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  1. The development of both chronic obstructive pulmonary disease (COPD) and lung cancer (LC) is influenced by smoking related chronic pulmonary inflammation caused by an excessive innate immune response to smoke ...

    Authors: Janna Berg, Ann Rita Halvorsen, May-Bente Bengtson, Kristin A. Taskén, Gunhild M. Mælandsmo, Arne Yndestad, Bente Halvorsen, Odd Terje Brustugun, Pål Aukrust, Thor Ueland and Åslaug Helland
    Citation: BMC Cancer 2018 18:739
    Content type: Research article Published on:

  2. HER2 positive (HER2+) breast cancers involve chromosomal structural alterations that act as oncogenic driver events.

    Authors: George Vasmatzis, Xue Wang, James B. Smadbeck, Stephen J. Murphy, Katherine B. Geiersbach, Sarah H. Johnson, Athanasios G. Gaitatzes, Yan W. Asmann, Farhad Kosari, Mitesh J. Borad, Daniel J. Serie, Sarah A. McLaughlin, Jennifer M. Kachergus, Brian M. Necela and E. Aubrey Thompson
    Citation: BMC Cancer 2018 18:738
    Content type: Research article Published on:

  3. Bone and soft tissue masses of the foot and ankle are not particularly rare but true neoplasia has to be strictly differentiated from pseudotumorous lesions. Diagnosis is often delayed as diagnostic errors are...

    Authors: Andreas Toepfer, Norbert Harrasser, Maximiliane Recker, Ulrich Lenze, Florian Pohlig, Ludger Gerdesmeyer and Rüdiger von Eisenhart-Rothe
    Citation: BMC Cancer 2018 18:735
    Content type: Research article Published on:

  4. Quality of cancer care (QoCC) has become an important item for providers, regulators and purchasers of care worldwide. Aim of this study is to present the results of some evidence-based quality indicators (QI)...

    Authors: Laura Ortelli, Alessandra Spitale, Luca Mazzucchelli and Andrea Bordoni
    Citation: BMC Cancer 2018 18:733
    Content type: Research article Published on:

  5. Adjuvant endocrine therapy (AET) significantly decreases the risk of breast cancer recurrence and mortality. Notwithstanding the demonstrated efficacy of AET, 31–73% of breast cancer survivors do not persist w...

    Authors: Leah K. Lambert, Lynda G. Balneaves, A. Fuchsia Howard, Stephen K. Chia and Carolyn C. Gotay
    Citation: BMC Cancer 2018 18:732
    Content type: Research article Published on:

  6. Targeted therapy has always been the focus in developing therapeutic approaches in cancer, especially in the treatment of acute myeloid leukemia (AML). A new small molecular inhibitor, JQ1, targeting BRD4, whi...

    Authors: Yafeng Zhou, Jianbiao Zhou, Xiao Lu, Tuan-Zea Tan and Wee-Joo Chng
    Citation: BMC Cancer 2018 18:731
    Content type: Research article Published on:

  8. A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. This is the first study to evaluate a bendamu...

    Authors: Therasa Kim, He Yun Choi, Hyun-Seo Lee, Sung-Hoon Jung, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee, Hee-Doo Yoo and Deok-Hwan Yang
    Citation: BMC Cancer 2018 18:729
    Content type: Research article Published on:

  9. The phenomenon of chemotherapy-resistant cancers has necessitated the development of new therapeutics as well as the identification of specific prognostic markers to predict the response to novel drugs. Primar...

    Authors: Anna A. Nushtaeva, Grigory A. Stepanov, Dmitry V. Semenov, Evgeny S. Juravlev, Evgenia A. Balahonova, Alexey V. Gerasimov, Sergey V. Sidorov, Eugeniy I. Savelyev, Elena V. Kuligina, Vladimir A. Richter and Olga A. Koval
    Citation: BMC Cancer 2018 18:728
    Content type: Research article Published on:

  10. Medication adherence refers to whether a patient takes medication according to the frequency prescribed, or continues to take a prescribed medication. Inadequate adherence to medication may cause alterations i...

    Authors: Yunxin He, Eng Hooi Tan, Andrea Li Ann Wong, Chuan Chien Tan, Patrick Wong, Soo Chin Lee and Bee Choo Tai
    Citation: BMC Cancer 2018 18:727
    Content type: Study protocol Published on:

  11. Circulating tumour DNA (ctDNA) may serve as a measure of tumour burden and a useful tool for non-invasive monitoring of cancer. However, ctDNA is not always detectable in patients at time of diagnosis of metas...

