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  1. The optimal therapeutic strategy in UICC stage T3 hepatocellular carcinoma (HCC) patients that maximizes both safety and long-term outcome has not yet been determined. Our aim was to compare clinical outcomes ...

    Authors: Chong Zhong, Yong-Fa Zhang, Jun-Hai Huang, Cheng-Ming Xiong, Zi-Yu Wang, Qing-Lian Chen and Rong-Ping Guo
    Citation: BMC Cancer 2018 18:643
    Content type: Research article Published on:

  2. Histone acetyltransferase p300 is a crucial transcriptional coactivator and has been implicated as a poor prognostic factor in human cancers. However, little is known about the substantial functions and mechan...

    Authors: Xue Hou, Run Gong, Jianhua Zhan, Ting Zhou, Yuxiang Ma, Yuanyuan Zhao, Yaxiong Zhang, Gang Chen, Zhonghan Zhang, Shuxiang Ma, Xi Chen, Fangfang Gao, Shaodong Hong, Fan Luo, Wenfeng Fang, Yunpeng Yang…
    Citation: BMC Cancer 2018 18:641
    Content type: Research article Published on:

  3. The genetic profile for human papilloma virus positive (HPV+) oropharyngeal squamous cell carcinomas (OPSCC) remains largely unknown. The purpose of this study was to sequence tissue material from a large coho...

    Authors: Christian Grønhøj, David H. Jensen, Tina Agander, Katalin Kiss, Estrid Høgdall, Lena Specht, Frederik Otzen Bagger, Finn Cilius Nielsen and Christian von Buchwald
    Citation: BMC Cancer 2018 18:640
    Content type: Research article Published on:

  5. Melanoma is the deadliest type of skin cancer with highest mortality rate. However, the annihilation in its early stage implies a high survival rate therefore, it demands early diagnosis. The accustomed diagno...

    Authors: M. Attique Khan, Tallha Akram, Muhammad Sharif, Aamir Shahzad, Khursheed Aurangzeb, Musaed Alhussein, Syed Irtaza Haider and Abdualziz Altamrah
    Citation: BMC Cancer 2018 18:638
    Content type: Research article Published on:

  6. Growing evidence demonstrates that exposure to organophosphate flame retardants (PFRs) is widespread and that these chemicals can alter thyroid hormone regulation and function. We investigated the relationship...

    Authors: Nicole C. Deziel, Huangdi Yi, Heather M. Stapleton, Huang Huang, Nan Zhao and Yawei Zhang
    Citation: BMC Cancer 2018 18:637
    Content type: Research article Published on:

  7. Novel therapeutic approaches are required to treat ovarian cancer and dependency on glycolysis may provide new targets for treatment. This study sought to investigate the variation of expression of molecular c...

    Authors: Chrysi Xintaropoulou, Carol Ward, Alan Wise, Suzanna Queckborner, Arran Turnbull, Caroline O. Michie, Alistair R. W. Williams, Tzyvia Rye, Charlie Gourley and Simon P. Langdon
    Citation: BMC Cancer 2018 18:636
    Content type: Research article Published on:

  9. Breast cancer is the most common malignancy encountered during pregnancy. However, the burden of pregnancy-associated breast cancer (PABC) and subsequent care is understudied in sub-Saharan Africa (SSA). Here,...

    Authors: Jean Marie Vianney Dusengimana, Vedaste Hategekimana, Ryan Borg, Bethany Hedt-Gauthier, Neil Gupta, Susan Troyan, Lawrence N. Shulman, Ignace Nzayisenga, Temidayo Fadelu, Tharcisse Mpunga and Lydia E. Pace
    Citation: BMC Cancer 2018 18:634
    Content type: Research article Published on:

  10. In patients with advanced hepatocellular carcinoma (HCC), evidence is unclear as to whether hepatic arterial infusion chemotherapy (HAIC) or sorafenib is superior. We performed a prospective, open-label, non-c...

