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  1. The aim of this study was to compare proximal fibular and proximal tibial sites regarding osteosarcoma in the proximal crus. Furthermore, we proposed a hypothesis explaining the differences.

    Authors: Hao Yao, Bo Wang, Lili Wen, Qinglin Jin, Hongbo Li, Gang Huang, Junqiang Yin, Changye Zou, Xianbiao Xie and Jingnan Shen
    Citation: BMC Cancer 2018 18:1195
    Content type: Research article Published on:

  2. The presence of hypoxic areas is common in all breast lesions but no data clearly correlate low oxygenation with the acquisition of malignant features by non-invasive cells, particularly by cells from ductal c...

    Authors: Yasamin Al-Qassab, Silvia Grassilli, Federica Brugnoli, Federica Vezzali, Silvano Capitani and Valeria Bertagnolo
    Citation: BMC Cancer 2018 18:1194
    Content type: Research article Published on:

  3. Osteosarcoma is the most common malignant bone tumor in children and young adults that produces aberrant osteoid. The aim of this study was to assess the utility of 2-deoxy-2-[18F-] fluoro-D-glucose ([18F] FDG) a...

    Authors: María Collantes, Naiara Martínez-Vélez, Marta Zalacain, Lucia Marrodán, Margarita Ecay, María José García-Velloso, Marta María Alonso, Ana Patiño-García and Iván Peñuelas
    Citation: BMC Cancer 2018 18:1193
    Content type: Research article Published on:

  4. To investigate whether PET/CT-guided bone marrow biopsy adds complementary information for evaluation of bone marrow involvement (BMI) in newly diagnosed lymphomas.

    Authors: Bing Hao, Long Zhao, Na-na Luo, Dan Ruan, Yi-zhen Pang, Wei Guo, Hao Fu, Xiu-yu Guo, Zuo-ming Luo, Jing Wu, Hao-jun Chen, Hua Wu and Long Sun
    Citation: BMC Cancer 2018 18:1192
    Content type: Research article Published on:

  5. The nudix family member enzyme MutT homologue-1 (MTH1) hydrolyses the oxidized nucleotides 8-oxo-dGTP and 2-hydroxy-dATP and thus prevents the incorporation of damaged nucleotides into nuclear and mitochondria...

    Authors: Mosche Pompsch, Julia Vogel, Fabian Classen, Philip Kranz, George Iliakis, Helena Riffkin, Ulf Brockmeier and Eric Metzen
    Citation: BMC Cancer 2018 18:1190
    Content type: Research article Published on:

  6. Recently, microRNA-20a (miR-20a) has been reported to influence the clinical features and may have prognostic value in human cancers. The present meta-analysis assessed the prognostic role of miR-20a in variou...

    Authors: Donghua Huang, Yizhong Peng, Kaige Ma, Xiangyu Deng, Lu Tang, Doudou Jing and Zengwu Shao
    Citation: BMC Cancer 2018 18:1189
    Content type: Research article Published on:

  7. Few studies have focused on quality of life (QoL) after treatment of malignant pleural mesothelioma (MPM). There are still questions as to which surgical procedure, extrapleural pneumonectomy (EPP) or pleurect...

    Authors: Rebecca M. Schwartz, Wil Lieberman-Cribbin, Andrea Wolf, Raja M. Flores and Emanuela Taioli
    Citation: BMC Cancer 2018 18:1188
    Content type: Research article Published on:

  8. Treatment with nab-paclitaxel plus gemcitabine increases survival in patients with metastatic pancreatic cancer. However, the assessment of treatment efficacy and safety in non-selected patients in a real-life...

    Authors: Ana Fernández, Mercedes Salgado, Adelaida García, Elvira Buxò, Ruth Vera, Jorge Adeva, Paula Jiménez-Fonseca, Guillermo Quintero, Cristina Llorca, Mamen Cañabate, Luis Jesús López, Andrés Muñoz, Patricia Ramírez, Paula González, Carlos López, Margarita Reboredo…
    Citation: BMC Cancer 2018 18:1185
    Content type: Research article Published on:

  9. Oesophageal carcinoma is one of the leading cancers in Sri Lanka. Recent advances in treatment modalities have drastically improved the survival of these patients. However, the quality of life (QoL) among the ...

