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  1. Aberrant DNA methylation profiles are a characteristic of all known cancer types, epitomized by the CpG island methylator phenotype (CIMP) in colorectal cancer (CRC). Hypermethylation has been observed at CpG ...

    Authors: Tyler McInnes, Donghui Zou, Dasari S. Rao, Francesca M. Munro, Vicky L. Phillips, John L. McCall, Michael A. Black, Anthony E. Reeve and Parry J. Guilford
    Citation: BMC Cancer 2017 17:228
    Content type: Research article Published on:

  2. ATP-binding cassette sub-family G member 2 (ABCG2) is a semi-transport protein that plays a major role in multidrug resistance. We aimed to evaluate the prognostic significance of ABCG2 expression in patients wit...

    Authors: Haofei Wang, Fangxiu Luo, Zhe Zhu, Zhaoping Xu, Xin Huang, Renyi Ma, Hongchao He, Yu Zhu, Kun Shao and Juping Zhao
    Citation: BMC Cancer 2017 17:222
    Content type: Research article Published on:

  4. Colorectal cancer is a major public health issue worldwide. Interleukin-17 (IL-17) and Th17 (T-helper cell type 17)-related molecules are involved in tumor development and in resistance to bevacizumab, an anti...

    Authors: Emilie Lereclus, Mira Tout, Alban Girault, Nadine Baroukh, Morgane Caulet, Christophe Borg, Olivier Bouché, David Ternant, Gilles Paintaud, Thierry Lecomte and William Raoul
    Citation: BMC Cancer 2017 17:220
    Content type: Research article Published on:

  5. Tumour stem cells are considered important to promote disease progression, recurrence and treatment resistance following chemotherapy in colon cancer. However, genomic analyses of colorectal cancer have mainly...

    Authors: Diana Cervantes-Madrid, Yvonne Wettergren, Peter Falk, Kent Lundholm and Annika G. Asting
    Citation: BMC Cancer 2017 17:219
    Content type: Research article Published on:

  6. Cancer-related fatigue is a common problem in persons with cancer, influencing health-related quality of life and causing a considerable challenge to society. Current evidence supports the beneficial effects o...

    Authors: Sveinung Berntsen, Neil K Aaronson, Laurien Buffart, Sussanne Börjeson, Ingrid Demmelmaier, Maria Hellbom, Pernille Hojman, Helena Igelström, Birgitta Johansson, Ronnie Pingel, Truls Raastad, Galina Velikova, Pernilla Åsenlöf and Karin Nordin
    Citation: BMC Cancer 2017 17:218
    Content type: Study protocol Published on:

  7. This study aimed to analyze the pattern of lymphogenous and hematogenous metastases in patients with stage IVb thymic carcinomas and identify prognostic factors for their survivals.

    Authors: Yu Yang, Xing-Wen Fan, Hong-Bing Wang, Yin Xu, Dou-Dou Li and Kai-Liang Wu
    Citation: BMC Cancer 2017 17:217
    Content type: Research article Published on:

  8. Former studies already revealed the anti-neoplastic properties of the anti-infective agent Taurolidine (TRD) against many tumor species in vitro and in vivo. Its anti-proliferative and cell death inducing capacit...

    Authors: M. Buchholz, B. Majchrzak-Stiller, S. Hahn, D. Vangala, R. W. Pfirrmann, W. Uhl, C. Braumann and A. M. Chromik
    Citation: BMC Cancer 2017 17:216
    Content type: Research article Published on:

  9. Multiple Myeloma (MM) is a B-cell malignancy in which clonal plasma cells progressively expand within the bone marrow (BM) as effect of complex interactions with extracellular matrix and a number of microenvir...

    Authors: S Ciavarella, A Laurenzana, S De Summa, B Pilato, A Chillà, R Lacalamita, C Minoia, F Margheri, A Iacobazzi, A Rana, F Merchionne, G Fibbi, M Del Rosso, A Guarini, S Tommasi and S Serratì
    Citation: BMC Cancer 2017 17:215
    Content type: Research article Published on:

  10. A high incidence of severe hematological adverse events during sunitinib treatment complicates decision making on dose and treatment cycle. We identified the characteristics of early-onset hematotoxicity of su...

