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  1. The epithelial to mesenchymal transition (EMT) plays a key role in lung cancer progression and drug resistance. The dynamics and stability of gene expression patterns as cancer cells transition from E to M at ...

    Authors: Daifeng Wang, John D. Haley and Patricia Thompson
    Citation: BMC Cancer 2017 17:830
    Content type: Research article Published on:

  2. Lymphocyte Function-Associated Antigen-1 (LFA-1; CD18/CD11a) is one of the main adhesion molecules used by immune cells to infiltrate the liver under inflammatory conditions. Recently, the expression of this i...

    Authors: Aitor Benedicto, Joana Marquez, Alba Herrero, Elvira Olaso, Elzbieta Kolaczkowska and Beatriz Arteta
    Citation: BMC Cancer 2017 17:827
    Content type: Research article Published on:

  3. Despite guidelines for cervical cancer prevention in low-resource countries, a very small proportion of women in these settings undergo screening, and even fewer women are successfully treated. Using pilot dat...

    Authors: Megan J. Huchko, James G. Kahn, Jennifer S. Smith, Robert A. Hiatt, Craig R. Cohen and Elizabeth Bukusi
    Citation: BMC Cancer 2017 17:826
    Content type: Study protocol Published on:

  4. The association of malnutrition in early life with breast cancer risk has been studied in Europe by investigating survivors of the Dutch Hunger Winter Famine, but not in China. We evaluated the effect of expos...

    Authors: Dandan He, Yuan Fang, Marc J. Gunter, Dongli Xu, Yanping Zhao, Jie Zhou, Hong Fang and Wang Hong Xu
    Citation: BMC Cancer 2017 17:824
    Content type: Research article Published on:

  5. The need for novel biomarkers that could aid in non-small cell lung cancer (NSCLC) detection, together with the relevance of Matrix Metalloproteases (MMPs) -1, -2, -7, -9 and -10 in lung tumorigenesis, prompte...

    Authors: Sonia Blanco-Prieto, Leticia Barcia-Castro, María Páez de la Cadena, Francisco Javier Rodríguez-Berrocal, Lorena Vázquez-Iglesias, María Isabel Botana-Rial, Alberto Fernández-Villar and Loretta De Chiara
    Citation: BMC Cancer 2017 17:823
    Content type: Research article Published on:

  6. Beyond survival of nowadays >80%, modern childhood cancer treatment strives to preserve long-term health and quality of life. However, the majority of today’s survivors suffer from short- and long-term adverse...

    Authors: Corina S. Rueegg, Susi Kriemler, Simeon J. Zuercher, Christina Schindera, Andrea Renner, Helge Hebestreit, Christian Meier, Prisca Eser and Nicolas X. von der Weid
    Citation: BMC Cancer 2017 17:822
    Content type: Study protocol Published on:

  7. In spite of the increasing incidence of in situ breast cancer, the information about the risk factors of in situ breast cancer (DCIS) is scarce as compared to the information available for invasive ductal brea...

    Authors: Hyeonyoung Ko, Jinyoung Shin, Jeong Eon Lee, Seok Jin Nam, Tuong Linh Nguyen, John Llewelyn Hopper and Yun-Mi Song
    Citation: BMC Cancer 2017 17:821
    Content type: Research article Published on:

  9. The efficacy and safety of eribulin in patients with locally advanced or metastatic breast cancer has been demonstrated in phase III trials. However, as patients receiving eribulin in daily practice do not nec...

    Authors: Sakura Iizumi, Tatsunori Shimoi, Natsuko Tsushita, Seiko Bun, Akihiko Shimomura, Emi Noguchi, Makoto Kodaira, Mayu Yunokawa, Kan Yonemori, Chikako Shimizu, Yasuhiro Fujiwara and Kenji Tamura
    Citation: BMC Cancer 2017 17:819
    Content type: Research article Published on:

  10. For metastatic spinal cord compression (MSCC), conventional radiotherapy with 10 × 3 Gy in 2 weeks results in better local progression-free survival (LPFS) than 5 × 4 Gy in 1 week. Since patients with MSCC are...