    Authors: Ishanka Ayeshwari Talagala and Carukshi Arambepola
    Citation: BMC Cancer 2018 18:1184
    Content type: Research article Published on:

  10. Standard therapy for stage III non-small cell lung cancer with chemotherapy and conventional radiation has suboptimal outcomes. We hypothesized that a combination of surgery followed by stereotactic body radia...

    Authors: Anurag K. Singh, Mark Hennon, Sung Jun Ma, Todd L. Demmy, Anthony Picone, Elizabeth U. Dexter, Chumy Nwogu, Kristopher Attwood, Wei Tan, Gregory M. Hermann, Simon Fung-Kee-Fung, Harish K. Malhotra, Sai Yendamuri and Jorge A. Gomez-Suescun
    Citation: BMC Cancer 2018 18:1183
    Content type: Research article Published on:

  11. To explore the diagnostic value of FAM19A4 methylation in high-risk human papilloma virus (hrHPV)-positive cervical samples from Chinese women for estimating cervical cancer or its precancerous lesions.

    Authors: Qiaowen Bu, Sanfeng Wang, Jian Ma, Xiangcheng Zhou, Guiying Hu, Hua Deng, Xiaoli Sun, Xiaoshan Hong, Hengying Wu, Liang Zhang and Xiping Luo
    Citation: BMC Cancer 2018 18:1182
    Content type: Research article Published on:

  12. Cancers of the upper gastrointestinal tract commonly result in malnutrition, which increases morbidity and mortality. Current nutrition best practice lacks a mechanism to provide early and intensive nutrition ...

    Authors: Kate Furness, Catherine E. Huggins, Lauren Hanna, Mary Anne Silvers, Paul Cashin, Liang Low, Daniel Croagh and Terry P. Haines
    Citation: BMC Cancer 2018 18:1181
    Content type: Study protocol Published on:

  13. Changes in cellular metabolism are now recognized as potential drivers of cancer development, rather than as secondary consequences of disease. Here, we explore the mechanism by which metabolic changes depende...

    Authors: Diana Andrejeva, Jan-Michael Kugler, Hung Thanh Nguyen, Anders Malmendal, Mette Lind Holm, Birgitte Groenkaer Toft, Anand C. Loya and Stephen M. Cohen
    Citation: BMC Cancer 2018 18:1180
    Content type: Research article Published on:

  14. The dysregulation of miR-663a is frequently observed in many human cancers. However, the functional role and precise mechanism of miR-663a have been controversial in hepatocellular carcinoma (HCC) and need to ...

    Authors: Chengshuo Zhang, Baomin Chen, Ao Jiao, Feng Li, Ning Sun, Guoqing Zhang and Jialin Zhang
    Citation: BMC Cancer 2018 18:1179
    Content type: Research article Published on:

  15. The aim of this study was to propose a prognostic scoring system based on preoperative serum apolipoprotein A-1 and C-reactive protein (ApoA-1 and CRP, AC score) levels and to evaluate the prognostic value of ...

    Authors: Minjie Mao, Xueping Wang, Hui Sheng, Yijun Liu, Lin Zhang, Shuqin Dai and Pei-dong Chi
    Citation: BMC Cancer 2018 18:1178
    Content type: Research article Published on:

  16. Previous epidemiological studies aimed at describing characteristics of breast (BC) and ovarian cancer (OC) patients tend to examine Hispanic populations using a mix of individuals that come from ethnically di...

    Authors: Ariel Rodriguez-Velazquez, Rosa Velez, Jean Carlo Lafontaine, Claudia B. Colon-Echevarria, Rocio D. Lamboy-Caraballo, Ingrid Ramirez, Adalberto Mendoza, Patricia Casbas-Hernandez and Guillermo N. Armaiz-Pena
    Citation: BMC Cancer 2018 18:1177
    Content type: Research article Published on:

  17. It has been proposed that mesenchymal stromal cells (MSCs) promote tumor progression by interacting with tumor cells and other stroma cells in the complex network of the tumor microenvironment. We characterize...