    Authors: Renpei Kato, Yoichiro Kato, Tomohiko Matsuura, Mitsugu Kanehira, Ryo Takata and Wataru Obara
    Citation: BMC Cancer 2017 17:214
    Content type: Research article Published on:

  11. Accurate prognosticating is needed when patients are nearing the end of life to ensure appropriate treatment decisions, and facilitate palliative care provision and transitioning to terminal care. People with ...

    Authors: Elise Button, Raymond Javan Chan, Shirley Chambers, Jason Butler and Patsy Yates
    Citation: BMC Cancer 2017 17:213
    Content type: Research article Published on:

  12. We evaluated possible diagnostic and prognostic values of serum midkine in malignant pleural mesothelioma in comparison with those of serum mesothelin, a well-established diagnostic biomarker.

    Authors: Guntulu Ak, Yuji Tada, Hideaki Shimada, Selma Metintas, Masaaki Ito, Kenzo Hiroshima, Masatoshi Tagawa and Muzaffer Metintas
    Citation: BMC Cancer 2017 17:212
    Content type: Research article Published on:

  13. We designed a single-arm, open-label phase II trial of everolimus in PIK3CA amplification/mutation and/or PTEN loss patients with advanced solid tumors refractory to standard therapy (#NCT02449538).

    Authors: Seung Tae Kim, Jeeyun Lee, Se Hoon Park, Joon Oh Park, Young Suk Park, Won Ki Kang and Ho Yeong Lim
    Citation: BMC Cancer 2017 17:211
    Content type: Research article Published on:

  14. Accurate measurement of tumor burden in breast cancer disease is essential to improve the clinical management of patients. In this study, we evaluate whether the fluctuations in the fraction of PIK3CA mutant a...

    Authors: José Angel García-Saenz, Patricia Ayllón, Marion Laig, Daniel Acosta-Eyzaguirre, Marta García-Esquinas, Myriam Montes, Julián Sanz, Miguel Barquín, Fernando Moreno, Vanesa Garcia-Barberan, Eduardo Díaz-Rubio, Trinidad Caldes and Atocha Romero
    Citation: BMC Cancer 2017 17:210
    Content type: Research article Published on:

  15. The scientific and public debate concerning organized mammography screening is unprecedentedly strong. With research evidence concerning its efficacy being ambiguous, the recommendations pertaining to the age-...

    Authors: Nanon H. M. Labrie, Ramona Ludolph and Peter J. Schulz
    Citation: BMC Cancer 2017 17:209
    Content type: Research article Published on:

  16. In definitive radiation therapy for head and neck cancer, clinically uninvolved cervical lymph nodes are irradiated with a so-called ‘elective dose’ in order to achieve control of clinically occult metastases....

    Authors: Sven van den Bosch, Tim Dijkema, Martina C. Kunze-Busch, Chris H. J. Terhaard, Cornelis P. J. Raaijmakers, Patricia A. H. Doornaert, Frank J. P. Hoebers, Marije R. Vergeer, Bas Kreike, Oda B. Wijers, Wim J. G. Oyen and Johannes H. A. M. Kaanders
    Citation: BMC Cancer 2017 17:208
    Content type: Study protocol Published on:

  17. Although meningioma is a common disease, there is a lack of understanding of the underlying molecular mechanisms behind its initiation and progression. We used combined miRNA-mRNA transcriptome analysis to dis...

    Authors: Altay Burak Dalan, Sukru Gulluoglu, Emre Can Tuysuz, Aysegul Kuskucu, Cumhur Kaan Yaltirik, Oguz Ozturk, Ugur Ture and Omer Faruk Bayrak
    Citation: BMC Cancer 2017 17:207
    Content type: Research article Published on:

  18. Autotransplantation of frozen-thawed ovarian tissue is a method to preserve ovarian function and fertility in patients undergoing gonadotoxic therapy. In oncology patients, the safety cannot yet be guaranteed,...

