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  1. Biliary tract cancer (BTC) is a dismal disease, even after curative intent surgery. We conducted this prospective, non-randomized phase II study to evaluate the feasibility and efficacy of cisplatin and gemcit...

    Authors: Alexander R. Siebenhüner, Heike Seifert, Helga Bachmann, Burkhardt Seifert, Thomas Winder, Jonas Feilchenfeldt, Stefan Breitenstein, Pierre-Alain Clavien, Roger Stupp, Alexander Knuth, Bernhard Pestalozzi and Panagiotis Samaras
    Citation: BMC Cancer 2018 18:72
    Content type: Research article Published on:

  2. Physical activity is consistently associated with a reduced risk of colorectal cancer in epidemiologic studies. This association among higher risk subgroups, such as those with a first-degree family history of...

    Authors: Eileen Shaw, Megan S. Farris, Chelsea R. Stone, Jeroen W. G. Derksen, Rhys Johnson, Robert J. Hilsden, Christine M. Friedenreich and Darren R. Brenner
    Citation: BMC Cancer 2018 18:71
    Content type: Research article Published on:

  3. RHEB is a unique member of the RAS superfamily of small GTPases expressed in all tissues and conserved from yeast to humans. Early studies on RHEB indicated a possible RHEB-RAF interaction, but this has not be...

    Authors: Jeffrey J. Heard, Ivy Phung, Mark I. Potes and Fuyuhiko Tamanoi
    Citation: BMC Cancer 2018 18:69
    Content type: Research article Published on:

  4. The prognostic variability of thyroid carcinomas has led to the search for accurate biomarkers at the molecular level. Follicular thyroid carcinoma (FTC) is a typical example of differentiated thyroid carcinom...

    Authors: Ricardo Celestino, Torfinn Nome, Ana Pestana, Andreas M. Hoff, A. Pedro Gonçalves, Luísa Pereira, Bruno Cavadas, Catarina Eloy, Trine Bjøro, Manuel Sobrinho-Simões, Rolf I. Skotheim and Paula Soares
    Citation: BMC Cancer 2018 18:68
    Content type: Research article Published on:

  5. Small GTP binding protein Rac1 is a component of NADPH oxidases and is essential for superoxide-induced cell death. Rac1 is activated by guanine nucleotide exchange factors (GEFs), and this activation can be b...

    Authors: Nan Wu, Dong Ren, Su Li, Wenli Ma, Shaoyan Hu, Yan Jin and Sheng Xiao
    Citation: BMC Cancer 2018 18:67
    Content type: Research article Published on:

  6. To assess the factorial structure, internal consistency, construct validity and reproducibility of the Quality of Working Life Questionnaire for Cancer Survivors (QWLQ-CS).

    Authors: Merel de Jong, Sietske J. Tamminga, Robert J. J. van Es, Monique H. W. Frings-Dresen and Angela G. E. M. de Boer
    Citation: BMC Cancer 2018 18:66
    Content type: Research article Published on:

  7. Metformin is associated with a reduced risk of some cancers but its effect on prostate cancer is unclear. Some studies suggest only Asians derive this benefit. Therefore, we undertook a systematic review with ...

    Authors: Christopher B. Chen, Maxim Eskin, Dean T. Eurich, Sumit R. Majumdar and Jeffrey A. Johnson
    Citation: BMC Cancer 2018 18:65
    Content type: Research article Published on:

  8. Prostate cancer is the most commonly diagnosed cancer in north-American men. Few dietary or lifestyle interventions have been tested to prevent prostate cancer progression. Omega-3 fatty acid supplementation r...

    Authors: Marie-Hélène Guertin, Karine Robitaille, Jean-François Pelletier, Thierry Duchesne, Pierre Julien, Josée Savard, Isabelle Bairati and Vincent Fradet
    Citation: BMC Cancer 2018 18:64
    Content type: Study protocol Published on:

  9. Staging laparoscopy(SL) is a recommended technique for the staging of Gastric Cancer(GC) and provides the indication for a radical surgery. Considering the medical practice in China, the standardized and regul...

