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  1. Daunorubicin is commonly used in the treatment of acute lymphoblastic leukaemia (ALL). The aim of this study was to explore the kinetics of double strand break (DSB) formation of three ALL cell lines following...

    Authors: Hussain Mubarak Al-Aamri, Heng Ku, Helen R. Irving, Joseph Tucci, Terri Meehan-Andrews and Christopher Bradley
    Citation: BMC Cancer 2019 19:179
    Content type: Research article Published on:

  2. Previous studies have highlighted cytokine growth differentiation factor 15 (GDF-15) as a potential biomarker for digestive system tumors (DST). This study sought to assess the feasibility of using GDF-15 as a...

    Authors: Yanqiu Wang, Tao Jiang, Mingyan Jiang and Shuijing Gu
    Citation: BMC Cancer 2019 19:177
    Content type: Research article Published on:

  3. Zoledronic acid (ZA), a nitrogen-containing bisphosphonate, inhibits osteoclastogenesis. Emerging evidence suggests that ZA has anti-tumor and anti-metastatic properties for breast cancer cells. In a mouse mod...

    Authors: Hsien Liu, Shih-Han Wang, Shin-Cheh Chen, Ching-Ying Chen and Tsun-Mei Lin
    Citation: BMC Cancer 2019 19:176
    Content type: Research article Published on:

  4. In lung cancer, epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor sensitizing mutations co-existing with rare minor EGFR mutations are known as compound mutations. These minor EGFR mutations can l...

    Authors: Kei Namba, Shuta Tomida, Takehiro Matsubara, Yuta Takahashi, Eisuke Kurihara, Yusuke Ogoshi, Takahiro Yoshioka, Tatsuaki Takeda, Hidejiro Torigoe, Hiroki Sato, Kazuhiko Shien, Hiromasa Yamamoto, Junichi Soh, Kazunori Tsukuda and Shinichi Toyooka
    Citation: BMC Cancer 2019 19:175
    Content type: Research article Published on:

  5. Insulinoma represents hypoglycemia as a predominant symptom; the autonomic symptoms may be resolved by chronically recurrent hypoglycemia resulting in the persistence of non-specific symptoms alone. Therefore,...

    Authors: Keiichi Torimoto, Yosuke Okada, Yoshiya Tanaka, Atsuko Matsuoka, Yushi Hirota, Wataru Ogawa, Yoshifumi Saisho, Isao Kurihara, Hiroshi Itoh, Shinya Inada and Masafumi Koga
    Citation: BMC Cancer 2019 19:174
    Content type: Research article Published on:

  6. The aim of this analysis was to model the effect of local control (LC) on overall survival (OS) in patients treated with stereotactic body radiotherapy (SBRT) for liver or lung metastases from colorectal cancer.

    Authors: Rainer J. Klement, N. Abbasi-Senger, S. Adebahr, H. Alheid, M. Allgaeuer, G. Becker, O. Blanck, J. Boda-Heggemann, T. Brunner, M. Duma, M. J. Eble, I. Ernst, S. Gerum, D. Habermehl, P. Hass, C. Henkenberens…
    Citation: BMC Cancer 2019 19:173
    Content type: Research article Published on:

  7. Primary intraosseous cavernous hemangiomas (PICHs) of the skull are extremely rare. To date, diffuse cranial hemangioma of skull has not been reported. In cancer patients, it is often misdiagnosed as metastasis.

    Authors: Huizhi Liu, Xiaojing Chang, Hua Shang, Feng Li, Huandi Zhou and Xiaoying Xue
    Citation: BMC Cancer 2019 19:172
    Content type: Case report Published on:

  8. Epithelial ovarian cancer (EOC) remains one of the most lethal gynecologic cancers, and its pathogenetic mechanism remains unclear. Here we show that MUC16 promotes the translocation of p120-catenin (p120ctn) ...

