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  1. A relatively high proportion of patients diagnosed with primary CNS lymphoma will experience recurrent disease, yet therapy options are limited in salvage therapy. This is the first study to evaluate a bendamu...

    Authors: Therasa Kim, He Yun Choi, Hyun-Seo Lee, Sung-Hoon Jung, Jae-Sook Ahn, Hyeoung-Joon Kim, Je-Jung Lee, Hee-Doo Yoo and Deok-Hwan Yang
    Citation: BMC Cancer 2018 18:729
    Content type: Research article Published on:

  2. The phenomenon of chemotherapy-resistant cancers has necessitated the development of new therapeutics as well as the identification of specific prognostic markers to predict the response to novel drugs. Primar...

    Authors: Anna A. Nushtaeva, Grigory A. Stepanov, Dmitry V. Semenov, Evgeny S. Juravlev, Evgenia A. Balahonova, Alexey V. Gerasimov, Sergey V. Sidorov, Eugeniy I. Savelyev, Elena V. Kuligina, Vladimir A. Richter and Olga A. Koval
    Citation: BMC Cancer 2018 18:728
    Content type: Research article Published on:

  3. Interleukin-2 (IL-2) is an important immunotherapy cytokine for various diseases including cancer. Some studies reported the efficacy and safety on cisplatin combined with IL-2 versus cisplatin alone for treat...

    Authors: Liping Han, Qiufang Jiang, Wei Yao, Tian Fu and Qingdi Zeng
    Citation: BMC Cancer 2018 18:725
    Content type: Research article Published on:

  4. Multiple myeloma (MM) patients with t(14;20) have a poor prognosis and their outcome has not improved following the introduction of bortezomib (Bzb). The mechanism underlying the resistance to proteasome inhib...

    Authors: Ya-Wei Qiang, Shiqiao Ye, Yuhua Huang, Yu Chen, Frits Van Rhee, Joshua Epstein, Brian A. Walker, Gareth J. Morgan and Faith E. Davies
    Citation: BMC Cancer 2018 18:724
    Content type: Research article Published on:

  5. High HOX gene expression has been described in many cancers, including oral squamous cell carcinoma and the functional roles of these genes are gradually being understood. The pattern of overexpression suggest...

    Authors: Christopher Platais, Raghu Radhakrishnan, Sven Niklander Ebensperger, Richard Morgan, Daniel W. Lambert and Keith D. Hunter
    Citation: BMC Cancer 2018 18:723
    Content type: Research article Published on:

  6. LIM and SH3 protein 1 (LASP1) is upregulated in several types of human cancer and implicated in cancer progression. However, the expression and intrinsic function of LASP1 in glioblastoma (GBM) remains unclear.

    Authors: Chuanhong Zhong, Yitian Chen, Bei Tao, Lilei Peng, Tangming Peng, Xiaobo Yang, Xiangguo Xia and Ligang Chen
    Citation: BMC Cancer 2018 18:722
    Content type: Research article Published on:

  7. The theory of field effect suggests that the tumor-adjacent area, besides histopathologically normal, undergoes genetic and epigenetic changes that can eventually affect epithelial homeostasis, predisposing th...

    Authors: Camile B. Lopes, Leandro L. Magalhães, Carolina R. Teófilo, Ana Paula N. N. Alves, Raquel C. Montenegro, Massimo Negrini and Ândrea Ribeiro-dos-Santos
    Citation: BMC Cancer 2018 18:721
    Content type: Research article Published on:

  8. People aged 40–60 years with a family history (FH) of colorectal cancer (CRC) in 1st degree relatives (FDRs) have a 2- to 4-fold increased risk of CRC compared to the average risk population. Therefore, expert...

    Authors: Kaja Tikk, Korbinian Weigl, Michael Hoffmeister, Svitlana Igel, Matthias Schwab, Jochen Hampe, Stefanie J. Klug, Ulrich Mansmann, Frank Kolligs and Hermann Brenner
    Citation: BMC Cancer 2018 18:720
    Content type: Study protocol Published on:

  9. Approximately 900 children/adolescents are treated with radiotherapy (RT) every year in France. However, among the 80% of survivors, the cumulative incidence of long-term morbidity – including second malignanc...

