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  1. Many patients diagnosed with oesophageal adenocarcinoma (OAC) present with advanced disease and approximately half present with metastatic disease. Patients with localised disease, who are managed with curativ...

    Authors: Becky A. S. Bibby, Cecelia S. Miranda, John V. Reynolds, Christopher J. Cawthorne and Stephen G. Maher
    Citation: BMC Cancer 2019 19:784
    Content type: Research article Published on:

  3. The most recent results of Global Cancer Statistics indicated that gastrointestinal cancers, including gastric, colorectal, esophageal, and liver cancers, are among the most commonly diagnosed cancers worldwid...

    Authors: Mohammad Hossein Somi, Roya Dolatkhah, Sepideh Sepahi, Mina Belalzadeh, Shahnaz Naghashi and Mohammad Asghari Jafarabadi
    Citation: BMC Cancer 2019 19:782
    Content type: Research article Published on:

  4. Numerous studies have highlighted that long non-coding RNAs (lncRNAs) can bind to microRNA (miRNA) sites as competing endogenous RNAs (ceRNAs), thereby affecting and regulating the expression of mRNAs and targ...

    Authors: Rui-Sheng Zhou, En-Xin Zhang, Qin-Feng Sun, Zeng-Jie Ye, Jian-Wei Liu, Dai-Han Zhou and Ying Tang
    Citation: BMC Cancer 2019 19:779
    Content type: Research article Published on:

  5. Lung cancer in young patients is rare and has unique clinicopathological features. However, the molecular features of lung cancer in these patients are unclear. In this study, we aimed to describe the molecula...

    Authors: Zhen Chen, Xiao Teng, Jing Zhang, Ke Huang, Qian Shen, He Cao, Huisong Luo, Yanting Yuan and Xiaodong Teng
    Citation: BMC Cancer 2019 19:777
    Content type: Research article Published on:

  8. Trastuzumab emtansine (Kadcyla®, T-DM1) is an antibody-drug conjugate used to treat HER2 (human epidermal growth factor receptor 2) overexpressing metastatic breast cancer. In this report, we present the first...

    Authors: Chung Young Kim, Namju Kim, Ho-Kyung Choung and Sang In Khwarg
    Citation: BMC Cancer 2019 19:774
    Content type: Case report Published on:

  9. The mTOR/S6K1 signaling pathway is often activated in cervical cancer, and thus considered a molecular target for cervical cancer therapies. Inhibiting mTOR is cytotoxic to cervical cancer cells and creates a ...

    Authors: Ki Hong Nam, Sang Ah Yi, Gibeom Nam, Jae Sung Noh, Jong Woo Park, Min Gyu Lee, Jee Hun Park, Hwamok Oh, Jieun Lee, Kang Ro Lee, Hyun-Ju Park, Jaecheol Lee and Jeung-Whan Han
    Citation: BMC Cancer 2019 19:773
    Content type: Research article Published on:

  10. Multiple primary melanomas (MPM) occur up to 8% of patients with cutaneous malignant melanoma (CMM). They are often sporadic harbouring several somatic mutations, but also familial cases harbouring a CDKN2A germl...

    Authors: Milena Casula, Panagiotis Paliogiannis, Fabrizio Ayala, Vincenzo De Giorgi, Ignazio Stanganelli, Mario Mandalà, Maria Colombino, Antonella Manca, Maria Cristina Sini, Corrado Caracò, Paolo Antonio Ascierto, Rosanna Rita Satta, Amelia Lissia, Antonio Cossu and Giuseppe Palmieri
    Citation: BMC Cancer 2019 19:772
    Content type: Research article Published on:

  11. Long non-coding RNAs (lncRNAs) represent a substantial portion of the human transcriptome. LncRNAs present a very stringent cell-type/tissue specificity being potential candidates for therapeutical application...

    Authors: Carla Pereira Gomes, Sandrina Nóbrega-Pereira, Beatriz Domingues-Silva, Kenny Rebelo, Catarina Alves-Vale, Sérgio Pires Marinho, Tânia Carvalho, Sérgio Dias and Bruno Bernardes de Jesus
    Citation: BMC Cancer 2019 19:771
    Content type: Research article Published on:

  12. Etoposide (E) at 100 mg/m2 combined with Cisplatin (P) at 20 mg/m2 represents an induction 2-day regimen embedded in our clinical practice for patients with advanced GCT or TN at high risk of early death. We eval...