    Authors: Xin Chen, Xiaoduan Li, Xinjing Wang, Qinyi Zhu, Xiaoli Wu and Xipeng Wang
    Citation: BMC Cancer 2019 19:171
    Content type: Research article Published on:

  9. Langerhans cell histiocytosis (LCH) is a rare clonal disease, characterized by hyperproliferation of Langerhans cells. It may rarely involve the thyroid gland. Its association with papillary thyroid carcinoma ...

    Authors: Mohammad A. Al Hamad, Hassan M. Albisher, Weam R. Al Saeed, Ahmed T. Almumtin, Fatimah M. Allabbad and Mohammed A. Shawarby
    Citation: BMC Cancer 2019 19:170
    Content type: Case report Published on:

  10. Liver metastases of breast cancer are frequent and can recur even after “complete/R0” resection in combination with systemic and hormonal treatments. The aim of this study was to analyze throughout repeat hepa...

    Authors: Aldrick Ruiz, Mylène Sebagh, Raphaël Saffroy, Marc-Antoine Allard, Nelly Bosselut, Giulia Hardoin, Julie Vasseur, Jocelyne Hamelin, René Adam, Jean-François Morère and Antoinette Lemoine
    Citation: BMC Cancer 2019 19:169
    Content type: Research article Published on:

  11. The association between performance status (PS) and the prognosis of metastatic renal cell carcinoma (mRCC) patients receiving tyrosine kinase inhibitors (TKIs) remains controversial. The aim of this study is ...

    Authors: Yawei Xu, Yuanyuan Zhang, Xianhao Wang, Jiaqi Kang and Xiaoqiang Liu
    Citation: BMC Cancer 2019 19:168
    Content type: Research article Published on:

  12. Glioblastoma, a high-grade glial infiltrating tumor, is the most frequent malignant brain tumor in adults and carries a dismal prognosis. External beam radiotherapy (EBRT) increases overall survival but this i...

    Authors: Anne Laprie, Soléakhéna Ken, Thomas Filleron, Vincent Lubrano, Laure Vieillevigne, Fatima Tensaouti, Isabelle Catalaa, Sergio Boetto, Jonathan Khalifa, Justine Attal, Guillaume Peyraga, Carlos Gomez-Roca, Emmanuelle Uro-Coste, Georges Noel, Gilles Truc, Marie-Pierre Sunyach…
    Citation: BMC Cancer 2019 19:167
    Content type: Study protocol Published on:

  13. Although rare cancers account for 27% of cancer diagnoses in the US, there is insufficient research on survivorship issues in these patients. An important issue cancer survivors face is an elevated risk of bei...

    Authors: Dianne M. Finkelstein, Nora K. Horick, Ritesh Ramchandani, Kristina L. Boyd, Huma Q. Rana and Brittany L. Bychkovsky
    Citation: BMC Cancer 2019 19:166
    Content type: Research article Published on:

  14. Diabetes is related with increased cancer mortality across multiple cancer types. Its role in lung cancer mortality is still unclear. We aim to determine the prognostic value of fasting plasma glucose (FPG) an...

    Authors: Milana Bergamino, Antonio J. Rullan, Maria Saigí, Inmaculada Peiró, Eduard Montanya, Ramón Palmero, José Carlos Ruffinelli, Arturo Navarro, María Dolores Arnaiz, Isabel Brao, Samantha Aso, Susana Padrones, Felipe Cardenal and Ernest Nadal
    Citation: BMC Cancer 2019 19:165
    Content type: Research article Published on:

  15. The association of ABO blood groups with gastric cancer risk was proposed decades ago, but the results have been inconsistent.

    Authors: Yingying Mao, Wenjun Yang, Qi Qi, Fei Yu, Tianpei Wang, Hongfei Zhang, Juncheng Dai, Hongxia Ma, Zhibin Hu, Hongbing Shen, Gang Li and Guangfu Jin
    Citation: BMC Cancer 2019 19:164
    Content type: Research article Published on:

  16. Small cell lung cancer (SCLC) is characterized by a high propensity for metastases and a poor prognosis irrespective of high sensitivity for initial chemotherapy. Although interstitial pneumonia (IP) is one of...