    Authors: Ziyu Li, Zhemin Li, Lianhai Zhang, Qian Liu, Zhenjun Wang, Zhongtao Zhang, Gang Xiao, Wei Fu, Xin Wang, Yingjiang Ye, Jianchun Yu, Fei Li, Lin Chen, Shibin Wang and Jiafu Ji
    Citation: BMC Cancer 2018 18:63
    Content type: Study protocol Published on:

  10. Chemotherapy-induced peripheral neuropathy (CIPN) is a common and clinically relevant side effect of chemotherapy. Approximately 50% of all leukemia, lymphoma, colorectal- and breast cancer patients are affected.

    Authors: Fiona Streckmann, Maryam Balke, Helmar C. Lehmann, Vanessa Rustler, Christina Koliamitra, Thomas Elter, Michael Hallek, Michael Leitzmann, Tilman Steinmetz, Petra Heinen, Freerk T. Baumann and Wilhelm Bloch
    Citation: BMC Cancer 2018 18:62
    Content type: Study protocol Published on:

  11. The circadian clock is the basis for biological time keeping in eukaryotic organisms. The clock mechanism relies on biochemical signaling pathways to detect environmental stimuli and to regulate the expression...

    Authors: Charles S. Goldsmith, Sam Moon Kim, Nirmala Karunarathna, Nichole Neuendorff, L. Gerard Toussaint, David J. Earnest and Deborah Bell-Pedersen
    Citation: BMC Cancer 2018 18:43
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:101

  12. Around the world, cervical cancer is the fourth most common cancer among women. MicroRNAs (miRNAs) and agents that target mRNAs have been introduced as novel diagnostic markers and therapeutic approaches, resp...

    Authors: Chunmei Li, Xiaojiao Zheng, Wei Li, Fumao Bai, Jianxin Lyu and Qing H. Meng
    Citation: BMC Cancer 2018 18:61
    Content type: Research article Published on:

  14. Informal caregivers provide extended support to people with cancer but they receive little support from the health care system to assist them in their caring role. The aim of this single-blind, multi-centre, r...

    Authors: Leila Heckel, Kate M. Fennell, John Reynolds, Anna Boltong, Mari Botti, Richard H. Osborne, Cathrine Mihalopoulos, Jacquie Chirgwin, Melinda Williams, Cadeyrn J. Gaskin, David M. Ashley and Patricia M. Livingston
    Citation: BMC Cancer 2018 18:59
    Content type: Research article Published on:

  15. New Zealand has major ethnic disparities in breast cancer survival with Māori (indigenous people) and Pacific women (immigrants or descended from immigrants from Pacific Islands) faring much worse than other e...

    Authors: Sandar Tin Tin, J. Mark Elwood, Charis Brown, Diana Sarfati, Ian Campbell, Nina Scott, Reena Ramsaroop, Sanjeewa Seneviratne, Vernon Harvey and Ross Lawrenson
    Citation: BMC Cancer 2018 18:58
    Content type: Research article Published on:

  16. Oxaliplatin + S-1 is a recognized treatment regimen in Japan, but there are no Japanese clinical data on an oxaliplatin dose of 130 mg/m2. The current research involves a single-arm, prospective, phase II clinica...

    Authors: Hiroshi Saeki, Yasunori Emi, Eiji Oki, Shoji Tokunaga, Yoshihiro Kakeji, Yoshito Akagi, Hideo Baba, Eishi Baba and Yoshihiko Maehara
    Citation: BMC Cancer 2018 18:57
    Content type: Study protocol Published on:

  17. To provide further information on the clinical and pathological prognostic factors in triple-negative breast cancer (TNBC), for which limited and inconsistent data are available.

    Authors: Silvana Anna Maria Urru, Silvano Gallus, Cristina Bosetti, Tiziana Moi, Ricardo Medda, Elisabetta Sollai, Alma Murgia, Francesca Sanges, Giovanna Pira, Alessandra Manca, Dolores Palmas, Matteo Floris, Anna Maria Asunis, Francesco Atzori, Ciriaco Carru, Maurizio D’Incalci…
    Citation: BMC Cancer 2018 18:56
    Content type: Research article Published on:

  18. Systemic treatment for advanced cancer offers uncertain and sometimes little benefit while the burden can be high. Hence, treatment decisions require Shared Decision Making (SDM). The CHOICE trial examines the...

    Authors: I. Henselmans, E. M. A. Smets, J. C. J. M. de Haes, M. G. W. Dijkgraaf, F. Y. de Vos and H. W. M. van Laarhoven
    Citation: BMC Cancer 2018 18:55
    Content type: Study protocol Published on:

  19. Though breast cancer remains a major health problem, there is a lack of information on health care provided to patients with this disease and associated costs. In addition, there is a need to update and valida...

