cells (CTCs) are malignant cells that have migrated from solid cancers into the blood, where they are typically present in rare numbers. There is great interest in using CTCs to monitor respo...

    Authors: Daniel E Campton, Arturo B Ramirez, Joshua J Nordberg, Nick Drovetto, Alisa C Clein, Paulina Varshavskaya, Barry H Friemel, Steve Quarre, Amy Breman, Michael Dorschner, Sibel Blau, C Anthony Blau, Daniel E Sabath, Jackie L Stilwell and Eric P Kaldjian
    Citation: BMC Cancer 2015 15:360
    Content type: Technical advance Published on:

  7. Metronomic oral vinorelbine could be a safe option for elderly patients with advanced non small cell lung cancer (NSCLC). Metronomic administration of chemotherapy leads to a cytostatic action shifting treatme...

    Authors: Andrea Camerini, Cheti Puccetti, Sara Donati, Chiara Valsuani, Maria Cristina Petrella, Gianna Tartarelli, Paolo Puccinelli and Domenico Amoroso
    Citation: BMC Cancer 2015 15:359
    Content type: Research article Published on:

  8. Multidrug resistance (MDR) is a major obstacle to the treatment of gastric cancer (GC). Using a phage display approach, we previously obtained the peptide GMBP1, which specifically binds to the surface of MDR ...

    Authors: Xiaojuan Wang, Yani Li, Guanghui Xu, Muhan Liu, Lin Xue, Lijuan Liu, Sijun Hu, Ying Zhang, Yongzhan Nie, Shuhui Liang, Biaoluo Wang and Jie Ding
    Citation: BMC Cancer 2015 15:358
    Content type: Research article Published on:

  9. ZFP36 is an mRNA binding protein that exerts anti-tumor activity in glioblastoma by triggering cell death, associated to an increase in the stability of the kinase RIP1.

    Authors: Tommaso Selmi, Claudia Alecci, Miriam dell’ Aquila, Lucia Montorsi, Andrea Martello, Filippo Guizzetti, Nicola Volpi, Sandra Parenti, Sergio Ferrari, Paolo Salomoni, Alexis Grande and Tommaso Zanocco-Marani
    Citation: BMC Cancer 2015 15:357
    Content type: Research article Published on:

  10. Malignant melanoma is an aggressive tumor type that often develops drug resistance to targeted therapeutics. The production of colony stimulating factor 1 (CSF-1) in tumors recruits myeloid cells such as M2-po...

    Authors: Stephen Mok, Jennifer Tsoi, Richard C Koya, Siwen Hu-Lieskovan, Brian L West, Gideon Bollag, Thomas G Graeber and Antoni Ribas
    Citation: BMC Cancer 2015 15:356
    Content type: Research article Published on:

  11. Despite the well-described benefits of laparoscopic surgery such as lower operative blood loss and enhanced postoperative recovery in gastric cancer surgery, the application of laparoscopic surgery in patients...

    Authors: Hoon Hur, Hyun Yong Lee, Hyuk-Joon Lee, Min Chan Kim, Woo Jin Hyung, Young Kyu Park, Wook Kim and Sang-Uk Han
    Citation: BMC Cancer 2015 15:355
    Content type: Study protocol Published on:

  12. Cancer treatment, and in particular end-of-life treatment, is associated with substantial healthcare costs. The purpose of this study was to analyse healthcare costs attributable to the treatment of patients w...

    Authors: Line Stjernholm Tipsmark, Cody Eric Bünger, Miao Wang, Søren Schmidt Morgen, Benny Dahl and Rikke Søgaard
    Citation: BMC Cancer 2015 15:354
    Content type: Research article Published on:

  13. In cervical cancer patients with intermediate-risk factors, the optimal adjuvant therapy is still controversial. We undertook a randomized trial (ClinicalTrials.gov Identifier: NCT01418859) to compare the effi...

    Authors: Wenze Sun, Tao Wang, Fan Shi, Jiquan Wang, Juan Wang, Beina Hui, Yingbing Zhang, Jinli Lu, Hongwei Chen and Zi Liu
    Citation: BMC Cancer 2015 15:353
    Content type: Research article Published on:

  14. Tumour relapse is recognized to be the prime fatal burden in patients affected by head and neck squamous cell carcinoma (HNSCC), but no discrete molecular trait has yet been identified to make reliable early p...