    Authors: Masayuki Shirasawa, Tomoya Fukui, Seiichiro Kusuhara, Yasuhiro Hiyoshi, Yoshiro Nakahara, Noriko Nishinarita, Satoshi Igawa and Katsuhiko Naoki
    Citation: BMC Cancer 2019 19:163
    Content type: Research article Published on:

  18. MicroRNAs (miRNA) and other small RNAs are frequently dysregulated in cancer and are promising biomarkers for colon cancer. Here we profile human, virus and bacteria small RNAs in normal and tumor tissue from ...

    Authors: Robin Mjelle, Wenche Sjursen, Liv Thommesen, Pål Sætrom and Eva Hofsli
    Citation: BMC Cancer 2019 19:161
    Content type: Research article Published on:

  19. The Delirium Observation Screening Scale (DOS) was developed to facilitate early recognition of delirium by nurses during routine clinical care. It has shown good validity in a variety of patient populations, ...

    Authors: Elisabeth C. W. Neefjes, Maurice J. D. L. van der Vorst, Manon S. A. Boddaert, Bea A. T. T. Verdegaal, Aart Beeker, Saskia C. C. Teunissen, Aartjan T. F. Beekman, Wouter W. A. Zuurmond, Johannes Berkhof and Henk M. W. Verheul
    Citation: BMC Cancer 2019 19:160
    Content type: Research article Published on:

  20. Identifying high-risk patients for platinum resistance is critical for improving clinical management of ovarian cancer. We aimed to use automated image analysis of hematoxylin & eosin (H&E) stained sections to...

    Authors: C. Lan, J. Li, X. Huang, A. Heindl, Y. Wang, S. Yan and Y. Yuan
    Citation: BMC Cancer 2019 19:159
    Content type: Research article Published on:

  21. Osteosarcoma strikes hundreds of people each year, of both advanced and younger ages, and is often terminal. Like many tumor types, these bone tumors will frequently undergo a neuroendocrine transition, utiliz...

    Authors: Marcus A. Weinman, Jacob A. Fischer, Dakota C. Jacobs, Cheri P. Goodall, Shay Bracha and Patrick E. Chappell
    Citation: BMC Cancer 2019 19:158
    Content type: Research article Published on:

  22. Glioblastoma (GBM) is the most common and aggressive type of primary brain cancer. With median survival of less than 15 months, identification and validation of new GBM therapeutic targets is of critical impor...

    Authors: Anna Ostrovskaya, Caroline Hick, Dana S. Hutchinson, Brett W. Stringer, Peter J. Wookey, Denise Wootten, Patrick M. Sexton and Sebastian G. B. Furness
    Citation: BMC Cancer 2019 19:157
    Content type: Research article Published on:

  23. We analyzed the efficacy and toxicity of cabazitaxel (CBZ) at high and low initial doses in Japanese patients with docetaxel-resistant castration-resistant prostate cancer (CRPC).

    Authors: Naoki Terada, Toshiyuki Kamoto, Hiromasa Tsukino, Shoichiro Mukai, Shusuke Akamatsu, Takahiro Inoue, Osamu Ogawa, Shintaro Narita, Tomonori Habuchi, Shinichi Yamashita, Koji Mitsuzuka, Yoichi Arai, Shuya Kandori, Takahiro Kojima, Hiroyuki Nishiyama, Yoshiaki Kawamura…
    Citation: BMC Cancer 2019 19:156
    Content type: Research article Published on:

  24. The human leucine-rich, repeat-containing G protein-coupled receptor 5 (LGR5) is a stem cell marker in numerous adult tissues and is overexpressed in a large number of human carcinoma including colon cancer, brea...

