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  1. Due to improvements in imaging and radiological techniques as well as the use of chemotherapy, distant metastasis has become the predominant mode of treatment failure in patients with locally advanced nasophar...

    Authors: Liang-Ru Ke, Wei-Xiong Xia, Wen-Ze Qiu, Xin-Jun Huang, Jing Yang, Ya-Hui Yu, Hu Liang, Guo-Ying Liu, Yan-Fang Ye, Yan-Qun Xiang, Xiang Guo and Xing Lv
    Citation: BMC Cancer 2017 17:134
    Content type: Research article Published on:

  2. Cetuximab combined with chemotherapy is one of the first-line treatments of metastatic colorectal cancer. Although disease progression inevitably occurs, rechallenge and maintenance therapies using cetuximab-b...

    Authors: Jian Ma, Quan-liang Yang and Yang Ling
    Citation: BMC Cancer 2017 17:132
    Content type: Case report Published on:

  3. Due to the uncommon nature of primary spinal epidural lymphomas (PSELs), there has been little research looking at prognostic indicators for the tumor. To our knowledge, this is the largest study to evaluate p...

    Authors: Le Xiong, Ling-Min Liao, Jian-Wu Ding, Zhi-Lin Zhang, An-Wen Liu and Long Huang
    Citation: BMC Cancer 2017 17:131
    Content type: Research article Published on:

  4. Despite our growing knowledge about the pathomechanisms of cancer cachexia, a whole clinical picture of the cachectic patient is still missing. Our objective was to evaluate the clinical characteristics in can...

    Authors: S. Schwarz, O. Prokopchuk, K. Esefeld, S. Gröschel, J. Bachmann, S. Lorenzen, H. Friess, M. Halle and M. E. Martignoni
    Citation: BMC Cancer 2017 17:130
    Content type: Research article Published on:

  5. Bacterial toxins have evolved to an effective therapeutic option for cancer therapy. The Clostridium perfringens enterotoxin (CPE) is a pore-forming toxin with selective cytotoxicity. The transmembrane tight junc...

    Authors: Jessica Pahle, Lutz Menzel, Nicole Niesler, Dennis Kobelt, Jutta Aumann, Maria Rivera and Wolfgang Walther
    Citation: BMC Cancer 2017 17:129
    Content type: Research article Published on:

  6. Skeletal involvement (SI) is observed at low prevalence in patients with diffuse large B-cell lymphoma (DLBCL). Due to the rareness of this particular condition, prospective trials for these patients are scarce.

    Authors: Nicola Lehners, Isabelle Krämer, Maral Saadati, Axel Benner, Anthony D. Ho and Mathias Witzens-Harig
    Citation: BMC Cancer 2017 17:128
    Content type: Research article Published on:

  7. Neurofibromatosis type 2 (NF2) is a rare autosomal dominant nervous system tumor predisposition disorder caused by constitutive inactivation of one of the two copies of NF2. Meningiomas affect about one half of N...

    Authors: Ramita Dewan, Alexander Pemov, Amalia S. Dutra, Evgenia D. Pak, Nancy A. Edwards, Abhik Ray-Chaudhury, Nancy F. Hansen, Settara C. Chandrasekharappa, James C. Mullikin, Ashok R. Asthagiri, John D. Heiss, Douglas R. Stewart and Anand V. Germanwala
    Citation: BMC Cancer 2017 17:127
    Content type: Case report Published on:

  8. Antiangiogenic therapies are considered promising for the treatment of glioblastoma (GB). The non-collagenous C-terminal globular NC1 domain of type VIII collagen a1 chain, Vastatin, is an endogenous antiangio...

    Authors: Yi Li, Jun Li, Yat Ming Woo, Zan Shen, Hong Yao, Yijun Cai, Marie Chia-mi Lin and Wai Sang Poon
    Citation: BMC Cancer 2017 17:126
    Content type: Research article Published on:

  9. There is a growing body of evidence indicating that pediatric survivors of cancer are at a greater risk of developing metabolic syndrome. This study evaluated some probable predictors of metabolic syndrome (MS...

