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  1. Knowledge about disease and treatment is necessary before patients can consent to treatment. One of the few established instruments for evaluating whether sufficient information has been provided, is the EORTC...

    Authors: Ola Berger, Bjørn Henning Grønberg, Jon Håvard Loge, Stein Kaasa and Kari Sand
    Citation: BMC Cancer 2018 18:381
    Content type: Research article Published on:

  2. This study aimed to systematically review and to meta-analyse the accuracy of digital breast tomosynthesis (DBT) versus digital mammography (DM) in women with mammographically dense breasts in screening and di...

    Authors: Xuan-Anh Phi, Alberto Tagliafico, Nehmat Houssami, Marcel J. W. Greuter and Geertruida H. de Bock
    Citation: BMC Cancer 2018 18:380
    Content type: Research article Published on:

  3. Temozolomide (TMZ)-induced side effects and drug tolerance to human gliomas are still challenging issues now. Our previous studies showed that honokiol, a major bioactive constituent of Magnolia officinalis (Houp...

    Authors: Chung-Ching Chio, Kung-Yen Chen, Cheng-Kuei Chang, Jian-Ying Chuang, Chih-Chung Liu, Shing-Hwa Liu and Ruei-Ming Chen
    Citation: BMC Cancer 2018 18:379
    Content type: Research article Published on:

  4. Treatment of localized gastric cancer (LGC) consists of surgical resection followed by adjuvant treatment. Both chemoradiation (CRT) and chemotherapy (CT) regimens have shown benefit in survival outcomes versu...

    Authors: Daniel M. Girardi, Mariana A. de Lima, Gabriel C. B. Pereira, Marcelo V. Negrão, Rossana V. M. López, Fernanda C. Capareli, Jorge Sabbaga and Paulo Marcelo G. Hoff
    Citation: BMC Cancer 2018 18:378
    Content type: Research article Published on:

  5. Gene expression can be employed for the discovery of prognostic gene or multigene signatures cancer. In this study, we assessed the prognostic value of a 35-gene expression signature selected by pathway and ma...

    Authors: Azeez A. Fatai and Junaid Gamieldien
    Citation: BMC Cancer 2018 18:377
    Content type: Research article Published on:

  7. With ongoing healthcare reform and shrinking numbers of oncologists, appropriate triaging of gynecologic cancer survivor care is crucial. Input from patients is a necessary part of this task. The objective of ...

    Authors: Matthew Schlumbrecht, Charlotte Sun, Marilyn Huang, Andrea Milbourne and Diane Bodurka
    Citation: BMC Cancer 2018 18:375
    Content type: Research article Published on:

  8. The combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) has been suggested to be safe and effective for adult acute promyelocytic leukaemia (APL). As of 2010, the role of cytarabine (Ara-C...

    Authors: Li Zhang, Yao Zou, Yumei Chen, Ye Guo, Wenyu Yang, Xiaojuan Chen, Shuchun Wang, Xiaoming Liu, Min Ruan, Jiayuan Zhang, Tianfeng Liu, Fang Liu, Benquan Qi, Wenbin An, Yuanyuan Ren, Lixian Chang…
    Citation: BMC Cancer 2018 18:374
    Content type: Research article Published on:

  9. Active smoking at the time of diagnosis of a first head & neck (H&N) or lung cancer is associated with a worse cancer outcome and increased mortality. However, the compared characteristics of active vs. former...

    Authors: Corinne Vannimenus, Hélène Bricout, Olivier Le Rouzic, François Mouawad, Dominique Chevalier, Eric Dansin, Laurence Rotsaert, Gautier Lefebvre, Olivier Cottencin, Henri Porte, Arnaud Scherpereel, Asmaa El Fahsi, Florence Richard and Benjamin Rolland
    Citation: BMC Cancer 2018 18:372
    Content type: Research article Published on:

  10. The anticancer immune response has been reported to correlate with cancer progression. Tumor-infiltrating lymphocytes (TILs), which are one of the indicators of host immunity, affect the tumor growth, metastas...

    Authors: Masatsune Shibutani, Kiyoshi Maeda, Hisashi Nagahara, Tatsunari Fukuoka, Shinji Matsutani, Shinichiro Kashiwagi, Hiroaki Tanaka, Kosei Hirakawa and Masaichi Ohira
    Citation: BMC Cancer 2018 18:371
    Content type: Research article Published on:

  11. It is still controversial whether laparoscopy-assisted colectomy (LAC) is suitable for patients with stage T4 colon cancer. This study aimed to compare the short- and long-term outcomes of LAC and open colecto...