    Authors: Anna Farnedi, Silvia Rossi, Nicoletta Bertani, Mariolina Gulli, Enrico Maria Silini, Maria Teresa Mucignat, Tito Poli, Enrico Sesenna, Davide Lanfranco, Lucio Montebugnoli, Elisa Leonardi, Claudio Marchetti, Renato Cocchi, Andrea Ambrosini-Spaltro, Maria Pia Foschini and Roberto Perris
    Citation: BMC Cancer 2015 15:352
    Content type: Research article Published on:

  15. The complex cellular networks within tumors, the cytokine milieu, and tumor immune escape mechanisms affecting infiltration and anti-tumor activity of immune cells are of great interest to understand tumor for...

    Authors: Ariane Giannattasio, Sandra Weil, Stephan Kloess, Nariman Ansari, Ernst H K Stelzer, Adelheid Cerwenka, Alexander Steinle, Ulrike Koehl and Joachim Koch
    Citation: BMC Cancer 2015 15:351
    Content type: Technical advance Published on:

  16. Plenty of studies have demonstrated the prognostic value of various inflammation-based indexes in cancer. This study was designed to investigate the prognostic value of the C-reactive protein/albumin (CRP/Alb)...

    Authors: Xiao-li Wei, Feng-hua Wang, Dong-sheng Zhang, Miao-zhen Qiu, Chao Ren, Ying Jin, Yi-xin Zhou, De-shen Wang, Ming-ming He, Long Bai, Feng Wang, Hui-yan Luo, Yu-hong Li and Rui-hua Xu
    Citation: BMC Cancer 2015 15:350
    Content type: Research article Published on:

  17. Clusterin (CLU) is a ubiquitous multifunctional factor involved in neoplastic transformation. The CLU transcript variants and protein forms play a crucial role in balancing cells proliferation and death.

    Authors: Paolo Fuzio, Anna Napoli, Anna Ciampolillo, Serafina Lattarulo, Angela Pezzolla, Nicoletta Nuzziello, Sabino Liuni, Francesco Giorgino, Eugenio Maiorano and Elda Perlino
    Citation: BMC Cancer 2015 15:349
    Content type: Research article Published on:

  18. The aim of this study was to evaluate the clinical efficacy of postoperative radiotherapy (PORT), administered using three-dimensional conformal radiotherapy (3D-CRT) and our institutional standard clinical ta...

    Authors: Wen Feng, Qin Zhang, Xiao-Long Fu, Xu-Wei Cai, Zheng-Fei Zhu, Huan-Jun Yang, Jia-Qing Xiang, Ya-Wei Zhang and Hai-Quan Chen
    Citation: BMC Cancer 2015 15:348
    Content type: Research article Published on:

  19. The pretreatment albumin to globulin ratio (AGR) has been reported to correlate with the long-term survival in patients with various cancers. However, there are no reports regarding the correlation between the...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Hiroshi Ohtani, Yasuhito Iseki, Tetsuro Ikeya, Kenji Sugano and Kosei Hirakawa
    Citation: BMC Cancer 2015 15:347
    Content type: Research article Published on:

  20. Previous study showed that mitochondrial ND6 (mitND6) gene missense mutation resulted in NADH dehydrogenase deficiency and was associated with tumor metastasis in several mouse tumor cell lines. In the present...

    Authors: Yang Yuan, Weixing Wang, Huizhong Li, Yongwei Yu, Jin Tao, Shengdong Huang and Zhiyong Zeng
    Citation: BMC Cancer 2015 15:346
    Content type: Research article Published on:

  21. MicroRNAs (miRNAs) are short non-coding RNA molecules that play a critical role in mRNA cleavage and translational repression, and are known to be altered in many diseases including breast cancer. MicroRNA-10a...

    Authors: Sonja Khan, Deirdre Wall, Catherine Curran, John Newell, Michael J Kerin and Roisin M Dwyer
    Citation: BMC Cancer 2015 15:345
    Content type: Research article Published on:

  22. Acute myeloid leukaemia (AML) with central nervous system (CNS) involvement in adults is uncommon, and studies of this subject are scant.

