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  1. Evidence suggests that risk of colorectal and prostate cancer is increased among those with a family history of the same disease, particularly among first-degree relatives. However, the aggregation of colorect...

    Authors: Jennifer L. Beebe-Dimmer, Cecilia Yee, Electra Paskett, Ann G. Schwartz, Dorothy Lane, Nynikka R. A. Palmer, Cathryn H. Bock, Rami Nassir and Michael S. Simon
    Citation: BMC Cancer 2017 17:848
    Content type: Research article Published on:

  2. In Chile, more than 500 women die every year from cervical cancer, and a majority of Chilean women are not up-to-date with their Papanicolau (Pap) test. Mobile health has great potential in many health areas, ...

    Authors: McKenzie C. Momany, Javiera Martinez-Gutierrez, Mauricio Soto, Daniel Capurro, Francis Ciampi, Beti Thompson and Klaus Puschel
    Citation: BMC Cancer 2017 17:847
    Content type: Study protocol Published on:

  3. p53R2 is a target of p53 gene, which is essential for DNA repair, mitochondrial DNA synthesis, protection against oxidative stress, chromosomal instability, chronic inflammation and tumorigenesis. This study i...

    Authors: Jiewei Chen, Shuman Li, Yongbo Xiao, Xuan Zou, Xinke Zhang, Mingshu Zhu, Muyan Cai and Dan Xie
    Citation: BMC Cancer 2017 17:846
    Content type: Research article Published on:

  4. Gastric cancers frequently overexpress the epidermal growth factor receptor (EGFR), which has been implicated in pathological processes including tumor cell motility, invasion and metastasis. Targeting EGFR wi...

    Authors: Simone Keller, Julia Kneissl, Verena Grabher-Meier, Stefan Heindl, Jan Hasenauer, Dieter Maier, Julian Mattes, Peter Winter and Birgit Luber
    Citation: BMC Cancer 2017 17:845
    Content type: Research article Published on:

  5. The clinical benefit of adjuvant chemotherapy for stage II colorectal cancer (CRC) is controversial. This study aimed to explore novel gene signature to predict outcome benefit of postoperative 5-Fu-based ther...

    Authors: Bangrong Cao, Liping Luo, Lin Feng, Shiqi Ma, Tingqing Chen, Yuan Ren, Xiao Zha, Shujun Cheng, Kaitai Zhang and Changmin Chen
    Citation: BMC Cancer 2017 17:844
    Content type: Research article Published on:

  6. The prevalence of Hereditary Non-Polyposis Colorectal Cancer (HNPCC) is 2 to 5% in the Caucasian population. HNPCC is caused by genomic mutations in DNA mismatch repair genes (MMR), namely MLH1, MSH2, MSH6, PMS2,

    Authors: Jasmine Lee, Yin-Yi Xiao, Yan Yu Sun, Jasminka Balderacchi, Bradley Clark, Jatin Desani, Vivek Kumar, Angela Saverimuthu, Khin Than Win, Yiwu Huang and Yiqing Xu
    Citation: BMC Cancer 2017 17:843
    Content type: Research article Published on:

  9. Computational intelligence methods, including non-linear classification algorithms, can be used in medical research and practice as a decision making tool. This study aimed to evaluate the usefulness of artifi...

    Authors: Bogdan Obrzut, Maciej Kusy, Andrzej Semczuk, Marzanna Obrzut and Jacek Kluska
    Citation: BMC Cancer 2017 17:840
    Content type: Research article Published on:

  11. The role of Spalt-like gene-2 (SALL2) in tumorigenesis remains incompletely elucidated. This study investigated the effects of SALL2 on human ovarian carcinoma (OC) A2780 cells and the probable mechanism.

    Authors: Fang Miao, Xueshan Zhang, Yanning Cao, Yue Wang and Xiaoshu Zhang
    Citation: BMC Cancer 2017 17:838
    Content type: Research article Published on:

  12. In Japan, S-1 plus cisplatin (SP) regimen has become a standard therapy for patients with advanced gastric cancer. Moreover, the S-1 plus oxaliplatin regimen is now a standard treatment.