    Authors: Gloria Pelizzo, Veronica Veschi, Melissa Mantelli, Stefania Croce, Vincenzo Di Benedetto, Paolo D’Angelo, Alice Maltese, Laura Catenacci, Tiziana Apuzzo, Emanuela Scavo, Antonia Moretta, Matilde Todaro, Giorgio Stassi, Maria Antonietta Avanzini and Valeria Calcaterra
    Citation: BMC Cancer 2018 18:1176
    Content type: Research article Published on:

  18. The incidence and mortality from prostate cancer is expected to increase in the next decade in Thailand. Despite the perceived lower risk in this population vs. developed, western countries, it is becoming an ...

    Authors: Christian S. Alvarez, Eduardo Villamor, Rafael Meza, Laura S. Rozek, Hutcha Sriplung and Alison M. Mondul
    Citation: BMC Cancer 2018 18:1175
    Content type: Research article Published on:

  19. Cachexia is a multisystem syndrome characterized by weight loss, anorexia, loss of muscle mass, systemic inflammation, insulin resistance, and functional decline. Management of cachexia involves addressing mul...

    Authors: Shailesh M. Advani, Pragati G. Advani, Helena M. VonVille and Syed H. Jafri
    Citation: BMC Cancer 2018 18:1174
    Content type: Research article Published on:

  20. To determine the psychometric properties and minimal clinically important differences (MCIDs) of the World Health Organization Quality of Life-BREF (WHOQOL-BREF) in advanced stage lung cancer patients.

    Authors: Mark de Mol, Sabine Visser, Joachim G. J. V. Aerts, Paul Lodder, Jolanda de Vries and Brenda L. den Oudsten
    Citation: BMC Cancer 2018 18:1173
    Content type: Research article Published on:

  21. Germline mutations in BAP1 have been associated with BAP1-Tumor Predisposition Syndrome (BAP1-TPDS), a predisposition to multiple tumors within a family that includes uveal melanoma (UM), cutaneous melanoma, mali...

    Authors: K. G. Ewens, E. Lalonde, J. Richards-Yutz, C. L. Shields and A. Ganguly
    Citation: BMC Cancer 2018 18:1172
    Content type: Research article Published on:

  22. Crizotinib can target against mesenchymal-epithelial transition (MET) and anaplastic lymphoma kinase (ALK), which has been considered as a multi-targeted tyrosine kinase inhibitor (TKI). The objective of this stu...

    Authors: Rui-Lian Chen, Jun Zhao, Xu-Chao Zhang, Na-Na Lou, Hua-Jun Chen, Xue Yang, Jian Su, Zhi Xie, Qing Zhou, Hai-Yan Tu, Wen-Zhao Zhong, Hong-Hong Yan, Wei-Bang Guo, Yi-Long Wu and Jin-Ji Yang
    Citation: BMC Cancer 2018 18:1171
    Content type: Research article Published on:

  23. Increasing evidence indicates that cetuximab (CET) combined with chemoradiotherapy may be effective for patients with esophageal cancer. However, the recent results are still contradictory and no consensus has...

    Authors: Ze-Hao Huang, Xiao-Wen Ma, Jing Zhang, Xiao Li, Na-Lin Lai and Sheng-Xiao Zhang
    Citation: BMC Cancer 2018 18:1170
    Content type: Research article Published on:

  24. There is evidence that derangement in serum electrolytes like sodium and potassium is associated with increased morbidity and mortality among hospitalized critically ill patients, but their role in the context...

    Authors: Arunangshu Ghoshal, Hans Garmo, Niklas Hammar, Ingmar Jungner, Håkan Malmström, Göran Walldius and Mieke Van Hemelrijck
    Citation: BMC Cancer 2018 18:1169
    Content type: Research article Published on:

  25. Wnt signaling has been linked with P-glycoprotein (P-gp) overexpression and which was mainly mediated by β-catenin nuclear translocation. Flavonoids have already been reported as modulators of the Wnt/β-cateni...

