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  1. Archival formalin-fixed paraffin-embedded (FFPE) cancer tissue samples are a readily available resource for microRNA (miRNA) biomarker identification. No established standard for reference miRNAs in FFPE tissu...

    Authors: Mogens Karsbøl Boisen, Christian Dehlendorff, Dorte Linnemann, Nicolai Aagaard Schultz, Benny Vittrup Jensen, Estrid Vilma Solyom Høgdall and Julia Sidenius Johansen
    Citation: BMC Cancer 2015 15:1024
    Content type: Research article Published on:

  2. nab-Paclitaxel is an albumin-bound formulation of paclitaxel approved for the treatment of metastatic breast cancer (MBC). This analysis was designed to characterize the treatment patterns, efficacy, and safety o...

    Authors: Caihua Liang, Ling Li, Cindy Duval Fraser, Amy Ko, Deyanira Corzo, Cheryl Enger and Debra Patt
    Citation: BMC Cancer 2015 15:1019
    Content type: Research article Published on:

  3. Breast cancer survival rates are significantly lower among African-American women compared to white women. In addition, African-American women with breast cancer are more likely than white women to die from co...

    Authors: Melinda R. Stolley, Lisa K. Sharp, Giamila Fantuzzi, Claudia Arroyo, Patricia Sheean, Linda Schiffer, Richard Campbell and Ben Gerber
    Citation: BMC Cancer 2015 15:1018
    Content type: Study protocol Published on:

  4. Patient satisfaction is an important element of quality improvement and patient-centered care, and is an indicator of the public’s confidence in the health care system. Although shorter wait times are believed...

    Authors: Maria Mathews, Dana Ryan and Donna Bulman
    Citation: BMC Cancer 2015 15:1017
    Content type: Research article Published on:

  5. Shifts in CD8+ T-cell subsets that are hallmarks of immunosenescence are observed in ageing and in conditions of chronic immune stimulation. Presently, there is limited documentation of such changes in lung ca...

    Authors: Oscar Okwudiri Onyema, Lore Decoster, Rose Njemini, Louis Nuvagah Forti, Ivan Bautmans, Marc De Waele and Tony Mets
    Citation: BMC Cancer 2015 15:1016
    Content type: Research article Published on:

  6. Cancer stem cell markers have become a major research focus because of their relationship with radiation or chemotherapy resistance in cancer therapy. Cancer stem cell markers including OCT4 and SOX2 have been...

    Authors: Bo Wook Kim, Hanbyoul Cho, Chel Hun Choi, Kris Ylaya, Joon-Yong Chung, Jae-Hoon Kim and Stephen M. Hewitt
    Citation: BMC Cancer 2015 15:1015
    Content type: Research article Published on:

  7. Photodynamic therapy (PDT) of solid cancers comprises the administration of a photosensitizer followed by illumination of the photosensitizer-replete tumor with laser light. This induces a state of local oxida...

    Authors: Ruud Weijer, Mans Broekgaarden, Rowan F. van Golen, Esther Bulle, Esther Nieuwenhuis, Aldo Jongejan, Perry D. Moerland, Antoine H. C. van Kampen, Thomas M. van Gulik and Michal Heger
    Citation: BMC Cancer 2015 15:1014
    Content type: Research article Published on:

  8. Treatment possibilities of metastatic renal cell carcinoma (mRCC) have recently changed dramatically prolonging the overall survival of the patients. This kind of development brings new challenges for the care...

    Authors: László Mangel, Krisztina Bíró, István Battyáni, Péter Göcze, Tamás Tornóczky and Endre Kálmán
    Citation: BMC Cancer 2015 15:1013
    Content type: Case report Published on:

  9. Serum 25-hydroxyvitamin D [25(OH)D], the major circulating form of vitamin D used for evaluating the vitamin D status of patients, has been associated with survival in a variety of cancers with conflicting evi...

    Authors: Pankaj G. Vashi, Persis Edwin, Brenten Popiel and Digant Gupta
    Citation: BMC Cancer 2015 15:1012
    Content type: Research article Published on:

  10. Glioblastoma multiforme (GBM) is characterized by extensive local invasion, which is in contrast with extremely rare systemic metastasis of GBM. Molecular mechanisms inhibiting systemic metastasis of GBM would...

    Authors: Se Jeong Lee, Won Young Kang, Yeup Yoon, Ju Youn Jin, Hye Jin Song, Jung Hyun Her, Sang Mi Kang, Yu Kyeong Hwang, Kyeong Jin Kang, Kyeung Min Joo and Do-Hyun Nam
    Citation: BMC Cancer 2015 15:1011
    Content type: Research article Published on:

  11. Transforming growth factor beta (TGFβ) signalling is involved in both tumour suppression and tumour progression. The mRNA expression levels of the TGFβ isoforms and receptors in breast tumours may have prognos...