    Authors: Charleen Chan Wah Hak, Christopher Coyle, Arwa Kocache, Dee Short, Naveed Sarwar, Michael J. Seckl and Michael A. Gonzalez
    Citation: BMC Cancer 2019 19:770
    Content type: Research article Published on:

  13. ROS1 rearrangements are validated drivers in lung cancer, which have been identified in a small subset (1–2%) of patients with non-small cell lung cancer (NSCLC). To date, 18 fusion genes of ROS1 have been identi...

    Authors: Shuguang Xu, Wenxian Wang, Chunwei Xu, Xingliang Li, Junhui Ye, Youcai Zhu and Ting Ge
    Citation: BMC Cancer 2019 19:769
    Content type: Case report Published on:

  14. Human papillomavirus is recognized as a major cause of cervical cancer. It is estimated that annually, 7,095 women are diagnosed with cervical cancer and 4,732 die from the disease in Ethiopia. Understanding that...

    Authors: Kirubel Eshetu Ali, Ibrahim Ali Mohammed, Mesfin Nigussie Difabachew, Dawit Solomon Demeke, Tasew Haile, Robert-Jan ten Hove, Tsegaye Hailu Kumssa, Zufan Lakew Woldu, Eshetu Lemma Haile and Kassu Desta Tullu
    Citation: BMC Cancer 2019 19:768
    Content type: Research article Published on:

  15. Positron emission tomography (PET) and PET/computed tomography (PET/CT) imaging with 3,4-dihydroxy-6-[18F] fluoro-L-phenylalanine (18F-FDOPA) has been used in the evaluation of gliomas. We performed a meta-analys...

    Authors: Jiarui Xiao, Yizi Jin, Ji Nie, Fukun Chen and Xuelei Ma
    Citation: BMC Cancer 2019 19:767
    Content type: Research article Published on:

  16. To describe the patterns of second-line treatment of patients with metastatic castration-resistant prostate cancer (mCRPC) after docetaxel treatment in a Spanish population, to identify the factors associated ...

    Authors: Javier Puente, Aranzazu González-del-Alba, Núria Sala-Gonzalez, María José Méndez-Vidal, Alvaro Pinto, Ángel Rodríguez, José Miguel Cuevas Sanz, Jacobo Rodrigo Muñoz del Toro, Eduardo Useros Rodríguez, Ángela García García-Porrero and Sergio Vázquez
    Citation: BMC Cancer 2019 19:766
    Content type: Research article Published on:

  17. Worldwide, over 500,000 people are diagnosed with head and neck cancer each year, a disease with major impact on life expectancy and quality of life. The purpose of the Netherlands Quality of life and Biomedic...

    Authors: I.M. Verdonck-de Leeuw, F. Jansen, R. H. Brakenhoff, J. A. Langendijk, R. Takes, C. H. J. Terhaard, R. J. Baatenburg de Jong, J. H. Smit and C. R. Leemans
    Citation: BMC Cancer 2019 19:765
    Content type: Study protocol Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:982

  18. MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers. A plethora of drugs wer...

    Authors: Ning Wang, Yanhua Fan, Chun-Mao Yuan, Jialei Song, Yao Yao, Wuling Liu, Babu Gajendran, Eldad Zacksenhaus, Yanmei Li, Jielin Liu, Xiao Jiang Hao and Yaacov Ben-David
    Citation: BMC Cancer 2019 19:764
    Content type: Research article Published on:

  19. Bladder leiomyosarcoma is the most frequent mesenchymal neoplasm of the bladder. However, the rarity of the disease and some morphological aspects could give serious problems to differential diagnosis.

    Authors: Vincenzo Fiorentino, Francesco Pierconti, Niccolò Lenci, Martina Calicchia, Giuseppe Palermo, Pierfrancesco Bassi, Luigi Maria Larocca and Maurizio Martini
    Citation: BMC Cancer 2019 19:763
    Content type: Case report Published on:

  20. Acquired immunodeficiency associated with thymoma is a rare disorder. Here we reported a case of acquired immunodeficiency with thymoma, with an unusual pattern of low CD4+ count with normal gammaglobulin levels.