    Authors: S. Mohana, M. Ganesan, N. Rajendra Prasad, D. Ananthakrishnan and D. Velmurugan
    Citation: BMC Cancer 2018 18:1168
    Content type: Research article Published on:

    The Retraction Note to this article has been published in BMC Cancer 2021 21:151

  26. Waixenicin A, a bioactive extract of soft coral Sarcothelia edmondsoni, has been shown to be anti-neoplastic. However, its mechanisms of action remain unclear. Cancer stem cells (CSCs) and associated stemness fac...

    Authors: Kai Liu, Shao-Hua Xu, Zhao Chen, Qing-Xin Zeng, Zhi-Jun Li and Zhou-Miao Chen
    Citation: BMC Cancer 2018 18:1167
    Content type: Research article Published on:

  27. Malignant bowel obstruction (MBO) is often a terminal event in end-stage cancer patients. The decision to intervene surgically is complex, given the risk of harm in patients with a limited lifespan. Therefore,...

    Authors: Sarah B. Bateni, Alicia A. Gingrich, Susan L. Stewart, Frederick J. Meyers, Richard J. Bold and Robert J. Canter
    Citation: BMC Cancer 2018 18:1166
    Content type: Research article Published on:

  28. Supradiaphragmatic lymph node metastases (SdLNM) are frequently identified using 18F-FDG positron emission tomography/computed tomography (PET/CT) in advanced epithelial ovarian cancers (AEOC). This study aimed t...

    Authors: In Ok Lee, Jung-Yun Lee, Hyun Jeong Kim, Eun Ji Nam, Sunghoon Kim, Sang Wun Kim, Chang Young Lee, Won Jun Kang and Young Tae Kim
    Citation: BMC Cancer 2018 18:1165
    Content type: Research article Published on:

  29. Insulin resistance (IR) is closely associated with the progression of hepatocellular carcinoma (HCC). Acyclic retinoid (ACR) targets retinoid X receptor α and reportedly prevents HCC recurrence in clinical pra...

    Authors: Norihisa Nishimura, Kosuke Kaji, Mitsuteru Kitade, Yosuke Aihara, Shinya Sato, Kenichiro Seki, Yasuhiko Sawada, Hiroaki Takaya, Yasushi Okura, Hideto Kawaratani, Kei Moriya, Tadashi Namisaki, Akira Mitoro and Hitoshi Yoshiji
    Citation: BMC Cancer 2018 18:1164
    Content type: Research article Published on:

  30. Breast cancer survivors have an elevated risk of cognitive impairment compared to age-matched women without cancer. Causes of this impairment are complex, including both treatment and psychological factors. Mi...

    Authors: Gabriella Cifu, Melinda C. Power, Sarah Shomstein and Hannah Arem
    Citation: BMC Cancer 2018 18:1163
    Content type: Research article Published on:

  31. Cervical cancer is the most common genital malignant tumor in women worldwide. However, the reliability of different detection methods may vary according to populations and epidemics. This study analyzed facto...

    Authors: Sulaiya Husaiyin, Lili Han, Lin Wang, Chunhua Ma, Zumurelaiti Ainiwaer, Nuermanguli Rouzi, Mireguli Akemujiang, Hatiguli Simayil, Zumulaiti Aniwa, Rouzi Nurimanguli and Mayinuer Niyazi
    Citation: BMC Cancer 2018 18:1162
    Content type: Research article Published on:

  32. Decision making with advanced cancer patients is often associated with decisional conflict regarding treatment outcomes. This longitudinal multicenter study investigated German physicians’ course of decisional...

    Authors: Catharina Schoenfeld, Yves Libert, Heribert Sattel, Delphine Canivet, France Delevallez, Andreas Dinkel, Pascal O. Berberat, Alexander Wuensch and Darius Razavi
    Citation: BMC Cancer 2018 18:1161
    Content type: Research article Published on:

  33. Because of the rarity of endometrioid borderline ovarian tumours (EBOTs), there is a paucity of data concerning the natural history and prognosis of this condition. Thus, the objective of our study was to esta...