    Authors: Susana García-Gutierrez, Miren Orive, Cristina Sarasqueta, Maria Jose Legarreta, Nerea Gonzalez, Maximino Redondo, Amado Rivero, Pedro Serrano-Aguilar, Xavier Castells, Jose Maria Quintana and Maria Sala
    Citation: BMC Cancer 2018 18:54
    Content type: Study protocol Published on:

  20. Moesin is a member of the ERM (ezrin, radixin and moesin) proteins that participate in cell migration and tumor invasion through transductional signals sent to actin filaments by glycoproteins, such as podopla...

    Authors: Francisco Bárbara Abreu Barros, Agnes Assao, Natália Galvão Garcia, Suely Nonogaki, André Lopes Carvalho, Fernando Augusto Soares, Luiz Paulo Kowalski and Denise Tostes Oliveira
    Citation: BMC Cancer 2018 18:53
    Content type: Research article Published on:

  21. Breast cancer is one of the most commonly diagnosed invasive cancers among women around the world. Among several subtypes, triple negative breast cancer (TNBC) is highly aggressive and chemoresistant. Treatmen...

    Authors: Dhiraj Kumar, Saikat Haldar, Mahadeo Gorain, Santosh Kumar, Fayaj A. Mulani, Amit S. Yadav, Lucio Miele, Hirekodathakallu V. Thulasiram and Gopal C. Kundu
    Citation: BMC Cancer 2018 18:52
    Content type: Research article Published on:

  22. The topic of trastuzumab therapy without chemotherapy in early breast cancer (EBC) has been repeatedly discussed at international consensus meetings, but is compromised by the lack of solid evidence from clini...

    Authors: Peter Dall, Thorsten Koch, Thomas Göhler, Johannes Selbach, Andreas Ammon, Jochen Eggert, Nidal Gazawi, Daniela Rezek, Arthur Wischnik, Carsten Hielscher, Nicolas Schleif, Ursula Cirrincione, Axel Hinke and Gabriele Feisel-Schwickardi
    Citation: BMC Cancer 2018 18:51
    Content type: Research article Published on:

  23. To revise the American Joint Committee on Cancer TNM staging system for colorectal cancer (CRC) based on a nomogram analysis of Surveillance, Epidemiology, and End Results (SEER) database, and to prove the rat...

    Authors: Xiangxing Kong, Jun Li, Yibo Cai, Yu Tian, Shengqiang Chi, Danyang Tong, Yeting Hu, Qi Yang, Jingsong Li, Graeme Poston, Ying Yuan and Kefeng Ding
    Citation: BMC Cancer 2018 18:50
    Content type: Research article Published on:

  24. Previous investigations have indicated that CD10 is associated with biological aggressivity in human cancers, but the use of this marker for diagnosis and prognosis is more complex. The aim of this study was t...

    Authors: Tahani Louhichi, Hanene Saad, Myriam Ben Dhiab, Sonia Ziadi and Mounir Trimeche
    Citation: BMC Cancer 2018 18:49
    Content type: Research article Published on:

  25. Surgical resection is necessary to conduct a pathological biopsy and to achieve a reduction of intracranial pressure in low-grade gliomas patients. This study aimed to determine whether a greater extent of res...

    Authors: Liang Xia, Chenyan Fang, Gao Chen and Caixing Sun
    Citation: BMC Cancer 2018 18:48
    Content type: Research article Published on:

  26. Exosomes, small-membrane vesicles, are secreted by cells and include several types of proteins and nucleic acids. Exosomes transfer cellular information derived from donor cells and are involved in various phy...

    Authors: Sayo Horibe, Toshihito Tanahashi, Shoji Kawauchi, Yoshiki Murakami and Yoshiyuki Rikitake
    Citation: BMC Cancer 2018 18:47
    Content type: Research article Published on:

  27. NRF2 is the key regulator of oxidative stress in normal cells and aberrant expression of the NRF2 pathway due to genetic alterations in the KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (nuclear factor eryt...

    Authors: Akhileshwar Namani, Md. Matiur Rahaman, Ming Chen and Xiuwen Tang
    Citation: BMC Cancer 2018 18:46
    Content type: Research article Published on:

  28. The objective of this study is to develop, implement, and evaluate a training program for healthcare providers to improve ability to provide psychosocial support to breast cancer survivors in Korea.