    Authors: Inge T. A. Peters, Merle A. van der Steen, Bertine W. Huisman, Carina G. J .M. Hilders, Vincent T. H. B. M. Smit, Alexander L. Vahrmeijer, Cornelis F. M. Sier, J. Baptist Trimbos and Peter J. K. Kuppen
    Citation: BMC Cancer 2017 17:206
    Content type: Research article Published on:

  20. Glioblastoma multiforme (GBM) is the most common, invasive and deadly primary type of malignant brain tumor. The Phosphatidylinositol-3-Kinase/AKT (PI3K/AKT) pathway is highly active in GBM and has been associ...

    Authors: Ravi S. Narayan, Carlos A. Fedrigo, Eelke Brands, Rogier Dik, Lukas J.A. Stalpers, Brigitta G. Baumert, Ben J. Slotman, Bart A. Westerman, Godefridus J. Peters and Peter Sminia
    Citation: BMC Cancer 2017 17:204
    Content type: Research article Published on:

  21. About 75–80% of breast tumors express the estrogen receptor alpha (ER-α) and are treated with endocrine-target therapeutics, making this the premier therapeutic modality in the breast cancer clinic. However, a...

    Authors: Mercè Padró, Raymond J. Louie, Brian V. Lananna, Adam J. Krieg, Luika A. Timmerman and Denise A. Chan
    Citation: BMC Cancer 2017 17:203
    Content type: Research article Published on:

  22. Tumour metastasis remains the major cause of death in cancer patients and, to date, the mechanism and signalling pathways governing this process are not completely understood. The TGF-β pathway is the most com...

    Authors: Jo-Anne de la Mare, Tamarin Jurgens and Adrienne L. Edkins
    Citation: BMC Cancer 2017 17:202
    Content type: Research article Published on:

  23. Y-box binding protein-1 is an evolutionary conserved transcription and translation regulating protein that is overexpressed in various human malignancies, including breast cancer. Despite reports of YB-1 and i...

    Authors: Jia Pei Lim, Sukanya Shyamasundar, Jayantha Gunaratne, Olivia Jane Scully, Ken Matsumoto and Boon Huat Bay
    Citation: BMC Cancer 2017 17:201
    Content type: Research article Published on:

  24. Aprepitant is an FDA-approved medication for chemotherapy-induced nausea and vomiting. It blocks substance P binding to neurokinin-1; substance P has been implicated in itch pathways both as a local and global...

    Authors: Johanna S. Song, Marianne Tawa, Nicole G. Chau, Thomas S. Kupper and Nicole R. LeBoeuf
    Citation: BMC Cancer 2017 17:200
    Content type: Case report Published on:

  25. Approximately 18–20% of all human breast cancers have overexpressed human epidermal growth factor receptor 2 (HER2). Standard clinical practice is to treat only overexpressed HER2 (HER2+) cancers with targeted...

    Authors: Yao Huang, David J. Burns, Benjamin E. Rich, Ian A. MacNeil, Abhijit Dandapat, Sajjad M. Soltani, Samantha Myhre, Brian F. Sullivan, Carol A. Lange, Leo T. Furcht and Lance G. Laing
    Citation: BMC Cancer 2017 17:199
    Content type: Research article Published on:

  26. Median age at diagnosis of patients with chronic lymphocytic leukemia (CLL) is > 70 years. However, the majority of clinical trials do not reflect the demographics of CLL patients treated in the community. We ...

    Authors: Chadi Nabhan, Anthony Mato, Christopher R. Flowers, David L. Grinblatt, Nicole Lamanna, Mark A. Weiss, Matthew S. Davids, Arlene S. Swern, Shriya Bhushan, Kristen Sullivan, E. Dawn Flick, Pavel Kiselev and Jeff P. Sharman
    Citation: BMC Cancer 2017 17:198
    Content type: Research article Published on:

  27. Collision tumors are uncommon but well described clinical entities composed of distinct tumor histologies occurring within the same anatomic site. Optimal management of patients with collision tumors remains h...