    Authors: Shuang-zheng Jia, Jun-ji Zhang, Zhi-yong Liang, Jun-jun Yang, Yang Xiang, Cong-wei Jia and Jin-hua Leng
    Citation: BMC Cancer 2018 18:1160
    Content type: Research article Published on:

  34. Papillary renal cell carcinoma (pRCC) is the 2nd most frequent histological type of kidney cancer and accounts for approximately 15% of all renal cell carcinoma. It has a poorer prognosis than clear cell RCC (...

    Authors: Philippe Rochigneux, Jeanne Thomassin-Piana, Sophy Laibe, Serge Brunelle, Naji Salem, Bernard Escudier, Gilles Vassal and Gwenaelle Gravis
    Citation: BMC Cancer 2018 18:1159
    Content type: Case report Published on:

  35. Rearrangements of the anaplastic lymphoma kinase (ALK) belong to the promising targets in the therapy of advanced non-small cell lung cancer (NSCLC) and are predominantly detected by immunohistochemistry (IHC)...

    Authors: Claudia Vollbrecht, Dido Lenze, Michael Hummel, Annika Lehmann, Markus Moebs, Nikolaj Frost, Philipp Jurmeister, Leonille Schweizer, Udo Kellner, Manfred Dietel and Maximilian von Laffert
    Citation: BMC Cancer 2018 18:1158
    Content type: Research article Published on:

  36. Glycosylation plays a critical role in the aggressiveness of pancreatic cancer (PC). Emerging evidences indicate significant involvement of cancer stem cells (CSCs) in PC aggressiveness. However, the importanc...

    Authors: Srikanth Barkeer, Seema Chugh, Saswati Karmakar, Garima Kaushik, Sanchita Rauth, Satyanarayana Rachagani, Surinder K. Batra and Moorthy P. Ponnusamy
    Citation: BMC Cancer 2018 18:1157
    Content type: Research article Published on:

  37. The group of colorectal cancer (CRC) survivors continues to grow worldwide. Understanding health-related quality of life (HRQOL) determinants and consequences of HRQOL impairments in long-term CRC survivors ma...

    Authors: Ilka Ratjen, Clemens Schafmayer, Janna Enderle, Romina di Giuseppe, Sabina Waniek, Manja Koch, Greta Burmeister, Ute Nöthlings, Jochen Hampe, Sabrina Schlesinger and Wolfgang Lieb
    Citation: BMC Cancer 2018 18:1156
    Content type: Research article Published on:

  38. Drug-drug interactions (DDIs) in subjects enrolling in clinical trials can impact not only safety of the patient but also study drug outcomes and data validity. This makes it critical to adequately screen and ...

    Authors: Lauren A. Marcath, Taylor D. Coe, Emily K. Hoylman, Bruce G. Redman and Daniel L. Hertz
    Citation: BMC Cancer 2018 18:1155
    Content type: Research article Published on:

  40. Three randomized trials have concluded at non inferiority of omission of complementary axillary lymph node dissection (cALND) for patients with involved sentinel node (SN). However, we can outline strong limit...

    Authors: Gilles Houvenaeghel, Monique Cohen, Pédro Raro, Jérémy De Troyer, Christine Tunon de Lara, Pierre Gimbergues, Tristan Gauthier, Christelle Faure-Virelizier, Véronique Vaini-Cowen, Stéphane Lantheaume, Claudia Regis, Emile Darai, Vivien Ceccato, Gauthier D’Halluin, Francesco Del Piano, Richard Villet…
    Citation: BMC Cancer 2018 18:1153
    Content type: Research article Published on:

  41. Following up on previous work demonstrating the involvement of the transcription factor forkhead box M1 (FOXM1) in the biology and outcome of a high-risk subset of newly diagnosed multiple myeloma (nMM), this ...

    Authors: Chunyan Gu, Xuefang Jing, Carol Holman, Ramakrishna Sompallae, Fenghuang Zhan, Guido Tricot, Ye Yang and Siegfried Janz
    Citation: BMC Cancer 2018 18:1152
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1238

  42. Individuals with cancer have reduced quality of life, functionality, range of motion, strength, and an increase in pain and fatigue. Exergaming appears to be an effective rehabilitation tool for Parkinson’s di...

