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  1. The insulin growth factor (IGF) pathway has been proposed as a potential therapeutic target in bladder cancer. We characterized the expression of components of the IGF pathway — insulin growth factor receptors...

    Authors: Yann Neuzillet, Elodie Chapeaublanc, Clémentine Krucker, Leanne De Koning, Thierry Lebret, François Radvanyi and Isabelle Bernard-Pierrot
    Citation: BMC Cancer 2017 17:636
    Content type: Research article Published on:

  2. Prostate cancer (PCa) is a heterogeneous disease with a variable natural history, genetics, and treatment outcome. The Hedgehog (Hh) signaling pathway is increasingly recognized as being potentially important ...

    Authors: Annelies Gonnissen, Sofie Isebaert, Christiaan Perneel, Chad M. McKee, Clare Verrill, Richard J. Bryant, Filip Van Utterbeeck, Evelyne Lerut, Karin Haustermans and Ruth J. Muschel
    Citation: BMC Cancer 2017 17:634
    Content type: Research article Published on:

  3. Extranodal NK/T-cell lymphoma (ENKTCL) reports from sub-Saharan Africa (SSA) are remarkably rare, despite early childhood acquisition and high prevalence of the causative infectious agent, Epstein-Barr virus (...

    Authors: Tamiwe Tomoka, Eric Powers, Toon van der Gronde, Amy Amuquandoh, Bal Mukunda Dhungel, Coxcilly Kampani, Steve Kamiza, Nathan D. Montgomery, Yuri Fedoriw and Satish Gopal
    Citation: BMC Cancer 2017 17:633
    Content type: Case report Published on:

  4. The numerous side effects of chemotherapy in patients with breast cancer are well known. However, the precise effects of chemotherapy on ovarian function in premenopausal women are poorly investigated. The pat...

    Authors: Antonia Wenners, Jana Grambach, Juliane Koss, Nicolai Maass, Walter Jonat, Andreas Schmutzler and Christoph Mundhenke
    Citation: BMC Cancer 2017 17:632
    Content type: Research article Published on:

  5. Neoplastic cells proliferate rapidly and obtain requisite building blocks by reprogramming metabolic pathways that favor growth. Previously, we observed that prostate cancer cells uptake and store lipids in th...

    Authors: Ranjana Mitra, Thuc T. Le, Priyatham Gorjala and Oscar B. Goodman Jr.
    Citation: BMC Cancer 2017 17:631
    Content type: Research article Published on:

  6. Acute myeloid leukemia (AML) is an aggressive malignancy only cured by intensive therapy. However, many elderly and unfit patients cannot receive such treatment due to an unacceptable risk of treatment-related...

    Authors: Håkon Reikvam, Randi Hovland, Rakel Brendsdal Forthun, Sigrid Erdal, Bjørn Tore Gjertsen, Hanne Fredly and Øystein Bruserud
    Citation: BMC Cancer 2017 17:630
    Content type: Research article Published on:

  7. The discrepant concordance between biopsy and radical prostatectomy (RP) specimen are well reported. To validate the clinical usefulness of neutrophil-lymphocyte ratio (NLR) in discriminating real GS ≥ 7 PCa f...

    Authors: Hanfeng Wang, Liangyou Gu, Yongjie Wu, Dan Feng, Junyao Duan, Xiaocong Wang, Yong Huang, Shengpan Wu, Jianwen Chen, Guangda Luo and Xu Zhang
    Citation: BMC Cancer 2017 17:629
    Content type: Research article Published on:

  8. The skeletal system is the most common site of distant metastasis in nasopharyngeal carcinoma (NPC); various prognostic factors have been reported for skeletal metastasis, though most studies have focused on a...

    Authors: Lin Yang, Liangping Xia, Yan Wang, Shasha He, Haiyang Chen, Shaobo Liang, Peijian Peng, Shaodong Hong and Yong Chen
    Citation: BMC Cancer 2017 17:628
    Content type: Research article Published on:

  9. Cancer Patient Pathways (CPPs) were introduced in 2000–2015 in several European countries, including Denmark, to reduce the time to diagnosis and treatment initiation and ultimately improve patient survival. Y...

