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  1. Often curative treatment for locally advanced resectable esophageal or gastro-esophageal junctional cancer consists of concurrent neoadjuvant radiotherapy and chemotherapy followed by surgery. Currently, one o...

    Authors: Mathieu Messager, Xavier Mirabel, Emmanuelle Tresch, Amaury Paumier, Véronique Vendrely, Laetitia Dahan, Olivier Glehen, Frederique Vasseur, Thomas Lacornerie, Guillaume Piessen, Farid El Hajbi, William B. Robb, Stéphanie Clisant, Andrew Kramar, Christophe Mariette and Antoine Adenis
    Citation: BMC Cancer 2016 16:318
    Content type: Study protocol Published on:

  2. We have previously demonstrated that the hydroxylated biphenyl compound D6 (3E,3′E)-4,4′-(5,5′,6,6′-tetramethoxy-[1,1′-biphenyl]-3,3′-diyl)bis(but-3-en-2-one), a structural analogue of curcumin, exerts a stron...

    Authors: Marina Pisano, Antonio Palomba, Alessandro Tanca, Daniela Pagnozzi, Sergio Uzzau, Maria Filippa Addis, Maria Antonietta Dettori, Davide Fabbri, Giuseppe Palmieri and Carla Rozzo
    Citation: BMC Cancer 2016 16:317
    Content type: Research article Published on:

  3. The BRM and BRG1 tumor suppressor genes are mutually exclusive ATPase subunits of the SWI/SNF chromatin remodeling complex. The human adrenal carcinoma SW13 cell line can switch between a subtype which express...

    Authors: McKale R. Davis, Juliane J. Daggett, Agnes S. Pascual, Jessica M. Lam, Kathryn J. Leyva, Kimbal E. Cooper and Elizabeth E. Hull
    Citation: BMC Cancer 2016 16:316
    Content type: Research article Published on:

  4. MicroRNA-663a expression is downregulated in several tumors. However, its functions and mechanisms in human non-small cell lung (NSCLC) cancer remain obscure. The present study aimed to identify the expression...

    Authors: Yi Zhang, Xiaoman Xu, Meng Zhang, Xin Wang, Xue Bai, Hui Li, Liang Kan, Yong Zhou, Huiyan Niu and Ping He
    Citation: BMC Cancer 2016 16:315
    Content type: Research article Published on:

  5. Chronic Myeloid Leukemia was always referred as a unique cancer due to the apparent independence from tumor suppressors’ deletions/mutations in the early stages of the disease. However, it is now well document...

    Authors: Sabrina Crivellaro, Giovanna Carrà, Cristina Panuzzo, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio and Alessandro Morotti
    Citation: BMC Cancer 2016 16:314
    Content type: Review Published on:

  6. Hyaluronan is a large extracellular matrix molecule involved in several biological processes such as proliferation, migration and invasion. In many cancers, hyaluronan synthesis is altered, which implicates di...

    Authors: Mari Poukka, Andrey Bykachev, Hanna Siiskonen, Kristiina Tyynelä-Korhonen, Päivi Auvinen, Sanna Pasonen-Seppänen and Reijo Sironen
    Citation: BMC Cancer 2016 16:313
    Content type: Research article Published on:

  7. Oral cancer malignancy consists of uncontrolled division of cells primarily in and around the floor of the oral cavity, gingiva, oropharynx, lower lip and base of the tongue. According to GLOBOCAN 2012 report,...

    Authors: Muraleedharan Parvathy, Sreeharshan Sreeja, Rakesh Kumar and Madhavan Radhakrishna Pillai
    Citation: BMC Cancer 2016 16(Suppl 1):293
    Content type: Research Published on:

    This article is part of a Supplement: Volume 16 Supplement 1

  8. BRCA1 is a main component of homologous recombination and induces resistance to platinum in preclinical models. It has been studied as a potential predictive marker in lung cancer. Several proteins modulate th...