    Authors: Valérie Bernier-chastagner, Liza Hettal, Véronique Gillon, Laurinda Fernandes, Cécile Huin-schohn, Marion Vazel, Priscillia Tosti, Julia Salleron, Aurélie François, Elise Cérimèle, Sandrine Perreira, Didier Peiffert, Pascal Chastagner and Guillaume Vogin
    Citation: BMC Cancer 2018 18:719
    Content type: Study protocol Published on:

  11. Epithelial-to-mesenchymal transition (EMT) is one mechanism of carcinoma migration, while complex tumour migration or bulk migration is another - best demontrated by tumour cells invading blood vessels.

    Authors: Martin Zacharias, Luka Brcic, Sylvia Eidenhammer and Helmut Popper
    Citation: BMC Cancer 2018 18:717
    Content type: Research article Published on:

  12. Although MASTL (microtubule-associated serine/threonine kinase-like) is a key mitotic kinase that regulates mitotic progression through the inactivation of tumor suppressor protein phosphatase 2A (PP2A), the a...

    Authors: Yi Na Yoon, Min Ho Choe, Kwan-Young Jung, Sang-Gu Hwang, Jeong Su Oh and Jae-Sung Kim
    Citation: BMC Cancer 2018 18:716
    Content type: Research article Published on:

  13. Trans-arterial radio-embolization (TARE) is an emerging treatment for the management of hepatocellular carcinoma (HCC). TARE may compete with systemic chemotherapy, sorafenib, in intermediate stage patients wi...

    Authors: Carla Rognoni, Oriana Ciani, Silvia Sommariva, Irene Bargellini, Sherrie Bhoori, Roberto Cioni, Antonio Facciorusso, Rita Golfieri, Annagiulia Gramenzi, Vincenzo Mazzaferro, Cristina Mosconi, Francesca Ponziani, Rodolfo Sacco, Franco Trevisani and Rosanna Tarricone
    Citation: BMC Cancer 2018 18:715
    Content type: Research article Published on:

  14. Sentinel lymph node metastasis is a common and early event in the metastatic process of head and neck squamous cell carcinoma (HNSCC) and is the most powerful prognostic factor for survival of HNSCC patients. 3-O

    Authors: Jeon Hwang-Bo, Mun Gyeong Bae, Jong-Hwa Park and In Sik Chung
    Citation: BMC Cancer 2018 18:714
    Content type: Research article Published on:

  15. Usually misdiagnosed, Inflammatory Breast Cancer (IBC) is the most aggressive form of non-metastatic breast cancer. This orphan disease is more frequent in North Africa. Despite intensive treatment, the surviv...

    Authors: Meriem Slaoui, Abdou Azaque Zoure, Fatima Zahra Mouh, Youssef Bensouda, Mohammed El Mzibri, Youssef Bakri and Mariam Amrani
    Citation: BMC Cancer 2018 18:713
    Content type: Research article Published on:

  16. Cancer is the second leading cause of death in the Caribbean, including the islands of Trinidad and Tobago (TT). The population of TT consists of over 1.3 million people with diverse ancestral and sociocultura...

    Authors: Wayne A. Warner, Tammy Y. Lee, Kimberly Badal, Tanisha M. Williams, Smriti Bajracharya, Vasavi Sundaram, Nigel A. Bascombe, Ravi Maharaj, Marjorie Lamont-Greene, Allana Roach, Melissa Bondy, Matthew J. Ellis, Timothy R. Rebbeck, Simeon Slovacek, Jingqin Luo, Adetunji T. Toriola…
    Citation: BMC Cancer 2018 18:712
    Content type: Research article Published on:

  17. YAP, a potent oncogene and major downstream effector of the mammalian Hippo tumor suppressor pathway can act as either oncogene or tumor suppressor gene based on the type of tissue involved. Despite various st...