    Authors: Ashleigh C. McEvoy, Lydia Warburton, Zeyad Al-Ogaili, Liesl Celliers, Leslie Calapre, Michelle R. Pereira, Muhammad A. Khattak, Tarek M. Meniawy, Michael Millward, Melanie Ziman and Elin S. Gray
    Citation: BMC Cancer 2018 18:726
    Content type: Research article Published on:

  12. Interleukin-2 (IL-2) is an important immunotherapy cytokine for various diseases including cancer. Some studies reported the efficacy and safety on cisplatin combined with IL-2 versus cisplatin alone for treat...

    Authors: Liping Han, Qiufang Jiang, Wei Yao, Tian Fu and Qingdi Zeng
    Citation: BMC Cancer 2018 18:725
    Content type: Research article Published on:

  13. Multiple myeloma (MM) patients with t(14;20) have a poor prognosis and their outcome has not improved following the introduction of bortezomib (Bzb). The mechanism underlying the resistance to proteasome inhib...

    Authors: Ya-Wei Qiang, Shiqiao Ye, Yuhua Huang, Yu Chen, Frits Van Rhee, Joshua Epstein, Brian A. Walker, Gareth J. Morgan and Faith E. Davies
    Citation: BMC Cancer 2018 18:724
    Content type: Research article Published on:

  14. High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggest...

    Authors: Christopher Platais, Raghu Radhakrishnan, Sven Niklander Ebensperger, Richard Morgan, Daniel W. Lambert and Keith D. Hunter
    Citation: BMC Cancer 2018 18:723
    Content type: Research article Published on:

  15. LIM and SH3 protein 1 (LASP1) is upregulated in several types of human cancer and implicated in cancer progression. However, the expression and intrinsic function of LASP1 in glioblastoma (GBM) remains unclear.

    Authors: Chuanhong Zhong, Yitian Chen, Bei Tao, Lilei Peng, Tangming Peng, Xiaobo Yang, Xiangguo Xia and Ligang Chen
    Citation: BMC Cancer 2018 18:722
    Content type: Research article Published on:

  16. The theory of field effect suggests that the tumor-adjacent area, besides histopathologically normal, undergoes genetic and epigenetic changes that can eventually affect epithelial homeostasis, predisposing th...

    Authors: Camile B. Lopes, Leandro L. Magalhães, Carolina R. Teófilo, Ana Paula N. N. Alves, Raquel C. Montenegro, Massimo Negrini and Ândrea Ribeiro-dos-Santos
    Citation: BMC Cancer 2018 18:721
    Content type: Research article Published on:

  17. People aged 40–60 years with a family history (FH) of colorectal cancer (CRC) in 1st degree relatives (FDRs) have a 2- to 4-fold increased risk of CRC compared to the average risk population. Therefore, expert...

    Authors: Kaja Tikk, Korbinian Weigl, Michael Hoffmeister, Svitlana Igel, Matthias Schwab, Jochen Hampe, Stefanie J. Klug, Ulrich Mansmann, Frank Kolligs and Hermann Brenner
    Citation: BMC Cancer 2018 18:720
    Content type: Study protocol Published on:

  18. Approximately 900 children/adolescents are treated with radiotherapy (RT) every year in France. However, among the 80% of survivors, the cumulative incidence of long-term morbidity – including second malignanc...

    Authors: Valérie Bernier-chastagner, Liza Hettal, Véronique Gillon, Laurinda Fernandes, Cécile Huin-schohn, Marion Vazel, Priscillia Tosti, Julia Salleron, Aurélie François, Elise Cérimèle, Sandrine Perreira, Didier Peiffert, Pascal Chastagner and Guillaume Vogin
    Citation: BMC Cancer 2018 18:719
    Content type: Study protocol Published on:

  20. Epithelial-to-mesenchymal transition (EMT) is one mechanism of carcinoma migration, while complex tumour migration or bulk migration is another - best demontrated by tumour cells invading blood vessels.

    Authors: Martin Zacharias, Luka Brcic, Sylvia Eidenhammer and Helmut Popper
    Citation: BMC Cancer 2018 18:717
    Content type: Research article Published on:

  21. Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the a...

    Authors: Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh and Jae-Sung Kim
    Citation: BMC Cancer 2018 18:716
    Content type: Research article Published on:

  22. Trans-arterial radio-embolization (TARE) is an emerging treatment for the management of hepatocellular carcinoma (HCC). TARE may compete with systemic chemotherapy, sorafenib, in intermediate stage patients wi...