    Authors: Takahisa Kawamura, Tateaki Naito, Haruki Kobayashi, Kazuhisa Nakashima, Shota Omori, Kazushige Wakuda, Akira Ono, Hirotsugu Kenmotsu, Haruyasu Murakami, Masahiro Endo and Toshiaki Takahashi
    Citation: BMC Cancer 2019 19:762
    Content type: Case report Published on:

  22. The role of sphere-forming culture in enriching subpopulations with stem-cell properties in hepatocellular carcinoma (HCC) is unclear. The present study investigates its value in enriching cancer stem cells (C...

    Authors: Xiao-Lu Ma, Yun-Fan Sun, Bei-Li Wang, Min-Na Shen, Yan Zhou, Jian-Wen Chen, Bo Hu, Zi-Jun Gong, Xin Zhang, Ya Cao, Bai-shen Pan, Jian Zhou, Jia Fan, Wei Guo and Xin-Rong Yang
    Citation: BMC Cancer 2019 19:760
    Content type: Research article Published on:

  24. Efficacy of treatments for colorectal liver metastases after failure of first-line chemotherapy is limited. The aim of this study was to prospectively evaluate the feasibility, tolerability, and pharmacokineti...

    Authors: Toshihiro Tanaka, Takeshi Sato, Hideyuki Nishiofuku, Tetsuya Masada, Shota Tatsumoto, Nagaaki Marugami, Toshio Otsuji, Masatoshi Kanno, Fumikazu Koyama, Masayuki Sho and Kimihiko Kichikawa
    Citation: BMC Cancer 2019 19:758
    Content type: Research article Published on:

  25. Doxorubicin is currently the most effective chemotherapeutic drug used to treat breast cancer. It has, however, been shown that doxorubicin can induce drug resistance resulting in poor patient prognosis and su...

    Authors: Claudia Christowitz, Tanja Davis, Ashwin Isaacs, Gustav van Niekerk, Suzel Hattingh and Anna-Mart Engelbrecht
    Citation: BMC Cancer 2019 19:757
    Content type: Research article Published on:

  26. Glioblastoma multiforme (GBM) is the most severe type of primary brain tumor with a high mortality rate. Although extensive treatments for GBM, including resection, irradiation, chemotherapy and immunotherapy,...

    Authors: Jui-Chieh Chen, I-Neng Lee, Cheng Huang, Yu-Ping Wu, Chiu-Yen Chung, Ming-Hsueh Lee, Martin Hsiu-Chu Lin and Jen-Tsung Yang
    Citation: BMC Cancer 2019 19:756
    Content type: Research article Published on:

  27. For brain metastases from non-specific primary tumors, the most frequently used and validated clinical prognostic assessment tool is Karnofsky performance status (KPS). Given the lack of prognostic factors of ...

    Authors: Jun Imaizumi, Dai Shida, Yoshitaka Narita, Yasuji Miyakita, Taro Tanabe, Atsuo Takashima, Narikazu Boku, Hiroshi Igaki, Jun Itami and Yukihide Kanemitsu
    Citation: BMC Cancer 2019 19:755
    Content type: Research article Published on:

  29. This study explored the attitudes of patients with advanced cancer towards MTP and return of results, prior to undergoing genomic testing within a research program.

    Authors: Megan C. Best, Nicole Bartley, Chris Jacobs, Ilona Juraskova, David Goldstein, Ainsley J. Newson, Jacqueline Savard, Bettina Meiser, Mandy Ballinger, Christine Napier, David Thomas, Barbara Biesecker and Phyllis Butow
    Citation: BMC Cancer 2019 19:753
    Content type: Research article Published on:

  32. Human inflammatory breast cancer (IBC) and canine inflammatory mammary cancer (IMC) are the most lethal mammary cancers. An exacerbated angiogenesis and the existence of vasculogenic mimicry (VM) are hallmarks...

    Authors: Lucía Barreno, Sara Cáceres, Ángela Alonso-Diez, Ana Vicente-Montaña, María Luisa García, Mónica Clemente, Juan Carlos Illera and Laura Peña
    Citation: BMC Cancer 2019 19:750
    Content type: Research article Published on:

  33. Evidence is emerging that older women may tolerate breast cancer therapies equally well as the young ones, providing that they receive good supportive care. It has also been reported that these patients remain...