    Authors: Sumayya Abdul Sattar Real, Farah Parveen, Asad Ur Rehman, Mohammad Aasif Khan, Sankaravamasam Venkata Suryanarayan Deo, Nootan Kumar Shukla and Syed Akhtar Husain
    Citation: BMC Cancer 2018 18:711
    Content type: Research article Published on:

  18. Although originally identified as a putative metastasis suppressor, increasing studies have confirmed a possible role for Nm23-H1 in DNA repair, through the base excision repair and nucleotide excision repair ...

    Authors: Ya Sheng, Mingfang Xu, Chongyi Li, Yanli Xiong, Yi Yang, Xunjie Kuang, Dong Wang and Xueqin Yang
    Citation: BMC Cancer 2018 18:710
    Content type: Research article Published on:

  19. HER2 over-expression is related with a poor prognosis in patients with invasive breast cancer tumors. Clinical associations have reported that somatic mutations of p53 more frequently detected in cases of spor...

    Authors: A. A. Román-Rosales, E. García-Villa, L. A. Herrera, P. Gariglio and J. Díaz-Chávez
    Citation: BMC Cancer 2018 18:709
    Content type: Research article Published on:

  20. The purpose of this case report is to describe a conjunctiva and eyelid Kaposi’s sarcoma (KS) as the initial manifestation of acquired immunodeficiency syndrome (AIDS), which led to the diagnosis of HIV infect...

    Authors: Filipe Sousa Neves, Joana Braga, João Cardoso da Costa, Joaquim Sequeira and Sandra Prazeres
    Citation: BMC Cancer 2018 18:708
    Content type: Case report Published on:

  21. A major challenge for those living with cancers of the upper gastrointestinal tract (oesophagus, stomach and pancreas), is the impact of the disease and treatment on nutritional status and quality of life. People...

    Authors: Lauren Hanna, Catherine E. Huggins, Kate Furness, Mary Anne Silvers, June Savva, Helena Frawley, Daniel Croagh, Paul Cashin, Liang Low, Judith Bauer, Helen Truby and Terrence Haines
    Citation: BMC Cancer 2018 18:707
    Content type: Study protocol Published on:

  22. The Union for International Cancer Control (UICC) tumor-node-metastasis (TNM) classification is a key gastric cancer prognosis system. This study aimed to create a new TNM system to provide a reference for the...

    Authors: Zhiqiong Wang, Mo Li, Zhen Xu, Yanlin Jiang, Huizi Gu, Ying Yu, Haitao Zhu, Hao Zhang, Ping Lu, Junchang Xin, Hong Xu and Caigang Liu
    Citation: BMC Cancer 2018 18:706
    Content type: Research article Published on:

  24. The treatment of acute lymphoblastic leukemia (ALL) and osteosarcoma (OSC) is very effective: the vast majority of patients recover and survive for decades. However, they still need to face serious adverse eff...

    Authors: Judit C. Sági, Bálint Egyed, Andrea Kelemen, Nóra Kutszegi, Márta Hegyi, András Gézsi, Martina Ayaka Herlitschke, Andrea Rzepiel, Lili E. Fodor, Gábor Ottóffy, Gábor T. Kovács, Dániel J. Erdélyi, Csaba Szalai and Ágnes F. Semsei
    Citation: BMC Cancer 2018 18:704
    Content type: Research article Published on:

  25. The role of forkhead-box A1 (FOXA1) and Androgen receptor (AR) in breast cancer (BC) has been extensively studied. However, the prognostic role of their co-expression in Estrogen receptor positive (ER+) BC has...

    Authors: Nelson Rangel, Nicoletta Fortunati, Simona Osella-Abate, Laura Annaratone, Claudio Isella, Maria Graziella Catalano, Letizia Rinella, Jasna Metovic, Renzo Boldorini, Davide Balmativola, Pietro Ferrando, Francesca Marano, Paola Cassoni, Anna Sapino and Isabella Castellano
    Citation: BMC Cancer 2018 18:703
    Content type: Research article Published on:

  26. The aim of this study was to compare the efficacies of the XELOX and DOS regimens as preoperative chemotherapy in patients with locally advanced gastric cancer.