    Authors: Chieh-Lung Cheng, Chi-Cheng Li, Hsin-An Hou, Wei-Quan Fang, Chin-Hao Chang, Chien-Ting Lin, Jih-Luh Tang, Wen-Chien Chou, Chien-Yuan Chen, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Shang-Ju Wu, Woei Tsay and Hwei-Fang Tien
    Citation: BMC Cancer 2015 15:344
    Content type: Research article Published on:

  23. We have preliminarily reported MTA2 expression in gastric cancer and its biological functions by using knockdown cell models, while the molecular mechanisms of MTA2 in regulating malignant behaviors are still ...

    Authors: Chenfei Zhou, Jun Ji, Qu Cai, Min Shi, Xuehua Chen, Yingyan Yu, Zhenggang Zhu and Jun Zhang
    Citation: BMC Cancer 2015 15:343
    Content type: Research article Published on:

  24. Wilms’ tumor gene 1 (WT1) can act as a suppressor or activator of tumourigenesis in different types of human malignancies. The role of WT1 in squamous cell carcinoma of the head and neck (SCCHN) is not clear. Ove...

    Authors: Xingru Li, Sofia Ottosson, Sihan Wang, Emma Jernberg, Linda Boldrup, Xiaolian Gu, Karin Nylander and Aihong Li
    Citation: BMC Cancer 2015 15:342
    Content type: Research article Published on:

  25. B-cell leukemia 3 (Bcl-3) is a member of the inhibitor of κB family, which regulates a wide range of biological processes by functioning as a transcriptional activator or as a repressor of target genes. Elevat...

    Authors: Karunakar Saamarthy, Sofie Björner, Martin Johansson, Göran Landberg, Ramin Massoumi, Karin Jirström and Katarzyna Chmielarska Masoumi
    Citation: BMC Cancer 2015 15:341
    Content type: Research article Published on:

  26. KRAS mutation occurs in 35%-40% of colorectal cancer (CRC). The aim of our study was to evaluate the pathological and molecular features of specific KRAS mutated colorectal carcinomas. KRAS and BRAF ...

    Authors: Wenbin Li, Tian Qiu, Wenxue Zhi, Susheng Shi, Shuangmei Zou, Yun Ling, Ling Shan, Jianming Ying and Ning Lu
    Citation: BMC Cancer 2015 15:340
    Content type: Research article Published on:

  27. Axitinib is an orally active and potent tyrosine kinase inhibitor of vascular endothelial growth factor receptors 1, 2 and 3. This phase II study assessed the efficacy and safety of axitinib combined with cisp...

    Authors: Igor M Bondarenko, Antonella Ingrosso, Paul Bycott, Sinil Kim and Cristina L Cebotaru
    Citation: BMC Cancer 2015 15:339
    Content type: Research article Published on:

  28. We analyzed the relationship between prostate cancer outcomes and pretreatment clinical factors and developed a prognostic nomogram of overall survival (OS) of patients with bone metastasis.

    Authors: Yasuhide Miyoshi, Kazumi Noguchi, Masahiro Yanagisawa, Masataka Taguri, Satoshi Morita, Ichiro Ikeda, Kiyoshi Fujinami, Takeshi Miura, Kazuki Kobayashi and Hiroji Uemura
    Citation: BMC Cancer 2015 15:338
    Content type: Research article Published on:

  29. DNA methylation variability regions (MVRs) across the oestrogen receptor alpha (ESR1) gene have been identified in peripheral blood cells from breast cancer patients and healthy individuals. In contrast to promot...

    Authors: Natalie S Shenker, Kirsty J Flower, Charlotte S Wilhelm-Benartzi, Wei Dai, Emma Bell, Edmund Gore, Mona El Bahrawy, Gillian Weaver, Robert Brown and James M Flanagan
    Citation: BMC Cancer 2015 15:337
    Content type: Research article Published on:

  31. Cancer cells exhibit increased glycolysis for ATP production (the Warburg effect) and macromolecular biosynthesis; it is also linked with therapeutic resistance that is generally associated with compromised re...

    Authors: Anant Narayan Bhatt, Ankit Chauhan, Suchit Khanna, Yogesh Rai, Saurabh Singh, Ravi Soni, Namita Kalra and Bilikere S Dwarakanath
    Citation: BMC Cancer 2015 15:335
    Content type: Research article Published on:

  32. Optimising population-based cervical screening policies is becoming more complex due to the expanding range of screening technologies available and the interplay with vaccine-induced changes in epidemiology. M...