    Authors: Henry Jensen, Marie Louise Tørring and Peter Vedsted
    Citation: BMC Cancer 2017 17:627
    Content type: Research article Published on:

  10. Gastric cancer (GC) accounts for the fourth most occurring malignancy and the third major cause of cancer death. Identifying novel molecular signaling pathways participating in gastric tumorigenesis and progre...

    Authors: Jianxin Ye, Jinsheng Huang, Jie Xu, Qiang Huang, Jinzhou Wang, Wenjing Zhong, Xinjian Lin, Yun Li and Xu Lin
    Citation: BMC Cancer 2017 17:626
    Content type: Research article Published on:

  11. Light at night creates a conflicting signal to the biological clock and disrupts circadian physiology. In rodents, light at night increases the risk to develop mood disorders, overweight, disrupted energy meta...

    Authors: Natalí N. Guerrero-Vargas, Raful Navarro-Espíndola, Mara A. Guzmán-Ruíz, María del Carmen Basualdo, Estefania Espitia-Bautista, Ana López-Bago, Ricardo Lascurain, Cinthya Córdoba-Manilla, Ruud M. Buijs and Carolina Escobar
    Citation: BMC Cancer 2017 17:625
    Content type: Research article Published on:

  12. Smoking is associated with an increased incidence of hormone receptor positive breast cancer. Data regarding worse breast cancer outcome in smokers are accumulating. Current literature regarding the impact of ...

    Authors: Hadar Goldvaser, Omer Gal, Shulamith Rizel, Daniel Hendler, Victoria Neiman, Tzippy Shochat, Aaron Sulkes, Baruch Brenner and Rinat Yerushalmi
    Citation: BMC Cancer 2017 17:624
    Content type: Research article Published on:

  13. Genetic counselling and testing for Lynch syndrome (LS) have recently been introduced in several Latin America countries. We aimed to characterize the clinical, molecular and mismatch repair (MMR) variants spe...

    Authors: Benedito Mauro Rossi, Edenir Inêz Palmero, Francisco López-Kostner, Carlos Sarroca, Carlos Alberto Vaccaro, Florencia Spirandelli, Patricia Ashton-Prolla, Yenni Rodriguez, Henrique de Campos Reis Galvão, Rui Manuel Reis, André Escremim de Paula, Luis Gustavo Capochin Romagnolo, Karin Alvarez, Adriana Della Valle, Florencia Neffa, Pablo German Kalfayan…
    Citation: BMC Cancer 2017 17:623
    Content type: Research article Published on:

  14. Replication-competent adenoviruses (Ad) produced cytotoxic effects on infected tumors and have been examined for the clinical applicability. A biomarkers to predict the cytotoxicity is valuable in a clinical s...

    Authors: Suguru Yamauchi, Boya Zhong, Kiyoko Kawamura, Shan Yang, Shuji Kubo, Masato Shingyoji, Ikuo Sekine, Yuji Tada, Koichiro Tatsumi, Hideaki Shimada, Kenzo Hiroshima and Masatoshi Tagawa
    Citation: BMC Cancer 2017 17:622
    Content type: Research article Published on:

  15. Prostate cancer is a major contributor to mortality worldwide, and significant efforts are being undertaken to decipher specific cellular and molecular pathways underlying the disease. Chronic stress is known ...

    Authors: Ivan E. Flores, Jorge A. Sierra-Fonseca, Olinamyr Davalos, Luis A. Saenz, Maria M. Castellanos, Jaidee K. Zavala and Kristin L. Gosselink
    Citation: BMC Cancer 2017 17:621
    Content type: Research article Published on:

  16. Several susceptibility genes have been established for female breast cancer, of which mutations in BRCA1 and especially in BRCA2 are also known risk factors for male breast cancer (MBC). The role of other breast ...