    Authors: Yan Wang, Xi Cheng, Yue-hong Cui, Jun Hou, Yuan Ji, Yi-hong Sun, Zhen-bin Shen, Feng-lin Liu and Tian-shu Liu
    Citation: BMC Cancer 2018 18:702
    Content type: Research article Published on:

  27. Eribulin mesylate is currently indicated as a sequential monotherapy to be administered after two chemotherapeutic regimens, including anthracycline and taxane treatments, for treatment of metastatic breast ca...

    Authors: Tetsu Hayashida, Hiromitsu Jinno, Katsuaki Mori, Hiroki Sato, Akira Matsui, Takashi Sakurai, Hiroaki Hattori, Shin Takayama, Masahiro Wada, Maiko Takahashi, Hirohito Seki, Tomoko Seki, Aiko Nagayama, Akiko Matsumoto and Yuko Kitagawa
    Citation: BMC Cancer 2018 18:701
    Content type: Research article Published on:

  28. Heat Shock Proteins (HSPs), a family of genes with key roles in proteostasis, have been extensively associated with cancer behaviour. However, the HSP family is quite large and many of its members have not bee...

    Authors: Felipe C. M. Zoppino, Martin E. Guerrero-Gimenez, Gisela N. Castro and Daniel R. Ciocca
    Citation: BMC Cancer 2018 18:700
    Content type: Research article Published on:

  29. The prognostic value of preoperative controlling nutritional status (CONUT) has been reported in many malignancies. In present study, we aimed to clarify the prognostic impact of CONUT in gastric cancer (GC) r...

    Authors: Xuechao Liu, Deyao Zhang, Enzi Lin, Yongming Chen, Wei Li, Yingbo Chen, Xiaowei Sun and Zhiwei Zhou
    Citation: BMC Cancer 2018 18:699
    Content type: Research article Published on:

  30. The advent of tyrosine kinase inhibitors (TKIs) has changed the treatment of RAI refractory, unresectable recurrent differentiated thyroid cancer (DTC), which was formerly treated with multidisciplinary remedies.

    Authors: Masayuki Tori and Toshirou Shimo
    Citation: BMC Cancer 2018 18:698
    Content type: Case report Published on:

  31. Genes associated with hereditary breast and ovarian cancer (HBOC) and colorectal cancer (CRC) predisposition have been shown to play a role in pancreatic cancer susceptibility. Growing evidence suggests that p...

    Authors: Erin L. Young, Bryony A. Thompson, Deborah W. Neklason, Matthew A. Firpo, Theresa Werner, Russell Bell, Justin Berger, Alison Fraser, Amanda Gammon, Cathryn Koptiuch, Wendy K. Kohlmann, Leigh Neumayer, David E. Goldgar, Sean J. Mulvihill, Lisa A. Cannon-Albright and Sean V. Tavtigian
    Citation: BMC Cancer 2018 18:697
    Content type: Research article Published on:

  32. Invasive cervical cancer (ICC) is caused by high-risk human papillomavirus types (HR-HPVs) and is usually preceded by a long phase of intraepithelial neoplasia (CIN). Before invasion, (epi) genetic changes, po...

    Authors: Barbara Pardini, Daniela De Maria, Antonio Francavilla, Cornelia Di Gaetano, Guglielmo Ronco and Alessio Naccarati
    Citation: BMC Cancer 2018 18:696
    Content type: Research article Published on:

  33. DNA mutations occur randomly and sporadically in growth-related genes, mostly on cytosines. Demethylation of cytosines may lead to genetic instability through spontaneous deamination. Aims were whole genome me...