    Authors: Carla Rognoni, Oriana Ciani, Silvia Sommariva, Irene Bargellini, Sherrie Bhoori, Roberto Cioni, Antonio Facciorusso, Rita Golfieri, Annagiulia Gramenzi, Vincenzo Mazzaferro, Cristina Mosconi, Francesca Ponziani, Rodolfo Sacco, Franco Trevisani and Rosanna Tarricone
    Citation: BMC Cancer 2018 18:715
    Content type: Research article Published on:

  23. Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O

    Authors: Jeon Hwang-Bo, Mun Gyeong Bae, Jong-Hwa Park and In Sik Chung
    Citation: BMC Cancer 2018 18:714
    Content type: Research article Published on:

  24. Usually misdiagnosed, Inflammatory Breast Cancer (IBC) is the most aggressive form of non-metastatic breast cancer. This orphan disease is more frequent in North Africa. Despite intensive treatment, the surviv...

    Authors: Meriem Slaoui, Abdou Azaque Zoure, Fatima Zahra Mouh, Youssef Bensouda, Mohammed El Mzibri, Youssef Bakri and Mariam Amrani
    Citation: BMC Cancer 2018 18:713
    Content type: Research article Published on:

  25. Cancer is the second leading cause of death in the Caribbean, including the islands of Trinidad and Tobago (TT). The population of TT consists of over 1.3 million people with diverse ancestral and sociocultura...

    Authors: Wayne A. Warner, Tammy Y. Lee, Kimberly Badal, Tanisha M. Williams, Smriti Bajracharya, Vasavi Sundaram, Nigel A. Bascombe, Ravi Maharaj, Marjorie Lamont-Greene, Allana Roach, Melissa Bondy, Matthew J. Ellis, Timothy R. Rebbeck, Simeon Slovacek, Jingqin Luo, Adetunji T. Toriola…
    Citation: BMC Cancer 2018 18:712
    Content type: Research article Published on:

  26. YAP, a potent oncogene and major downstream effector of the mammalian Hippo tumor suppressor pathway can act as either oncogene or tumor suppressor gene based on the type of tissue involved. Despite various st...

    Authors: Sumayya Abdul Sattar Real, Farah Parveen, Asad Ur Rehman, Mohammad Aasif Khan, Sankaravamasam Venkata Suryanarayan Deo, Nootan Kumar Shukla and Syed Akhtar Husain
    Citation: BMC Cancer 2018 18:711
    Content type: Research article Published on:

  27. Although originally identified as a putative metastasis suppressor, increasing studies have confirmed a possible role for Nm23-H1 in DNA repair, through the base excision repair and nucleotide excision repair ...

    Authors: Ya Sheng, Mingfang Xu, Chongyi Li, Yanli Xiong, Yi Yang, Xunjie Kuang, Dong Wang and Xueqin Yang
    Citation: BMC Cancer 2018 18:710
    Content type: Research article Published on:

  28. HER2 over-expression is related with a poor prognosis in patients with invasive breast cancer tumors. Clinical associations have reported that somatic mutations of p53 more frequently detected in cases of spor...

    Authors: A. A. Román-Rosales, E. García-Villa, L. A. Herrera, P. Gariglio and J. Díaz-Chávez
    Citation: BMC Cancer 2018 18:709
    Content type: Research article Published on:

  29. The purpose of this case report is to describe a conjunctiva and eyelid Kaposi’s sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infect...

    Authors: Filipe Sousa Neves, Joana Braga, João Cardoso da Costa, Joaquim Sequeira and Sandra Prazeres
    Citation: BMC Cancer 2018 18:708
    Content type: Case report Published on:

  30. A major challenge for those living with cancers of the upper gastrointestinal tract (oesophagus, stomach and pancreas), is the impact of the disease and treatment on nutritional status and quality of life. People...

    Authors: Lauren Hanna, Catherine E. Huggins, Kate Furness, Mary Anne Silvers, June Savva, Helena Frawley, Daniel Croagh, Paul Cashin, Liang Low, Judith Bauer, Helen Truby and Terrence Haines
    Citation: BMC Cancer 2018 18:707
    Content type: Study protocol Published on:

  31. The Union for International Cancer Control (UICC) tumor-node-metastasis (TNM) classification is a key gastric cancer prognosis system. This study aimed to create a new TNM system to provide a reference for the...