    Authors: Lourdes Barbosa-Cortés, Mardia López-Alarcón, Juan Manuel Mejía-Aranguré, Miguel Klünder-Klünder, María del Carmen Rodríguez-Zepeda, Hugo Rivera-Márquez, Alan de la Vega-Martínez, Jorge Martin-Trejo, Juan Shum-Luis, Karina Solis-Labastida, Enrique López-Aguilar, Guadalupe Matute-González and Roberto Bernaldez-Rios
    Citation: BMC Cancer 2017 17:125
    Content type: Research article Published on:

  10. Proliferation may predict response to neoadjuvant therapy of breast cancer and is commonly assessed by manual scoring of slides stained by immunohistochemistry (IHC) for Ki-67 similar to ER and PgR. This metho...

    Authors: Hans-Peter Sinn, Andreas Schneeweiss, Marius Keller, Kornelia Schlombs, Mark Laible, Julia Seitz, Sotirios Lakis, Elke Veltrup, Peter Altevogt, Sebastian Eidt, Ralph M. Wirtz and Frederik Marmé
    Citation: BMC Cancer 2017 17:124
    Content type: Research article Published on:

  11. Photodynamic therapy (PDT) has proven to be a promising alternative to current cancer treatments, especially if combined with conventional approaches. The technique is based on the administration of a non-toxi...

    Authors: Laura Marise de Freitas, Rodolfo Bortolozo Serafim, Juliana Ferreira de Sousa, Thaís Fernanda Moreira, Cláudia Tavares dos Santos, Amanda Martins Baviera, Valeria Valente, Christiane Pienna Soares and Carla Raquel Fontana
    Citation: BMC Cancer 2017 17:123
    Content type: Research article Published on:

  12. Healthcare provider (HCP) activities and attitudes towards patients strongly influence medication adherence. The aim of this study was to assess current clinical practices to support patients in adhering to tr...

    Authors: Lonneke Timmers, Christel C. L. M. Boons, Mathieu Verbrugghe, Bart J. F. van den Bemt, Ann Van Hecke and Jacqueline G. Hugtenburg
    Citation: BMC Cancer 2017 17:122
    Content type: Research article Published on:

  13. Dispersal of glioblastoma (GBM) cells leads to recurrence and poor prognosis. Accordingly, molecular pathways involved in dispersal are potential therapeutic targets. The mitogen activated protein kinase/extra...

    Authors: Stephen Shannon, Dongxuan Jia, Ildiko Entersz, Paul Beelen, Miao Yu, Christian Carcione, Jonathan Carcione, Aria Mahtabfar, Connan Vaca, Michael Weaver, David Shreiber, Jeffrey D. Zahn, Liping Liu, Hao Lin and Ramsey A. Foty
    Citation: BMC Cancer 2017 17:121
    Content type: Research article Published on:

  15. Infantile myofibromatosis belongs to a family of soft tissue tumors. The majority of these tumors have benign behavior but resistant and malignant courses are known, namely in tumors with visceral involvement....

    Authors: Peter Mudry, Ondrej Slaby, Jakub Neradil, Jana Soukalova, Kristyna Melicharkova, Ondrej Rohleder, Marta Jezova, Anna Seehofnerova, Elleni Michu, Renata Veselska and Jaroslav Sterba
    Citation: BMC Cancer 2017 17:119
    Content type: Case report Published on:

  16. We previously identified three short single peptides (P4, P6 and P7) representing different B-cell epitopes on the extracellular domain of Her-2/neu for a vaccine that was tested in a phase-I clinical trial. H...

    Authors: Joshua Tobias, Joanna Jasinska, Karin Baier, Michael Kundi, Nicholas Ede, Christoph Zielinski and Ursula Wiedermann
    Citation: BMC Cancer 2017 17:118
    Content type: Research article Published on:

  17. Chemokine (C–C motif) ligand 17 (CCL17) is a chemokine mainly produced by myeloid dendritic cells. It is a ligand for CC chemokine receptor 4 (CCR4) and CC chemokine receptor 8 (CCR8). The aim of this study wa...

    Authors: Ying Xiong, Li Liu, Yu Xia, Jiajun Wang, Wei Xi, Qi Bai, Yang Qu, Jiejie Xu and Jianming Guo
    Citation: BMC Cancer 2017 17:117
    Content type: Research article Published on:

  18. As in many other European countries, a nationwide screening program for colorectal cancer (CRC) has recently been introduced in the Netherlands. As a side effect, such a screening program will inherently yield...