    Authors: Sanna Hallamies, Liisa M. Pelttari, Paula Poikonen-Saksela, Antti Jekunen, Arja Jukkola-Vuorinen, Päivi Auvinen, Carl Blomqvist, Kristiina Aittomäki, Johanna Mattson and Heli Nevanlinna
    Citation: BMC Cancer 2017 17:620
    Content type: Research article Published on:

  17. Breast cancer is the common cancer in China. In previous study, we determined that 3,6-dihydroxyflavone (3,6-DHF) increases miR-34a significantly in breast carcinogenesis, but the mechanism remains unclear.

    Authors: Xiaoli Peng, Hui Chang, Junli Chen, Qianyong Zhang, Xiaoping Yu and Mantian Mi
    Citation: BMC Cancer 2017 17:619
    Content type: Research article Published on:

  18. Programmed cell death 1 (PD1) inhibitors have recently shown promising anti-cancer effects in a number of solid tumor types. A predictive biomarker to this class of drugs has not been clearly identified; howev...

    Authors: Basile Tessier-Cloutier, Steve E. Kalloger, Mohammad Al-Kandari, Katy Milne, Dongxia Gao, Brad H. Nelson, Daniel J. Renouf, Brandon S. Sheffield and David F. Schaeffer
    Citation: BMC Cancer 2017 17:618
    Content type: Research article Published on:

  19. The malignant potential of triple negative breast cancer (TNBC) is also dependent on a sub-population of cells with a stem-like phenotype. Among the cancer stem cell markers, CD133 and EpCAM strongly correlate...

    Authors: Federica Brugnoli, Silvia Grassilli, Paola Lanuti, Marco Marchisio, Yasamin Al-Qassab, Federica Vezzali, Silvano Capitani and Valeria Bertagnolo
    Citation: BMC Cancer 2017 17:617
    Content type: Research article Published on:

  20. To assess the trends in risk classification and primary therapy of Japanese prostate cancer patients who were diagnosed between 2004 and 2012.

    Authors: Nobumichi Tanaka, Yasushi Nakai, Makito Miyake, Satoshi Anai, Takeshi Inoue, Tomomi Fujii, Noboru Konishi and Kiyohide Fujimoto
    Citation: BMC Cancer 2017 17:616
    Content type: Research article Published on:

  21. We aimed to explore the clinical benefit of adjuvant chemotherapy (AC) with fluoropyrimidine in patients with ypT0-3N0 rectal cancer after preoperative chemoradiation therapy (CRT) followed by total mesorectal...

    Authors: Chang Gon Kim, Joong Bae Ahn, Sang Joon Shin, Seung Hoon Beom, Su Jin Heo, Hyung Soon Park, Jee Hung Kim, Eun Ah Choe, Woong Sub Koom, Hyuk Hur, Byung Soh Min, Nam Kyu Kim, Hoguen Kim, Chan Kim, Inkyung Jung and Minkyu Jung
    Citation: BMC Cancer 2017 17:615
    Content type: Research article Published on:

  22. Identifying older people affected by cancer who are more at risk of negative health outcomes is a major issue in health initiatives focusing on medical effectiveness. In this regard, psychological risk factors...

    Authors: Sarah Schroyen, Pierre Missotten, Guy Jerusalem, M. Van den Akker, F. Buntinx and Stéphane Adam
    Citation: BMC Cancer 2017 17:614
    Content type: Research article Published on:

  23. The optimal postoperative treatment strategy for small cell lung cancer (SCLC) remains unclear, especially in patients with lymph node metastasis. We aimed to compare the outcomes of patients with SCLC and lym...

    Authors: Hirokazu Urushiyama, Taisuke Jo, Hideo Yasunaga, Yasuhiro Yamauchi, Hiroki Matsui, Wakae Hasegawa, Hideyuki Takeshima, Yoshihisa Hiraishi, Akihisa Mitani, Kiyohide Fushimi and Takahide Nagase
    Citation: BMC Cancer 2017 17:613
    Content type: Research article Published on:

  24. A solitary fibrous tumour is a rare, mainly benign spindle cell mesenchymal tumour most commonly originating from the pleura. An intrapericardial location of a solitary fibrous tumour is extremely unusual. We ...