    Authors: Diana Mendes, Iren Bains, Tazio Vanni and Mark Jit
    Citation: BMC Cancer 2015 15:334
    Content type: Research article Published on:

  33. Cancer-associated fibroblasts (CAFs), which reside around tumor cells, are suggested to play a pivotal role in tumor progression. Here we performed microarray analyses to compare gene expression profiles betwe...

    Authors: Chao Sun, Hirokazu Fukui, Ken Hara, Xinxing Zhang, Yoshitaka Kitayama, Hirotsugu Eda, Toshihiko Tomita, Tadayuki Oshima, Shojiro Kikuchi, Jiro Watari, Mitsuru Sasako and Hiroto Miwa
    Citation: BMC Cancer 2015 15:333
    Content type: Research article Published on:

  34. Talin-1 is a cytoskeletal protein that plays an important role in tumourgenesis, migration and metastasis in several malignant tumors. The aim of this study was to evaluate the expression and prognostic value ...

    Authors: Ya-Fei Xu, Xian-Yue Ren, Ying-Qin Li, Qing-Mei He, Xin-Ran Tang, Ying Sun, Jian-Yong Shao, Wei-Hua Jia, Tie-Bang Kang, Mu-Sheng Zeng, Na Liu and Jun Ma
    Citation: BMC Cancer 2015 15:332
    Content type: Research article Published on:

  35. DNA damage repair genes JWA, XRCC1 and BRCA1 were associated with clinical outcomes and could convert the response to the cisplatin-based therapy in some carcinomas. The synergistic effects of JWA, XRCC1 and B...

    Authors: Bin Wei, Qin Han, Lijuan Xu, Xiaohui Zhang, Jing Zhu, Li Wan, Yan Jin, Zhaoye Qian, Jingjing Wu, Yong Gao, Jianwei Zhou and Xiaofei Chen
    Citation: BMC Cancer 2015 15:331
    Content type: Research article Published on:

  36. The aim of our study was to investigate the incidence of papillary thyroid microcarcinoma (PTMC) in patients operated for benign thyroid diseases (BTD) and its relation to age, sex, extent of surgery and type ...

    Authors: Nikola Slijepcevic, Vladan Zivaljevic, Jelena Marinkovic, Sandra Sipetic, Aleksandar Diklic and Ivan Paunovic
    Citation: BMC Cancer 2015 15:330
    Content type: Research article Published on:

  37. Screening for the early detection of colorectal cancer is important to improve patient survival. The aim of this study was to investigate the potential of circulating cell-free miRNAs as biomarkers of CRC, and...

    Authors: Sinéad T Aherne, Stephen F Madden, David J Hughes, Barbara Pardini, Alessio Naccarati, Miroslav Levy, Pavel Vodicka, Paul Neary, Paul Dowling and Martin Clynes
    Citation: BMC Cancer 2015 15:329
    Content type: Research article Published on:

  38. A cancer diagnosis elicits greater distress than any other medical diagnosis, and yet very few studies have evaluated the efficacy of structured online self-help therapeutic programs to alleviate this distress...

    Authors: Lisa Beatty, Emma Kemp, Tracey Wade and Bogda Koczwara
    Citation: BMC Cancer 2015 15:328
    Content type: Study protocol Published on:

  39. The optimal sequence of chemotherapeutic agents is not firmly established for the treatment of metastatic colorectal cancer (mCRC). This phase II multi-centre study investigated the efficacy and tolerability o...

    Authors: Pilar Garcia-Alfonso, Manuel Chaves, Andrés Muñoz, Antonieta Salud, Maria García-Gonzalez, Cristina Grávalos, Bartomeu Massuti, Encarna González-Flores, Bernardo Queralt, Amelia López-Ladrón, Ferran Losa, Maria Jose Gómez, Amparo Oltra and Enrique Aranda
    Citation: BMC Cancer 2015 15:327
    Content type: Research article Published on:

  40. The local invasion of tumor cells into the surrounding tissue is the first and most critical step of the metastatic cascade. Cells can invade either collectively, or individually. Individual cancer cell invasi...

    Authors: Katarína Vaškovičová, Emilia Szabadosová, Vladimír Čermák, Aneta Gandalovičová, Lenka Kasalová, Daniel Rösel and Jan Brábek
    Citation: BMC Cancer 2015 15:326
    Content type: Research article Published on:

  41. Hepatocyte carcinoma (HCC) is one of the most common malignancies worldwide. Despite many achievements in diagnosis and treatment, HCC mortality remains high due to the malignant nature of the disease. Novel a...

