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  1. Despite rising incidence rates of colorectal malignancies, only a few prognostic tools have been implemented in proven clinical routine. Cell division and proliferation play a significant role in malignancies....

    Authors: A. Hendricks, F. Gieseler, S. Nazzal, J. H. Bräsen, R. Lucius, B. Sipos, J. H. Claasen, Th. Becker, S. Hinz, G. Burmeister, C. Schafmayer and C. Schrader
    Citation: BMC Cancer 2019 19:429
    Content type: Research article Published on:

  2. Several studies have documented that blood biomarkers can improve basic prognostic models in radiotherapy and radio-chemotherapy for non-small cell lung cancer. The current study evaluated the prognostic impac...

    Authors: Rafał Suwinski, Monika Giglok, Katarzyna Galwas-Kliber, Adam Idasiak, Bozena Jochymek, Regina Deja, Barbara Maslyk, Jolanta Mrochem-Kwarciak and Dorota Butkiewicz
    Citation: BMC Cancer 2019 19:427
    Content type: Research article Published on:

  5. pressurized intraperitoneal aerosol chemotherapy (PIPAC), with or without electrostatic precipitation (ePIPAC), was recently introduced in the treatment of peritoneal metastases (PM) from ovarian cancer (OC). ...

    Authors: Leen Van de Sande, Wouter Willaert, Sarah Cosyns, Kaat De Clercq, Molood Shariati, Katrien Remaut and Wim Ceelen
    Citation: BMC Cancer 2019 19:424
    Content type: Technical advance Published on:

  6. The clinical behavior of prostate cancer (PCa) is variable, and while the majority of cases remain indolent, 10% of patients progress to deadly forms of the disease. Current clinical predictors used at the tim...

    Authors: Constantin Georgescu, Joshua M. Corbin, Sandra Thibivilliers, Zachary D. Webb, Yan D. Zhao, Jan Koster, Kar-Ming Fung, Adam S. Asch, Jonathan D. Wren and Maria J. Ruiz-Echevarría
    Citation: BMC Cancer 2019 19:423
    Content type: Research article Published on:

  7. Ovarian carcinomas presenting homologous recombination deficiency (HRD), which is observed in about 50% of cases, are more sensitive to platinum and PARP inhibitor therapies. Although platinum resistant diseas...

    Authors: Alexandre A. B. A. da Costa, Luisa M. do Canto, Simon Jonas Larsen, Adriana Regina Gonçalves Ribeiro, Carlos Eduardo Stecca, Annabeth Høgh Petersen, Mads M. Aagaard, Louise de Brot, Jan Baumbach, Glauco Baiocchi, Maria Isabel Achatz and Silvia Regina Rogatto
    Citation: BMC Cancer 2019 19:422
    Content type: Research article Published on:

  8. Although the prognostic biomarkers associated with colorectal cancer (CRC) survival are well known, there are limited data on the association between the molecular characteristics and survival after recurrence...

    Authors: Dae-Won Lee, Sae-Won Han, Yongjun Cha, Jeong Mo Bae, Hwang-Phill Kim, Jaemyun Lyu, Hyojun Han, Hyoki Kim, Hoon Jang, Duhee Bang, Jae-Kyung Won, Seung-Yong Jeong, Kyu Joo Park, Gyeong Hoon Kang and Tae-You Kim
    Citation: BMC Cancer 2019 19:421
    Content type: Research article Published on:

  9. At present, palliative systemic chemotherapy is the standard treatment in the Netherlands for gastric cancer patients with peritoneal dissemination. In contrast to lymphatic and haematogenous dissemination, pe...

    Authors: W. J. Koemans, R. T. van der Kaaij, H. Boot, T. Buffart, A. A. F. A. Veenhof, K. J. Hartemink, C. Grootscholten, P. Snaebjornsson, V. P. Retel, H. van Tinteren, S. Vanhoutvin, V. van der Noort, A. Houwink, C. Hahn, A. D. R. Huitema, M. Lahaye…
    Citation: BMC Cancer 2019 19:420
    Content type: Study protocol Published on:

  10. One-third of cervical cancer patients are still diagnosed at advanced stages. The five-year survival rate is decreased in about 50% of advanced stage cervical cancer patients worldwide, and the clinical outcom...

    Authors: Sunyoung Park, Jungho Kim, Kiyoon Eom, Sehee Oh, Sunghyun Kim, Geehyuk Kim, Sungwoo Ahn, Kwang Hwa Park, Dawn Chung and Hyeyoung Lee
    Citation: BMC Cancer 2019 19:419
    Content type: Research article Published on:

  11. The best strategy for surveillance testing in stage II and III colon cancer patients following curative treatment is unknown. Previous randomized controlled trials have suffered from design limitations and yie...