    Authors: Csilla Czimbalmos, Ibolya Csecs, Miklos Polos, Elektra Bartha, Nikolette Szucs, Attila Toth, Pal Maurovich-Horvat, David Becker, Zoltan Sapi, Zoltan Szabolcs, Bela Merkely and Hajnalka Vago
    Citation: BMC Cancer 2017 17:612
    Content type: Case report Published on:

  25. Throughout most of sub-Saharan Africa (and, indeed, most resource-limited areas), lack of death registries prohibits linkage of cancer diagnoses and precludes the most expeditious approach to determining cance...

    Authors: Aggrey Semeere, Esther Freeman, Megan Wenger, David Glidden, Mwebesa Bwana, Micheal Kanyesigye, Fredrick Chite Asirwa, Elyne Rotich, Naftali Busakhala, Emmanuel Oga, Elima Jedy-Agba, Vivian Kwaghe, Kenneth Iregbu, Clement Adebamowo, Antoine Jaquet, Francois Dabis…
    Citation: BMC Cancer 2017 17:611
    Content type: Research article Published on:

  26. Molecular biomarkers capable of predicting recurrence patterns and prognosis are helpful for risk stratification and providing appropriate treatment to patients with hepatocellular carcinoma (HCC). In this stu...

    Authors: Shinichi Umeda, Mitsuro Kanda, Hiroyuki Sugimoto, Haruyoshi Tanaka, Masamichi Hayashi, Suguru Yamada, Tsutomu Fujii, Hideki Takami, Yukiko Niwa, Naoki Iwata, Chie Tanaka, Daisuke Kobayashi, Michitaka Fujiwara and Yasuhiro Kodera
    Citation: BMC Cancer 2017 17:610
    Content type: Research article Published on:

  27. Larynx preservation (LP) is recommended for up to low-volume T4 laryngeal cancer as an evidence-based treatment option that does not compromise survival. However, a reevaluation of the current literature raise...

    Authors: Gerhard Dyckhoff, Peter K. Plinkert and Heribert Ramroth
    Citation: BMC Cancer 2017 17:609
    Content type: Research article Published on:

  28. Protein Induced by Vitamin K Absence or Antagonist-II (PIVKA-II) is an efficient biomarker specific for hepatocellular carcinoma (HCC). Some researchers have proved that levels of PIVKA-II reflect HCC oncogene...

    Authors: Rentao Yu, Zhaoxia Tan, Xiaomei Xiang, Yunjie Dan and Guohong Deng
    Citation: BMC Cancer 2017 17:608
    Content type: Research article Published on:

  29. MiRNAs are often deregulated in colorectal cancer and might function as tumor suppressors or as oncogenes. They participate in controlling key signaling pathways involved in proliferation, invasion and apoptos...

    Authors: Edita Baltruskeviciene, Diana Schveigert, Vaidotas Stankevicius, Ugnius Mickys, Tadas Zvirblis, Jaroslav Bublevic, Kestutis Suziedelis and Eduardas Aleknavicius
    Citation: BMC Cancer 2017 17:607
    Content type: Research article Published on:

  30. Due to the presence of both classical estrogen receptor (ERα) and another ER subtype (ERβ) in ovarian cancer, hormonal treatment is an attractive option. However, response to tamoxifen in ovarian cancer is mod...

    Authors: Karen K. L. Chan, Michelle K. Y. Siu, Yu-xin Jiang, Jing-jing Wang, Yan Wang, Thomas H. Y. Leung, Stephanie S. Liu, Annie N. Y. Cheung and Hextan Y. S. Ngan
    Citation: BMC Cancer 2017 17:606
    Content type: Research article Published on:

  31. N-acetyltransferase 10 (NAT10) is a histone acetyltransferase which is involved in a wide range of cellular processes. Recent evidences indicate that NAT10 is involved in the development of human cancers. Prev...

    Authors: Qijiong Li, Xiaofeng Liu, Kemin Jin, Min Lu, Chunfeng Zhang, Xiaojuan Du and Baocai Xing
    Citation: BMC Cancer 2017 17:605
    Content type: Research article Published on:

  32. The recently developed reagent, eribulin mesylate (eribulin), is a microtubule dynamics inhibitor with a mechanism of action that differs from those of taxanes and vinca alkaloids. This drug is considered to b...