    Authors: Yasuyuki Kawamoto, Yoshito Komatsu, Satoshi Yuki, Kentaro Sawada, Tetsuhito Muranaka, Kazuaki Harada, Hiroshi Nakatsumi, Hiraku Fukushima, Atsushi Ishiguro, Masayoshi Dazai, Kazuteru Hatanaka, Michio Nakamura, Ichiro Iwanaga, Minoru Uebayashi, Susumu Sogabe, Yoshimitsu Kobayashi…
    Citation: BMC Cancer 2017 17:837
    Content type: Study protocol Published on:

  13. A systematic review was conducted to assess the diagnostic test accuracy of polymerase chain reaction (PCR)-based microsatellite instability (MSI) testing for identifying Lynch syndrome in patients with colore...

    Authors: Helen Coelho, Tracey Jones-Hughes, Tristan Snowsill, Simon Briscoe, Nicola Huxley, Ian M. Frayling and Chris Hyde
    Citation: BMC Cancer 2017 17:836
    Content type: Research article Published on:

  14. Low serum selenium status has been associated with increased risk of esophageal squamous cell carcinoma (ESCC). East Africa is a region of high ESCC incidence and is known to have low soil selenium levels, but...

    Authors: Natalie R. Pritchett, Stephen L. Burgert, Gwen A. Murphy, John D. Brockman, Russell E. White, Justus Lando, Robert Chepkwony, Mark D. Topazian, Christian C. Abnet, Sanford M. Dawsey and Michael M. Mwachiro
    Citation: BMC Cancer 2017 17:835
    Content type: Research article Published on:

  16. Breast cancer related lymphedema (BCRL) is a prevalent complication secondary to cancer treatments which significantly impacts the physical and psychological health of breast cancer survivors. Previous researc...

    Authors: G. David Baxter, Lizhou Liu, Simone Petrich, Angela Spontelli Gisselman, Cathy Chapple, Juanita J. Anders and Steve Tumilty
    Citation: BMC Cancer 2017 17:833
    Content type: Research article Published on:

  17. Despite recent advances in the diagnosis and treatment of breast cancer, metastasis remains the main cause of death. Since migration of tumor cells is considered a prerequisite for tumor cell invasion and meta...

    Authors: Thao N. D. Pham, Bethany E. Perez White, Huiping Zhao, Fariborz Mortazavi and Debra A. Tonetti
    Citation: BMC Cancer 2017 17:832
    Content type: Research article Published on:

  18. Leukocytoclastic vasculitis is typically mediated by deposition of immune complexes and is related to many causes, including medication. To the best of our knowledge, leukocytoclastic vasculitis related to cis...

    Authors: Júlia Coelho França Quintanilha, Marília Berlofa Visacri, Laís Sampaio Amaral, Carmen Silvia Passos Lima, Maria Letícia Cintra and Patricia Moriel
    Citation: BMC Cancer 2017 17:831
    Content type: Case report Published on:

  19. The epithelial to mesenchymal transition (EMT) plays a key role in lung cancer progression and drug resistance. The dynamics and stability of gene expression patterns as cancer cells transition from E to M at ...

    Authors: Daifeng Wang, John D. Haley and Patricia Thompson
    Citation: BMC Cancer 2017 17:830
    Content type: Research article Published on:

  20. To appraise the ability of a radiomics based analysis to predict local response and overall survival for patients with hepatocellular carcinoma.

    Authors: Luca Cozzi, Nicola Dinapoli, Antonella Fogliata, Wei-Chung Hsu, Giacomo Reggiori, Francesca Lobefalo, Margarita Kirienko, Martina Sollini, Davide Franceschini, Tiziana Comito, Ciro Franzese, Marta Scorsetti and Po-Ming Wang
    Citation: BMC Cancer 2017 17:829
    Content type: Research article Published on:

  21. Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 i...