    Authors: Laura Bonanno, Carlota Costa, Margarita Majem, Jose-Javier Sanchez, Ignacio Rodriguez, Ana Gimenez-Capitan, Miquel Angel Molina-Vila, Alain Vergnenegre, Bartomeu Massuti, Adolfo Favaretto, Massimo Rugge, Cinta Pallares, Miquel Taron and Rafael Rosell
    Citation: BMC Cancer 2016 16:312
    Content type: Research article Published on:

  9. Serving military personnel are more likely to smoke, and to smoke more heavily, than civilians. The aim of our study was to examine whether veterans have an increased risk of a range of smoking-related cancers...

    Authors: Beverly P. Bergman, Daniel F. Mackay, David Morrison and Jill P. Pell
    Citation: BMC Cancer 2016 16:311
    Content type: Research article Published on:

  10. Glioblastoma multiforme is a highly aggressive brain tumor with a poor prognosis, and advances in treatment have led to only marginal increases in overall survival. We and others have shown previously that the...

    Authors: Danielle M. Lussier, Eric C. Woolf, John L. Johnson, Kenneth S. Brooks, Joseph N. Blattman and Adrienne C. Scheck
    Citation: BMC Cancer 2016 16:310
    Content type: Research article Published on:

  11. Pancreatic cancer is recognized as one of the most fatal tumors due to its aggressiveness and resistance to therapy. Statins were previously shown to inhibit the proliferation of cancer cells via various signalin...

    Authors: K. Vanova, S. Boukalova, H. Gbelcova, L. Muchova, J. Neuzil, R. Gurlich, T. Ruml and L. Vitek
    Citation: BMC Cancer 2016 16:309
    Content type: Research article Published on:

  12. Small molecule inhibitor of tyrosine kinase activity, compound SU11274, was reported to have antitumorigenic and antimetastatic effect in melanoma. In this study, we evaluated, whether similar effect could be ...

    Authors: Lucia Kucerova, Lucia Demkova, Svetlana Skolekova, Roman Bohovic and Miroslava Matuskova
    Citation: BMC Cancer 2016 16:308
    Content type: Research article Published on:

  13. The development of metastases is a negative prognostic parameter for the clinical outcome of breast cancer. Bone constitutes the first site of distant metastases for many affected women. The purpose of this re...

    Authors: Joachim Diessner, Manfred Wischnewsky, Tanja Stüber, Roland Stein, Mathias Krockenberger, Sebastian Häusler, Wolfgang Janni, Rolf Kreienberg, Maria Blettner, Lukas Schwentner, Achim Wöckel and Catharina Bartmann
    Citation: BMC Cancer 2016 16:307
    Content type: Research article Published on:

  14. The addition of bevacizumab to cytotoxic agents prolongs survival in patients with nonsquamous non-small cell lung cancer (NSCLC). To date, there is no evidence to suggest that treatment with a cytotoxic agent...

    Authors: Toshiyuki Kozuki, Naoyuki Nogami, Hiromoto Kitajima, Shunichiro Iwasawa, Emiko Sakaida, Yuichi Takiguchi, Satoshi Ikeda, Masahiro Yoshida, Terufumi Kato, Shingo Miyamoto, Kentaro Sakamaki, Tetsu Shinkai and Koshiro Watanabe
    Citation: BMC Cancer 2016 16:306
    Content type: Research article Published on:

  15. The CXCL12-CXCR4 signaling axis in malignant tumor biology has increased in importance, and these peptides are implicated in tumor growth, invasion and metastasis. The aim of our study was to examine the impor...

    Authors: Mamoru Morimoto, Yoichi Matsuo, Shuji Koide, Ken Tsuboi, Tomoya Shamoto, Takafumi Sato, Kenta Saito, Hiroki Takahashi and Hiromitsu Takeyama
    Citation: BMC Cancer 2016 16:305
    Content type: Research article Published on:

  16. Tamoxifen, a common anti-estrogen breast cancer medication, is a prodrug that undergoes bioactivation via cytochrome P450 enzymes, CYP2D6 and to a lesser degree, CYP3A4 to form the active metabolite endoxifen. Wi...