    Authors: Dirk Rades, Jon Cacicedo, Antonio J. Conde-Moreno, Claudia Doemer, Jürgen Dunst, Darejan Lomidze, Barbara Segedin, Denise Olbrich and Niels Henrik Holländer
    Citation: BMC Cancer 2017 17:818
    Content type: Study protocol Published on:

  11. Danish cancer patients have lower survival rates than patients in many other western countries. Half of the patients present with non-alarm symptoms and thus have a long diagnostic pathway. Consequently, an ur...

    Authors: Esben Næser, Henrik Møller, Ulrich Fredberg, Jan Frystyk and Peter Vedsted
    Citation: BMC Cancer 2017 17:817
    Content type: Research article Published on:

  12. Recent advances in methodologies utilizing “big data” have allowed researchers to investigate the use of common internet search engines as a real time tool to track disease. Little is known about its utility w...

    Authors: Xiaodong Huang, Peter Baade, Danny R. Youlden, Philippa H. Youl, Wenbiao Hu and Michael G. Kimlin
    Citation: BMC Cancer 2017 17:816
    Content type: Research article Published on:

  14. In the absence of routine ovarian cancer screening, promoting help-seeking in response to ovarian symptoms is a potential route to early diagnosis. The factors influencing women’s anticipated time to presentat...

    Authors: Stephanie Smits, Jacky Boivin, Usha Menon and Kate Brain
    Citation: BMC Cancer 2017 17:814
    Content type: Research article Published on:

  15. Genistein has been known to inhibit proliferation and induce apoptosis in several kinds of cancer cells. While knowledge of genistein in regulating epithelial mesenchymal transition (EMT) of colon cancer cells...

    Authors: Panpan Zhou, Chunling Wang, Zebin Hu, Wenruo Chen, Wentao Qi and Aike Li
    Citation: BMC Cancer 2017 17:813
    Content type: Research article Published on:

  16. Serum C-reactive protein (CRP) level can be an indicator of the early stage of infectious complications. However, its utility in advanced esophageal cancer patients who receive radical esophagectomy with two- ...

    Authors: Kazuki Kano, Toru Aoyama, Tetsushi Nakajima, Yukio Maezawa, Tsutomu Hayashi, Takanobu Yamada, Tsutomu Sato, Takashi Oshima, Yasushi Rino, Munetaka Masuda, Haruhiko Cho, Takaki Yoshikawa and Takashi Ogata
    Citation: BMC Cancer 2017 17:812
    Content type: Research article Published on:

  17. Epithelial cell adhesion molecule (EpCAM) is a promising biomarker for squamous cell carcinoma (SCC) of the uterine cervix, because it is over-expressed in various cancers of epithelial origin. However, EpCAM ...

    Authors: Warangkana Chantima, Charin Thepthai, Pornsuk Cheunsuchon and Tararaj Dharakul
    Citation: BMC Cancer 2017 17:811
    Content type: Research article Published on:

  18. Epigenetic alterations have been recognized as important contributors to the pathogenesis of PDAC. However, the role of histone variants in pancreatic tumor progression is still not completely understood. The ...

    Authors: Monika Bauden, Theresa Kristl, Agata Sasor, Bodil Andersson, György Marko-Varga, Roland Andersson and Daniel Ansari
    Citation: BMC Cancer 2017 17:810
    Content type: Research article Published on:

  19. In 2012 a new cancer patient pathway for patients with non-specific symptoms and signs of cancer (NSSC-CPP) was introduced in Denmark. Limited information is available about the patients referred to the NSSC-C...

    Authors: Sara Falk Jørgensen, Pernille Ravn, Søren Thorsen and Signe Westring Worm
    Citation: BMC Cancer 2017 17:809
    Content type: Research article Published on:

  20. Autopsy studies demonstrate the prevalence pool of incidental breast cancer in the population, but estimates are uncertain due to small numbers in any primary study. We aimed to conduct a systematic review of ...

