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  1. Blood-based methods using cell-free DNA (cfDNA) are under development as an alternative to existing screening tests. However, early-stage detection of cancer using tumor-derived cfDNA has proven challenging be...

    Authors: Nathan Wan, David Weinberg, Tzu-Yu Liu, Katherine Niehaus, Eric A. Ariazi, Daniel Delubac, Ajay Kannan, Brandon White, Mitch Bailey, Marvin Bertin, Nathan Boley, Derek Bowen, James Cregg, Adam M. Drake, Riley Ennis, Signe Fransen…
    Citation: BMC Cancer 2019 19:832
    Content type: Research article Published on:

  2. The concept of head and neck cancers (HNSCC) having unique molecular signatures is well accepted but relating this to clinical presentation and disease behaviour is essential for patient benefit. Currently the...

    Authors: Fatima Qadir, Anand Lalli, Huma Habib Dar, Sungjae Hwang, Hebah Aldehlawi, Hong Ma, Haiyan Dai, Ahmad Waseem and Muy-Teck Teh
    Citation: BMC Cancer 2019 19:830
    Content type: Research article Published on:

  3. Carbon ion (12C) radiotherapy is becoming very promising to kill highly metastatic cancer cells keeping adjacent normal cells least affected. Our previous study shows that combined PARP-1 inhibition with 12C ion ...

    Authors: Priyanka Chowdhury, Payel Dey, Sourav Ghosh, Asitikantha Sarma and Utpal Ghosh
    Citation: BMC Cancer 2019 19:829
    Content type: Research article Published on:

  4. Sexuality is an important aspect of quality of life for adolescent and young adults that remains understudied in cancer patients. Most current knowledge about how cancer and cancer treatments can affect patien...

    Authors: Julian Mütsch, Michael Friedrich, Katja Leuteritz, Annekathrin Sender, Kristina Geue, Anja Hilbert and Yve Stöbel-Richter
    Citation: BMC Cancer 2019 19:828
    Content type: Research article Published on:

  5. SMARCB1-deficient sinonasal carcinoma (SDSC) is an aggressive subtype of head and neck cancers that has a poor prognosis despite multimodal therapy. We present a unique case with next generation sequencing dat...

    Authors: Horacio Gomez-Acevedo, John D. Patterson, Sehrish Sardar, Murat Gokden, Bhaskar C. Das, David W. Ussery and Analiz Rodriguez
    Citation: BMC Cancer 2019 19:827
    Content type: Case report Published on:

  6. Radiotherapy (RT) is considered an important therapeutic strategy in the fight against colorectal cancer (CRC). However, the existence of some radioresistance factors becomes the main challenge for the RT. Rec...

    Authors: Hongbin Li, Xiaodong Jin, Bingtao Liu, Pengcheng Zhang, Weiqiang Chen and Qiang Li
    Citation: BMC Cancer 2019 19:826
    Content type: Research article Published on:

  7. To develop a new 18 high-risk human papillomavirus (HR HPV) detection and genotyping assay, which is important to evaluate the risk degree of HR HPV for causing cancers.

    Authors: Xushan Cai, Qinghua Guan, Yu Huan, Ziyu Liu, Jiehua Qi and Shichao Ge
    Citation: BMC Cancer 2019 19:825
    Content type: Research article Published on:

  8. Genomic initiatives such as The Cancer Genome Atlas (TCGA) contain data from -omics profiling of thousands of tumor samples, which may be used to decipher cancer signaling, and related alterations. Managing an...

    Authors: Marta Lucchetta, Isabelle da Piedade, Mohamed Mounir, Marina Vabistsevits, Thilde Terkelsen and Elena Papaleo
    Citation: BMC Cancer 2019 19:824
    Content type: Research article Published on:

  9. Natural killer (NK) cell dysfunction following cancer surgery has been shown to promote metastases. Recent studies demonstrate an emerging role for lipids in the modulation of NK cell innate responses. However...