    Authors: Robert B. Hines, Md Jibanul Haque Jiban, Adrian V. Specogna, Priya Vishnubhotla, Eunkyung Lee and Shunpu Zhang
    Citation: BMC Cancer 2019 19:418
    Content type: Research article Published on:

  13. Postoperative chemotherapy is beneficial for many pancreatic cancer patients. However, some patients require dose reduction or the discontinuation of adjuvant chemotherapy because of adverse treatment-related ...

    Authors: Yoshifumi Morita, Takanori Sakaguchi, Ryo Kitajima, Satoru Furuhashi, Ryota Kiuchi, Makoto Takeda, Takanori Hiraide, Yasushi Shibasaki, Hirotoshi Kikuchi, Hiroyuki Konno and Hiroya Takeuchi
    Citation: BMC Cancer 2019 19:416
    Content type: Research article Published on:

  14. While recent years have seen a revolution in the treatment of metastatic cutaneous melanoma, no treatment has yet been able to demonstrate any prolonged survival in metastatic uveal melanoma. Thus, metastatic ...

    Authors: Henrik Jespersen, Roger Olofsson Bagge, Gustav Ullenhag, Ana Carneiro, Hildur Helgadottir, Ingrid Ljuslinder, Max Levin, Charlotta All-Eriksson, Bengt Andersson, Ulrika Stierner, Lisa M. Nilsson, Jonas A. Nilsson and Lars Ny
    Citation: BMC Cancer 2019 19:415
    Content type: Study protocol Published on:

  15. Chemotherapy-induced peripheral neuropathy (CIPN) can affect functional performance and quality of life considerably. Since balance training has proven to enhance physical function, it might be a promising str...

    Authors: S. Kneis, A. Wehrle, J. Müller, C. Maurer, G. Ihorst, A. Gollhofer and H. Bertz
    Citation: BMC Cancer 2019 19:414
    Content type: Research article Published on:

  16. Immunotherapies targeting the PD1/PD-L1 pathway have had a large impact on the treatment of advanced NSCLC. Concerning multimodality tumor therapy, only few trials until today have been performed investigating...

    Authors: Florian Eichhorn, Laura V. Klotz, Helge Bischoff, Michael Thomas, Felix Lasitschka, Hauke Winter, Hans Hoffmann and Martin E. Eichhorn
    Citation: BMC Cancer 2019 19:413
    Content type: Study protocol Published on:

  17. The SK-PN-DW cell line was established in 1979 and is commercially available. Despite the use of this cell line as an in vitro model for functional and therapeutic studies of malignant primitive neuroectoderma...

    Authors: Na Du, Wanguo Bao, Kaiyu Zhang, Xianglan Lu, Rebecca Crew, Xianfu Wang, Guangming Liu and Feng Wang
    Citation: BMC Cancer 2019 19:412
    Content type: Research article Published on:

  18. Autoantibodies function as markers of tumorigenesis and have been proposed to enhance early detection of malignancies. We recently reported, using immunoscreening of a T7 complementary DNA (cDNA) library of br...

    Authors: Siddhesh Aras, Marie-Claire Maroun, Yeohan Song, Sudeshna Bandyopadhyay, Azadeh Stark, Zeng-Quan Yang, Michael P. Long, Lawrence I. Grossman and Félix Fernández-Madrid
    Citation: BMC Cancer 2019 19:411
    Content type: Research article Published on:

  19. Systemic treatment of advanced non-small cell lung cancer (NSCLC) has changed dramatically since the introduction of targeted therapies. The analysis of circulating tumor DNA (ctDNA) is a valuable approach to ...

    Authors: Marzia Del Re, Eleonora Rofi, Carla Cappelli, Gianfranco Puppo, Stefania Crucitta, Simona Valeggi, Antonio Chella, Romano Danesi and Iacopo Petrini
    Citation: BMC Cancer 2019 19:410
    Content type: Case report Published on:

  20. To validate the robust predictive values of tumor vascularity and hand-foot-skin reaction (HFSR) in combination treatment of transarterial chemoembolization (TACE) and sorafenib for patients with intermediate ...

    Authors: Enxin Wang, Dongdong Xia, Wei Bai, Jie Yuan, Xiaomei Li, Jing Niu, Zhanxin Yin, Jielai Xia, Hongwei Cai, Daiming Fan, Guohong Han and Lei Liu
    Citation: BMC Cancer 2019 19:409
    Content type: Research article Published on:

  21. A tumor comprising of different types of tissues (such as hair, muscle, bone, etc.) is known as a teratoma. It is a type of germ cell (cells that make sperm or eggs) tumor. When these germ cells have rapid can...