    Authors: Elizabeth T. Thomas, Chris Del Mar, Paul Glasziou, Gordon Wright, Alexandra Barratt and Katy J. L. Bell
    Citation: BMC Cancer 2017 17:808
    Content type: Research article Published on:

  21. Cancer clinical trials are essential for testing new treatments and represent state-of-the-art cancer treatment, but only a small percentage of patients ever enroll in a trial. Under-enrollment is an even grea...

    Authors: Susan Eggly, Lauren M. Hamel, Elisabeth Heath, Mark A. Manning, Terrance L. Albrecht, Ellen Barton, Mark Wojda, Tanina Foster, Michael Carducci, Dina Lansey, Ting Wang, Rehab Abdallah, Narineh Abrahamian, Seongho Kim, Nicole Senft and Louis A. Penner
    Citation: BMC Cancer 2017 17:807
    Content type: Study protocol Published on:

  22. Médecins Sans Frontières is supporting comprehensive HIV care and treatment for Kaposi Sarcoma (KS) in Guinea, where antiretroviral coverage is low and access to KS treatment is very limited. We aimed to evalu...

    Authors: Cavin E. Bekolo, Mohamed M. Soumah, Ousseni W. Tiemtore, Abdourahimi Diallo, Joseph-Desire Yuma, Letizia Di Stefano, Carol Metcalf and Mohamed Cisse
    Citation: BMC Cancer 2017 17:806
    Content type: Research article Published on:

  23. MicroRNAs (miRNAs) exhibit essential regulatory functions related to cell growth, apoptosis, development and differentiation. Dysregulated expression of miRNAs is associated with a wide variety of human diseas...

    Authors: Guanyu Wang, Fulu Dong, Zhiyao Xu, Sherven Sharma, Xiaotong Hu, Dafang Chen, Lumin Zhang, Jinping Zhang and Qinghua Dong
    Citation: BMC Cancer 2017 17:805
    Content type: Research article Published on:

  24. Breast cancer is the most common malignancy accounting for 25% of all cancers in females. In Africa, breast cancer prevalence and mortality are steadily increasing. Knowledge of hormone receptors and human epi...

    Authors: Asmerom Tesfamariam Sengal, Nada Suliman Haj-Mukhtar, Ahmed Mohammed Elhaj, Shahinaz Bedri, Eva Johanna Kantelhardt and Ahmed A. Mohamedani
    Citation: BMC Cancer 2017 17:804
    Content type: Research article Published on:

  25. Breast cancer is one of the most common cancer and a leading cause of death in women. Up to date the most commonly used breast cancer cell lines are originating from Caucasians or Afro-Americans but rarely cel...

    Authors: Rizwan Ali, Nosaibah Samman, Hajar Al Zahrani, Atef Nehdi, Sabhi Rahman, Abdul Latif Khan, Mohamed Al Balwi, Lolwah Abdullah Alriyees, Manal Alzaid, Ahmed Al Askar and Mohamed Boudjelal
    Citation: BMC Cancer 2017 17:803
    Content type: Research article Published on:

  26. Transcriptomic profiling of breast tumors provides opportunity for subtyping and molecular-based patient stratification. In diagnostic applications the specimen profiled should be representative of the express...

    Authors: Govindasamy-Muralidharan Karthik, Mattias Rantalainen, Gustav Stålhammar, John Lövrot, Ikram Ullah, Amjad Alkodsi, Ran Ma, Lena Wedlund, Johan Lindberg, Jan Frisell, Jonas Bergh and Johan Hartman
    Citation: BMC Cancer 2017 17:802
    Content type: Research article Published on:

  27. Acute gastric volvulus (GV) is a rare disease with high mortality rate often associated with anatomic abnormalities. Thymoma is the most common neoplasm located in the anterior mediastinum. There is no reporte...