    Authors: Munveer S. Bhangoo, Jenny Y. Zhou, Siraj M. Ali, Russell Madison, Alexa B. Schrock and Carrie Costantini
    Citation: BMC Cancer 2017 17:197
    Content type: Case report Published on:

  28. Authors: Debra Anderson, Charrlotte Seib, Dian Tjondronegoro, Jane Turner, Leanne Monterosso, Amanda McGuire, Janine Porter-Steele, Wei Song, Patsy Yates, Neil King, Leonie Young, Kate White, Kathryn Lee, Sonj Hall, Mei Krishnasamy, Kathy Wells…
    Citation: BMC Cancer 2017 17:196
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2017 17:98

  29. Authors: Rumyana Ivanova Dodova, Atanaska Velichkova Mitkova, Daniela Rosenova Dacheva, Lina Basam Hadjo, Alexandrina Ivanova Vlahova, Margarita Stoyanova Taushanova – Hadjieva, Spartak Stoyanov Valev, Marija Mitko Caulevska, Stanislava Dimitrova Popova, Ivan Emilov Popov, Tihomir Iliichev Dikov, Theophil Angelov Sedloev, Atanas Stefanov Ionkov, Konstanta Velinova Timcheva, Svetlana Liubomirova Christova, Ivo Marinov Kremensky…
    Citation: BMC Cancer 2017 17:195
    Content type: Erratum Published on:

    The original article was published in BMC Cancer 2015 15:523

  30. Breast cancer is the main cause of mortality among women. The disease presents high recurrence mainly due to incomplete efficacy of primary treatment in killing all cancer cells. Photodynamic therapy (PDT), an...

    Authors: Ancély F. dos Santos, Letícia F. Terra, Rosangela A. M. Wailemann, Talita C. Oliveira, Vinícius de Morais Gomes, Marcela Franco Mineiro, Flávia Carla Meotti, Alexandre Bruni-Cardoso, Maurício S. Baptista and Leticia Labriola
    Citation: BMC Cancer 2017 17:194
    Content type: Research article Published on:

  31. This RCT with two parallel arms will evaluate the efficacy of an internet-delivered transdiagnostic cognitive behavioural therapy (iCBT) intervention for the treatment of clinical depression and/or anxiety in ...

    Authors: M. J. Murphy, J. M. Newby, P. Butow, L. Kirsten, K. Allison, S. Loughnan, M. A. Price, J. Shaw, H. Shepherd, J. Smith and G. Andrews
    Citation: BMC Cancer 2017 17:193
    Content type: Study protocol Published on:

    The Correction to this article has been published in BMC Cancer 2017 17:667

  32. Renal cell carcinomas (RCCs) overexpress fatty acid binding protein 7 (FABP7). We chose to study the TUHR14TKB cell line, because it expresses higher levels of FABP7 than other cell lines derived from renal ca...

    Authors: Naohisa Takaoka, Tatsuya Takayama and Seiichiro Ozono
    Citation: BMC Cancer 2017 17:192
    Content type: Research article Published on:

  33. Targeted therapies are emerging treatment options for gastric cancer (GC). Patient-derived tumor xenograft(PDX) models of GC closely retain the features of the original clinical cancer, offering a powerful too...

    Authors: Haiyong Wang, Jun Lu, Jian Tang, Shitu Chen, Kuifeng He, Xiaoxia Jiang, Weiqin Jiang and Lisong Teng
    Citation: BMC Cancer 2017 17:191
    Content type: Research article Published on:

  34. Cancer cachexia is a multifactorial syndrome that dramatically decreases survival. Loss of white adipose tissue (WAT) is one of the key characteristics of cachexia. WAT wasting is paralleled by microarchitectu...

    Authors: Michele Joana Alves, Raquel Galvão Figuerêdo, Flavia Figueiredo Azevedo, Diego Alexandre Cavallaro, Nelson Inácio Pinto Neto, Joanna Darck Carola Lima, Emidio Matos-Neto, Katrin Radloff, Daniela Mendes Riccardi, Rodolfo Gonzalez Camargo, Paulo Sérgio Martins De Alcântara, José Pinhata Otoch, Miguel Luiz Batista Junior and Marília Seelaender
    Citation: BMC Cancer 2017 17:190
    Content type: Research article Published on:

  35. The inhibition of Delta-like 4 (Dll4)/Notch signaling has been shown to result in excessive, nonfunctional vessel proliferation and significant tumor growth suppression. However, safety concerns emerged with t...