    Authors: Hang Sun, Hongxin Ding, Jianjun Wang, Emma Zhang, Yihua Fang, Zhenhua Li, Xiao Yu, Chongren Wang, Yifan Zhao, Kan Chen, Siwan Wen, Liang Li, Shan Shan, Liu Hong, Face Chen and Pu Su
    Citation: BMC Cancer 2019 19:408
    Content type: Research article Published on:

  22. Sunitinib plays an important role in managing the metastatic renal cell cancer (mRCC). Sunitinib-induced hypothyroidism is a common side-effect of the drug. There have been attempts to link hypothyroidism with...

    Authors: Theofanis Vasileiadis, Michail Chrisofos, Michail Safioleas, Konstantinos Kontzoglou, Konstantinos Papazisis and Athina Sdrolia
    Citation: BMC Cancer 2019 19:407
    Content type: Research article Published on:

  23. CA125 is a well-established ovarian cancer (OC) serum biomarker. The CA125 heavily glycosylated epitope is carried by the MUC16 mucin, a high molecular weight transmembrane mucin. Upon proteolytic cleavage, th...

    Authors: Isabelle Matte, Perrine Garde-Granger, Paul Bessette and Alain Piché
    Citation: BMC Cancer 2019 19:406
    Content type: Research article Published on:

  24. Wilms’ tumor is also called nephroblastoma and is the most common pediatric renal cancer. Several genetic and epigenetic factors have been found to account for the development of Wilms’ tumor. MiRNAs play impo...

    Authors: Zhuo Liu, Feng He, Shengrong OuYang, Yuanyuan Li, Feifei Ma, Huibo Chang, Dingding Cao and Jianxin Wu
    Citation: BMC Cancer 2019 19:405
    Content type: Research article Published on:

  25. Preoperative chemoradiotherapy (pre-CRT) followed by total mesorectal excision (TME) is currently a standard therapy for locally advanced mid-to-low rectal cancer. Less aggressive, organ-preserving option such...

    Authors: Jong Lyul Lee, Seok-Byung Lim, Chang Sik Yu, In Ja Park, Yong Sik Yoon, Chan Wook Kim, Seong Ho Park, Jong Seok Lee, Yong Sang Hong, Sun Young Kim, Jeong Eun Kim, Jong Hoon Kim, Jin-hong Park, Jihun Kim and Minkyu Han
    Citation: BMC Cancer 2019 19:404
    Content type: Study protocol Published on:

  27. Different 3D-cell culture approaches with varying degrees of complexity have been developed to serve as melanoma models for drug testing or mechanistic studies. While these 3D-culture initiatives are already o...

    Authors: Julia Klicks, Christoph Maßlo, Andreas Kluth, Rüdiger Rudolf and Mathias Hafner
    Citation: BMC Cancer 2019 19:402
    Content type: Research article Published on:

  28. Endometrial cancer (EC) is the most common malignancy of the female reproductive tract. Despite years of research, the accurate screening strategy is still not available in this disease and it is usually diagn...

    Authors: Anna Torres, Małgorzata Pac-Sosińska, Krzysztof Wiktor, Tomasz Paszkowski, Ryszard Maciejewski and Kamil Torres
    Citation: BMC Cancer 2019 19:401
    Content type: Research article Published on:

  29. Oral squamous cell carcinoma (OSCC) is an oral and maxillofacial malignancy with a high incidence worldwide. Accumulating evidence indicates that circular RNAs (circRNAs) play a vital role in modulating tumor ...

    Authors: Wen Su, Yufan Wang, Feng Wang, Shuai Sun, Minghua Li, Yuehong Shen and Hongyu Yang
    Citation: BMC Cancer 2019 19:400
    Content type: Research article Published on:

  30. A causal association has been suggested between certain bacteria and colorectal cancer (CRC). Only a few studies have, however, investigated the presence of these bacteria directly in colon tissue with conflic...

    Authors: Caspar Bundgaard-Nielsen, Ulrik T. Baandrup, Lars P. Nielsen and Suzette Sørensen
    Citation: BMC Cancer 2019 19:399
    Content type: Research article Published on:

  31. The search of useful serum biomarkers for the early detection of cervical cancers has been of a high priority. The activation of Macrophage-Colony Stimulating Factor (M-CSF) and Vascular Endothelial Growth Fac...