    Authors: Swetlana Rot, Tom Kaune, Helge Taubert, Thomas Greither, Johanna Kotrba, Antje Güttler, Henri Wichmann, Udo Bilkenroth, Andreas Wienke, Bilal Al-Nawas, Matthias Bache, Dirk Vordermark, Claudia Wickenhauser, Daniel Bethmann, Alexander W. Eckert and Matthias Kappler
    Citation: BMC Cancer 2019 19:155
    Content type: Research article Published on:

  25. The aim of this study was to evaluate the prevalence of some gynecological cancer risk factors in a population of female relatives of cancer patients in Hacettepe University Oncology Hospital. Additionally, wh...

    Authors: Nooria Atta, Saadettin Kilickap, Deniz Yuce and Mutlu Hayran
    Citation: BMC Cancer 2019 19:154
    Content type: Research article Published on:

  26. Programmed cell death ligand 1 (PD-L1) is an important immune-inhibitory protein expressed on cancer cells to mediate cancer escape through interaction with PD-1 expressed on activated T lymphocytes (T cells)....

    Authors: Mingshui Chen, Aditi Sharma, Yanling Lin, Yanheng Wu, Qi He, Yushu Gu, Zhi Ping Xu, Michael Monteiro and Wenyi Gu
    Citation: BMC Cancer 2019 19:153
    Content type: Research article Published on:

  27. Following publication of the original article [1], the authors notified us of an error in the reported percentages in Table 3.

    Authors: Charlotte Woodhead, Ruth Cunningham, Mark Ashworth, Elizabeth Barley, Robert J. Stewart and Max J. Henderson
    Citation: BMC Cancer 2019 19:152
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2016 16:819

  28. Chemotherapy-induced thrombocytopenia (CIT) is a potentially serious complication that can lead to chemotherapy dose delays, dose reductions, or discontinuation, and increases the risk of serious bleeding even...

    Authors: Derek Weycker, Mark Hatfield, Aaron Grossman, Ahuva Hanau, Alex Lonshteyn, Anjali Sharma and David Chandler
    Citation: BMC Cancer 2019 19:151
    Content type: Research article Published on:

  29. Cognitive impairment is commonly reported in patients receiving chemotherapy, but the acuity of onset is not known. This study utilized the psychomotor vigilance test (PVT) and trail-making test B (TMT-B) to a...

    Authors: Omar F. Khan, Ellen Cusano, Soundouss Raissouni, Mica Pabia, Johanna Haeseker, Nicholas Bosma, Jenny J. Ko, Haocheng Li, Aalok Kumar, Michael M. Vickers and Patricia A. Tang
    Citation: BMC Cancer 2019 19:150
    Content type: Research article Published on:

  30. Chemotherapy-induced alopecia has been well documented as a cause of distress to patients undergoing cancer treatment. Almost all traditional chemotherapeutic agents cause severe alopecia. Despite advances in ...

    Authors: Young-Cheol Lim, Hyeongi Kim, Sang Moo Lim and Jin Su Kim
    Citation: BMC Cancer 2019 19:149
    Content type: Research article Published on:

  31. A hypoxic microenvironment leads to an increase in the invasiveness and the metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition (EMT) and cancer stemness acquisition. H...

    Authors: Nahyeon Kang, Su Yeon Choi, Bit Na Kim, Chang Dong Yeo, Chan Kwon Park, Young Kyoon Kim, Tae-Jung Kim, Seong-Beom Lee, Sug Hyung Lee, Jong Y. Park, Mi Sun Park, Hyeon Woo Yim and Seung Joon Kim
    Citation: BMC Cancer 2019 19:148
    Content type: Research article Published on:

  32. The patient satisfaction of symptoms improvement and disease factors that may affect long-term treatment efficacy of radiofrequency ablation (RFA) for non-functioning solid benign thyroid nodules (TNs) over a ...

    Authors: Yang Guang, Wen He, Yukun Luo, Hongxia Zhang, Yukang Zhang, Bin Ning and Tengfei Yu
    Citation: BMC Cancer 2019 19:147
    Content type: Research article Published on:

  34. The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and o...

    Authors: Wen-Ya Li, Ting-Ting Zhao, Hui-Mian Xu, Zhen-Ning Wang, Ying-Ying Xu, Yunan Han, Yong-Xi Song, Jian-Hua Wu, Hao Xu, Song-Cheng Yin, Xing-Yu Liu and Zhi-Feng Miao
    Citation: BMC Cancer 2019 19:145
    Content type: Research article Published on:

  35. Previous related studies have mainly focused on renal cell carcinoma (RCC) with venous tumor thrombus, specifically inferior vena cava tumor thrombus with renal vein tumor thrombus (RVTT). However, only a few ...