    Authors: Béla Molnár, Orsolya Galamb, Bálint Péterfia, Barnabás Wichmann, István Csabai, András Bodor, Alexandra Kalmár, Krisztina Andrea Szigeti, Barbara Kinga Barták, Zsófia Brigitta Nagy, Gábor Valcz, Árpád V. Patai, Péter Igaz and Zsolt Tulassay
    Citation: BMC Cancer 2018 18:695
    Content type: Research article Published on:

  34. Esophageal adenocarcinoma (EAC) incidence is increasing rapidly. Esophageal cancer has the second lowest 5-year survival rate of people diagnosed with cancer in Canada. Given the poor survival and the potentia...

    Authors: Hla-Hla Thein, Nathaniel Jembere, Kednapa Thavorn, Kelvin K. W. Chan, Peter C. Coyte, Claire de Oliveira, Chin Hur and Craig C. Earle
    Citation: BMC Cancer 2018 18:694
    Content type: Research article Published on:

  35. Effective treatment options for advanced pancreatic cancer are finite. NAPOLI-1, a phase III randomized trial, demonstrated the efficacy of nanoliposomal irinotecan with fluorouracil/leucovorin (nal-IRI + 5-FU...

    Authors: Danielle C. Glassman, Randze L. Palmaira, Christina M. Covington, Avni M. Desai, Geoffrey Y. Ku, Jia Li, James J. Harding, Anna M. Varghese, Eileen M. O’Reilly and Kenneth H. Yu
    Citation: BMC Cancer 2018 18:693
    Content type: Research article Published on:

  36. Emerging inflammatory response biomarkers are developed to predict the survival of patients with cancer, the aim of our study is to establish an inflammation-related nomogram based on the classical predictive ...

    Authors: Ying Wang, Xiao Qu, Ngar-Woon Kam, Kai Wang, Hongchang Shen, Qi Liu and Jiajun Du
    Citation: BMC Cancer 2018 18:692
    Content type: Research article Published on:

  37. The neuronal intermediate filament alpha-internexin (α-internexin) is a cytoskeleton protein which is involved in the tumor initiation and progression. In this study, we examined the expression and prognosis v...

    Authors: Yuhong Wang, Yuanjia Chen, Xiaoxing Li, Wanming Hu, Yu Zhang, Luohai Chen, Minhu Chen and Jie Chen
    Citation: BMC Cancer 2018 18:691
    Content type: Research article Published on:

  38. Orphan nuclear receptors ERRα, ERRβ and ERRγ that belong to NR3B or type IV nuclear receptor family are well studied for their role in breast cancer pathophysiology. Their homology with the canonical estrogen ...

    Authors: Kanchan Kumari, Amit K. Adhya, Arabinda Kumar Rath, P. B. Reddy and Sandip K. Mishra
    Citation: BMC Cancer 2018 18:690
    Content type: Research article Published on:

  39. Cancer cells require increased levels of nutrients such as amino acids to sustain their rapid growth. In particular, leucine and glutamine have been shown to be important for growth and proliferation of some b...

    Authors: Michelle van Geldermalsen, Lake-Ee Quek, Nigel Turner, Natasha Freidman, Angel Pang, Yi Fang Guan, James R. Krycer, Renae Ryan, Qian Wang and Jeff Holst
    Citation: BMC Cancer 2018 18:689
    Content type: Research article Published on:

  40. Pancreatic cancer is the fourth-leading cause of cancer deaths in the United States. The silent nature of the disease and its poor prognosis, the need for further research, along with the need to assess the ou...

    Authors: Anas M. Saad, Tarek Turk, Muneer J. Al-Husseini and Omar Abdel-Rahman
    Citation: BMC Cancer 2018 18:688
    Content type: Research article Published on:

  41. Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells. In this work we analyze changes in the patterns of express...

    Authors: Ainara Crespo, Olivia García-Suárez, Iván Fernández-Vega, María Pilar Solis-Hernandez, Beatriz García, Sonia Castañón and Luis M. Quirós
    Citation: BMC Cancer 2018 18:687
    Content type: Research article Published on:

  42. Oral cancer is a serious problem owing to its poor prognosis and destruction of patients’ eating ability as well as facial appearance. Epidemiological studies can provide aetiological clues for prevention. The...