    Authors: Masahiro Hatooka, Tomokazu Kawaoka, Hiroshi Aikata, Yuki Inagaki, Kei Morio, Takashi Nakahara, Eisuke Murakami, Masataka Tsuge, Akira Hiramatsu, Michio Imamura, Yoshiiku Kawakami, Kazuo Awai, Keiichi Masaki, Koji Waki, Hirotaka Kohno, Hiroshi Kohno…
    Citation: BMC Cancer 2018 18:633
    Content type: Research article Published on:

  11. Within a dramatic socio-political context, cancer represents a growing health burden in the Gaza Strip. We investigated the survival experience of people diagnosed with breast (BC) or colorectal (CRC) cancer f...

    Authors: Chiara Panato, Khaled Abusamaan, Ettore Bidoli, Mokhtar Hamdi-Cherif, Daniela Pierannunzio, Stefano Ferretti, Mahmoud Daher, Fouad Elissawi and Diego Serraino
    Citation: BMC Cancer 2018 18:632
    Content type: Research article Published on:

  13. Primary malignant melanoma of the vagina is extremely rare, with a poorer prognosis than cutaneous malignant melanoma. Previous studies have explored the repurposing of itraconazole, a common oral anti-fungal ...

    Authors: Kayo Inoue, Hiroshi Tsubamoto, Roze Isono-Nakata, Kazuko Sakata and Nami Nakagomi
    Citation: BMC Cancer 2018 18:630
    Content type: Case report Published on:

  14. Adolescent and young adults (AYA) enrolment rates into cancer clinical trials (CCT) are the lowest of any age group globally. As AYA have distinct biological, psychosocial and relational needs, we aimed to exp...

    Authors: Jennifer A.H. Bell, Victoria Forcina, Laura Mitchell, Seline Tam, Kate Wang, Abha A. Gupta and Jeremy Lewin
    Citation: BMC Cancer 2018 18:629
    Content type: Research article Published on:

  15. Knowledge on periprosthetic infection and mortality rate following total knee arthroplasty (TKA) is essential for justifying this treatment in patients with cancer; however, relevant data from population-based...

    Authors: Feng-Chen Kao, Yao-Chun Hsu, Pang-Yu Lai, Chang-Bi Wang, Yuan-Kun Tu and Wen-Kang Chen
    Citation: BMC Cancer 2018 18:628
    Content type: Research article Published on:

  17. Indole-3-carbinol, derived from Cruciferous vegetables is an estrogen receptor antagonist considered a preventive agent that is naturally present in diet. There are no previous studies on its effects in human ...

    Authors: Asunción Martín-Ruiz, Laura Peña, Alfredo González-Gil, Lucía Teresa Díez-Córdova, Sara Cáceres and Juan Carlos Illera
    Citation: BMC Cancer 2018 18:626
    Content type: Research article Published on:

  18. Pancreatic cancer is acquiring increasing prominence as a cause of cancer death in the population. The purpose of this study was to analyze long-term pancreatic cancer mortality trends in Spain and evaluate th...

    Authors: Daniel Seoane-Mato, Olivier Nuñez, Nerea Fernández-de-Larrea, Beatriz Pérez-Gómez, Marina Pollán, Gonzalo López-Abente and Nuria Aragonés
    Citation: BMC Cancer 2018 18:625
    Content type: Research article Published on:

  19. This study examined the prognostic significance of microtubule-associated protein light chain 3B (LC3B) expression in oropharyngeal and oral cavity squamous cell carcinoma (SCC). The prognostic significance of...

    Authors: Kenneth Lai, Slade Matthews, James S. Wilmott, Murray C. Killingsworth, Jim L. Yong, Nicole J. Caixeiro, James Wykes, Allan Samakeh, Dion Forstner, Mark Lee, John McGuinness, Navin Niles, Angela Hong, Ardalan Ebrahimi and Cheok Soon Lee
    Citation: BMC Cancer 2018 18:624
    Content type: Research article Published on:

  20. Currently, young colon cancer (CC) patients continue to increase and represent a heterogeneous patient group. The aim of this study was to explore the optimal minimum lymph node count after CC resection for yo...

    Authors: Xu Guan, Yuliuming Wang, Hanqing Hu, Zhixun Zhao, Zheng Jiang, Zheng Liu, Yinggang Chen, Guiyu Wang and Xishan Wang
    Citation: BMC Cancer 2018 18:623
    Content type: Research article Published on:

  21. Metastasis is a complex process which is difficult to study and model. Experimental ingenuity is therefore essential when seeking to elucidate the biological mechanisms involved.