    Authors: Jun An, Zhigang Zhang, Zhiyong Liu, Ruizhi Wang, Dayang Hui and Yi Jin
    Citation: BMC Cancer 2017 17:828
    Content type: Research article Published on:

  22. Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this i...

    Authors: Aitor Benedicto, Joana Marquez, Alba Herrero, Elvira Olaso, Elzbieta Kolaczkowska and Beatriz Arteta
    Citation: BMC Cancer 2017 17:827
    Content type: Research article Published on:

  23. Despite guidelines for cervical cancer prevention in low-resource countries, a very small proportion of women in these settings undergo screening, and even fewer women are successfully treated. Using pilot dat...

    Authors: Megan J. Huchko, James G. Kahn, Jennifer S. Smith, Robert A. Hiatt, Craig R. Cohen and Elizabeth Bukusi
    Citation: BMC Cancer 2017 17:826
    Content type: Study protocol Published on:

  24. 18F–fluoro-deoxyglucose positron emission tomography with computed tomography (FDG PET/CT) has been employed to define radiotherapy targets using a threshold based on the standardised ...

    Authors: Alta Y. T. Lai, Jose A. U. Perucho, Xiaopei Xu, Edward S. Hui and Elaine Y. P. Lee
    Citation: BMC Cancer 2017 17:825
    Content type: Research article Published on:

  25. The association of malnutrition in early life with breast cancer risk has been studied in Europe by investigating survivors of the Dutch Hunger Winter Famine, but not in China. We evaluated the effect of expos...

    Authors: Dandan He, Yuan Fang, Marc J. Gunter, Dongli Xu, Yanping Zhao, Jie Zhou, Hong Fang and Wang Hong Xu
    Citation: BMC Cancer 2017 17:824
    Content type: Research article Published on:

  26. The need for novel biomarkers that could aid in non-small cell lung cancer (NSCLC) detection, together with the relevance of Matrix Metalloproteases (MMPs) -1, -2, -7, -9 and -10 in lung tumorigenesis, prompte...

    Authors: Sonia Blanco-Prieto, Leticia Barcia-Castro, María Páez de la Cadena, Francisco Javier Rodríguez-Berrocal, Lorena Vázquez-Iglesias, María Isabel Botana-Rial, Alberto Fernández-Villar and Loretta De Chiara
    Citation: BMC Cancer 2017 17:823
    Content type: Research article Published on:

  27. Beyond survival of nowadays >80%, modern childhood cancer treatment strives to preserve long-term health and quality of life. However, the majority of today’s survivors suffer from short- and long-term adverse...

    Authors: Corina S. Rueegg, Susi Kriemler, Simeon J. Zuercher, Christina Schindera, Andrea Renner, Helge Hebestreit, Christian Meier, Prisca Eser and Nicolas X. von der Weid
    Citation: BMC Cancer 2017 17:822
    Content type: Study protocol Published on:

  28. In spite of the increasing incidence of in situ breast cancer, the information about the risk factors of in situ breast cancer (DCIS) is scarce as compared to the information available for invasive ductal brea...

    Authors: Hyeonyoung Ko, Jinyoung Shin, Jeong Eon Lee, Seok Jin Nam, Tuong Linh Nguyen, John Llewelyn Hopper and Yun-Mi Song
    Citation: BMC Cancer 2017 17:821
    Content type: Research article Published on:

  30. The efficacy and safety of eribulin in patients with locally advanced or metastatic breast cancer has been demonstrated in phase III trials. However, as patients receiving eribulin in daily practice do not nec...

    Authors: Sakura Iizumi, Tatsunori Shimoi, Natsuko Tsushita, Seiko Bun, Akihiko Shimomura, Emi Noguchi, Makoto Kodaira, Mayu Yunokawa, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara and Kenji Tamura
    Citation: BMC Cancer 2017 17:819
    Content type: Research article Published on:

  31. For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are...

    Authors: Dirk Rades, Jon Cacicedo, Antonio J. Conde-Moreno, Claudia Doemer, Jürgen Dunst, Darejan Lomidze, Barbara Segedin, Denise Olbrich and Niels Henrik Holländer
    Citation: BMC Cancer 2017 17:818
    Content type: Study protocol Published on:

  32. Danish cancer patients have lower survival rates than patients in many other western countries. Half of the patients present with non-alarm symptoms and thus have a long diagnostic pathway. Consequently, an ur...