    Authors: Eunyoung Park, Junghee Yoon, Eun-kyung Choi, Im Ryung Kim, Danbee Kang, Se-Kyung Lee, Jeong Eon Lee, Seok Jin Nam, Jin Seok Ahn, Adriaan Visser and Juhee Cho
    Citation: BMC Cancer 2018 18:45
    Content type: Research article Published on:

  29. Bone metastases commonly occur in conjunction with solid tumors, and are associated with serious bone complications. Population-based estimates of bone metastasis incidence are limited, often based on autopsy ...

    Authors: Rohini K. Hernandez, Sally W. Wade, Adam Reich, Melissa Pirolli, Alexander Liede and Gary H. Lyman
    Citation: BMC Cancer 2018 18:44
    Content type: Research article Published on:

  30. The 21-gene recurrence score (RS) assay determines the benefit of adding chemotherapy to endocrine therapy for patients with early stage, estrogen receptor (ER)-positive, HER2-negative breast cancer. The RS ri...

    Authors: Gulisa Turashvili, Edi Brogi, Monica Morrow, Maura Dickler, Larry Norton, Clifford Hudis and Hannah Y. Wen
    Citation: BMC Cancer 2018 18:42
    Content type: Research article Published on:

  32. Interventions to improve fecal testing for colorectal cancer (CRC) exist, but are not yet routine practice. We conducted this systematic review to determine how implementation strategies and contextual factors...

    Authors: Melinda M. Davis, Michele Freeman, Jackilen Shannon, Gloria D. Coronado, Kurt C. Stange, Jeanne-Marie Guise, Stephanie B. Wheeler and David I. Buckley
    Citation: BMC Cancer 2018 18:40
    Content type: Research article Published on:

  34. Colorectal cancer is the 4th common cancer in China. Most colorectal cancers are due to modifiable lifestyle factors, but few studies have provided a systematic evidence-based assessment of the burden of color...

    Authors: Meng-Jia Gu, Qiu-Chi Huang, Cheng-Zhen Bao, Ying-Jun Li, Xiao-Qin Li, Ding Ye, Zhen-Hua Ye, Kun Chen and Jian-Bing Wang
    Citation: BMC Cancer 2018 18:38
    Content type: Research article Published on:

  35. Breast cancer anti-estrogen resistance 1 (BCAR1/p130cas) is a hub for diverse oncogenic signaling cascades and promotes tumor development and progression.

    Authors: Asmus Heumann, Nina Heinemann, Claudia Hube-Magg, Dagmar S. Lang, Katharina Grupp, Martina Kluth, Sarah Minner, Christina Möller-Koop, Markus Graefen, Hans Heinzer, Maria Christina Tsourlakis, Waldemar Wilczak, Corinna Wittmer, Frank Jacobsen, Hartwig Huland, Ronald Simon…
    Citation: BMC Cancer 2018 18:37
    Content type: Research article Published on:

  36. Activated pancreatic stellate cells (PaSCs) are the key cellular source of cancer-associated fibroblasts in the pancreatic stroma of patients with pancreatic ductal adenocarcinoma (PDAC), however, the activati...

    Authors: Haiyan Song and Yuxiang Zhang
    Citation: BMC Cancer 2018 18:36
    Content type: Research article Published on:

  37. Sessile serrated adenomas with BRAF mutation progress rapidly to cancer following the development of dysplasia (SSAD). Approximately 75% of SSADs methylate the mismatch repair gene MLH1, develop mismatch repair d...

    Authors: Lochlan J. Fennell, Saara Jamieson, Diane McKeone, Tracie Corish, Megan Rohdmann, Tori Furner, Mark Bettington, Cheng Liu, Futoshi Kawamata, Catherine Bond, Jolieke Van De Pols, Barbara Leggett and Vicki Whitehall
    Citation: BMC Cancer 2018 18:35
    Content type: Research article Published on:

  40. Breast cancer has a high case fatality rate in sub-Saharan Africa, and this is chiefly because of late detection and inadequate treatment resources. Progressive renovations in diagnostic and management modalit...

    Authors: Bibiana Ateh Nzeangung, Martin Essomba Biwole, Benjamin Momo Kadia, Ndemazie Nkafu Bechem, Christian Akem Dimala and Albert Mouelle Sone
    Citation: BMC Cancer 2018 18:32
    Content type: Research article Published on:

  41. The Intratumoral Microvessel Density (IMVD) is commonly used to quantify tumoral vascularization and is usually assessed by pan-endothelial markers, such as CD31. Endoglin (CD105) is a protein predominantly ex...