    Authors: Ailing Liu, Xin Gao and Lin Zhao
    Citation: BMC Cancer 2017 17:801
    Content type: Case report Published on:

  28. Cancer cachexia in elderly patients may substantially impact physical function and medical dependency. The aim of this study was to estimate the impact of cachexia on activity of daily living (ADL), length of ...

    Authors: Tateaki Naito, Taro Okayama, Takashi Aoyama, Takuya Ohashi, Yoshiyuki Masuda, Madoka Kimura, Hitomi Shiozaki, Haruyasu Murakami, Hirotsugu Kenmotsu, Tetsuhiko Taira, Akira Ono, Kazushige Wakuda, Hisao Imai, Takuya Oyakawa, Takeshi Ishii, Shota Omori…
    Citation: BMC Cancer 2017 17:800
    Content type: Research article Published on:

  29. Female breast cancer is frequently diagnosed at a later stage and the leading cause of cancer deaths world-wide. Levels of cell-free circulating microRNAs (miRNAs) can potentially be used as biomarkers to meas...

    Authors: Amal Qattan, Haya Intabli, Wafa Alkhayal, Chafica Eltabache, Taher Tweigieri and Suad Bin Amer
    Citation: BMC Cancer 2017 17:799
    Content type: Research article Published on:

  30. In Europe, treatment of metastatic colorectal cancer (mCRC) with panitumumab requires prior confirmation of RAS wild-type mutation status. Two studies – a physician survey and a medical records review (MRR) – wer...

    Authors: J. Han van Krieken, George Kafatos, James Bennett, Laurent Mineur, Jiří Tomášek, Etienne Rouleau, Pavel Fabian, Giovanna De Maglio, Pilar García-Alfonso, Giuseppe Aprile, Parijan Parkar, Gerald Downey, Gaston Demonty and Jörg Trojan
    Citation: BMC Cancer 2017 17:798
    Content type: Research article Published on:

  31. There have been few data on the chemotherapy in elderly advanced non-small cell lung cancer (NSCLC) patients with poor performance status (PS), and usefulness of chemotherapy for such patients remains unclear....

    Authors: Satoshi Ikeda, Hiroshige Yoshioka, Satoshi Ikeo, Mitsunori Morita, Naoyuki Sone, Takashi Niwa, Akihiro Nishiyama, Toshihide Yokoyama, Akimasa Sekine, Takashi Ogura and Tadashi Ishida
    Citation: BMC Cancer 2017 17:797
    Content type: Research article Published on:

  32. Subjective cognitive impairment can be a significant and prevalent problem for gynaecological cancer survivors. The aims of this study were to assess subjective cognitive functioning in gynaecological cancer s...

    Authors: Yingchun Zeng, Andy S. K. Cheng, Ting Song, Xiujie Sheng, Yang Zhang, Xiangyu Liu and Chetwyn C. H. Chan
    Citation: BMC Cancer 2017 17:796
    Content type: Research article Published on:

  33. As the important suppressor of P53, iASPP is found to be overexpressed in leukemia, and functions as oncogene that inhibited apoptosis of leukemia cells. Sertad1 is identified as one of the proteins that can b...

    Authors: Shaowei Qiu, Shuang Liu, Tengteng Yu, Jing Yu, Min Wang, Qing Rao, Haiyan Xing, Kejing Tang, Yinchang Mi and Jianxiang Wang
    Citation: BMC Cancer 2017 17:795
    Content type: Research article Published on:

  34. Utilisation of radiation therapy for regional Australia and around the world has been the focus of much health policy the last decade. Radiation therapy centres have been built in Australian regional and rural...

    Authors: Sandra C. Thompson, Shelley Cheetham and Siddhartha Baxi
    Citation: BMC Cancer 2017 17:794
    Content type: Research article Published on:

  35. Despite smoking and risky alcohol drinking being modifiable risk factors for cancer as well as postoperative complications, perioperative cessation counselling is often ignored. Little is known about how cance...