    Authors: Esben Næser, Henrik Møller, Ulrich Fredberg, Jan Frystyk and Peter Vedsted
    Citation: BMC Cancer 2017 17:817
    Content type: Research article Published on:

  33. Recent advances in methodologies utilizing “big data” have allowed researchers to investigate the use of common internet search engines as a real time tool to track disease. Little is known about its utility w...

    Authors: Xiaodong Huang, Peter Baade, Danny R. Youlden, Philippa H. Youl, Wenbiao Hu and Michael G. Kimlin
    Citation: BMC Cancer 2017 17:816
    Content type: Research article Published on:

  35. In the absence of routine ovarian cancer screening, promoting help-seeking in response to ovarian symptoms is a potential route to early diagnosis. The factors influencing women’s anticipated time to presentat...

    Authors: Stephanie Smits, Jacky Boivin, Usha Menon and Kate Brain
    Citation: BMC Cancer 2017 17:814
    Content type: Research article Published on:

  36. Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells...

    Authors: Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi and Aike Li
    Citation: BMC Cancer 2017 17:813
    Content type: Research article Published on:

  37. Serum C-reactive protein (CRP) level can be an indicator of the early stage of infectious complications. However, its utility in advanced esophageal cancer patients who receive radical esophagectomy with two- ...

    Authors: Kazuki Kano, Toru Aoyama, Tetsushi Nakajima, Yukio Maezawa, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Haruhiko Cho, Takaki Yoshikawa and Takashi Ogata
    Citation: BMC Cancer 2017 17:812
    Content type: Research article Published on:

  38. Epithelial cell adhesion molecule (EpCAM) is a promising biomarker for squamous cell carcinoma (SCC) of the uterine cervix, because it is over-expressed in various cancers of epithelial origin. However, EpCAM ...

    Authors: Warangkana Chantima, Charin Thepthai, Pornsuk Cheunsuchon and Tararaj Dharakul
    Citation: BMC Cancer 2017 17:811
    Content type: Research article Published on:

  39. Epigenetic alterations have been recognized as important contributors to the pathogenesis of PDAC. However, the role of histone variants in pancreatic tumor progression is still not completely understood. The ...

    Authors: Monika Bauden, Theresa Kristl, Agata Sasor, Bodil Andersson, György Marko-Varga, Roland Andersson and Daniel Ansari
    Citation: BMC Cancer 2017 17:810
    Content type: Research article Published on:

  40. In 2012 a new cancer patient pathway for patients with non-specific symptoms and signs of cancer (NSSC-CPP) was introduced in Denmark. Limited information is available about the patients referred to the NSSC-C...

    Authors: Sara Falk Jørgensen, Pernille Ravn, Søren Thorsen and Signe Westring Worm
    Citation: BMC Cancer 2017 17:809
    Content type: Research article Published on:

  41. Autopsy studies demonstrate the prevalence pool of incidental breast cancer in the population, but estimates are uncertain due to small numbers in any primary study. We aimed to conduct a systematic review of ...

    Authors: Elizabeth T. Thomas, Chris Del Mar, Paul Glasziou, Gordon Wright, Alexandra Barratt and Katy J. L. Bell
    Citation: BMC Cancer 2017 17:808
    Content type: Research article Published on:

  42. Cancer clinical trials are essential for testing new treatments and represent state-of-the-art cancer treatment, but only a small percentage of patients ever enroll in a trial. Under-enrollment is an even grea...