    Authors: Alexandre Trindade, Dusan Djokovic, Joana Gigante, Liliana Mendonça and António Duarte
    Citation: BMC Cancer 2017 17:189
    Content type: Research article Published on:

  36. To evaluate the efficacy of cetuximab combined with modified FOLFIRI (mFOLFIRI) as a second-line treatment in metastatic gastric cancer patients and to identify potential biomarkers of clinical outcomes.

    Authors: Xin Liu, Weijian Guo, Wen Zhang, Jiliang Yin, Jun Zhang, Xiaodong Zhu, Tianshu Liu, Zhiyu Chen, Biyun Wang, Jianhua Chang, Fangfang Lv, Xiaonan Hong, Huijie Wang, Jialei Wang, Xinmin Zhao, Xianghua Wu…
    Citation: BMC Cancer 2017 17:188
    Content type: Research article Published on:

  37. Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cel...

    Authors: F. M. Sullivan, Eoghan Farmer, Frances S. Mair, Shaun Treweek, Denise Kendrick, Cathy Jackson, Chris Robertson, Andrew Briggs, Colin McCowan, Laura Bedford, Ben Young, Kavita Vedhara, Stephanie Gallant, Roberta Littleford, John Robertson, Herb Sewell…
    Citation: BMC Cancer 2017 17:187
    Content type: Study protocol Published on:

  38. Approximately one third of cancer survivors in the United Kingdom face ongoing and debilitating psychological and physical symptoms related to poor quality of life. Very little is known about current post-canc...

    Authors: M. Duncan, J. Deane, P. D. White, D. Ridge, R. Roylance, A. Korszun, T. Chalder, K. S. Bhui, M. A. Thaha and L. Bourke
    Citation: BMC Cancer 2017 17:186
    Content type: Research article Published on:

  39. The purpose of this retrospective study was to determine whether RFA could provide an alternative treatment modality for selected patients who are not candidates for hepatic resection.

    Authors: Jin Won Lee, Moon Hyung Choi, Young Joon Lee, Bandar Ali, Han Mo Yoo, Kyo Young Song and Cho Hyun Park
    Citation: BMC Cancer 2017 17:185
    Content type: Research article Published on:

  40. Most cancer deaths result from tumor cells that have metastasized beyond their tissue of origin, or have developed drug resistance. Across many cancer types, patients with advanced stage disease would benefit ...

    Authors: Cai M. Roberts, Sophia A. Shahin, Joana Loeza, Thanh H. Dellinger, John C. Williams and Carlotta A. Glackin
    Citation: BMC Cancer 2017 17:184
    Content type: Research article Published on:

  41. Chronic Helicobacter pylori infection plays a central role in the development of gastric cancer as shown by biological and epidemiological studies. The H. pylori antibody and serum pepsinogen (PG) tests have been...

    Authors: Chisato Hamashima, Shizuka Sasazuki, Manami Inoue and Shoichiro Tsugane
    Citation: BMC Cancer 2017 17:183
    Content type: Research article Published on:

  42. In this era of oxaliplatin-based adjuvant therapy, the optimal sequence in which chemoradiotherapy should be administered for pathological stage N2 rectal cancer is unknown. The aim of this study was to invest...

    Authors: Yan-Ru Feng, Jing Jin, Hua Ren, Xin Wang, Shu-Lian Wang, Wei-Hu Wang, Yong-Wen Song, Yue-Ping Liu, Yuan Tang, Ning Li, Xin-Fan Liu, Hui Fang, Zi-Hao Yu and Ye-Xiong Li
    Citation: BMC Cancer 2017 17:182
    Content type: Research article Published on:

  43. A shift towards less burdening and more patient friendly treatments for breast cancer is currently ongoing. In low-risk patients with early-stage disease, accelerated partial breast irradiation (APBI) is an al...