    Authors: Sara L. Henderson, Wendy A. Teft and Richard B. Kim
    Citation: BMC Cancer 2016 16:304
    Content type: Case report Published on:

  17. Gastrointestinal (GI) cancer is frequently diagnosed in people of working age, and many GI cancer patients experience work-related problems. Although these patients often experience difficulties returning to w...

    Authors: AnneClaire G.N.M. Zaman, Kristien M.A.J. Tytgat, Jean H.G. Klinkenbijl, Monique H.W. Frings-Dresen and Angela G.E.M. de Boer
    Citation: BMC Cancer 2016 16:303
    Content type: Study protocol Published on:

  18. Mitogen/extracellular signal-regulated kinase kinase-5 (MEK5) has been confirmed to play a pivotal role in tumor carcinogenesis and progression. However, few studies have investigated the role of MEK5 in color...

    Authors: Dechang Diao, Lei Wang, Jin Wan, Zhiqiang Chen, Junsheng Peng, Huanliang Liu, Xinlin Chen, Wei Wang and Liaonan Zou
    Citation: BMC Cancer 2016 16:302
    Content type: Research article Published on:

  19. The optimal conduct of follow-up (FU) of patients with osteosarcoma is uncertain. In the absence of any formal validation of optimal timing and method of surveillance, guidance is provided by oncology societie...

    Authors: Christian Rothermundt, Beatrice M. Seddon, Palma Dileo, Sandra J. Strauss, Joanne Coleman, Timothy W. Briggs, Sarah R. Haile and Jeremy S. Whelan
    Citation: BMC Cancer 2016 16:301
    Content type: Research article Published on:

  20. Circulating tumor cells (CTCs) are typically collected into CellSave fixative tubes, which kills the cells, but preserves their morphology. Currently, the clinical utility of CTCs is mostly limited to their en...

    Authors: Steingrimur Stefansson, Daniel L. Adams, William B. Ershler, Huyen Le and David H. Ho
    Citation: BMC Cancer 2016 16:300
    Content type: Technical advance Published on:

  21. Current surgical and ablative treatment options for prostate cancer (PCa) may result in a high incidence of (temporary) incontinence, erectile dysfunction and/or bowel damage. These side effects are due to pro...

    Authors: Matthijs J. V. Scheltema, Willemien van den Bos, Daniel M. de Bruin, Hessel Wijkstra, M. Pilar Laguna, Theo M. de Reijke and Jean JMCH de la Rosette
    Citation: BMC Cancer 2016 16:299
    Content type: Study protocol Published on:

  22. Chemokines are well known inflammatory factors critical for tumor development in diverse tissues, including lung cancer. Chemokine (C-C motif) Ligand 2 (CCL2) was one of such chemokines important for both prim...

    Authors: Xu Li, Fangcai Lin and Hong Zhou
    Citation: BMC Cancer 2016 16:298
    Content type: Research article Published on:

  23. Immunomodulatory drugs (IMiDs), such as lenalidomide, are therapeutically active compounds that bind and modulate the E3 ubiquitin ligase substrate recruiter cereblon, thereby affect steady-state levels of cer...

    Authors: Qinqin Xu, Yue-xian Hou, Paul Langlais, Patrick Erickson, James Zhu, Chang-Xin Shi, Moulun Luo, Yuanxiao Zhu, Ye Xu, Lawrence J. Mandarino, Keith Stewart and Xiu-bao Chang
    Citation: BMC Cancer 2016 16:297
    Content type: Research article Published on:

  24. The study aimed to compare urinary symptoms in patients with clinically localized prostate cancer after a combination of either low-dose-rate or high-dose-rate interstitial brachytherapy along with intensity-m...