    Authors: Susanne Vahr Lauridsen, Thordis Thomsen, Gudrun Kaldan, Line Noes Lydom and Hanne Tønnesen
    Citation: BMC Cancer 2017 17:793
    Content type: Research article Published on:

  36. There is a dramatic rise in the incidence of Human papillomavirus (HPV) – associated head and neck squamous cell carcinoma (HNSCC) in the world, with considerable variation by geography, gender and ethnicity. ...

    Authors: Mushfiq H. Shaikh, Aminul I. Khan, Anwar Sadat, Ahmed H. Chowdhury, Shahed A. Jinnah, Vinod Gopalan, Alfred K. Lam, Daniel T. W. Clarke, Nigel A. J. McMillan and Newell W. Johnson
    Citation: BMC Cancer 2017 17:792
    Content type: Research article Published on:

  37. Where resources are available, the World Health Organization recommends cervical cancer screening with human papillomavirus (HPV) DNA testing and subsequent treatment of HPV-positive women with timely cryother...

    Authors: Nicole G. Campos, Vivien Tsu, Jose Jeronimo, Mercy Mvundura and Jane J. Kim
    Citation: BMC Cancer 2017 17:791
    Content type: Research article Published on:

  38. Novel theranostic options for high-risk non-muscle invasive bladder cancer are urgently needed. This requires a thorough evaluation of experimental approaches in animal models best possibly reflecting human di...

    Authors: Doreen Huebner, Christiane Rieger, Ralf Bergmann, Martin Ullrich, Sebastian Meister, Marieta Toma, Ralf Wiedemuth, Achim Temme, Vladimir Novotny, Manfred P. Wirth, Michael Bachmann, Jens Pietzsch and Susanne Fuessel
    Citation: BMC Cancer 2017 17:790
    Content type: Research article Published on:

  39. The magnitude and rapidity of the tumor response to androgen deprivation is known to predict the durability of the therapy. We have investigated the predictive value of categorizing patients by the half-life o...

    Authors: Yong Jin Kang, Won Sik Jang, Jong Kyou Kwon, Cheol Yong Yoon, Joo Yong Lee, Won Sik Ham and Young Deuk Choi
    Citation: BMC Cancer 2017 17:789
    Content type: Research article Published on:

  40. To evaluate the incidence of neck muscle spasm in nasopharyngeal carcinoma (NPC) patients that received intensity-modulated radiotherapy (IMRT), and to analyse the patient- and treatment-related risk factors a...

    Authors: Lu-Lu Zhang, Guan-Qun Zhou, Zhen-Yu Qi, Xiao-Jun He, Jia-Xiang Li, Ling-Long Tang, Yan-Ping Mao, Ai-Hua Lin, Jun Ma and Ying Sun
    Citation: BMC Cancer 2017 17:788
    Content type: Research article Published on:

  41. Colorectal cancer is a heterogeneous group of malignancies with complex molecular subtypes. While colon cancer has been widely investigated, studies on rectal cancer are very limited. Here, we performed multi-...

    Authors: Mingshan Liu, Yang Liu, Jiabo Di, Zhe Su, Hong Yang, Beihai Jiang, Zaozao Wang, Meng Zhuang, Fan Bai and Xiangqian Su
    Citation: BMC Cancer 2017 17:787
    Content type: Research article Published on:

  42. ESR1 mutations have attracted attention as a potentially important marker and treatment target in endocrine therapy-resistant breast cancer patients. The E380Q mutation, which is one o...

    Authors: Takashi Takeshita, Yutaka Yamamoto, Mutsuko Yamamoto-Ibusuki, Aiko Sueta, Mai Tomiguchi, Keiichi Murakami, Yoko Omoto and Hirotaka Iwase
    Citation: BMC Cancer 2017 17:786
    Content type: Research article Published on:

  43. In recent years growing interest has been posed on alternative ways to screen women for breast cancer involving different imaging techniques or adjusting screening interval by breast cancer risk estimates. A n...