    Authors: R. K. Charaghvandi, B. van Asselen, M. E. P. Philippens, H. M. Verkooijen, C. H. van Gils, P. J. van Diest, R. M. Pijnappel, M. G. G. Hobbelink, A. J. Witkamp, T. van Dalen, E. van der Wall, T. C. van Heijst, R. Koelemij, M. van Vulpen and H. J. G. D. van den Bongard
    Citation: BMC Cancer 2017 17:181
    Content type: Study protocol Published on:

  44. This paper describes the multi-institutional prospective phase II clinical trial, SPARK: Stereotactic Prostate Adaptive Radiotherapy utilizing Kilovoltage Intrafraction Monitoring (KIM). KIM is a real-time image ...

    Authors: Paul Keall, Doan Trang Nguyen, Ricky O’Brien, Jeremy Booth, Peter Greer, Per Poulsen, Val Gebski, Andrew Kneebone and Jarad Martin
    Citation: BMC Cancer 2017 17:180
    Content type: Study protocol Published on:

  45. Virtually all prostate cancer deaths occur due to obtaining the castration-resistant phenotype after prostate cancer cells escaped from apoptosis and/or growth suppression initially induced by androgen recepto...

    Authors: Linjie Chen, Dennis W. Wolff, Yan Xie, Ming-Fong Lin and Yaping Tu
    Citation: BMC Cancer 2017 17:179
    Content type: Research article Published on:

  46. Glioblastoma is the most frequent and most malignant brain tumor with the patients having a median survival of only 14.6 months. Although glioblastoma patients are treated with surgery, radiation and chemother...

    Authors: Stine S. Jensen, Stine A. Petterson, Bo Halle, Charlotte Aaberg-Jessen and Bjarne W. Kristensen
    Citation: BMC Cancer 2017 17:178
    Content type: Research article Published on:

  47. We previously showed that 1-methylnicotinamide (1-MNA) and its analog 1,4-dimethylpyridine (1,4-DMP) could inhibit the formation of lung metastases and enhance the efficacy of cyclophosphamide-based chemothera...

    Authors: Agnieszka Denslow, Marta Switalska, Marcin Nowak, Magdalena Maciejewska, Stefan Chlopicki, Andrzej Marcinek, Jerzy Gebicki and Joanna Wietrzyk
    Citation: BMC Cancer 2017 17:177
    Content type: Research article Published on:

  48. Myeloid ecotropic viral integration site 1 (MEIS1) protein plays a synergistic causative role in acute myeloid leukemia (AML). However, MEIS1 has also shown to be a potential tumor suppressor in some other can...

    Authors: Jie Zhu, Liang Cui, Axiang Xu, Xiaotao Yin, Fanglong Li and Jiangping Gao
    Citation: BMC Cancer 2017 17:176
    Content type: Research article Published on:

  49. Our previous study showed that GATA6 plays important roles in cholangiocarcinoma (CCA) cell invasion and metastasis. However, the regulation mechanism of GATA6 in CCA is not clear. In this study, we studied th...

    Authors: Feng Tian, Jian Chen, Shuguo Zheng, Dajiang Li, Xin Zhao, Peng Jiang, Jianwei Li and Shuguang Wang
    Citation: BMC Cancer 2017 17:175
    Content type: Research article Published on:

  50. Unperturbed tumor growth kinetics is one of the more studied cancer topics; however, it is poorly understood. Mathematical modeling is a useful tool to elucidate new mechanisms involved in tumor growth kinetic...

    Authors: Maraelys Morales González, Javier Antonio González Joa, Luis Enrique Bergues Cabrales, Ana Elisa Bergues Pupo, Baruch Schneider, Suleyman Kondakci, Héctor Manuel Camué Ciria, Juan Bory Reyes, Manuel Verdecia Jarque, Miguel Angel O’Farril Mateus, Tamara Rubio González, Soraida Candida Acosta Brooks, José Luis Hernández Cáceres and Gustavo Victoriano Sierra González
    Citation: BMC Cancer 2017 17:174
    Content type: Research article Published on:

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