    Authors: Hao Wang, Xiaoyu Chen, Hao Liu, Tingyu Mou, Haijun Deng, Liying Zhao and Guoxin Li
    Citation: BMC Cancer 2018 18:370
    Content type: Research article Published on:

  12. A randomized trial demonstrated that capecitabine is at least as effective as fluorouracil in the adjuvant treatment of patients with locally advanced rectal cancer. However, not all patients receive all plann...

    Authors: Flavius Sandra-Petrescu, Florian Herrle, Iris Burkholder, Peter Kienle and Ralf-Dieter Hofheinz
    Citation: BMC Cancer 2018 18:369
    Content type: Research article Published on:

  13. Prostate cancer patients on androgen deprivation therapy (ADT) experience adverse effects such as lean mass loss, known as sarcopenia, fat gain, and changes in cardiometabolic factors that increase risk of met...

    Authors: Jacqueline K. Dawson, Tanya B. Dorff, E. Todd Schroeder, Christianne J. Lane, Mitchell E. Gross and Christina M. Dieli-Conwright
    Citation: BMC Cancer 2018 18:368
    Content type: Research article Published on:

  15. Macrophage heterogeneity is the main feature of the tumour microenvironment. Breast cancer is one of the most life-threatening cancers. However, macrophage polarization patterns in different tumour stages and ...

    Authors: Chih-Hsing Hung, Fang-Ming Chen, Yi-Ching Lin, Mei-Lan Tsai, Shih-Ling Wang, Yen-Chun Chen, Yi-Ting Chen and Ming-Feng Hou
    Citation: BMC Cancer 2018 18:366
    Content type: Research article Published on:

  16. Identifying preferences for stool collection devices may help increase uptake rates for colorectal cancer screening via fecal immunochemical test (FIT). This study surveyed satisfaction with different devices ...

    Authors: Hye Young Shin, Mina Suh, Kui Son Choi, Sang-Hyun Hwang, Jae Kwan Jun, Dong Soo Han, You Kyoung Lee, Jae Hwan Oh, Chan Wha Lee and Do-Hoon Lee
    Citation: BMC Cancer 2018 18:365
    Content type: Research article Published on:

  17. Brief interventions for smoking cessation and alcohol moderation may contribute considerably to the prevention of cancer among populations at risk, such as cancer survivors, in addition to improving their gene...

    Authors: Ajla Mujcic, Matthijs Blankers, Brigitte Boon, Rutger Engels and Margriet van Laar
    Citation: BMC Cancer 2018 18:364
    Content type: Study protocol Published on:

  18. Understanding what influences people to seek help can inform interventions to promote earlier diagnosis of cancer, and ultimately better cancer survival. We aimed to examine relationships between negative canc...

    Authors: Anette Fischer Pedersen, Lindsay Forbes, Kate Brain, Line Hvidberg, Christian Nielsen Wulff, Magdalena Lagerlund, Senada Hajdarevic, Samantha L. Quaife and Peter Vedsted
    Citation: BMC Cancer 2018 18:363
    Content type: Research article Published on:

  19. Volatile organic compounds (VOCs) emitted from exhaled breath from human bodies have been proven to be a useful source of information for early lung cancer diagnosis. To date, there are still arguable informat...

    Authors: Reena Thriumani, Ammar Zakaria, Yumi Zuhanis Has-Yun Hashim, Amanina Iymia Jeffree, Khaled Mohamed Helmy, Latifah Munirah Kamarudin, Mohammad Iqbal Omar, Ali Yeon Md Shakaff, Abdul Hamid Adom and Krishna C. Persaud
    Citation: BMC Cancer 2018 18:362
    Content type: Research article Published on:

  20. The phenomenon that malignant cells can acquire stemness under specific stimuli, encompassed under the concept of cancer cell plasticity, has been well-described in epithelial malignancies. To our knowledge, c...

    Authors: Chengsheng Wu, Nidhi Gupta, Yung-Hsing Huang, Hai-Feng Zhang, Abdulraheem Alshareef, Alexandra Chow and Raymond Lai
    Citation: BMC Cancer 2018 18:361
    Content type: Research article Published on:

  21. Cancer cachexia is a cancer-induced metabolic disorder and a major cause of cancer-induced death. The constituents of cancer cachexia include an increase in energy expenditure, hepatic gluconeogenesis, fat lip...