    Authors: Virginia Di Paolo, Ida Russo, Renata Boldrini, Lucilla Ravà, Marco Pezzullo, Maria Chiara Benedetti, Angela Galardi, Marta Colletti, Rossella Rota, Domenico Orlando, Alessandro Crocoli, Hector Peinado, Giuseppe Maria Milano and Angela Di Giannatale
    Citation: BMC Cancer 2018 18:31
    Content type: Research article Published on:

  42. Protein neddylation is a post-translational modification by a covalent conjugation with the neural precursor cell expressed, developmentally downregulated 8 (NEDD8). Although this process has been reported to ...

    Authors: Sung Yeon Park, Jong-Wan Park, Gun-Woo Lee, Lan Li and Yang-Sook Chun
    Citation: BMC Cancer 2018 18:30
    Content type: Research article Published on:

  43. Lin28B and its paralog Lin28A are small RNA binding proteins that have similar inhibitory effects, although they target separate steps in the maturation of let-7 miRNAs in mammalian cells. Because Lin28B parti...

    Authors: Ting-ting Qu, Fei Chen, Jing Wang, Yan-jun Zhang, Mo-bin Cheng, Wen-zheng Sun, Yu-fei Shen and Ye Zhang
    Citation: BMC Cancer 2018 18:27
    Content type: Research article Published on:

  44. Early diagnosis of colorectal cancer (CRC) simplifies treatment and improves treatment outcomes. We previously described a diagnostic metabolomic biomarker derived from semi-quantitative gas chromatography-mas...

    Authors: Farshad Farshidfar, Karen A. Kopciuk, Robert Hilsden, S. Elizabeth McGregor, Vera C. Mazurak, W. Donald Buie, Anthony MacLean, Hans J. Vogel and Oliver F. Bathe
    Citation: BMC Cancer 2018 18:26
    Content type: Research article Published on:

  45. We examined incidence and survival in relation to age, gender, socioeconomic deprivation, rurality and trends over time. We also examined the association between volume of patients treated by hospitals and sur...

    Authors: Ravi Maheswaran and Nick Morley
    Citation: BMC Cancer 2018 18:25
    Content type: Research article Published on:

  46. Although cases of multiple primary malignant neoplasms are increasing, reports of more than three or four primary metachronous malignant neoplasms are extremely rare. Moreover, very few publications have provi...

    Authors: Keiichi Arakawa, Keisuke Hata, Yoko Yamamoto, Takeshi Nishikawa, Toshiaki Tanaka, Tomomichi Kiyomatsu, Kazushige Kawai, Hiroaki Nozawa, Masafumi Yoshida, Hiroshi Fukuhara, Mitsuhiro Fujishiro, Teppei Morikawa, Tatsuya Yamasoba, Kazuhiko Koike, Masashi Fukayama and Toshiaki Watanabe
    Citation: BMC Cancer 2018 18:24
    Content type: Case report Published on:

  47. The Grainyhead-like (GRHL) transcription factors have been linked to many different types of cancer. However, no previous study has attempted to investigate potential correlations in expression of different GRHL ...

    Authors: Agnieszka Kikulska, Tobias Rausch, Ewa Krzywinska, Magdalena Pawlak, Bartek Wilczynski, Vladimir Benes, Piotr Rutkowski and Tomasz Wilanowski
    Citation: BMC Cancer 2018 18:23
    Content type: Research article Published on:

  49. Though the incidence of Testicular cancer among young is rising, little attention is given to promoting testicular self-examination which is recommended for its early prevention in developing countries. This stud...

    Authors: Hordofa Gutema, Yamrot Debela, Bizuayehu Walle, Kidist Reba and Habtamu Wondiye
    Citation: BMC Cancer 2018 18:21
    Content type: Research article Published on:

  50. Body image is a complex post-treatment concern among female patients with breast cancer, and various tools have been developed and applied to measure this multifaceted issue. However, these available tools wer...

    Authors: Kaina Zhou, Xiaole He, Lanting Huo, Jinghua An, Minjie Li, Wen Wang and Xiaomei Li
    Citation: BMC Cancer 2018 18:19
    Content type: Research article Published on:

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