    Authors: Chuanzhen Cao, Xingang Bi, Jing Liang, Lin Li, Huijuan Zhang, Zhendong Xiao, Zejun Xiao, Jun Tian, Dong Wang, Kaopeng Guan, Changling Li, Jianhui Ma, Shan Zheng and Jianzhong Shou
    Citation: BMC Cancer 2019 19:144
    Content type: Research article Published on:

  36. The nucleic acid mutation status in intracranial metastasis is markedly significant clinically. The goal of the current study was to explore whether the tumor-associated mutations can be detected by different ...

    Authors: Mengxi Ge, Qiong Zhan, Zhenzhen Zhang, Xiaoyu Ji, Xinli Zhou, Ruofan Huang and Xiaohua Liang
    Citation: BMC Cancer 2019 19:143
    Content type: Research article Published on:

  37. Patients suffering from high risk stage II colon cancer (CC) may benefit from adjuvant onco-therapy, but additional prognostic markers are needed for better treatment stratification. We investigated the progno...

    Authors: Ann C. Eriksen, Flemming B. Sørensen, Jan Lindebjerg, Henrik Hager, René dePont Christensen, Sanne Kjær-Frifeldt and Torben F. Hansen
    Citation: BMC Cancer 2019 19:142
    Content type: Research article Published on:

  38. Despite the recent progress in the development of anti-cancer drugs, the treatment of metastatic tumors is usually ineffective. The systemic inflammatory response performs key roles in different stages of the ...

    Authors: O. Abu-Shawer, M. Abu-Shawer, N. Hirmas, A. Alhouri, A. Massad, B. Alsibai, H. Sultan, H. Hammo, M. Souleiman, Y. Shebli and M. Al-Hussaini
    Citation: BMC Cancer 2019 19:141
    Content type: Research article Published on:

  39. The prognostic value of body composition in cancer patients has been widely studied during the last decade. The main finding of these studies is that sarcopenia, or skeletal muscle depletion, assessed by CT im...

    Authors: Nicolas Charette, Caroline Vandeputte, Lieveke Ameye, Camille Van Bogaert, Jonathan Krygier, Thomas Guiot, Amélie Deleporte, Thierry Delaunoit, Karen Geboes, Jean-Luc Van Laethem, Marc Peeters, Gauthier Demolin, Stéphane Holbrechts, Patrick Flamen, Marianne Paesmans and Alain Hendlisz
    Citation: BMC Cancer 2019 19:134
    Content type: Research article Published on:

  40. Evidence from clinical trials suggests that the addition of bevacizumab to chemotherapy in the first-line treatment of patients with HER2-negative metastatic breast cancer improves progression-free survival (P...

    Authors: Audrey Petitjean, Jayne Smith-Palmer, William Valentine, Bertrand Tehard and Stephané Roze
    Citation: BMC Cancer 2019 19:140
    Content type: Research article Published on:

  41. Intracranial and intraspinal tumours are the most numerous solid tumours in children. Some recently defined subtypes are relatively frequent in childhood. Many cancer registries routinely ascertain CNS tumours...

    Authors: Charles A. Stiller, Anita M. Bayne, Aruna Chakrabarty, Tom Kenny and Paul Chumas
    Citation: BMC Cancer 2019 19:139
    Content type: Research article Published on:

  42. Human papillomavirus (HPV) is an etiological agent of cervical cancer. Yet co-factors are believed to be involved in HPV-mediated carcinogenesis. Polycyclic aromatic hydrocarbons (PAHs) are considered as one o...