    Authors: Satoshi Nakamura, Naoya Murakami, Koji Inaba, Akihisa Wakita, Kazuma Kobayashi, Kana Takahashi, Hiroyuki Okamoto, Rei Umezawa, Madoka Morota, Minako Sumi, Hiroshi Igaki, Yoshinori Ito and Jun Itami
    Citation: BMC Cancer 2016 16:296
    Content type: Research article Published on:

  25. Inhibitors of mutant BRAF are emerging as standard of care in patients with metastatic melanoma who carry relevant oncogenic mutations. However, BRAF inhibitors are found to induce cutaneous squamous cell carc...

    Authors: Haojie Li, Lars Pedersen, Mette Nørgaard, Sinna P. Ulrichsen, Sandra K. Thygesen and Jeanenne J. Nelson
    Citation: BMC Cancer 2016 16:295
    Content type: Research article Published on:

  26. No study has been conducted to investigate the spatial pattern and association of socioeconomic status (such as income) with breast and colorectal cancer incidence in Texas, United States. This study aimed to ...

    Authors: Zheyu Liu, Kai Zhang and Xianglin L. Du
    Citation: BMC Cancer 2016 16:294
    Content type: Research article Published on:

  27. This study was performed to design a predictive tool that allows the estimation of overall survival (OS) of elderly myeloma patients (aged ≥65 years) presenting with myeloma-induced spinal cord compression (SCC).

    Authors: Dirk Rades, Antonio Jose Conde-Moreno, Jon Cacicedo, Theo Veninga, Niklas Gebauer, Tobias Bartscht and Steven E. Schild
    Citation: BMC Cancer 2016 16:292
    Content type: Research article Published on:

  28. Clinically significant levels of fear of cancer recurrence (FCR) affect up to 49 % of cancer survivors and are more prevalent among women. FCR is associated with psychological distress, lower quality of life, ...

    Authors: Christine Maheu, Sophie Lebel, Christine Courbasson, Monique Lefebvre, Mina Singh, Lori J. Bernstein, Linda Muraca, Aronela Benea, Lynne Jolicoeur, Cheryl Harris, Agnihotram V. Ramanakumar, Sarah Ferguson and Souraya Sidani
    Citation: BMC Cancer 2016 16:291
    Content type: Study protocol Published on:

  29. Despite novel therapeutic agents, most multiple myeloma (MM) patients eventually relapse. Two large phase III trials have shown significantly improved response rates (RR) of lenalidomide/dexamethasone compared...

    Authors: Marc-Andrea Baertsch, Jana Schlenzka, Elias K. Mai, Maximilian Merz, Jens Hillengaß, Marc S. Raab, Dirk Hose, Patrick Wuchter, Anthony D. Ho, Anna Jauch, Thomas Hielscher, Christina Kunz, Steffen Luntz, Stefan Klein, Ingo G. H. Schmidt-Wolf, Martin Goerner…
    Citation: BMC Cancer 2016 16:290
    Content type: Study protocol Published on:

  30. The aim of this study was to compare surgical treatment received by Aboriginal and non-Aboriginal people with non-small cell lung cancer (NSCLC) in New South Wales (NSW), Australia and to examine whether patie...

    Authors: Alison Gibberd, Rajah Supramaniam, Anthony Dillon, Bruce K. Armstrong and Dianne L. O’Connell
    Citation: BMC Cancer 2016 16:289
    Content type: Research article Published on:

  31. Increasing the biological effective dose (BED) of radiotherapy for non-small cell lung cancer (NSCLC) can increase local control rates and improve overall survival. Compared with conventional fractionated radi...