    Authors: Shinichiro Kashiwagi, Wakaba Fukushima, Yuka Asano, Wataru Goto, Koji Takada, Satoru Noda, Tsutomu Takashima, Naoyoshi Onoda, Masahiko Ohsawa, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2017 17:604
    Content type: Research article Published on:

  33. Large gap exists between clinical practice and recommended care and large room exists for the improvement of care quality for non-small cell lung cancer (NSCLC) in China. Results of some studies have shown tha...

    Authors: Xinyu Wang, Shaofei Su, Shouyi Li, Han Bao, Meiqi Zhang, Dan Liu, Hao Jiang, Jiaying Wang and Meina Liu
    Citation: BMC Cancer 2017 17:603
    Content type: Research article Published on:

  34. Describe a single-center real-world experience with comprehensive genomic profiling (CGP) to identify genotype directed therapy (GDT) options for patients with malignancies refractory to standard treatment opt...

    Authors: Talal Hilal, Mary Nakazawa, Jacob Hodskins, John L. Villano, Aju Mathew, Guarav Goel, Lars Wagner, Susanne M. Arnold, Philip DeSimone, Lowell B. Anthony and Peter J. Hosein
    Citation: BMC Cancer 2017 17:602
    Content type: Research article Published on:

  35. Long Interspersed Nuclear Elements-1 (LINEs-1) methylation from white blood cells (WBCs) DNA has been proposed as biomarker associated with different types of cancer. The aim of the present study was to invest...

    Authors: Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Carolina Canto, Nadia La Rosa, Maria Antonietta Cantarella, Giuseppa Spampinato, Aurora Scalisi and Antonella Agodi
    Citation: BMC Cancer 2017 17:601
    Content type: Research article Published on:

  36. Lung cancer survivors are more likely to develop colorectal and stomach cancer than the general population. However, little is known about the current status of gastrointestinal cancer screening practices and ...

    Authors: Sang Min Park, Jongmog Lee, Young Ae Kim, Yoon Jung Chang, Moon Soo Kim, Young Mog Shim, Jae Ill Zo and Young Ho Yun
    Citation: BMC Cancer 2017 17:600
    Content type: Research article Published on:

  37. Cancer survivorship is of increasing importance in post-treatment care. Sexual health (SH) and femininity can be crucial issues for women surviving cancer. We aimed to determine a more complete understanding o...

    Authors: Anne Oberguggenberger, Caroline Martini, Nathalie Huber, Lesley Fallowfield, Michael Hubalek, Martin Daniaux, Barbara Sperner-Unterweger, Bernhard Holzner, Monika Sztankay, Eva Gamper and Verena Meraner
    Citation: BMC Cancer 2017 17:599
    Content type: Research article Published on:

  38. Treatment of tonsil cancer, a subset of oropahryngeal cancer, varies between surgery and radiotherapy. Well-designed studies in tonsil cancer have been rare and it is still controversial which treatment is opt...

    Authors: Sanghyuk Song, Hong-Gyun Wu, Chang Geol Lee, Ki Chang Keum, Mi Sun Kim, Yong Chan Ahn, Dongryul Oh, Hyo Jung Park, Sang-Wook Lee, Geumju Park, Sung Ho Moon, Kwan Ho Cho, Yeon-Sil Kim, Yongkyun Won, Young-Taek Oh, Won-Taek Kim…
    Citation: BMC Cancer 2017 17:598
    Content type: Research article Published on:

  39. Racial disparities in the incidence of major cancers may be attributed to differences in the prevalence of established, modifiable risk factors such as obesity, smoking, physical activity and diet.

    Authors: Tomi Akinyemiju, Howard Wiener and Maria Pisu
    Citation: BMC Cancer 2017 17:597
    Content type: Research article Published on:

  40. Lung cancer (LC) is the leading cause of cancer deaths in men and the second most frequent cause of cancer deaths in women in Estonia. The study aimed to analyze time trends in LC incidence and mortality in Es...