    Authors: Janusz Kocik, Małgorzata Pajączek and Tomasz Kryczka
    Citation: BMC Cancer 2019 19:749
    Content type: Research article Published on:

  34. Primary retroperitoneal serous adenocarcinoma (PRSA) is an extremely uncommon malignancy exclusively reported in females. Due to the rarity of the disease, it is difficult to establish a standardized treatment.

    Authors: Young Kwang Chae, Naira Saleem, Yoonhwan Roh, Haris Bilal, Pedro Viveiros, Bhoomika Sukhadia, Xiaoqi Lin, Muhammad Mubbashir Sheikh and Lee Chun Park
    Citation: BMC Cancer 2019 19:748
    Content type: Case report Published on:

  35. Phospholipase Cγ1 (PLCγ1) is highly expressed in human tumours. Our previous studies reported that both stable and inducible PLCγ1 down-regulation can inhibit formation of breast-cancer-derived experimental lu...

    Authors: Rossano Lattanzio, Manuela Iezzi, Gianluca Sala, Nicola Tinari, Marco Falasca, Saverio Alberti, Simonetta Buglioni, Marcella Mottolese, Letizia Perracchio, Pier Giorgio Natali and Mauro Piantelli
    Citation: BMC Cancer 2019 19:747
    Content type: Research article Published on:

  36. Expression of human chorionic gonadotropin beta subunit by cancers is extensively documented, yet regulation of the multiple genes that can code for this protein is poorly understood. The aim of the study was ...

    Authors: Aleksandra Śliwa, Marta Kubiczak, Anna Szczerba, Grzegorz Walkowiak, Ewa Nowak-Markwitz, Beata Burczyńska, Stephen Butler, Ray Iles, Piotr Białas and Anna Jankowska
    Citation: BMC Cancer 2019 19:746
    Content type: Research article Published on:

  37. Estrogen receptor β (ERβ) has been repeatedly suggested to play important roles in hormone-dependent cancer like in tumors of the breast, ovary or prostate. In this study, we intended to further elucidate its ...

    Authors: Oliver Treeck, Elisabeth Diepolder, Maciej Skrzypczak, Susanne Schüler-Toprak and Olaf Ortmann
    Citation: BMC Cancer 2019 19:745
    Content type: Research article Published on:

  38. Gestational choriocarcinoma is a rare malignancy believed to arise from the trophoblast cells of the placenta. Despite the frequently aggressive clinical nature, choriocarcinoma has been routinely curable with...

    Authors: Philip Savage, David Monk, Jose R. Hernandez Mora, Nick van der Westhuizen, Jennifer Rauw, Anna Tinker, Wendy Robinson, Qianqian Song, Michael J. Seckl and Rosemary A. Fisher
    Citation: BMC Cancer 2019 19:744
    Content type: Research article Published on:

  39. Salivary adenoid cystic carcinoma (SACC) can recur after removal of the primary tumor and treatment, where they can keep no clinical symptoms and dormant state for 10–15 years. NR2F1 has been demonstrated to r...

    Authors: Xiao-lei Gao, Min Zheng, Hao-fan Wang, Lu-ling Dai, Xiang-hua Yu, Xiao Yang, Xin Pang, Li Li, Mei Zhang, Sha-sha Wang, Jing-biao Wu, Ya-Jie Tang, Xin-hua Liang and Ya-ling Tang
    Citation: BMC Cancer 2019 19:743
    Content type: Research article Published on:

  40. There are different contouring guidelines for the clinical target volume (CTV) in anal cancer (AC) which vary concerning recommendations for radiation margins in different anatomical regions, especially on ing...

    Authors: Hendrik Dapper, Kilian Schiller, Stefan Münch, Jan C. Peeken, Kai Borm, Wolfgang Weber and Stephanie E. Combs
    Citation: BMC Cancer 2019 19:742
    Content type: Research article Published on:

  41. The overall prognosis of non-small cell lung cancer (NSCLC) is poor, and currently only patients with localized disease are potentially curable. Therefore, preferably non-invasively determined biomarkers that ...

    Authors: Dijana Djureinovic, Victor Pontén, Per Landelius, Sahar Al Sayegh, Kai Kappert, Masood Kamali-Moghaddam, Patrick Micke and Elisabeth Ståhle
    Citation: BMC Cancer 2019 19:741
    Content type: Research article Published on:

  42. Emerging evidence has shown that miR-1275 plays a critical role in tumour metastasis and the progression of various types of cancer. In this study, we analysed the role and mechanism of miR-1275 in the progres...