    Authors: Meta C. J. van Lanschot, Beatriz Carvalho, Veerle M. H. Coupé, Manon van Engeland, Evelien Dekker and Gerrit A. Meijer
    Citation: BMC Cancer 2017 17:116
    Content type: Study protocol Published on:

  19. Breast cancer is a heterogeneous and a hormone-dependent disease. The detection of the estrogen receptor (ER) and progesterone receptor (PgR) is crucial for prognostic evaluation and treatment choice of breast...

    Authors: Ahoua Benjamin Effi, Nguiessan Alphonse Aman, Baumaney Sylvanus Koui, Kouadio Donatien Koffi, Zie Cheick Traoré and Mohamed Kouyate
    Citation: BMC Cancer 2017 17:115
    Content type: Research article Published on:

  20. The incidence of thyroid cancer among South Koreans is more than 10-fold greater than its incidence in other countries, although its associated mortality rate is similar. Amidst concerns regarding the over-dia...

    Authors: Yoon Jae Cho, Do Young Kim, Eun-Cheol Park and Kyu-Tae Han
    Citation: BMC Cancer 2017 17:114
    Content type: Research article Published on:

  21. Protease activated receptor (PAR)-1 expression is increased in a variety of tumor cells. In preclinical models, tumor cell PAR-1 appeared to be involved in the regulation of lung tumor growth and metastasis; h...

    Authors: Cong Lin, Christof J. Majoor, Joris J. T. H. Roelofs, Martijn D. de Kruif, Hugo M. Horlings, Keren Borensztajn and C. Arnold Spek
    Citation: BMC Cancer 2017 17:113
    Content type: Research article Published on:

  22. Second primary malignancies are a major cause of excess morbidity and mortality in cancer survivors. Hodgkin lymphoma survivors who were treated with infradiaphragmatic radiotherapy and/or high-dose procarbazi...

    Authors: Lisanne S. Rigter, Manon C. W. Spaander, Leon M. Moons, Tanya M. Bisseling, Berthe M. P. Aleman, Jan Paul de Boer, Pieternella J. Lugtenburg, Cecile P. M. Janus, Eefke J. Petersen, Judith M. Roesink, John M. M. Raemaekers, Richard W. M. van der Maazen, Annemieke Cats, Eveline M. A. Bleiker, Petur Snaebjornsson, Beatriz Carvalho…
    Citation: BMC Cancer 2017 17:112
    Content type: Study protocol Published on:

  23. The French EMS study prospectively collected exhaustive data from STS patients diagnosed in the Rhone-Alpes region from 2005 to 07.

    Authors: Isabelle Ray-Coquard, Olivier Collard, Françoise Ducimetiere, Mathieu Laramas, Florence Mercier, Nadine Ladarre, Stephanie Manson, Bertrand Tehard, Sébastien Clippe, Jean-Philippe Suchaud, Laetitia Stefani and Jean-Yves Blay
    Citation: BMC Cancer 2017 17:111
    Content type: Research article Published on:

  24. The “TOPical Imiquimod treatment of high-grade Cervical intraepithelial neoplasia” (TOPIC) trial was stopped preliminary, due to lagging inclusions. This study aimed to evaluate the treatment efficacy and clin...

    Authors: M. M. Koeneman, A. J. Kruse, L. F. S. Kooreman, A. zur Hausen, A. H. N. Hopman, S. J. S. Sep, T. Van Gorp, B. F. M. Slangen, H. J. van Beekhuizen, A. J. M. van de Sande, C. G. Gerestein, H. W. Nijman and R. F. P. M. Kruitwagen
    Citation: BMC Cancer 2017 17:110
    Content type: Correspondence Published on:

  25. Gastric cancer is one of the most common malignancies worldwide. Recent studies have shown that microRNAs play crucial roles in regulating cellular proliferation process in gastric cancer. MicroRNA-29c (miR-29...

    Authors: Beiqin Yu, Xuehua Chen, Jianfang Li, Qinlong Gu, Zhenggang Zhu, Chen Li, Liping Su and Bingya Liu
    Citation: BMC Cancer 2017 17:109
    Content type: Research article Published on:

  26. Little is known about the role of glial host cells in brain tumours. However, supporting stromal cells have been shown to foster tumour growth in other cancers.