    Authors: Shirley Jean Keeton, Jean Marie Delalande, Mark Cranfield, Alan Burns and Philip Richard Dash
    Citation: BMC Cancer 2018 18:622
    Content type: Technical advance Published on:

  22. It is essential to understand the mechanisms responsible for hepatocellular carcinoma (HCC) progression and chemoresistance in order to identify prognostic biomarkers as well as potential therapeutic avenues. ...

    Authors: Lui Ng, Ariel K. M. Chow, Johnny H. W. Man, Thomas C. C. Yau, Timothy M. H. Wan, Deepak N. Iyer, Virginia H. T. Kwan, Ronnie T. P. Poon, Roberta W. C. Pang and Wai-Lun Law
    Citation: BMC Cancer 2018 18:621
    Content type: Research article Published on:

  23. Immune checkpoint inhibitors are standard treatments for non-small cell lung cancer. Unique cases with paradoxical acceleration of the disease after immunotherapy have been reported. These have been described ...

    Authors: Taro Shinozaki, Eri Iwami, Shinnosuke Ikemura, Tatsu Matsuzaki, Takahiro Nakajima, Kazuhiko Hashimoto and Takeshi Terashima
    Citation: BMC Cancer 2018 18:620
    Content type: Case report Published on:

  24. This study was performed to examine the usefulness of combined androgen blockade (CAB) therapy with a gonadotropin-releasing hormone (GnRH) antagonist (CAB-antagonist therapy), instead of CAB therapy with GnRH...

    Authors: Takeshi Kashiwabara and Sayo Suda
    Citation: BMC Cancer 2018 18:619
    Content type: Research article Published on:

  26. For the expanding population of bladder cancer survivors in Korea, the development of subsequent cancers is a significant concern. Here, we provide the second primary cancer incidence rates and types in Korean...

    Authors: Whi-An Kwon, Jae Young Joung, Jiwon Lim, Chang-Mo Oh, Kyu-Won Jung, Sung Han Kim, Ho Kyung Seo, Weon Seo Park, Jinsoo Chung, Kang Hyun Lee and Young-Joo Won
    Citation: BMC Cancer 2018 18:617
    Content type: Research article Published on:

  27. Earlier epidemiological studies indicate that associations between obesity and breast cancer risk may not only depend on menopausal status and use of exogenous hormones, but might also differ by tumor subtype....

    Authors: Cina J. Nattenmüller, Mark Kriegsmann, Disorn Sookthai, Renée Turzanski Fortner, Annika Steffen, Britta Walter, Theron Johnson, Jutta Kneisel, Verena Katzke, Manuela Bergmann, Hans Peter Sinn, Peter Schirmacher, Esther Herpel, Heiner Boeing, Rudolf Kaaks and Tilman Kühn
    Citation: BMC Cancer 2018 18:616
    Content type: Research article Published on:

  28. Emergency presentations (EP) represent over a third of all lung cancer admissions in England. Such presentations usually reflect late stage disease and are associated with poor survival. General practitioners ...

    Authors: Camille Maringe, Nora Pashayan, Francisco Javier Rubio, George Ploubidis, Stephen W. Duffy, Bernard Rachet and Rosalind Raine
    Citation: BMC Cancer 2018 18:615
    Content type: Research article Published on:

  31. Prostate Stem Cell Antigen (PSCA) is frequently expressed in prostate cancer but its exact function is unclear.

    Authors: Marie-Christine Heinrich, Cosima Göbel, Martina Kluth, Christian Bernreuther, Charlotte Sauer, Cornelia Schroeder, Christina Möller-Koop, Claudia Hube-Magg, Patrick Lebok, Eike Burandt, Guido Sauter, Ronald Simon, Hartwig Huland, Markus Graefen, Hans Heinzer, Thorsten Schlomm…
    Citation: BMC Cancer 2018 18:612
    Content type: Research article Published on:

  32. Activation of c-Met, a receptor tyrosine kinase, induces radiation therapy resistance in non-small cell lung cancer (NSCLC). The activated residual of c-Met is located in lipid rafts (Duhon et al. Mol Carcinog...