    Authors: Seyedeh Raheleh Niavarani, Christine Lawson, Orneala Bakos, Marie Boudaud, Cory Batenchuk, Samuel Rouleau and Lee-Hwa Tai
    Citation: BMC Cancer 2019 19:823
    Content type: Research article Published on:

  10. There is currently no evidence that hepatitis C virus (HCV) genotype affects survival in patients with hepatocellular carcinoma (HCC). This study aimed to investigate whether the HCV genotype affected the surv...

    Authors: Hye Kyong Park, Sang Soo Lee, Chang Bin Im, Changjo Im, Ra Ri Cha, Wan Soo Kim, Hyun Chin Cho, Jae Min Lee, Hyun Jin Kim, Tae Hyo Kim, Woon Tae Jung and Ok-Jae Lee
    Citation: BMC Cancer 2019 19:822
    Content type: Research article Published on:

  11. miR-182-5p (miR-182) is an oncogenic microRNA (miRNA) found in different tumor types and one of the most up-regulated miRNA in colorectal cancer (CRC). Although this microRNA is expressed in the early steps of...

    Authors: Lisa Perilli, Sofia Tessarollo, Laura Albertoni, Matteo Curtarello, Anna Pastò, Efrem Brunetti, Matteo Fassan, Massimo Rugge, Stefano Indraccolo, Alberto Amadori, Stefania Bortoluzzi and Paola Zanovello
    Citation: BMC Cancer 2019 19:821
    Content type: Research article Published on:

  12. Progression of breast cancer involves both genetic and epigenetic factors. Parkin gene has been identified as a tumor suppressor gene in the pathogenesis of various cancers. Nevertheless, the putative role of Par...

    Authors: Khushnuma Wahabi, Ahmad Perwez, Shabeena Kamarudheen, Zafar Iqbal Bhat, Anurag Mehta and M. Moshahid A. Rizvi
    Citation: BMC Cancer 2019 19:820
    Content type: Research article Published on:

  13. Treatment of acute myeloid leukemia (AML) in elderly patients remains a great challenge. In this prospective single arm study (ChiCTR-OPC-15006492), we evaluated the efficacy and safety of a novel consolidatio...

    Authors: Xiaoyang Li, Yuexin Dong, Ya Li, Ruibao Ren, Wen Wu, Hongming Zhu, Yunxiang Zhang, Jiong Hu and Junmin Li
    Citation: BMC Cancer 2019 19:819
    Content type: Research article Published on:

  14. The aim of this study was to investigate the potential of cell-free DNA (cfDNA) as a disease biomarker in oesophageal squamous cell carcinoma (ESCC) that can be used for treatment response evaluation and early...

    Authors: Pei Meng, Jiacong Wei, Yiqun Geng, Shaobin Chen, Miente Martijn Terpstra, Qiongyi Huang, Qian Zhang, Zuoqing Su, Wanchun Yu, Min Su, Klaas Kok, Anke van den Berg and Jiang Gu
    Citation: BMC Cancer 2019 19:818
    Content type: Research article Published on:

  15. Adoptive transfer of immune cells such as T cells and natural killer (NK) cells has emerged as a targeted method of controlling the immune system against cancer. Despite their significant therapeutic potential...

    Authors: Jung-Won Choi, Eui Soo Lee, Se Young Kim, Su Il Park, Sena Oh, Jung Hwa Kang, Hyun Aae Ryu and Seahyoung Lee
    Citation: BMC Cancer 2019 19:817
    Content type: Research article Published on:

  16. Stereotactic ablative radiotherapy (SABR) has emerged as a new treatment option for patients with oligometastatic disease. SABR delivers precise, high-dose, hypofractionated radiotherapy, and achieves excellen...

    Authors: David A. Palma, Robert Olson, Stephen Harrow, Rohann J. M. Correa, Famke Schneiders, Cornelis J. A. Haasbeek, George B. Rodrigues, Michael Lock, Brian P. Yaremko, Glenn S. Bauman, Belal Ahmad, Devin Schellenberg, Mitchell Liu, Stewart Gaede, Joanna Laba, Liam Mulroy…
    Citation: BMC Cancer 2019 19:816
    Content type: Study protocol Published on:

  17. Current advancements in neoadjuvant therapy and total mesorectal excision have engendered increased local control. However, the survival benefit of preoperative radiotherapy (RT; 5 × 5 Gy) in rectal cancer pat...