    Authors: Jia-Wei Mei, Zi-Yi Yang, Hong-Gang Xiang, Runfa Bao, Yuan-Yuan Ye, Tai Ren, Xue-Feng Wang and Yi-Jun Shu
    Citation: BMC Cancer 2019 19:740
    Content type: Research article Published on:

  43. Genipin is a compound derived from gardenia fruit extract. Although Genipin has anti-tumor effects in various cancers, its effect and mechanism in gastric cancer remain unclear. Here, we investigated the relat...

    Authors: Min Jee Jo, Soyeon Jeong, Hye Kyeong Yun, Dae Yeong Kim, Bo Ram Kim, Jung Lim Kim, Yoo Jin Na, Seong Hye Park, Yoon A. Jeong, Bu Gyeom Kim, Hassan Ashktorab, Duane T. Smoot, Jun Young Heo, Jeongsu Han, Dae-Hee Lee and Sang Cheul Oh
    Citation: BMC Cancer 2019 19:739
    Content type: Research article Published on:

  44. Breast cancer is the most common cancer type in female. As microRNAs play vital role in breast cancer, this study aimed to explore the molecular mechanism and clinical value of miR-21 in breast cancer.

    Authors: Hui Wang, Zheqiong Tan, Hui Hu, Hongzhou Liu, Tangwei Wu, Chao Zheng, Xiuling Wang, Zhenzhao Luo, Jing Wang, Shuiyi Liu, Zhongxin Lu and Jiancheng Tu
    Citation: BMC Cancer 2019 19:738
    Content type: Research article Published on:

  45. Patients with breast cancer undergoing chemotherapy and radiotherapy experience fatigue and other treatment side effects. Integrative therapies combining physical activity and dietary counseling are recommende...

    Authors: Marion Carayol, Gregory Ninot, Pierre Senesse, Jean-Pierre Bleuse, Sophie Gourgou, Hélène Sancho-Garnier, Chakib Sari, Isabelle Romieu, Gilles Romieu and William Jacot
    Citation: BMC Cancer 2019 19:737
    Content type: Research article Published on:

  46. SET domain containing 5 (SETD5) is related to the aggressiveness of prostate and mammary cancers, but its association with non-small cell lung cancer (NSCLC) is unknown. Therefore, the purpose of this research...

    Authors: Hairu Yu, Jiayi Sun, Congxuan Zhao, Haotian Wang, Yeqiu Liu, Jiajia Xiong, Jing Chang, Mixue Wang, Wenhui Wang, Dongman Ye, Hongyan Zhou and Tao Yu
    Citation: BMC Cancer 2019 19:736
    Content type: Research article Published on:

  47. Many older patients don’t receive appropriate oncological treatment. Our aim was to analyse whether there are age differences in the use of adjuvant chemotherapy and preoperative radiotherapy in patients with ...

    Authors: C. Sarasqueta, A. Perales, A. Escobar, M. Baré, M. Redondo, N. Fernández de Larrea, E. Briones, J. M. Piera, M. V. Zunzunegui and J. M. Quintana
    Citation: BMC Cancer 2019 19:735
    Content type: Research article Published on:

  48. Fast-track colonoscopy to detect patients with colorectal cancer based on high-risk symptoms is associated with low sensitivity and specificity. The aim was to derive a predictive score of advanced colonic neo...

    Authors: Fernando Fernández-Bañares, Ramon Clèries, Jaume Boadas, Josepa Ribes, Joan Carles Oliva, Antoni Alsius, Xavier Sanz, Eva Martínez-Bauer, Sara Galter, Mar Pujals, Marta Pujol, Patricia del Pozo and Rafel Campo
    Citation: BMC Cancer 2019 19:734
    Content type: Research article Published on:

  49. The 8th edition of the tumor-node-metastasis (TNM) classification classifies inguinal lymph nodes as regional lymph nodes for anal canal carcinoma but non-regional lymph nodes for rectal carcinoma. This differ...

    Authors: Taro Tanabe, Dai Shida, Sho Komukai, Yuya Nakamura, Shunsuke Tsukamoto and Yukihide Kanemitsu
    Citation: BMC Cancer 2019 19:733
    Content type: Research article Published on:

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