    Authors: Zhiqiong Wang, Mo Li, Zhen Xu, Yanlin Jiang, Huizi Gu, Ying Yu, Haitao Zhu, Hao Zhang, Ping Lu, Junchang Xin, Hong Xu and Caigang Liu
    Citation: BMC Cancer 2018 18:706
    Content type: Research article Published on:

  33. The treatment of acute lymphoblastic leukemia (ALL) and osteosarcoma (OSC) is very effective: the vast majority of patients recover and survive for decades. However, they still need to face serious adverse eff...

    Authors: Judit C. Sági, Bálint Egyed, Andrea Kelemen, Nóra Kutszegi, Márta Hegyi, András Gézsi, Martina Ayaka Herlitschke, Andrea Rzepiel, Lili E. Fodor, Gábor Ottóffy, Gábor T. Kovács, Dániel J. Erdélyi, Csaba Szalai and Ágnes F. Semsei
    Citation: BMC Cancer 2018 18:704
    Content type: Research article Published on:

  34. The role of forkhead-box A1 (FOXA1) and Androgen receptor (AR) in breast cancer (BC) has been extensively studied. However, the prognostic role of their co-expression in Estrogen receptor positive (ER+) BC has...

    Authors: Nelson Rangel, Nicoletta Fortunati, Simona Osella-Abate, Laura Annaratone, Claudio Isella, Maria Graziella Catalano, Letizia Rinella, Jasna Metovic, Renzo Boldorini, Davide Balmativola, Pietro Ferrando, Francesca Marano, Paola Cassoni, Anna Sapino and Isabella Castellano
    Citation: BMC Cancer 2018 18:703
    Content type: Research article Published on:

  35. The aim of this study was to compare the efficacies of the XELOX and DOS regimens as preoperative chemotherapy in patients with locally advanced gastric cancer.

    Authors: Yan Wang, Xi Cheng, Yue-hong Cui, Jun Hou, Yuan Ji, Yi-hong Sun, Zhen-bin Shen, Feng-lin Liu and Tian-shu Liu
    Citation: BMC Cancer 2018 18:702
    Content type: Research article Published on:

  36. Eribulin mesylate is currently indicated as a sequential monotherapy to be administered after two chemotherapeutic regimens, including anthracycline and taxane treatments, for treatment of metastatic breast ca...

    Authors: Tetsu Hayashida, Hiromitsu Jinno, Katsuaki Mori, Hiroki Sato, Akira Matsui, Takashi Sakurai, Hiroaki Hattori, Shin Takayama, Masahiro Wada, Maiko Takahashi, Hirohito Seki, Tomoko Seki, Aiko Nagayama, Akiko Matsumoto and Yuko Kitagawa
    Citation: BMC Cancer 2018 18:701
    Content type: Research article Published on:

  37. Heat Shock Proteins (HSPs), a family of genes with key roles in proteostasis, have been extensively associated with cancer behaviour. However, the HSP family is quite large and many of its members have not bee...

    Authors: Felipe C. M. Zoppino, Martin E. Guerrero-Gimenez, Gisela N. Castro and Daniel R. Ciocca
    Citation: BMC Cancer 2018 18:700
    Content type: Research article Published on:

  38. The prognostic value of preoperative controlling nutritional status (CONUT) has been reported in many malignancies. In present study, we aimed to clarify the prognostic impact of CONUT in gastric cancer (GC) r...

    Authors: Xuechao Liu, Deyao Zhang, Enzi Lin, Yongming Chen, Wei Li, Yingbo Chen, Xiaowei Sun and Zhiwei Zhou
    Citation: BMC Cancer 2018 18:699
    Content type: Research article Published on:

  39. The advent of tyrosine kinase inhibitors (TKIs) has changed the treatment of RAI refractory, unresectable recurrent differentiated thyroid cancer (DTC), which was formerly treated with multidisciplinary remedies.

    Authors: Masayuki Tori and Toshirou Shimo
    Citation: BMC Cancer 2018 18:698
    Content type: Case report Published on:

  40. Genes associated with hereditary breast and ovarian cancer (HBOC) and colorectal cancer (CRC) predisposition have been shown to play a role in pancreatic cancer susceptibility. Growing evidence suggests that p...

    Authors: Erin L. Young, Bryony A. Thompson, Deborah W. Neklason, Matthew A. Firpo, Theresa Werner, Russell Bell, Justin Berger, Alison Fraser, Amanda Gammon, Cathryn Koptiuch, Wendy K. Kohlmann, Leigh Neumayer, David E. Goldgar, Sean J. Mulvihill, Lisa A. Cannon-Albright and Sean V. Tavtigian
    Citation: BMC Cancer 2018 18:697
    Content type: Research article Published on:

  41. Invasive cervical cancer (ICC) is caused by high-risk human papillomavirus types (HR-HPVs) and is usually preceded by a long phase of intraepithelial neoplasia (CIN). Before invasion, (epi) genetic changes, po...