    Authors: Susan Eggly, Lauren M. Hamel, Elisabeth Heath, Mark A. Manning, Terrance L. Albrecht, Ellen Barton, Mark Wojda, Tanina Foster, Michael Carducci, Dina Lansey, Ting Wang, Rehab Abdallah, Narineh Abrahamian, Seongho Kim, Nicole Senft and Louis A. Penner
    Citation: BMC Cancer 2017 17:807
    Content type: Study protocol Published on:

  43. Médecins Sans Frontières is supporting comprehensive HIV care and treatment for Kaposi Sarcoma (KS) in Guinea, where antiretroviral coverage is low and access to KS treatment is very limited. We aimed to evalu...

    Authors: Cavin E. Bekolo, Mohamed M. Soumah, Ousseni W. Tiemtore, Abdourahimi Diallo, Joseph-Desire Yuma, Letizia Di Stefano, Carol Metcalf and Mohamed Cisse
    Citation: BMC Cancer 2017 17:806
    Content type: Research article Published on:

  44. MicroRNAs (miRNAs) exhibit essential regulatory functions related to cell growth, apoptosis, development and differentiation. Dysregulated expression of miRNAs is associated with a wide variety of human diseas...

    Authors: Guanyu Wang, Fulu Dong, Zhiyao Xu, Sherven Sharma, Xiaotong Hu, Dafang Chen, Lumin Zhang, Jinping Zhang and Qinghua Dong
    Citation: BMC Cancer 2017 17:805
    Content type: Research article Published on:

  45. Breast cancer is the most common malignancy accounting for 25% of all cancers in females. In Africa, breast cancer prevalence and mortality are steadily increasing. Knowledge of hormone receptors and human epi...

    Authors: Asmerom Tesfamariam Sengal, Nada Suliman Haj-Mukhtar, Ahmed Mohammed Elhaj, Shahinaz Bedri, Eva Johanna Kantelhardt and Ahmed A. Mohamedani
    Citation: BMC Cancer 2017 17:804
    Content type: Research article Published on:

  46. Breast cancer is one of the most common cancer and a leading cause of death in women. Up to date the most commonly used breast cancer cell lines are originating from Caucasians or Afro-Americans but rarely cel...

    Authors: Rizwan Ali, Nosaibah Samman, Hajar Al Zahrani, Atef Nehdi, Sabhi Rahman, Abdul Latif Khan, Mohamed Al Balwi, Lolwah Abdullah Alriyees, Manal Alzaid, Ahmed Al Askar and Mohamed Boudjelal
    Citation: BMC Cancer 2017 17:803
    Content type: Research article Published on:

  47. Transcriptomic profiling of breast tumors provides opportunity for subtyping and molecular-based patient stratification. In diagnostic applications the specimen profiled should be representative of the express...

    Authors: Govindasamy-Muralidharan Karthik, Mattias Rantalainen, Gustav Stålhammar, John Lövrot, Ikram Ullah, Amjad Alkodsi, Ran Ma, Lena Wedlund, Johan Lindberg, Jan Frisell, Jonas Bergh and Johan Hartman
    Citation: BMC Cancer 2017 17:802
    Content type: Research article Published on:

  48. Acute gastric volvulus (GV) is a rare disease with high mortality rate often associated with anatomic abnormalities. Thymoma is the most common neoplasm located in the anterior mediastinum. There is no reporte...

    Authors: Ailing Liu, Xin Gao and Lin Zhao
    Citation: BMC Cancer 2017 17:801
    Content type: Case report Published on:

  49. There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and usefulness of chemotherapy for such patients remains unclear....

    Authors: Satoshi Ikeda, Hiroshige Yoshioka, Satoshi Ikeo, Mitsunori Morita, Naoyuki Sone, Takashi Niwa, Akihiro Nishiyama, Toshihide Yokoyama, Akimasa Sekine, Takashi Ogura and Tadashi Ishida
    Citation: BMC Cancer 2017 17:797
    Content type: Research article Published on:

  50. Utilisation of radiation therapy for regional Australia and around the world has been the focus of much health policy the last decade. Radiation therapy centres have been built in Australian regional and rural...

    Authors: Sandra C. Thompson, Shelley Cheetham and Siddhartha Baxi
    Citation: BMC Cancer 2017 17:794
    Content type: Research article Published on:

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