    Authors: Tiiu Aareleid, Mari-Liis Zimmermann, Aleksei Baburin and Kaire Innos
    Citation: BMC Cancer 2017 17:596
    Content type: Research article Published on:

  41. Central venous access device (CVAD) associated complications are a preventable source of patient harm, frequently resulting in morbidity and delays to vital treatment. Dressing and securement products are used...

    Authors: Amanda J. Ullman, Tricia Kleidon, Victoria Gibson, Craig A. McBride, Gabor Mihala, Marie Cooke and Claire M. Rickard
    Citation: BMC Cancer 2017 17:595
    Content type: Research article Published on:

  42. Epithelial ovarian cancer exhibits extensive interpatient and intratumoral heterogeneity, which can hinder successful treatment strategies. Herein, we investigated the efficacy of an emerging oncolytic, Maraba...

    Authors: Jessica G. Tong, Yudith Ramos Valdes, Milani Sivapragasam, John W. Barrett, John C. Bell, David Stojdl, Gabriel E. DiMattia and Trevor G. Shepherd
    Citation: BMC Cancer 2017 17:594
    Content type: Research article Published on:

  44. The EGFR and downstream signaling pathways play an important role in tumorigenesis in oral squamous cell carcinoma (OSCC). Gene copy number alteration is one mechanism for overexpressing the EGFR protein and w...

    Authors: Shiang-Fu Huang, Huei-Tzu Chien, Sou-De Cheng, Wen-Yu Chuang, Chun-Ta Liao and Hung-Ming Wang
    Citation: BMC Cancer 2017 17:592
    Content type: Research article Published on:

  46. Neuron-Specific enolase (NSE) has been used as a typical tumor marker and shows a potential to diagnose malignant pleural effusion (MPE). The ability of NSE in diagnosing MPE has been investigated in many stud...

    Authors: Jing Zhu, Mei Feng, Liqun Liang, Ni Zeng, Chun Wan, Ting Yang, Yongchun Shen and Fuqiang Wen
    Citation: BMC Cancer 2017 17:590
    Content type: Research article Published on:

  47. Cancer is one of the major health problems worldwide. In this article, we present for the first time the cancer incidence trends, the distribution and the socioeconomic profile of incident cancer cases in East...

    Authors: Manal Elidrissi Errahhali, Mounia Elidrissi Errahhali, Meryem Ouarzane, Redouane Boulouiz and Mohammed Bellaoui
    Citation: BMC Cancer 2017 17:587
    Content type: Research article Published on:

  48. The variable prognosis in stage III cutaneous melanoma is partially due to unknown prognostic factors. Improved prognostic tools are required to define patients with an increased risk of developing metastatic ...

    Authors: Johan Falkenius, Hemming Johansson, Rainer Tuominen, Marianne Frostvik Stolt, Johan Hansson and Suzanne Egyhazi Brage
    Citation: BMC Cancer 2017 17:584
    Content type: Research article Published on:

  49. The Cancer Genome Atlas Research Network reported that high-grade serous carcinoma (HGSC) can be classified based on gene expression profiles into four subtypes, termed “immunoreactive,” “differentiated,” “pro...

    Authors: Takuma Ohsuga, Ken Yamaguchi, Aki Kido, Ryusuke Murakami, Kaoru Abiko, Junzo Hamanishi, Eiji Kondoh, Tsukasa Baba, Ikuo Konishi and Noriomi Matsumura
    Citation: BMC Cancer 2017 17:580
    Content type: Research article Published on:

  50. Neurofibromatosis type 1 is a relatively common inherited disorder. Patients with neurofibromatosis type 1 are at high risk of developing neurogenic, neuroendocrine and mesenchymal intra-abdominal tumors. Alth...

    Authors: Nihed Abdessayed, Rahul Gupta, Sarra Mestiri, Ahlem Bdioui, Mounir Trimech and Moncef Mokni
    Citation: BMC Cancer 2017 17:579
    Content type: Case report Published on:

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