    Authors: Xiao-Cang Ren, Quan-Yu Wang, Rui Zhang, Xue-Ji Chen, Na Wang, Yue-E Liu, Jie Zong, Zhi-Jun Guo, Dong-Ying Wang and Qiang Lin
    Citation: BMC Cancer 2016 16:288
    Content type: Research article Published on:

  32. Ependymal tumors in adults are rare, accounting for less than 4 % of primary tumors of the central nervous system in this age group. The low prevalence of intracranial ependymoma in adults limits the ability t...

    Authors: Dorothee Gramatzki, Patrick Roth, Jörg Felsberg, Silvia Hofer, Elisabeth J. Rushing, Bettina Hentschel, Manfred Westphal, Dietmar Krex, Matthias Simon, Oliver Schnell, Wolfgang Wick, Guido Reifenberger and Michael Weller
    Citation: BMC Cancer 2016 16:287
    Content type: Research article Published on:

  34. Adequate circadian timing of cancer treatment schedules (chronotherapy) can enhance tolerance and efficacy several-fold in experimental and clinical situations. However, the optimal timing varies according to ...

    Authors: Elisabet Ortiz-Tudela, Pasquale F. Innominato, Maria Angeles Rol, Francis Lévi and Juan Antonio Madrid
    Citation: BMC Cancer 2016 16:285
    Content type: Research article Published on:

  36. Alcohol consumption is associated with increased risk of breast cancer (BC), and the underlying mechanism is thought to be sex-hormone driven. In vitro and observational studies suggest a mechanism involving p...

    Authors: Tine Iskov Kopp, Ditte Marie Jensen, Gitte Ravn-Haren, Arieh Cohen, Helle Molgaard Sommer, Lars Ove Dragsted, Anne Tjonneland, David Michael Hougaard and Ulla Vogel
    Citation: BMC Cancer 2016 16:283
    Content type: Research article Published on:

  37. Primary central nervous system lymphoma (PCNSL) is a highly aggressive Non-Hodgkin lymphoma (NHL) with rising incidence over the past 30 years in immunocompetent patients. Although outcomes have improved, PCNS...

    Authors: Elisabeth Schorb, Juergen Finke, Andrés J. M. Ferreri, Gabriele Ihorst, Kristina Mikesch, Benjamin Kasenda, Kristina Fritsch, Heidi Fricker, Elvira Burger, Olga Grishina, Elke Valk, Emanuele Zucca and Gerald Illerhaus
    Citation: BMC Cancer 2016 16:282
    Content type: Study protocol Published on:

  38. Participation in low-dose CT (LDCT) lung cancer screening offered in the trial context has been poor, especially among smokers from socioeconomically deprived backgrounds; a group for whom the risk-benefit rat...

    Authors: Samantha L. Quaife, Mamta Ruparel, Rebecca J. Beeken, Andy McEwen, John Isitt, Gary Nolan, Karen Sennett, David R. Baldwin, Stephen W. Duffy, Samuel M. Janes and Jane Wardle
    Citation: BMC Cancer 2016 16:281
    Content type: Study protocol Published on:

  39. Few new compounds are available for relapsed osteosarcoma. We retrospectively evaluated the activity of gemcitabine (G) plus docetaxel (D) in patients with relapsed high-grade osteosarcoma and high-grade spind...

    Authors: E. Palmerini, R. L. Jones, E. Marchesi, A. Paioli, M. Cesari, A. Longhi, C. Meazza, L. Coccoli, F. Fagioli, S. Asaftei, G. Grignani, A. Tamburini, S. M. Pollack, P. Picci and S. Ferrari
    Citation: BMC Cancer 2016 16:280
    Content type: Research article Published on:

  40. Acquired resistance towards apoptosis is a hallmark of cancer. Elimination of cells bearing activated oncogenes or stimulation of tumor suppressor mediators may provide a selection pressure to overcome resista...