    Authors: Iwona Sidorkiewicz, Monika Zbucka-Krętowska, Kamil Zaręba, Emilia Lubowicka, Monika Zajkowska, Maciej Szmitkowski, Ewa Gacuta and Sławomir Ławicki
    Citation: BMC Cancer 2019 19:398
    Content type: Research article Published on:

  32. The importance of definitive radiotherapy for elderly patients with esophageal and esophagogastric-junction cancer is pronounced. However, little is known in terms of the best way to combine radiotherapy with ...

    Authors: Chen Li, Xiaomin Wang, Xin Wang, Chun Han, Ping Wang, Qingsong Pang, Junqiang Chen, Xinchen Sun, Lan Wang, Wencheng Zhang, Yu Lin, Xiaolin Ge, Zongmei Zhou, Wenjie Ni, Xiao Chang, Jun Liang…
    Citation: BMC Cancer 2019 19:397
    Content type: Study protocol Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:492

  33. With the introduction of Olaparib treatment for BRCA-deficient recurrent ovarian cancer, testing for somatic and/or germline mutations in BRCA1/2 genes in tumor tissues became essential for treatment decisions. I...

    Authors: Falk Zakrzewski, Laura Gieldon, Andreas Rump, Michael Seifert, Konrad Grützmann, Alexander Krüger, Sina Loos, Silke Zeugner, Karl Hackmann, Joseph Porrmann, Johannes Wagner, Karin Kast, Pauline Wimberger, Gustavo Baretton, Evelin Schröck, Daniela Aust…
    Citation: BMC Cancer 2019 19:396
    Content type: Technical advance Published on:

  34. The liver microenvironment plays a key role in the progression and metastasis of hepatocellular carcinoma (HCC). Gene expression profiling of non-cancerous hepatic tissues obtained from patients with metastati...

    Authors: Weimin Li, Xia Liao, Pengbo Ning, Yu Cao, Mei Zhang, Yang Bu, Jun Lv and Qingan Jia
    Citation: BMC Cancer 2019 19:395
    Content type: Research article Published on:

  35. Locally advanced pancreatic cancer (LAPC) represents more than one third of pancreatic cancers and owns poor survival after the standard chemotherapy. Irreversible electroporation (IRE) is a novel method and h...

    Authors: Chaobin He, Jun Wang, Shuxin Sun, Yu Zhang, Xiaojun Lin, Xiangming Lao, Bokang Cui and Shengping Li
    Citation: BMC Cancer 2019 19:394
    Content type: Research article Published on:

  36. In Ethiopia, the incidence of new cases of breast cancer is currently increasing resulting to high rates of morbidity and mortality. Breast cancer is by far the most common cancer accounting for more than one ...

    Authors: Biniyam Tefera Deressa, Nikola Cihoric, Eugenia Vlaskou Badra, Alexandros Tsikkinis and Daniel Rauch
    Citation: BMC Cancer 2019 19:393
    Content type: Research article Published on:

  37. A review of therapies for advanced cancers licenced by the EMA between 2009 and 2013 concluded that for more than half of these drugs there was little evidence of overall survival or quality of life benefit. R...

    Authors: Martin Connock, Xavier Armoiry, Alexander Tsertsvadze, G. J. Melendez-Torres, Pamela Royle, Lazaros Andronis and Aileen Clarke
    Citation: BMC Cancer 2019 19:392
    Content type: Research article Published on:

  38. Oral cancer has been estimated as the sixth most frequent solid cancer all over the world, in which tongue squamous cell carcinoma (TSCC) is the most common type of oral cancers. However, the mechanism of TSCC...

    Authors: Jin-Yun Li, Wen-Xiao Huang, Xiao Zhou, Jie Chen and Zan Li
    Citation: BMC Cancer 2019 19:391
    Content type: Research article Published on:

  39. Upfront cytoreductive surgery with HIPEC (CRS-HIPEC) is the standard treatment for isolated resectable colorectal peritoneal metastases (PM) in the Netherlands. This study investigates whether addition of peri...

    Authors: Koen P. Rovers, Checca Bakkers, Geert A. A. M. Simkens, Jacobus W. A. Burger, Simon W. Nienhuijs, Geert-Jan M. Creemers, Anna M. J. Thijs, Alexandra R. M. Brandt-Kerkhof, Eva V. E. Madsen, Ninos Ayez, Nadine L. de Boer, Esther van Meerten, Jurriaan B. Tuynman, Miranda Kusters, Nina R. Sluiter, Henk M. W. Verheul…
    Citation: BMC Cancer 2019 19:390
    Content type: Study protocol Published on:

  40. The impact of Tet oncogene family member 2 (TET2) mutations on the prognosis of acute myeloid leukemia (AML) is still controversial. A meta analysis is needed in order to assess the prognostic significance of TET...