    Authors: Daniel Tough, Jonathan Robinson, Steven Gowling, Peter Raby, John Dixon and Samantha L. Harrison
    Citation: BMC Cancer 2018 18:1151
    Content type: Research article Published on:

  43. Hepatocellular carcinoma (HCC) is a malignant tumor that threatens global human health. High PKM2 expression is widely reported in multiple cancers, especially in HCC. This study aimed to explore the effects o...

    Authors: Wen-Wen Lv, Dahai Liu, Xing-Cun Liu, Tie-Nan Feng, Lei Li, Bi-Yun Qian and Wen-Xing Li
    Citation: BMC Cancer 2018 18:1150
    Content type: Research article Published on:

  44. The effect of sleep duration on cancer risk remains controversial. We aimed to quantify the available evidence on this relationship using categorical and dose–response meta-analyses.

    Authors: Yuheng Chen, Fengwei Tan, Luopei Wei, Xin Li, Zhangyan Lyu, Xiaoshuang Feng, Yan Wen, Lanwei Guo, Jie He, Min Dai and Ni Li
    Citation: BMC Cancer 2018 18:1149
    Content type: Research article Published on:

  45. Radiomics is an emerging field in oncological research. In this study, we aimed at developing a radiomics score (rad-score) to estimate postoperative recurrence and survival in patients with solitary hepatocel...

    Authors: Bo-Hao Zheng, Long-Zi Liu, Zhi-Zhi Zhang, Jie-Yi Shi, Liang-Qing Dong, Ling-Yu Tian, Zhen-bin Ding, Yuan Ji, Sheng-Xiang Rao, Jian Zhou, Jia Fan, Xiao-Ying Wang and Qiang Gao
    Citation: BMC Cancer 2018 18:1148
    Content type: Research article Published on:

  46. Fertility sparing surgery has been extensively performed among patients with borderline ovarian tumors due to their age and favorable prognosis. Nevertheless, the prognosis and obstetric outcomes in these pati...

    Authors: Chenyan Fang, Lingqin Zhao, Xi Chen, Aijun Yu, Liang Xia and Ping Zhang
    Citation: BMC Cancer 2018 18:1147
    Content type: Research article Published on:

  47. Adults with relapsed acute lymphoblastic leukemia (ALL) have a poor prognosis, especially in patients who relapsed within 6 months of complete remission 1 (CR1). Allogeneic hematopoietic stem cell transplantat...

    Authors: Shupeng Wen, Zhiyun Niu, Lina Xing, Ying Wang, Hang Li, Na Kuang, Jianmin Luo, Xuejun Zhang and Fuxu Wang
    Citation: BMC Cancer 2018 18:1143
    Content type: Case report Published on:

  48. Anal canal cancer occasionally accompanies extramammary Paget disease. Although most of them are squamous cell carcinoma, anal canal adenocarcinoma with neuroendocrine features accompanying secondary extramamm...

    Authors: Masamichi Yamaura, Takeshi Yamada, Rei Watanabe, Hitomi Kawai, Suguru Hirose, Hiroki Tajima, Masashi Sato, Yuichi Uchida, Daisuke Suganuma, Yoshiyuki Yamamoto, Toshikazu Moriwaki and Ichinosuke Hyodo
    Citation: BMC Cancer 2018 18:1142
    Content type: Case report Published on:

  50. Multiple primary malignant tumors (MPMT) refers to the presence of two or more primary cancers of different organs in the same patient. MPMT is a sparse disease in the past, but there has been a gradual increa...

    Authors: Bo Jin, Simeng Zhang, Xin Chuang, Ping Yu, Ying Chen, Yuee Teng, Xiaofang Che, Yibo Fan, Chunlei Zheng, Xiaohan Li, Xueshan Qiu, Xiujuan Qu and Yunpeng Liu
    Citation: BMC Cancer 2018 18:1138
    Content type: Case report Published on:

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