    Authors: Juan Zeng, Heying Zhang, Yonggang Tan, Cheng Sun, Yusi Liang, Jinyang Yu and Huawei Zou
    Citation: BMC Cancer 2018 18:611
    Content type: Research article Published on:

  33. Gene-expression companion diagnostic tests, such as the Oncotype DX test, assess the risk of early stage Estrogen receptor (ER) positive (+) breast cancers, and guide clinicians in the decision of whether or n...

    Authors: Jon Whitney, German Corredor, Andrew Janowczyk, Shridar Ganesan, Scott Doyle, John Tomaszewski, Michael Feldman, Hannah Gilmore and Anant Madabhushi
    Citation: BMC Cancer 2018 18:610
    Content type: Research article Published on:

  34. Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related death worldwide. The disease recurrent rate is relatively high resulted in poor 5-year survival in advanced HCC. Cancer stem cells (...

    Authors: Wei-Chieh Huang, Shiao-Lin Tung, Yao-Li Chen, Po-Ming Chen and Pei-Yi Chu
    Citation: BMC Cancer 2018 18:609
    Content type: Research article Published on:

  36. Breast cancer (BC) is highly heterogeneous with ~ 60–70% of estrogen receptor positive BC patient’s response to anti-hormone therapy. Estrogen receptors (ERs) play an important role in breast cancer progressio...

    Authors: B. Madhu Krishna, Sanjib Chaudhary, Dipti Ranjan Mishra, Sanoj K. Naik, S. Suklabaidya, A. K. Adhya and Sandip K. Mishra
    Citation: BMC Cancer 2018 18:607
    Content type: Research article Published on:

  37. In the intensity-modulated radiotherapy (IMRT) era, great improvement has been made in survival of nasopharyngeal carcinoma (NPC). The 7th edition of the International Union against Cancer/American Joint Commi...

    Authors: Xing-Li Yang, Yan Wang, Shao-Bo Liang, Sha-Sha He, Dan-Ming Chen, Hai-Yang Chen, Li-Xia Lu and Yong Chen
    Citation: BMC Cancer 2018 18:606
    Content type: Research article Published on:

  38. Aberrant hyperactivation of epithelial proliferation, AKT signaling, and association with unopposed estrogen (E2) exposure is the most common endometrial cancer dysfunction. In the normal uterus, progesterone ...

    Authors: Jung-Yoon Yoo, Hee-Bum Kang, Russell R. Broaddus, John I. Risinger, Kyung-Chul Choi and Tae Hoon Kim
    Citation: BMC Cancer 2018 18:605
    Content type: Research article Published on:

  39. Haemophagocytic lymphohistiocytosis (HLH) is considered to be a large challenge for clinicians due to the variable overlaps of symptoms with other severe diseases and a high rate of mortality. Prompt diagnosis...

    Authors: Fei Li, Xiaojie Zhang, Yunyun Wang, Ailin Yang, Zhanglin Zhang, Weiping Tang, Nan Zhong and Huidong Shi
    Citation: BMC Cancer 2018 18:604
    Content type: Case report Published on:

  41. Cancer remains one of the leading causes of death around the world, where incidence and mortality rates are at a constant increase. Tumourigenic cells are characteristically seen to over-express the 37 kDa/67 ...

    Authors: Leila Vania, Thalia M. Rebelo, Eloise Ferreira and Stefan F. T. Weiss
    Citation: BMC Cancer 2018 18:602
    Content type: Research article Published on:

  42. The survival of patients with ovarian cancer has improved because of surgery and chemotherapy. This study aimed to estimate the changes in survival rates among Korean women with ovarian cancer prior to the int...

    Authors: Jung-Yun Lee, Sunghoon Kim, Young Tae Kim, Myong Cheol Lim, Boram Lee, Kyu-Won Jung, Jae Weon Kim, Sang-Yoon Park and Young-Joo Won
    Citation: BMC Cancer 2018 18:601
    Content type: Research article Published on:

  43. Lung adenocarcinoma is the most common type of lung cancer and one of the most lethal and prevalent cancers. Aberrant glycosylation was common and essential in tumorigenesis, with fucosylation as one of the mo...