    Authors: Barbara Pardini, Daniela De Maria, Antonio Francavilla, Cornelia Di Gaetano, Guglielmo Ronco and Alessio Naccarati
    Citation: BMC Cancer 2018 18:696
    Content type: Research article Published on:

  42. DNA mutations occur randomly and sporadically in growth-related genes, mostly on cytosines. Demethylation of cytosines may lead to genetic instability through spontaneous deamination. Aims were whole genome me...

    Authors: Béla Molnár, Orsolya Galamb, Bálint Péterfia, Barnabás Wichmann, István Csabai, András Bodor, Alexandra Kalmár, Krisztina Andrea Szigeti, Barbara Kinga Barták, Zsófia Brigitta Nagy, Gábor Valcz, Árpád V. Patai, Péter Igaz and Zsolt Tulassay
    Citation: BMC Cancer 2018 18:695
    Content type: Research article Published on:

  43. Esophageal adenocarcinoma (EAC) incidence is increasing rapidly. Esophageal cancer has the second lowest 5-year survival rate of people diagnosed with cancer in Canada. Given the poor survival and the potentia...

    Authors: Hla-Hla Thein, Nathaniel Jembere, Kednapa Thavorn, Kelvin K. W. Chan, Peter C. Coyte, Claire de Oliveira, Chin Hur and Craig C. Earle
    Citation: BMC Cancer 2018 18:694
    Content type: Research article Published on:

  44. Effective treatment options for advanced pancreatic cancer are finite. NAPOLI-1, a phase III randomized trial, demonstrated the efficacy of nanoliposomal irinotecan with fluorouracil/leucovorin (nal-IRI + 5-FU...

    Authors: Danielle C. Glassman, Randze L. Palmaira, Christina M. Covington, Avni M. Desai, Geoffrey Y. Ku, Jia Li, James J. Harding, Anna M. Varghese, Eileen M. O’Reilly and Kenneth H. Yu
    Citation: BMC Cancer 2018 18:693
    Content type: Research article Published on:

  45. Emerging inflammatory response biomarkers are developed to predict the survival of patients with cancer, the aim of our study is to establish an inflammation-related nomogram based on the classical predictive ...

    Authors: Ying Wang, Xiao Qu, Ngar-Woon Kam, Kai Wang, Hongchang Shen, Qi Liu and Jiajun Du
    Citation: BMC Cancer 2018 18:692
    Content type: Research article Published on:

  46. The neuronal intermediate filament alpha-internexin (α-internexin) is a cytoskeleton protein which is involved in the tumor initiation and progression. In this study, we examined the expression and prognosis v...

    Authors: Yuhong Wang, Yuanjia Chen, Xiaoxing Li, Wanming Hu, Yu Zhang, Luohai Chen, Minhu Chen and Jie Chen
    Citation: BMC Cancer 2018 18:691
    Content type: Research article Published on:

  47. Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology. Their homology with the canonical estrogen ...

    Authors: Kanchan Kumari, Amit K. Adhya, Arabinda Kumar Rath, P. B. Reddy and Sandip K. Mishra
    Citation: BMC Cancer 2018 18:690
    Content type: Research article Published on:

  48. Cancer cells require increased levels of nutrients such as amino acids to sustain their rapid growth. In particular, leucine and glutamine have been shown to be important for growth and proliferation of some b...

    Authors: Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Yi Fang Guan, James R. Krycer, Renae Ryan, Qian Wang and Jeff Holst
    Citation: BMC Cancer 2018 18:689
    Content type: Research article Published on:

  49. Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells. In this work we analyze changes in the patterns of express...

    Authors: Ainara Crespo, Olivia García-Suárez, Iván Fernández-Vega, María Pilar Solis-Hernandez, Beatriz García, Sonia Castañón and Luis M. Quirós
    Citation: BMC Cancer 2018 18:687
    Content type: Research article Published on:

  50. Oral cancer is a serious problem owing to its poor prognosis and destruction of patients’ eating ability as well as facial appearance. Epidemiological studies can provide aetiological clues for prevention. The...

    Authors: Jin-Ye Fu, Chun-Xiao Wu, Chen-Ping Zhang, Jing Gao, Jian-Feng Luo, Shu-Kun Shen, Ying Zheng and Zhi-Yuan Zhang
    Citation: BMC Cancer 2018 18:686
    Content type: Research article Published on:

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