    Authors: Chuqing Zhang, Yunjing Luo, Rugang Zhong, Priscilla T. Y. Law, Siaw Shi Boon, Zigui Chen, Chi-Hang Wong and Paul K. S. Chan
    Citation: BMC Cancer 2019 19:138
    Content type: Research article Published on:

  43. Cancer-associated fibroblasts (CAFs), activated by tumour cells, are the predominant type of stromal cells in cancer tissue and play an important role in interacting with neoplastic cells to promote cancer pro...

    Authors: Cassandra Ringuette Goulet, Audrey Champagne, Geneviève Bernard, Dominique Vandal, Stéphane Chabaud, Frédéric Pouliot and Stéphane Bolduc
    Citation: BMC Cancer 2019 19:137
    Content type: Research article Published on:

  44. MicroRNAs are noncoding RNA molecules of ~ 22 nucleotides with diagnostic and therapeutic action [Curr Drug Targets, 2015. 16(12): p. 1381-403], affecting the expression of mRNAs involved in invasion, migratio...

    Authors: Olga D’Almeida, Omar Mothar, Esther Apraku Bondzie, Yolande Lieumo, Laure Tagne, Sumeet Gupta, Thomas Volkert, Stuart Levine and Jean-Bosco Tagne
    Citation: BMC Cancer 2019 19:136
    Content type: Research article Published on:

  45. Breast carcinoma is the commonest cancer among UAE population and the most common cancer among females. Examination of the 5′ promoter regions of trefoil factor 3 (TFF3) gene has identified putative estrogen a...

    Authors: Suhail Al-Salam, Manjusha Sudhadevi, Aktham Awwad and Mohamed Al Bashir
    Citation: BMC Cancer 2019 19:135
    Content type: Research article Published on:

  46. Differentiating between cancer patients who will experience metastasis within a short time and who will be long-term survivors without metastasis is a critical aim in healthcare. The microsatellite instability...

    Authors: Michelle E. Penney, Patrick S. Parfrey, Sevtap Savas and Yildiz E. Yilmaz
    Citation: BMC Cancer 2019 19:133
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:437

  47. There are inconsistencies in the literature regarding the prevalence and assessment of chemotherapy-induced peripheral neuropathy (CIPN). This study explored CIPN natural history and its characteristics in pat...

    Authors: Alex Molassiotis, Hui Lin Cheng, Violeta Lopez, Joseph S. K. Au, Alexandre Chan, Aishwarya Bandla, K. T. Leung, Y. C. Li, K. H. Wong, Lorna K. P. Suen, Choi Wan Chan, Janelle Yorke, Carole Farrell and Raghav Sundar
    Citation: BMC Cancer 2019 19:132
    Content type: Research article Published on:

  48. Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) have been emerged as the standard selection in non-small cell lung cancer (NSCLC) patients with EGFR sensitive mutations. However, primar...

    Authors: Junhui Wang and Jianxin Chen
    Citation: BMC Cancer 2019 19:131
    Content type: Case report Published on:

  49. Cancer is the leading cause of death in the developed world, and yet healthcare practitioners infrequently discuss goals of care (GoC) with hospitalized cancer patients. We sought to identify barriers to GoC d...

    Authors: Katrina Lynn Piggott, Ameen Patel, Arthur Wong, Leslie Martin, Alexandra Patel, Matthew Patel, Yudong Liu, Sukhbinder Dhesy-Thind and John J. You
    Citation: BMC Cancer 2019 19:130
    Content type: Research article Published on:

  50. Serum exosomal microRNAs (miRNAs) have been suggested as novel biomarkers for various diseases, especially gastric cancer (GC). But circulating biomarkers for Chronic atrophic gastritis (CAG) which is defined ...

    Authors: Hong Liu, Pei-wu Li, Wei-qin Yang, Hong Mi, Jing-lin Pan, Yuan-cheng Huang, Zheng-kun Hou, Qiu-ke Hou, Qi Luo and Feng-bin Liu
    Citation: BMC Cancer 2019 19:129
    Content type: Research article Published on:

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