    Authors: Jin-Ye Fu, Chun-Xiao Wu, Chen-Ping Zhang, Jing Gao, Jian-Feng Luo, Shu-Kun Shen, Ying Zheng and Zhi-Yuan Zhang
    Citation: BMC Cancer 2018 18:686
    Content type: Research article Published on:

  43. Evidence suggests reallocating daily sedentary time to physical activity or sleep confers important health benefits in cancer survivors. Despite emerging research suggesting physical activity as a treatment fo...

    Authors: Diane K. Ehlers, Jason Fanning, Elizabeth A. Salerno, Susan Aguiñaga, Josh Cosman, Joan Severson, Arthur F. Kramer and Edward McAuley
    Citation: BMC Cancer 2018 18:685
    Content type: Research article Published on:

  44. Uterine serous carcinoma (USC) is a rare but aggressive subtype of endometrial carcinoma. Large-scale comprehensive efforts have resulted in an improved molecular understanding of its pathogenesis, and the p53...

    Authors: Katharina Bischof, Stian Knappskog, Ingunn Stefansson, Emmet Martin McCormack, Jone Trovik, Henrica Maria Johanna Werner, Kathrine Woie, Bjorn Tore Gjertsen and Line Bjorge
    Citation: BMC Cancer 2018 18:684
    Content type: Research article Published on:

  45. The insurance reimbursement rate of medical cost affects the quality and quantity of health services provided in China. The nature of this relationship, however, has not been reliably described in the field of...

    Authors: Xi Li, Qi Zhou, Xinyu Wang, Shaofei Su, Meiqi Zhang, Hao Jiang, Jiaying Wang and Meina Liu
    Citation: BMC Cancer 2018 18:683
    Content type: Research article Published on:

  46. Progesterone receptor (PR) is expressed from a single gene as two isoforms, PRA and PRB. In normal breast human tissue, PRA and PRB are expressed in equimolar ratios, but isoform ratio is altered during malign...

    Authors: María José Carlini, María Sol Recouvreux, Marina Simian and Maria Aparecida Nagai
    Citation: BMC Cancer 2018 18:682
    Content type: Research article Published on:

  47. MicroRNAs can be used in the prognosis of malignancies; however, their regulatory mechanisms are unknown, especially in pancreatic ductal adenocarcinoma (PDAC).

    Authors: Ce Li, Qian Dong, Xiaofang Che, Ling Xu, Zhi Li, Yibo Fan, Kezuo Hou, Shuo Wang, Jinglei Qu, Lu Xu, Ti Wen, Xianghong Yang, Xiujuan Qu and Yunpeng Liu
    Citation: BMC Cancer 2018 18:681
    Content type: Research article Published on:

  48. We previously showed that knockdown of nuclear factor E2-related factor 2 (Nrf2) resulted in suppression of hepatitis C virus (HCV) infection. In this study, whether brusatol, an Nrf2 inhibitor, has dual anti-...

    Authors: Yuko Murakami, Kazuo Sugiyama, Hirotoshi Ebinuma, Nobuhiro Nakamoto, Keisuke Ojiro, Po-sung Chu, Nobuhito Taniki, Yoshimasa Saito, Toshiaki Teratani, Yuzo Koda, Takahiro Suzuki, Kyoko Saito, Masayoshi Fukasawa, Masanori Ikeda, Nobuyuki Kato, Takanori Kanai…
    Citation: BMC Cancer 2018 18:680
    Content type: Research article Published on:

  49. Novel non-invasive biomarkers for gastric cancer (GC) are needed, because the present diagnostic methods for GC are either invasive or insensitive and non-specific in clinic. The presence of stable circulating...

    Authors: Gaoping Zhao, Tao Jiang, Yanzhuo Liu, Guoli Huai, Chunbin Lan, Guiquan Li, Guiqing Jia, Kang Wang and Maozhu Yang
    Citation: BMC Cancer 2018 18:676
    Content type: Research article Published on:

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