    Authors: Lina Leiss, Ercan Mutlu, Anne Øyan, Tao Yan, Oleg Tsinkalovsky, Linda Sleire, Kjell Petersen, Mohummad Aminur Rahman, Mireille Johannessen, Sidhartha S. Mitra, Hege K. Jacobsen, Krishna M. Talasila, Hrvoje Miletic, Inge Jonassen, Xingang Li, Nicolaas H. Brons…
    Citation: BMC Cancer 2017 17:108
    Content type: Research article Published on:

  27. Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive disease, that can be described as a member of the family of small round blue cell tumors. The molecular diagnostic marker is the t(11...

    Authors: S. Uboldi, I. Craparotta, G. Colella, E. Ronchetti, L. Beltrame, S. Vicario, S. Marchini, N. Panini, G. Dagrada, F. Bozzi, S. Pilotti, C. M. Galmarini, M. D’Incalci and R. Gatta
    Citation: BMC Cancer 2017 17:107
    Content type: Research article Published on:

  28. Colorectal cancer (CRC) survivors are at increased risk of developing the disease again. Surveillance guidelines are aimed at maximising the early detection of recurring or new cancers and pre-cancerous polyps...

    Authors: Mariko Carey, Robert Sanson-Fisher, Finlay Macrae, Emilie Cameron, David Hill, Catherine D’Este and Christopher Doran
    Citation: BMC Cancer 2017 17:106
    Content type: Research article Published on:

  29. Cytoplasmic linker-associated protein 2 (CLASP2) belongs to a family of microtubule plus-end tracking proteins that localizes to the distal ends of microtubules and regulate microtubule dynamics. We speculated...

    Authors: Bisong Zhu, Lin Qi, Sulai Liu, Wentao Liu, Zhenyu Ou, Minfeng Chen, Longfei Liu, Xiongbing Zu, Jun Wang and Yuan Li
    Citation: BMC Cancer 2017 17:105
    Content type: Research article Published on:

  30. Breast cancer is the most frequently diagnosed cancer in women. Resident macrophages at distant sites provide a highly responsive and immunologically dynamic innate immune response against foreign infiltrates....

    Authors: Ritu Jaiswal, Michael S. Johnson, Deep Pokharel, S. Rajeev Krishnan and Mary Bebawy
    Citation: BMC Cancer 2017 17:104
    Content type: Research article Published on:

  31. Clinical research has established the efficacy of exercise in reducing treatment-related side-effects and increasing wellbeing in people with cancer. Major oncology organisations have identified the importance...

    Authors: Prue Cormie, Stephanie Lamb, Robert U. Newton, Lani Valentine, Sandy McKiernan, Nigel Spry, David Joseph, Dennis R. Taaffe, Christopher M. Doran and Daniel A. Galvão
    Citation: BMC Cancer 2017 17:103
    Content type: Study protocol Published on:

  32. Ovarian cancer remains the most deadly gynecological cancer with a poor aggregate survival rate; however, the specific rates are highly dependent on the stage of the disease upon diagnosis. Current screening a...

    Authors: Karissa B. Tilbury, Kirby R. Campbell, Kevin W. Eliceiri, Sana M. Salih, Manish Patankar and Paul J. Campagnola
    Citation: BMC Cancer 2017 17:102
    Content type: Research article Published on:

  33. Body mass index (BMI) is largely investigated as a prognostic and predictive factor in triple-negative breast cancer (TNBC). Overweight and obesity are linked to a variety of pathways regulating tumor-promotin...

    Authors: Maddalena Barba, Patrizia Vici, Laura Pizzuti, Luigi Di Lauro, Domenico Sergi, Anna Di Benedetto, Cristiana Ercolani, Francesca Sperati, Irene Terrenato, Claudio Botti, Lucia Mentuccia, Laura Iezzi, Teresa Gamucci, Clara Natoli, Ilio Vitale, Marcella Mottolese…
    Citation: BMC Cancer 2017 17:101
    Content type: Research article Published on:

  34. Women with breast cancer undergoing chemotherapy suffer from a range of detrimental disease and treatment related side-effects. Exercise has shown to be able to counter some of these side-effects and improve p...