    Authors: Chenfeng Chen, Kong-Nan Zhao, Paul P. Masci, Sunil R. Lakhani, Annika Antonsson, Peter T. Simpson and Luis Vitetta
    Citation: BMC Cancer 2015 15:1010
    Content type: Research article Published on:

  12. Tumor immune-escape has been related to the ability of cancer cells to inhibit T cell activation and dendritic cell (DC) differentiation. We previously identified a tumor initiating population, expressing the ...

    Authors: Cristina Grange, Marta Tapparo, Stefania Tritta, Maria Chiara Deregibus, Antonino Battaglia, Paolo Gontero, Bruno Frea and Giovanni Camussi
    Citation: BMC Cancer 2015 15:1009
    Content type: Research article Published on:

  13. Signs and symptoms of a rapidly enlarging breast mass are not only important for all clinicians to recognize and assess, but also are not uncommon occurrences. We describe a similar but unique case that develo...

    Authors: Vivek Verma, Sanjay Muttineni, Rajesh R. Kulkarni, Edibaldo Silva-Lopez, William W. West and Robert B. Thompson
    Citation: BMC Cancer 2015 15:1008
    Content type: Case report Published on:

  15. Neuropilin and tolloid-like 2 (NETO2) has been found to be overexpressed in different human cancers, but its expression pattern and clinical relevance in colorectal carcinoma (CRC) remains unknown.

    Authors: Liang Hu, Hai-Yang Chen, Jian Cai, Guang-Zhen Yang, Dan Feng, Yan-Xia Zhai, Hui Gong, Chen-Ye Qi, Yu Zhang, Hao Fu, Qing-Ping Cai and Chun-Fang Gao
    Citation: BMC Cancer 2015 15:1006
    Content type: Research article Published on:

  17. The objective of the study was to explore the clinical expression, radiological and pathological features, differential diagnosis, and biological behavior of a clear cell myomelanocytic tumor. In a case involv...

    Authors: Zu-Sen Wang, Lin Xu, Lin Ma, Meng-Qi Song, Li-Qun Wu and Xuan Zhou
    Citation: BMC Cancer 2015 15:1004
    Content type: Case report Published on:

  18. Thyroid cancer has been indicated to have a higher global proportion of DNA methylation and a decreased level of histone acetylation. Previous studies showed that histone gene reviser and epigenetic changes ro...

    Authors: Seok-Mo Kim, Ki-Cheong Park, Jeong-Yong Jeon, Bup-Woo Kim, Hyeung-Kyoo Kim, Ho-Jin Chang, Seung-Hoon Choi, Cheong-Soo Park and Hang-Seok Chang
    Citation: BMC Cancer 2015 15:1003
    Content type: Research article Published on:

  19. Use of FDG-PET/CT for staging and restaging of lymphoma patients is widely incorporated into current practice guidelines. Our aim was to prospectively evaluate the diagnostic performance of FDG-PET/MRI and WB-...

    Authors: Ken Herrmann, Marcelo Queiroz, Martin W. Huellner, Felipe de Galiza Barbosa, Andreas Buck, Niklaus Schaefer, Paul Stolzman and Patrick Veit-Haibach
    Citation: BMC Cancer 2015 15:1002
    Content type: Research article Published on:

  20. The mixture of volatile organic compounds in the headspace gas of urine may be able to distinguish lung cancer patients from relevant control populations.

    Authors: Peter J. Mazzone, Xiao-Feng Wang, Sung Lim, Humberto Choi, James Jett, Anil Vachani, Qi Zhang, Mary Beukemann, Meredith Seeley, Ray Martino and Paul Rhodes
    Citation: BMC Cancer 2015 15:1001
    Content type: Research article Published on:

  21. People from lower socioeconomic groups have worse survival outcomes for cancer, which in part reflects later-stage disease at diagnosis. The mechanisms underlying delayed cancer symptom presentation in lower s...

    Authors: Grace M. McCutchan, Fiona Wood, Adrian Edwards, Rebecca Richards and Kate E. Brain
    Citation: BMC Cancer 2015 15:1000
    Content type: Research article Published on:

  22. Reactivation of hepatitis B or C virus can occur in patients undergoing chemotherapy. Recommendations for selective or systematic hepatitis B virus testing prior chemotherapy for solid tumors differ. The prima...