    Authors: Feng Wang, Hongyi Liu, Lijuan Hu, Yunfei Liu, Yijie Duan, Rui Cui and Wencong Tian
    Citation: BMC Cancer 2018 18:360
    Content type: Research article Published on:

  22. Treatment of chronic myeloid leukemia with a tyrosine kinase inhibitor (TKI) offers significant improvements over previous treatments in terms of survival and toxicity yet nevertheless is associated with reduc...

    Authors: Ehab Atallah, Charles A. Schiffer, Kevin P. Weinfurt, Mei-Jie Zhang, Jerald P. Radich, Vivian G. Oehler, Javier Pinilla-Ibarz, Michael W. N. Deininger, Li Lin, Richard A. Larson, Michael J. Mauro, Joseph O. Moore, Ellen K. Ritchie, Neil P. Shah, Richard T. Silver, Martha Wadleigh…
    Citation: BMC Cancer 2018 18:359
    Content type: Study protocol Published on:

  23. Giant Cell Tumour of Bone (GCT) is a locally aggressive primary bone tumour that usually occurs at the epiphyses of the long bones of the appendicular skeleton with a tendency to recurrence. Recurrent somatic H3F...

    Authors: Federica Scotto di Carlo, Giuseppina Divisato, Maurizio Iacoangeli, Teresa Esposito and Fernando Gianfrancesco
    Citation: BMC Cancer 2018 18:358
    Content type: Research article Published on:

  24. Cervical cancer is a major cause of cancer-related mortality in women in the developing world. Cancer Stem cells (CSC) have been implicated in treatment resistance and metastases development; hence understandi...

    Authors: Shifa Javed, Bal Krishan Sharma, Swati Sood, Sanjeev Sharma, Rashmi Bagga, Shalmoli Bhattacharyya, Charan Singh Rayat, Lakhbir Dhaliwal and Radhika Srinivasan
    Citation: BMC Cancer 2018 18:357
    Content type: Research article Published on:

  25. The accumulated evidence has indicated the diagnostic role of cytokeratin (CK) and vimentin protein immunoassay in primary esophageal spindle cell carcinoma (PESC), which is a rare malignant tumor with epithel...

    Authors: Xin Min Li, Xin Song, Xue Ke Zhao, Shou Jia Hu, Rang Cheng, Shuang Lv, Dan Feng Du, Xiang Yang Zhang, Jian Liang Lu, Jian Wei Ku, Dong Yun Zhang, Yao Zhang, Zong Min Fan and Li Dong Wang
    Citation: BMC Cancer 2018 18:356
    Content type: Research article Published on:

  26. Mounting evidence suggests that one of the ways that cells adapt to hypoxia is through alternative splicing. The aim of this study was firstly to examine the effect of hypoxia on the alternative splicing of ca...

    Authors: Elizabeth Bowler, Sean Porazinski, Simon Uzor, Philippe Thibault, Mathieu Durand, Elvy Lapointe, Kasper M. A. Rouschop, John Hancock, Ian Wilson and Michael Ladomery
    Citation: BMC Cancer 2018 18:355
    Content type: Research article Published on:

  27. Recent retrospective data suggest that neoadjuvant androgen deprivation therapy can improve the prognosis of high-risk prostate cancer (PCa) patients. Novel androgen receptor pathway inhibitors are nowadays av...

    Authors: Lorenzo Tosco, Annouschka Laenen, Thomas Gevaert, Isabelle Salmon, Christine Decaestecker, Elai Davicioni, Christine Buerki, Frank Claessens, Johan Swinnen, Karolien Goffin, Raymond Oyen, Wouter Everaerts, Lisa Moris, Gert De Meerleer, Karin Haustermans and Steven Joniau
    Citation: BMC Cancer 2018 18:354
    Content type: Study protocol Published on:

  28. The increasing incidence of colorectal cancer in Taiwan has generated a need for a disease-specific quality-of-life measuring instrument. We aimed to validate the Taiwan Chinese version of the European Organis...

    Authors: Ming-Hung Shen, Ling-Ping Chen, Thien-Fiew Ho, Ying-Yih Shih, Ching-Shui Huang, Wei-Chu Chie and Chi-Cheng Huang
    Citation: BMC Cancer 2018 18:353
    Content type: Research article Published on:

  29. Previous studies have indicated that people with malignant pleural mesothelioma (MPM) have a poor quality of life (QOL); however, information about the QOL of people with MPM in Japan is anecdotal. The aims of...