    Authors: Y. Wengström, K. A. Bolam, S. Mijwel, C. J. Sundberg, M. Backman, M. Browall, J. Norrbom and H. Rundqvist
    Citation: BMC Cancer 2017 17:100
    Content type: Study protocol Published on:

  35. Glioblastoma Multiforme (GBM) is the most common and lethal form of primary brain tumor in adults. Following standard treatment of surgery, radiation and chemotherapy, patients are expected to survive 12–14 mo...

    Authors: Zachary C. Gersey, Gregor A. Rodriguez, Eric Barbarite, Anthony Sanchez, Winston M. Walters, Kelechi C. Ohaeto, Ricardo J. Komotar and Regina M. Graham
    Citation: BMC Cancer 2017 17:99
    Content type: Research article Published on:

  36. Despite advances in cancer diagnosis and treatment have significantly improved survival rates, patients post-treatment-related health needs are often not adequately addressed by current health services. The ai...

    Authors: Debra Anderson, Charrlotte Seib, Dian Tjondronegoro, Jane Turner, Leanne Monterosso, Amanda McGuire, Janine Porter-Steele, Wei Song, Patsy Yates, Neil King, Leonie Young, Kate White, Kathryn Lee, Sonj Hall, Mei Krishnasamy, Kathy Wells…
    Citation: BMC Cancer 2017 17:98
    Content type: Study protocol Published on:

    The Erratum to this article has been published in BMC Cancer 2017 17:196

  37. The del1518 (rs3730485) polymorphism is an in/del variant in the MDM2 promoter P1. The variant is in complete linkage disequilibrium with MDM2 SNP309 (rs2279744) and has previously been found associated with an i...

    Authors: Liv B. Gansmo, Merete Bjørnslett, Mari Kyllesø Halle, Helga B. Salvesen, Pål Romundstad, Kristian Hveem, Lars Vatten, Anne Dørum, Per E. Lønning and Stian Knappskog
    Citation: BMC Cancer 2017 17:97
    Content type: Research article Published on:

  38. The roles of carcinoembryonic antigen (CEA), cytokeratin 19 fragments (CYFRA21-1) and neuron-specific enolase (NSE) in metastases occurrence and poor diagnosis in specific histological classifications of lung ...

    Authors: Li Zhang, Dan Liu, Lei Li, Dan Pu, Ping Zhou, Yuting Jing, He Yu, Yanwen Wang, Yihan Zhu, Yanqi He, Yalun Li, Shuang Zhao, Zhixin Qiu and Weimin Li
    Citation: BMC Cancer 2017 17:96
    Content type: Research article Published on:

  39. Australia and New Zealand have the highest incidence of colorectal cancer (CRC) in the world, presenting considerable health, economic, and societal burden. Over a third of the Australian population live in re...

    Authors: Michael J. Ireland, Sonja March, Fiona Crawford-Williams, Mandy Cassimatis, Joanne F. Aitken, Melissa K. Hyde, Suzanne K. Chambers, Jiandong Sun and Jeff Dunn
    Citation: BMC Cancer 2017 17:95
    Content type: Research article Published on:

  41. Advanced urothelial carcinomas represent a considerable clinical challenge as they are difficult to treat. Platinum-based combination regimens obtain response rates ranging from 40 to 70% in first-line therapy...

    Authors: Sergey A. Dyshlovoy, Ramin Madanchi, Jessica Hauschild, Katharina Otte, Winfried H. Alsdorf, Udo Schumacher, Vladimir I. Kalinin, Alexandra S. Silchenko, Sergey A. Avilov, Friedemann Honecker, Valentin A. Stonik, Carsten Bokemeyer and Gunhild von Amsberg
    Citation: BMC Cancer 2017 17:93
    Content type: Research article Published on:

  42. Multiple types of extracellular vesicles (EVs), including microvesicles (MVs) and exosomes (EXOs), are released by all cells constituting part of the cellular EV secretome. The bioactive cargo of EVs can be sh...

    Authors: Elisa Lázaro-Ibáñez, Taral R. Lunavat, Su Chul Jang, Carmen Escobedo-Lucea, Jorge Oliver-De La Cruz, Pia Siljander, Jan Lötvall and Marjo Yliperttula
    Citation: BMC Cancer 2017 17:92
    Content type: Research article Published on:

  43. The purpose of this study was to develop an effective nomogram capable of estimating the individual survival outcomes of patients with hepatocellular carcinoma (HCC), and compare the predictive accuracy and di...