    Authors: Ruiqi Wang, Xiaoning Gao and Li Yu
    Citation: BMC Cancer 2019 19:389
    Content type: Research article Published on:

  41. Gene expression profiling provides key information for prognosis of breast cancer to establish treatment strategy. However, the genetic assessment should be available before induction of treatment to be useful...

    Authors: Jeeyeon Lee, Eun Hye Lee, Ho Yong Park, Wan Wook Kim, Ryu Kyung Lee, Yee Soo Chae, Soo Jung Lee, Jee-Eun Kim, Byeong-il Kang, Jee Young Park, Ji-Young Park and Jin Hyang Jung
    Citation: BMC Cancer 2019 19:388
    Content type: Research article Published on:

  42. Effector CD8+ T cell activation and its cytotoxic function to eradicate tumor cells depend on the T cell recognition of tumor neoantigens, and are positively associated with improved survival in breast cancer. Tu...

    Authors: Lingeng Lu, Huatian Huang, Jing Zhou, Wenxue Ma, Sean Mackay and Zuoheng Wang
    Citation: BMC Cancer 2019 19:387
    Content type: Research article Published on:

  43. Previous neurocognitive assessments in non-central nervous system cancers highlight the high incidence of neurocognitive dysfunction in this study population. However, there have been few studies exploring neu...

    Authors: Yingchun Zeng, Andy S. K. Cheng, Ting Song, Xiujie Sheng, Huaidong Cheng, Yingwei Qiu, Jianfei Xie and Chetwyn C. H. Chan
    Citation: BMC Cancer 2019 19:386
    Content type: Research article Published on:

  44. Current recommendation for locally advanced cervical cancer includes pelvic external beam radiation therapy (EBRT) with concurrent chemotherapy followed by brachytherapy. Involvement of pelvic lymph nodes is a...

    Authors: Caryn Wujanto, Bok Ai Choo, David Tan, Arunachalam Ilancheran, Joseph Ng, Jeffrey J. H. Low, Liang Shen, Johann Tang and Vicky Koh
    Citation: BMC Cancer 2019 19:385
    Content type: Research article Published on:

  45. Little is known about the pathway to diagnosis of lymphoma in Sub-Saharan Africa, despite the increased risk of lymphoma in people living with HIV (PLHIV). The challenges of diagnosis in this setting include d...

    Authors: Katherine Antel, Carly Levetan, Zainab Mohamed, Vernon J Louw, Jenna Oosthuizen, Gary Maartens and Estelle Verburgh
    Citation: BMC Cancer 2019 19:384
    Content type: Research article Published on:

  46. Malignant pleural mesothelioma (MPM) is a fatal and rare disease that is caused by the inhalation of asbestos. Treatment and care requests made by MPM patients to their physicians were collected and analyzed.

    Authors: Yasuko Nagamatsu, Isao Oze, Keisuke Aoe, Katsuyuki Hotta, Katsuya Kato, Junko Nakagawa, Keiko Hara, Takumi Kishimoto and Nobukazu Fujimoto
    Citation: BMC Cancer 2019 19:383
    Content type: Research article Published on:

  47. Lung cancer patients undergoing palliative chemotherapy exhibit many symptoms related to the disease, such as adverse events and infectious complications during treatment, which impacts directly their health-r...

    Authors: Daniel D’Almeida Preto, Mariana Toledo Baston, Camilla Centurion Geraige, Sarah Bertazzi Augusto, Marco Antonio de Oliveira, Augusto Elias Mamere, Gustavo Dix Junqueira Pinto, Josiane Mourão Dias, Pedro Rafael Martins De Marchi, Bianca Sakamoto Ribeiro Paiva and Carlos Eduardo Paiva
    Citation: BMC Cancer 2019 19:382
    Content type: Study protocol Published on:

  48. Salinomycin is a monocarboxylic polyether antibiotic and is a potential chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth and targeted CSCs in prostate cancer. However, the ...

    Authors: Yunsheng Zhang, Fang Li, Luogen Liu, Hongtao Jiang, Hua Hu, Xiaobo Du, Xin Ge, Jingsong Cao and Yi Wang
    Citation: BMC Cancer 2019 19:381
    Content type: Research article Published on:

  49. The healthcare system (HCS) improved in Tibet Autonomous Region (TAR), China. The present study aimed to investigate whether these improvements might alter the clinicopathological characteristics of a Tibetan ...

    Authors: Yulan Zhao, Hanhuan Luo, Xintian Zhang, Tashi Bianba, Lin Li, Qian Wang, Lei Guo, Dian Wang, Yongge Ze and Shan Zheng
    Citation: BMC Cancer 2019 19:380
    Content type: Research article Published on:

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