    Authors: Mathilde Brasseur, Alexandra Heurgué-Berlot, Coralie Barbe, Cloé Brami, Jean-Baptiste Rey, Juliette Vella-Boucaud, Fadia Dabouz, Gaëtan Deslée, Florent Grange, Julien Volet and Olivier Bouché
    Citation: BMC Cancer 2015 15:999
    Content type: Research article Published on:

  23. Leiomyosarcoma (LMS) is an aggressive soft tissue sarcoma derived from smooth muscle cells typically of uterine, gastrointestinal or soft tissue origin.

    Authors: Alberto Bongiovanni, Nada Riva, Marianna Ricci, Laura Mercatali, Chiara Liverani, Federico La Manna, Alessandro De Vita, Davide Cavaliere, Federica Pieri, Devil Oboldi, Giorgio Maria Verdecchia, Dino Amadori and Toni Ibrahim
    Citation: BMC Cancer 2015 15:998
    Content type: Case report Published on:

  24. Managing therapy-related side-effects and improving health-related quality of life in patients with colorectal cancer is still challenging. The need for an effective management of adverse events and unmet supp...

    Authors: Alexander Bauer, Dirk Vordermark, Thomas Seufferlein, Hans-Joachim Schmoll, Henning Dralle, Wilfried Mau, Susanne Unverzagt, Stephanie Boese, Eva-Maria Fach and Margarete Landenberger
    Citation: BMC Cancer 2015 15:997
    Content type: Study protocol Published on:

  25. Paraneoplastic syndromes are most frequently associated with small cell lung carcinoma, hematologic and gynecologic malignancies while reports in head and neck cancer are rare.

    Authors: Florian Huemer, Thomas Melchardt, Wolfgang Tränkenschuh, Daniel Neureiter, Gerhard Moser, Teresa Magnes, Lukas Weiss, Alexander Schlattau, Clemens Hufnagl, Gerda Ricken, Romana Höftberger, Richard Greil and Alexander Egle
    Citation: BMC Cancer 2015 15:996
    Content type: Case report Published on:

  26. Membrane androgen receptors (mAR) are functionally expressed in a variety of tumor-cells including the breast tumor-cell line MCF-7. They are specifically activated by testosterone albumin conjugates (TAC). Th...

    Authors: Guilai Liu, Sabina Honisch, Guoxing Liu, Sebastian Schmidt, Saad Alkahtani, Abdullah A. AlKahtane, Christos Stournaras and Florian Lang
    Citation: BMC Cancer 2015 15:995
    Content type: Research article Published on:

  27. Decreasing trends of nasopharyngeal carcinoma (NPC) incidence have been consistently reported in endemic populations but the etiology of NPC remains unclear. The objective of our study was to assess the intern...

    Authors: Zhi-Ming Mai, Ching-Man Lo, Jun Xu, King-Pan Chan, Chit-Ming Wong, Maria Li Lung and Tai-Hing Lam
    Citation: BMC Cancer 2015 15:994
    Content type: Research article Published on:

  28. Hypereosinophilia, defined by an absolute eosinophil count of more than 1500/mm3, is rarely observed in patients treated for cancer, and rarely imputable to anti-cancer agents. Drug-induced hypereosinophilia u...

    Authors: Diaddin Hamdan, Christophe Leboeuf, Cathy Pereira, Nathalie Jourdan, Laurence Verneuil, Guilhem Bousquet and Anne Janin
    Citation: BMC Cancer 2015 15:993
    Content type: Case report Published on:

  29. Given evidence shows physical activity, a healthful diet and weight management can improve cancer outcomes and reduce chronic disease risk, the major cancer organisations and health authorities have endorsed r...

    Authors: Elizabeth G. Eakin, Sandra C. Hayes, Marion R. Haas, Marina M. Reeves, Janette L. Vardy, Frances Boyle, Janet E. Hiller, Gita D. Mishra, Ana D. Goode, Michael Jefford, Bogda Koczwara, Christobel M. Saunders, Wendy Demark-Wahnefried, Kerry S. Courneya, Kathryn H. Schmitz, Afaf Girgis…
    Citation: BMC Cancer 2015 15:992
    Content type: Study protocol Published on:

  30. The study was to investigate whether 18F-fluorodeoxyglucose (18F-FDG) uptake, analyzed by positron emission tomography (PET), can be used preoperatively to predict survival in Chinese patients with colorectal car...

    Authors: Debing Shi, Guoxiang Cai, Junjie Peng, Dawei Li, Xinxiang Li, Ye Xu and Sanjun Cai
    Citation: BMC Cancer 2015 15:991
    Content type: Research article Published on:

  31. Retinoblastoma protein-interacting zinc-finger gene 1 (RIZ1) displays strong tumor suppressive activities, and its expression is often silenced in many types of human tumors. However, the relationship between ...