    Authors: Yasuko Nagamatsu, Isao Oze, Keisuke Aoe, Katsuyuki Hotta, Katsuya Kato, Junko Nakagawa, Keiko Hara, Takumi Kishimoto and Nobukazu Fujimoto
    Citation: BMC Cancer 2018 18:350
    Content type: Research article Published on:

  30. Androgen receptor (AR) is widely expressed in breast cancer (BC) but its role in estrogen receptor (ER)-positive tumors is still controversial. The AR/ER ratio has been reported to impact prognosis and respons...

    Authors: Giuseppe Bronte, Andrea Rocca, Sara Ravaioli, Maurizio Puccetti, Maria Maddalena Tumedei, Emanuela Scarpi, Daniele Andreis, Roberta Maltoni, Samanta Sarti, Lorenzo Cecconetto, Anna Fedeli, Elisabetta Pietri, Valeria De Simone, Silvia Asioli, Dino Amadori and Sara Bravaccini
    Citation: BMC Cancer 2018 18:348
    Content type: Research article Published on:

  31. Ovarian carcinoma is the most lethal gynecological malignancy due to early dissemination and acquired resistance to platinum-based chemotherapy. Reliable markers that are independent and complementary to clini...

    Authors: Cécile Le Page, Kurosh Rahimi, Martin Köbel, Patricia N. Tonin, Liliane Meunier, Lise Portelance, Monique Bernard, Brad H. Nelson, Marcus Q. Bernardini, John M. S. Bartlett, Dimcho Bachvarov, Walter H. Gotlieb, Blake Gilks, Jessica N. McAlpine, Mark W. Nachtigal, Alain Piché…
    Citation: BMC Cancer 2018 18:347
    Content type: Research article Published on:

  33. Reg IV is a member of the regenerating gene family and has been demonstrated to be overexpressed in gastric cancer. However, the functional mechanism of Reg IV in gastric cancer is still unclear.

    Authors: Na Zhang, Dandan Chai, Huifen Du, Kesheng Li, Wenguang Xie, Xingwen Li, Rong Yang, Xiaowen Lian and Yang Xu
    Citation: BMC Cancer 2018 18:344
    Content type: Research article Published on:

  34. Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm (MPN) with less than 40 cases of patients being reported or clinically suspected meeting with 2008 World Health Organization (“WHO”) di...

    Authors: Xue Bin Wu, Wei Wei Wu, Yue Zhou, Xuan Wang, Jia Li and Yang Yu
    Citation: BMC Cancer 2018 18:343
    Content type: Case report Published on:

  35. We have previously demonstrated the anticancer effect of anthocyanins. In this study, we explored the biological activities of delphinidin, the most common of the anthocyanidin monomers, that were related to a...

    Authors: Jingyao Chen, Yanfeng Zhu, Weiwei Zhang, Xiaoli Peng, Jie Zhou, Fei Li, Bin Han, Xin Liu, Yu Ou and Xiaoping Yu
    Citation: BMC Cancer 2018 18:342
    Content type: Research article Published on:

  36. The primary clinical manifestation of skin field cancerization is the presence of actinic keratoses (AKs). Current treatments for AKs related to skin field cancerization include photodynamic therapy (PDT) and ...

    Authors: Anna Carolina Miola, Eliane Roio Ferreira, Luciana Patricia Fernandes Abbade, Juliano Vilaverde Schmitt and Helio Amante Miot
    Citation: BMC Cancer 2018 18:340
    Content type: Study protocol Published on:

  37. Desmoplastic small round cell tumor (DSRCT) is a rare malignant sarcoma with poor prognosis due to lack of effective treatments. Apatinib is a new potent oral small-molecule tyrosine kinase inhibitor, and targ...

    Authors: Chunyu Shi, Ye Feng, Lei Chao Zhang, Da Yong Ding, Ming Yu Yan and Lu Pan
    Citation: BMC Cancer 2018 18:338
    Content type: Case report Published on:

  38. Fasting in disease prevention and treatment has recently become a popular topic, particularly in the context of oncology. Unfortunately, the growing attention paid by the media has created a background of spec...

    Authors: Riccardo Caccialanza, Emanuele Cereda, Francesco De Lorenzo, Gabriella Farina and Paolo Pedrazzoli
    Citation: BMC Cancer 2018 18:337
    Content type: Debate Published on:

  40. Patient-derived tumor models are the new standard for pre-clinical drug testing and biomarker discovery. However, the emerging technology of primary pancreatic cancer organoids has not yet been broadly impleme...