    Authors: Christiana G. Savva, Sotirios Totokotsopoulos, Kyriakos C. Nicolaou, Christiana M. Neophytou and Andreas I. Constantinou
    Citation: BMC Cancer 2016 16:279
    Content type: Research article Published on:

  41. Metronomic oral vinorelbine is effective in metastatic NSCLC and malignant pleural mesothelioma, but all the studies published thus far were based upon a variety of empirical and possibly suboptimal schedules,...

    Authors: Xavier Elharrar, Dominique Barbolosi, Joseph Ciccolini, Christophe Meille, Christian Faivre, Bruno Lacarelle, Nicolas André and Fabrice Barlesi
    Citation: BMC Cancer 2016 16:278
    Content type: Study protocol Published on:

  42. To assess whether intraoperative use of contrast-enhanced ultrasound (CEUS)-CT/MR image fusion can accurately evaluate ablative margin (AM) and guide supplementary ablation to improve AM after hepatocellular c...

    Authors: Kai Li, Zhong-Zhen Su, Er-Jiao Xu, Jin-Xiu Ju, Xiao-Chun Meng and Rong-Qin Zheng
    Citation: BMC Cancer 2016 16:277
    Content type: Research article Published on:

  43. Surviving expression might serve as a prognostic biomarker predicting the clinical outcome of non-small cell lung cancer (NSCLC). The study was conducted to explore the potential correlation of survivin protei...

    Authors: Liang Duan, Xuefei Hu, Yuxing Jin, Ruijun Liu and Qingjun You
    Citation: BMC Cancer 2016 16:276
    Content type: Research article Published on:

  45. The influence of the tumor microenvironment and tumor-stromal interactions on the heterogeneity of response within breast cancer subtypes have just begun to be explored. This study focuses on patients with est...

    Authors: Alexander S. Brodsky, Jinjun Xiong, Dongfang Yang, Christoph Schorl, Mary Anne Fenton, Theresa A. Graves, William M. Sikov, Murray B. Resnick and Yihong Wang
    Citation: BMC Cancer 2016 16:274
    Content type: Research article Published on:

  46. Despite recent progress, investigating the impact of targeted therapies on Head and Neck Squamous Cell Carcinoma (HNSCC) remains a challenge. We investigated whether short-term culture of tumour fragments woul...

    Authors: Jérôme Donnadieu, Emma Lachaier, Marine Peria, Zuzana Saidak, Stéphanie Dakpe, Jean-Fortune Ikoli, Bruno Chauffert, Cyril Page and Antoine Galmiche
    Citation: BMC Cancer 2016 16:273
    Content type: Research article Published on:

  48. The incidence of and mortality from colorectal cancers (CRC) can be reduced by early detection. Currently there is a lack of established markers to detect early neoplastic changes. We aimed to identify the cop...

    Authors: B. M. Shivakumar, Sanjiban Chakrabarty, Harish Rotti, Venu Seenappa, Lakshmi Rao, Vasudevan Geetha, B. V. Tantry, Hema Kini, Rajesh Dharamsi, C. Ganesh Pai and Kapaettu Satyamoorthy
    Citation: BMC Cancer 2016 16:271
    Content type: Research article Published on:

  49. Rituximab (R) in combination with DHAP is a widely accepted salvage regimen for patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL). A common adverse effect of this protocol is renal tox...

    Authors: K. Lisenko, F. McClanahan, T. Schöning, M. A. Schwarzbich, M. Cremer, T. Dittrich, A. D. Ho and M. Witzens-Harig
    Citation: BMC Cancer 2016 16:267
    Content type: Research article Published on:

  50. Endostatin inhibits the pro-angiogenic action of basic fibroblast growth factor and vascular endothelial growth factor in different human cancers. This study assessed the efficacy of endostatin combined with c...

    Authors: Xiao-Jiang Sun, Qing-Hua Deng, Xin-Min Yu, Yong-Lin Ji, Yuan-Da Zheng, Hao Jiang, Ya-Ping Xu and Sheng-Lin Ma
    Citation: BMC Cancer 2016 16:266
    Content type: Research article Published on:

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