    Authors: Gang Wan, Fangyuan Gao, Jialiang Chen, Yuxin Li, Mingfan Geng, Le Sun, Yao Liu, Huimin Liu, Xue Yang, Rui Wang, Ying Feng and Xianbo Wang
    Citation: BMC Cancer 2017 17:91
    Content type: Research article Published on:

  44. The insulin-like growth factor (IGF) system plays an important role in the development and progression of cancer. However, little is known about the expression of the IGF system components and their clinicopat...

    Authors: Xinwei Feng, Jianhua Lin, Shan Xing, Wanli Liu and Ge Zhang
    Citation: BMC Cancer 2017 17:90
    Content type: Research article Published on:

  45. BK-UM (CRM197) is a mutant form of diphtheria toxin and a specific inhibitor of heparin-binding epidermal growth factor-like growth factor (HB-EGF). We assessed the safety, pharmacokinetics, recommended dose, ...

    Authors: Shingo Miyamoto, Fusanori Yotsumoto, Taeko Ueda, Tatsuya Fukami, Ayako Sanui, Kohei Miyata, Sung Ouk Nam, Satoshi Fukagawa, Takahiro Katsuta, Miyako Maehara, Haruhiko Kondo, Daisuke Miyahara, Kyoko Shirota, Toshiyuki Yoshizato, Masahide Kuroki, Hiroaki Nishikawa…
    Citation: BMC Cancer 2017 17:89
    Content type: Research article Published on:

  46. The role of the chemokine CCL2 in breast cancer is controversial. While CCL2 recruits and activates pro-tumor macrophages, it is also reported to enhance neutrophil-mediated anti-tumor activity. Moreover, loss...

    Authors: Nicole Lavender, Jinming Yang, Sheau-Chiann Chen, Jiqing Sai, C. Andrew Johnson, Philip Owens, Gregory D. Ayers and Ann Richmond
    Citation: BMC Cancer 2017 17:88
    Content type: Research article Published on:

  47. Discoidin domain receptor 1 (DDR1), a receptor tyrosine kinase that utilizes collagen as a ligand, is a key molecule in the progression of solid tumors as it regulates the interaction of cancer cells with the ...

    Authors: Hoon Hur, In-Hye Ham, Dakeun Lee, Hyejin Jin, Kristina Y. Aguilera, Hye Jeong Oh, Sang-Uk Han, Ji Eun Kwon, Young-Bae Kim, Ke Ding and Rolf A. Brekken
    Citation: BMC Cancer 2017 17:87
    Content type: Research article Published on:

  48. Concurrent cisplatin radiotherapy (CCRT) is a current standard-of-care for locally advanced head and neck squamous cell carcinoma (HNSCC). However, CCRT is frequently ineffective in patients with advanced dise...

    Authors: Martin McLaughlin, Holly E. Barker, Aadil A. Khan, Malin Pedersen, Magnus Dillon, David C. Mansfield, Radhika Patel, Joan N. Kyula, Shreerang A. Bhide, Kate L. Newbold, Christopher M. Nutting and Kevin J. Harrington
    Citation: BMC Cancer 2017 17:86
    Content type: Research article Published on:

  49. Cancers of Unknown Primary (CUP) are the 3-4th most common causes of cancer death and recent clinical guidelines recommend that patients should be directed to a team dedicated to their care. Our aim was to inform...

    Authors: William Jones, Gwen Allardice, Iona Scott, Karin Oien, David Brewster and David S. Morrison
    Citation: BMC Cancer 2017 17:85
    Content type: Research article Published on:

  50. Atypical hyperplasia (AH) and mammographic breast density (MBD) are established risk factors for breast cancer (BC), but their joint contributions are not well understood. We examine associations of MBD and BC...

    Authors: Robert A. Vierkant, Amy C. Degnim, Derek C. Radisky, Daniel W. Visscher, Ethan P. Heinzen, Ryan D. Frank, Stacey J. Winham, Marlene H. Frost, Christopher G. Scott, Matthew R. Jensen, Karthik Ghosh, Armando Manduca, Kathleen R. Brandt, Dana H. Whaley, Lynn C. Hartmann and Celine M. Vachon
    Citation: BMC Cancer 2017 17:84
    Content type: Research article Published on:

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