    Authors: Chenran Zhang, Qiubei Zhu, Hua He, Lei Jiang, Qiang Qiang, Liuhua Hu, Guohan Hu, Ying Jiang, Xuehua Ding and Yicheng Lu
    Citation: BMC Cancer 2015 15:990
    Content type: Research article Published on:

    The Erratum to this article has been published in BMC Cancer 2016 16:26

  32. To investigate the prognostic significance of patient characteristics and clinical laboratory test results in locally advanced non-small cell lung cancer (NSCLC), and in particular the impact of diabetes melli...

    Authors: Hisao Imai, Kyoichi Kaira, Keita Mori, Akira Ono, Hiroaki Akamatsu, Shunichi Matsumoto, Tetsuhiko Taira, Hirotsugu Kenmotsu, Hideyuki Harada, Tateaki Naito, Haruyasu Murakami, Masahiro Endo, Takashi Nakajima, Masanobu Yamada and Toshiaki Takahashi
    Citation: BMC Cancer 2015 15:989
    Content type: Research article Published on:

  33. Lung cancer is the leading cause of cancer deaths worldwide. Surgery, radiotherapy at conventional and high dose and chemotherapy are the mainstay for lung cancer treatment. Insufficient migration and activati...

    Authors: Seyer Safi, Philipp Beckhove, Arne Warth, Axel Benner, Falk Roeder, Stefan Rieken, Juergen Debus, Hendrik Dienemann, Hans Hoffmann and Peter E. Huber
    Citation: BMC Cancer 2015 15:988
    Content type: Study protocol Published on:

  34. To assess the significance of alpha-fetoprotein (AFP) normalization as a prognostic surrogate after stereotactic body radiotherapy (SBRT) for patients with small hepatocellular carcinoma (HCC).

    Authors: Jinhong Jung, Sang Min Yoon, Seungbong Han, Ju Hyun Shim, Kang Mo Kim, Young-Suk Lim, Han Chu Lee, So Yeon Kim, Jin-hong Park and Jong Hoon Kim
    Citation: BMC Cancer 2015 15:987
    Content type: Research article Published on:

  35. Triple negative breast cancers (TNBC) are a more aggressive subset of breast cancer. A better understanding of its biology could allow the rational development of targeted therapies.

    Authors: William Jacot, Caroline Mollevi, Frédéric Fina, Evelyne Lopez-Crapez, Pierre-Marie Martin, Pierre-Emmanuel Colombo, Frédéric Bibeau, Gilles Romieu and Pierre-Jean Lamy
    Citation: BMC Cancer 2015 15:986
    Content type: Research article Published on:

  36. Chronic hepatitis B (CHB) virus infection is a major cause of hepatocellular carcinoma (HCC), as late diagnosis is the main factor for the poor survival of patients. There is an urgent need for accurate biomar...

    Authors: Ana Maria Passos-Castilho, Valdemir Melechco Carvalho, Karina Helena Morais Cardozo, Luciana Kikuchi, Aline Lopes Chagas, Michele Soares Gomes-Gouvêa, Fernanda Malta, Ana Catharina de Seixas-Santos Nastri, João Renato Rebello Pinho, Flair José Carrilho and Celso Francisco Hernandes Granato
    Citation: BMC Cancer 2015 15:985
    Content type: Research article Published on:

  37. Anaplastic thyroid carcinoma is the most undifferentiated form of thyroid cancer and one of the deadliest of all adult solid malignancies. Here we report the first genomic and transcriptomic profile of anaplas...

    Authors: Katayoon Kasaian, Sam M. Wiseman, Blair A. Walker, Jacqueline E. Schein, Yongjun Zhao, Martin Hirst, Richard A. Moore, Andrew J. Mungall, Marco A. Marra and Steven JM Jones
    Citation: BMC Cancer 2015 15:984
    Content type: Research article Published on:

  38. The MexTAg transgenic mouse model of mesothelioma replicates many aspects of human mesothelioma, including induction by asbestos, pathogenicity and response to cytotoxic chemotherapy, despite high levels of th...

    Authors: Cleo Robinson, Ian M. Dick, Michael J. Wise, Andrew Holloway, Dileepa Diyagama, Bruce W. S. Robinson, Jenette Creaney and Richard A. Lake
    Citation: BMC Cancer 2015 15:983
    Content type: Research article Published on:

  39. This study was aimed at identifying prognostic biomarkers for stage II-IIIA non-small cell lung cancer (NSCLC) according to histology and at investigating the effect of vorinostat on the expression of these bi...