    Authors: Xing Wei, Kun Zhang, Haifeng Qin, Jinlong Zhu, Qiaoxi Qin, Yang Yu and Hong Wang
    Citation: BMC Cancer 2018 18:600
    Content type: Research article Published on:

  44. Glioma is the most common primary brain tumor in adults with a poor prognosis. As a member of ARF subfamily GTPase, ARL2 plays a key role in regulating the dynamics of microtubules and mitochondrial functions....

    Authors: Yulin Wang, Gefei Guan, Wen Cheng, Yang Jiang, Fengping Shan, Anhua Wu, Peng Cheng and Zongze Guo
    Citation: BMC Cancer 2018 18:599
    Content type: Research article Published on:

  45. Erlotinib is approved for the first line treatment of epidermal growth factor receptor (EGFR) mutation-positive non-small cell lung cancer. Since the number of prospective studies in Caucasian patients treated...

    Authors: Zsolt Markóczy, Veronika Sárosi, Iveta Kudaba, Gabriella Gálffy, Ülkü Yilmaz Turay, Ahmet Demirkazik, Gunta Purkalne, Attila Somfay, Zsolt Pápai-Székely, Erzsébet Rásó and Gyula Ostoros
    Citation: BMC Cancer 2018 18:598
    Content type: Research article Published on:

  46. Hepatocellular carcinoma (HCC) is one of the major causes of tumor death; thus, the identification of markers related to its diagnosis and prognosis is critical. Previous studies have revealed that epithelial-...

    Authors: Yuki Shimoda, Yasunari Ubukata, Tadashi Handa, Takehiko Yokobori, Takayoshi Watanabe, Dolgormaa Gantumur, Kei Hagiwara, Takahiro Yamanaka, Mariko Tsukagoshi, Takamichi Igarashi, Akira Watanabe, Norio Kubo, Kenichiro Araki, Norifumi Harimoto, Ayaka Katayama, Toshiaki Hikino…
    Citation: BMC Cancer 2018 18:597
    Content type: Research article Published on:

  47. Prognosis of pancreatic cancer is poor with a 5-year survival rate of only 7%. Although several new chemotherapy treatments have shown promising results, all patients will eventually progress, and we need to d...

    Authors: Yoshiki Hirooka, Hideki Kasuya, Takuya Ishikawa, Hiroki Kawashima, Eizaburo Ohno, Itzel B. Villalobos, Yoshinori Naoe, Toru Ichinose, Nobuto Koyama, Maki Tanaka, Yasuhiro Kodera and Hidemi Goto
    Citation: BMC Cancer 2018 18:596
    Content type: Research article Published on:

  48. Metastatic breast cancer carries a poor prognosis despite the success of newly targeted therapies. Treatment options remain especially limited for the subtype of triple negative breast cancer (TNBC). Several s...

    Authors: Carrie D. House, Valentina Grajales, Michelle Ozaki, Elizabeth Jordan, Helmae Wubneh, Danielle C. Kimble, Jana M. James, Marianne K. Kim and Christina M. Annunziata
    Citation: BMC Cancer 2018 18:595
    Content type: Research article Published on:

  49. Resistance to preoperative radiotherapy is a major clinical problem in the treatment for locally advanced rectal cancer. The role of NDRG1 in resistance to ionizing radiation in rectal cancer has not been fully e...

    Authors: Soon-Chan Kim, Young-Kyoung Shin, Ye-Ah Kim, Sang-Geun Jang and Ja-Lok Ku
    Citation: BMC Cancer 2018 18:594
    Content type: Research article Published on:

  50. High Dose Rate Brachytherapy (HDRB) boost is a well-established treatment for prostate cancer (PC). We describe the PROstate Multicentre External beam radioTHErapy Using Stereotactic boost (PROMETHEUS) study. ...

    Authors: Matthew Richardson, Mark Sidhom, Sarah Gallagher, Mel Grand, David Pryor, Joseph Bucci, Lee Wilton, Sankar Arumugam, Sarah Keats and Jarad M. Martin
    Citation: BMC Cancer 2018 18:588
    Content type: Study protocol Published on:

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