    Authors: Hao Liu, Qun Wei, Jia Wang, Xiaoming Huang, Chunchun Li, Qiaoli Zheng, Jiang Cao and Zhenyu Jia
    Citation: BMC Cancer 2015 15:325
    Content type: Research article Published on:

  42. No previous study has addressed the efficacy of NF-κB blockade when bladder tumors develop acquired resistance toward CDDP-treatments. We investigated the changes in NF-κB activation and therapeutic impact of ...

    Authors: Yujiro Ito, Eiji Kikuchi, Nobuyuki Tanaka, Takeo Kosaka, Eriko Suzuki, Ryuichi Mizuno, Toshiaki Shinojima, Akira Miyajima, Kazuo Umezawa and Mototsugu Oya
    Citation: BMC Cancer 2015 15:324
    Content type: Research article Published on:

  43. Chemoradiation therapy (CRT) is one of the most useful treatments for esophageal squamous cell carcinoma (ESCC). However, because some patients respond well to CRT and others do not, it is important to be able...

    Authors: Kiyokazu Tamotsu, Hiroshi Okumura, Yasuto Uchikado, Yoshiaki Kita, Ken Sasaki, Itaru Omoto, Tetsuhiro Owaki, Takaaki Arigami, Yoshikazu Uenosono, Akihiro Nakajo, Yuko Kijima, Sumiya Ishigami and Shoji Natsugoe
    Citation: BMC Cancer 2015 15:323
    Content type: Research article Published on:

  44. The efficacy and safety of preoperative chemoradiation therapy (CRT) for advanced esophago-gastric adenocarcinoma are still in question, and the prognosis of these patients is poor.

    Authors: Tao Fu, Zhao-De Bu, Zi-Yu Li, Lian-Hai Zhang, Xiao-Jiang Wu, Ai-Wen Wu, Fei Shan, Xin Ji, Qiu-Shi Dong and Jia-Fu Ji
    Citation: BMC Cancer 2015 15:322
    Content type: Research article Published on:

  45. Sexual dysfunction is a prevalent, long-term complication of breast cancer and its treatment and can be treated effectively with face-to-face sexual counselling. However, relatively few women actually opt for ...

    Authors: Susanna B Hummel, Jacques JDM van Lankveld, Hester SA Oldenburg, Daniela EE Hahn, Eva Broomans and Neil K Aaronson
    Citation: BMC Cancer 2015 15:321
    Content type: Study protocol Published on:

  46. The spectrum of RB1gene mutations in Retinoblastoma (RB) patients and the necessity of multiple traditional methods for complete variant analysis make the molecular diagnosis a cumbersome, labor-intensive and tim...

    Authors: Bharanidharan Devarajan, Logambiga Prakash, Thirumalai Raj Kannan, Aloysius A Abraham, Usha Kim, Veerappan Muthukkaruppan and Ayyasamy Vanniarajan
    Citation: BMC Cancer 2015 15:320
    Content type: Research article Published on:

  47. Histologically similar tumors even from the same anatomical position may still show high variability at molecular level hindering analysis of genome-wide data. Leveling the analysis to a gene regulatory networ...

    Authors: Chengyu Liu, Riku Louhimo, Marko Laakso, Rainer Lehtonen and Sampsa Hautaniemi
    Citation: BMC Cancer 2015 15:319
    Content type: Research Article Published on:

  48. The optimal treatment for patients with brain metastasis from gestational trophoblastic neoplasia (GTN) has not been established. This study aims to investigate the clinical characteristics and the management ...

    Authors: Changji Xiao, Junjun Yang, Jing Zhao, Tong Ren, Fengzhi Feng, Xirun Wan and Yang Xiang
    Citation: BMC Cancer 2015 15:318
    Content type: Research article Published on:

  49. To evaluate the effects of intravesical administration of paclitaxel (PTX-30W), which was prepared by solubilization with a water-soluble amphiphilic polymer composed of PMB30W, a copolymer of 2-methacryloylox...

    Authors: Koetsu Tamura, Eiji Kikuchi, Tomohiro Konno, Kazuhiko Ishihara, Kazuhiro Matsumoto, Akira Miyajima and Mototsugu Oya
    Citation: BMC Cancer 2015 15:317
    Content type: Research article Published on:

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