    Authors: Eunju Lee, DongHao Jin, Bo Bin Lee, Yujin Kim, Joungho Han, Young Mog Shim and Duk-Hwan Kim
    Citation: BMC Cancer 2015 15:982
    Content type: Research article Published on:

  40. The impact of cumulative dose of cisplatin on clinical outcomes of nasopharyngeal carcinoma (NPC) patients who received intensity-modulated radiotherapy (IMRT) was evaluated.

    Authors: Shan-Shan Guo, Lin-Quan Tang, Lu Zhang, Qiu-Yan Chen, Li-Ting Liu, Ling Guo, Hao-Yuan Mo, Dong-Hua Luo, Pei-Yu Huang, Yan-Qun Xiang, Rui Sun, Ming-Yuan Chen, Lin Wang, Xing Lv, Chong Zhao, Xiang Guo…
    Citation: BMC Cancer 2015 15:977
    Content type: Research article Published on:

  41. Lymph nodes’ examination in colorectal cancer (CRC) resection specimens is an important determinant that aids in the accuracy of CRC staging and treatment outcomes. Current guidelines call for the examination ...

    Authors: Hassan Ashktorab, Temitayo Ogundipe, Hassan Brim, Anahita Shahnazi, Adeyinka O. Laiyemo, Edward Lee, Babak Shokrani and Mehdi Nouraie
    Citation: BMC Cancer 2015 15:976
    Content type: Research article Published on:

  43. Rare sites of metastases, atypical symptoms and paraneoplastic syndromes are often neglected or misinterpreted, especially when they represent early symptoms of an underlying malignant disease. Hence, an inter...

    Authors: Sebastian P. Haen, Philipp Stroebel, Alexander Marx, Daniela Suesskind, Falko Fend, Ursula Reichmann, Hans-Georg Kopp, Lothar Kanz and Frank Mayer
    Citation: BMC Cancer 2015 15:972
    Content type: Case report Published on:

  45. KIF23 (kinesin family member 23) is a kinesin-like motor protein and plays an important role in cytokinesis. In search for genes associated with hepatocellular carcinoma (HCC) by cDNA microarray, we found that...

    Authors: Xiaotong Sun, Zhongtian Jin, Xiao Song, Jingjing Wang, Yan Li, Xiaoping Qian, Yu zhang and Yanhui Yin
    Citation: BMC Cancer 2015 15:961
    Content type: Research article Published on:

  46. The tumor suppressor gene CDH1 is critical for intercellular adhesion. In our previous work, we reported a nonfunctional CDH1 transcript that lacks the final 83 base pairs of exon 8 (1054del83). In this work, we ...

    Authors: Xiao-Wei Li, Bing-Yu Shi, Qing-Lan Yang, Jie Wu, Hui-Min Wu, Yu-Feng Wang, Zhi-Jiao Wu, Yi-Mei Fan and Ya-Ping Wang
    Citation: BMC Cancer 2015 15:954
    Content type: Research article Published on:

  47. Several studies have shown, that circulating tumor cells (CTC) have a negative prognostic value in colorectal cancer patients. Aim of this study was to evaluate the role of CTC in specifically rectal cancer pa...

    Authors: Sebastian Hinz, Christian Röder, Jürgen Tepel, Alexander Hendricks, Clemens Schafmayer, Thomas Becker and Holger Kalthoff
    Citation: BMC Cancer 2015 15:953
    Content type: Research article Published on:

  48. Current knowledge indicate that epirubicin administration in late pregnancy is almost devoid of any fetal cardiotoxicity. We report a twin pregnancy complicated by breast cancer in which epirubicin administrat...

    Authors: Marialuisa Framarino-dei-Malatesta, Giuseppina Perrone, Antonella Giancotti, Flavia Ventriglia, Martina Derme, Isabella Iannini, Valentina Tibaldi, Paola Galoppi, Paolo Sammartino, Gianluca Cascialli and Roberto Brunelli
    Citation: BMC Cancer 2015 15:951
    Content type: Case report Published on:

  50. Adults in the United States (U.S) can be simultaneously exposed to more than one social risk factor over their lifetime. However, cancer epidemiology tends to focus on single social risk factors at a time. We ...

    Authors: Rishi Caleyachetty, Parisa Tehranifar, Jeanine M. Genkinger, Justin B. Echouffo-Tcheugui and Peter Muennig
    Citation: BMC Cancer 2015 15:945
    Content type: Research article Published on:

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