    Authors: Livia Giordano, Federica Gallo, Elisabetta Petracci, Giovanna Chiorino and Nereo Segnan
    Citation: BMC Cancer 2017 17:785
    Content type: Study protocol Published on:

  44. The KHP PCaBB was established in 2013 and recruits donors from the Urology or Oncology Departments at Guy’s Hospital in London (UK). Prostate cancer patients may be approached to give their consent for biobank...

    Authors: S. R. Saifuddin, W. Devlies, A. Santaolalla, F. Cahill, G. George, D. Enting, S. Rudman, P. Cathcart, B. Challacombe, P. Dasgupta, C. Galustian, A. Chandra, S. Chowdhury, C. Gillett and M. Van Hemelrijck
    Citation: BMC Cancer 2017 17:784
    Content type: Database Published on:

  45. Among colorectal cancer (CRC) survivors, how the prior tumor location affects the risk of subsequent primary colorectal cancer (SPCRC) and the outcome of those suffering from SPCRC remain unknown.

    Authors: Jiao Yang, Xianglin L. Du, Shuting Li, Yinying Wu, Meng Lv, Danfeng Dong, Lingxiao Zhang, Zheling Chen, Biyuan Wang, Fan Wang, Yanwei Shen, Enxiao Li, Min Yi and Jin Yang
    Citation: BMC Cancer 2017 17:783
    Content type: Research article Published on:

  46. Gastric cancer (GC) is one of the most frequently diagnosed digestive tract cancers and carries a high risk of mortality. Acetaldehyde (AA), a carcinogenic intermediate of ethanol metabolism contributes to the...

    Authors: Sudakshina Ghosh, Biswabandhu Bankura, Soumee Ghosh, Makhan Lal Saha, Arup Kumar Pattanayak, Souvik Ghatak, Manalee Guha, Senthil Kumar Nachimuthu, Chinmoy Kumar Panda, Suvendu Maji, Subrata Chakraborty, Biswanath Maity and Madhusudan Das
    Citation: BMC Cancer 2017 17:782
    Content type: Research article Published on:

  47. Recommending the optimal treatment for an individual patient requires a well-balanced consideration of various medical, social and ethical factors. The interplay of these factors, interpretation of the patient...

    Authors: I. Otte, S. Salloch, A. Reinacher-Schick and J. Vollmann
    Citation: BMC Cancer 2017 17:780
    Content type: Research article Published on:

  48. Pseudoprogression refers to a specific pattern of response sometimes observed in malignant melanoma patients receiving treatment with immune-checkpoint inhibitors. Although cases with pseudoprogression documen...

    Authors: Yukinori Ozaki, Junichi Shindoh, Yuji Miura, Hiromichi Nakajima, Ryosuke Oki, Miyuki Uchiyama, Jun Masuda, Keiichi Kinowaki, Chihiro Kondoh, Yuko Tanabe, Tsuyoshi Tanaka, Shusuke Haruta, Masaki Ueno, Shigehisa Kitano, Takeshi Fujii, Harushi Udagawa…
    Citation: BMC Cancer 2017 17:778
    Content type: Case report Published on:

  49. Pediatric papillary thyroid carcinoma frequently presents with lymph node involvement and distant metastases. Sorafenib, an oral multikinase inhibitor, has been used to treat radioactive iodine (RAI) therapy-r...

    Authors: Yousuke Higuchi, Takayuki Motoki, Hisashi Ishida, Kiichiro Kanamitsu, Kana Washio, Takanori Oyama, Takuo Noda, Yasuko Tsurumaru, Ayumi Okada, Hirokazu Tsukahara and Akira Shimada
    Citation: BMC Cancer 2017 17:775
    Content type: Case report Published on:

  50. Brain metastases (BM) from non-small cell lung cancer (NSCLC) are the most frequent intracranial tumors. To identify patients who might benefit from intracranial surgery, we compared the six existing prognosti...

    Authors: Xiaoyu Ji, Yingjie Zhuang, Xiangye Yin, Qiong Zhan, Xinli Zhou and Xiaohua Liang
    Citation: BMC Cancer 2017 17:774
    Content type: Research article Published on:

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