    Authors: Susan Tsai, Laura McOlash, Katie Palen, Bryon Johnson, Christine Duris, Qiuhui Yang, Michael B. Dwinell, Bryan Hunt, Douglas B. Evans, Jill Gershan and Michael A. James
    Citation: BMC Cancer 2018 18:335
    Content type: Research article Published on:

  41. The incidence of colorectal cancer in adolescent and young adult patients is increasing. However, survival and clinical features of young patients, especially those with stage IV disease, relative to adult pat...

    Authors: Dai Shida, Yuka Ahiko, Taro Tanabe, Takefumi Yoshida, Shunsuke Tsukamoto, Hiroki Ochiai, Atsuo Takashima, Narikazu Boku and Yukihide Kanemitsu
    Citation: BMC Cancer 2018 18:334
    Content type: Research article Published on:

  42. In this prospective non-interventional study, the effectiveness and tolerability of erlotinib in elderly patients with non-small-cell lung cancer (NSCLC) after ≥1 platinum-based chemotherapy were assessed.

    Authors: Wolfgang M. Brueckl, H. Jost Achenbach, Joachim H. Ficker and Wolfgang Schuette
    Citation: BMC Cancer 2018 18:333
    Content type: Research article Published on:

  43. Topoisomerase II alpha (TOP2A) protein has been shown to be a proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of TOP2A seems different among different subtypes of breast ...

    Authors: Xin An, Fei Xu, Rongzhen Luo, Qiufan Zheng, Jiabin Lu, Yanhua Yang, Tao Qin, Zhongyu Yuan, Yanxia Shi, Wenqi Jiang and Shusen Wang
    Citation: BMC Cancer 2018 18:331
    Content type: Research article Published on:

  44. Concurrent chemoradiotherapy followed by adjuvant chemotherapy (CCRT-AC) is currently recommended as the standard treatment for locally advanced nasopharyngeal carcinoma (LA-NPC). Neoadjuvant chemotherapy foll...

    Authors: Jiraporn Setakornnukul and Kullathorn Thephamongkhol
    Citation: BMC Cancer 2018 18:329
    Content type: Research article Published on:

  45. HER2 mutation has been found to be an oncogenic driver gene in non-small cell lung cancers(NSCLC) and HER2-directed therapies have shown promising results in this unique population, while little is known about it...

    Authors: Yan Wang, Shijia Zhang, Fengying Wu, Jing Zhao, Xuefei Li, Chao Zhao, Shengxiang Ren and Caicun Zhou
    Citation: BMC Cancer 2018 18:326
    Content type: Research article Published on:

  46. Nucleocytoplasmic transport is a tightly regulated process carried out by specific transport machinery, the defects of which may lead to a number of diseases including cancer. Karyopherin alpha 7 (KPNA7), the ...

    Authors: Elisa M. Vuorinen, Nina K. Rajala, Teemu O. Ihalainen and Anne Kallioniemi
    Citation: BMC Cancer 2018 18:325
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:57

  47. The prevalence of high-risk human papillomavirus (HPV) DNA in cases of oral cavity squamous cell carcinoma (SCC) varies widely. The aim of this study is to investigate the frequency of high-risk HPV DNA in a l...

    Authors: Priscila Marinho de Abreu, Anna Clara Gregório Có, Pedro Leite Azevedo, Isabella Bittencourt do Valle, Karine Gadioli de Oliveira, Sônia Alves Gouvea, Melissa Freitas Cordeiro-Silva, Iúri Drummond Louro, José Roberto Vasconcelos de Podestá, Jeferson Lenzi, Agenor Sena, Elismauro Francisco Mendonça and Sandra Lúcia Ventorin von Zeidler
    Citation: BMC Cancer 2018 18:324
    Content type: Research article Published on:

  48. Little is known about the prognostic difference of anti-EGFR therapy, cetuximab (CTX) or nimotuzumab (NTZ), concurrently with induction chemotherapy (IC, investigational arm) or RT (control arm) for patients w...

    Authors: Hao Peng, Ling-Long Tang, Xu Liu, Lei Chen, Wen-Fei Li, Yan-Ping Mao, Yuan Zhang, Li-Zhi Liu, Li Tian, Ying Guo, Ying Sun and Jun Ma
    Citation: BMC Cancer 2018 18:323
    Content type: Research article Published on:

  49. Whether the emotional distress around cancer diagnosis is associated with the long-term outcomes and care utilization is unknown. We aimed to examine the association of mental disorders around cancer diagnosis...

    Authors: Jianwei Zhu, Arvid Sjölander, Katja Fall, Unnur Valdimarsdottir and Fang Fang
    Citation: BMC Cancer 2018 18:322
    Content type: Research article Published on:

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