    Authors: Yi-Hung Kuo, Chia-Hsuan Lai, Cheng-Yi Huang, Chih-Jung Chen, Yun-Ching Huang, Wen-Shih Huang and Chih-Chien Chin
    Citation: BMC Cancer 2019 19:815
    Content type: Research article Published on:

  18. The co-occurrence of type 1 autoimmune pancreatitis (AIP) and pancreatic tumor (PaT) has been previously reported. Pure AIP cases have favorable prognosis and are primarily treated with steroids, while AIP cas...

    Authors: Pei Xiang, Xiaoling Zhang, Chaoyang Wang, Yuejiao Lang, Ling Xu, Li Huang, Jingxian Shen and Shi-Ting Feng
    Citation: BMC Cancer 2019 19:814
    Content type: Research article Published on:

  20. Reactive oxygen species (ROS), including hydrogen peroxide, drive differentiation of normal fibroblasts into activated fibroblasts, which can generate high amounts of hydrogen peroxide themselves, thereby incr...

    Authors: Agnieszka Jezierska-Drutel, Shireen Attaran, Barbara L. Hopkins, John J. Skoko, Steven A. Rosenzweig and Carola A. Neumann
    Citation: BMC Cancer 2019 19:812
    Content type: Research article Published on:

  21. Diets that restrict energy or macronutrient intake (e.g. fasting/ketogenic diets (KDs)) may selectively protect non-tumour cells during cancer treatment. Previous reviews have focused on a subset of dietary re...

    Authors: Ellie Shingler, Rachel Perry, Alexandra Mitchell, Clare England, Claire Perks, Georgia Herbert, Andy Ness and Charlotte Atkinson
    Citation: BMC Cancer 2019 19:811
    Content type: Research article Published on:

  22. Endometrial cancer is the most common gynecological cancer. G-protein coupled receptor 64 (GPR64) belongs to a family of adhesion GPCRs and plays an important role in male fertility. However, the function of G...

    Authors: Jong Il Ahn, Jung-Yoon Yoo, Tae Hoon Kim, Young Im Kim, Russell R. Broaddus, Ji Yeon Ahn, Jeong Mook Lim and Jae-Wook Jeong
    Citation: BMC Cancer 2019 19:810
    Content type: Research article Published on:

  23. Eradication of minimal residual disease (MRD), at the end of Fludarabine-Cyclophosphamide-Rituximab (FCR) treatment, is a validated surrogate marker for progression-free and overall survival in chronic lymphoc...

    Authors: Martin Gauthier, Françoise Durrieu, Elodie Martin, Michael Peres, François Vergez, Thomas Filleron, Lucie Obéric, Fontanet Bijou, Anne Quillet Mary and Loic Ysebaert
    Citation: BMC Cancer 2019 19:809
    Content type: Research article Published on:

  24. Communication between health care provider and patients in oncology presents challenges. Communication skills training have been frequently developed to address those. Given the complexity of communication tra...

    Authors: F. Fischer, S. Helmer, A. Rogge, J. I. Arraras, A. Buchholz, A. Hannawa, M. Horneber, A. Kiss, M. Rose, W. Söllner, B. Stein, J. Weis, P. Schofield and C. M. Witt
    Citation: BMC Cancer 2019 19:808
    Content type: Research article Published on:

  25. The association between oral contraceptive (OC) use and long-term mortality remains uncertain and previous studies have reported conflicting findings. We aim to assess the long-term impact of OC use on all-cau...

    Authors: Ula Nur, Darline El Reda, Dana Hashim and Elisabete Weiderpass
    Citation: BMC Cancer 2019 19:807
    Content type: Research article Published on:

  26. Few diagnostic and prognostic biomarkers are available for head-and-neck squamous cell carcinoma (HNSCC). Long non-coding RNAs (lncRNAs) have shown promise as biomarkers in other cancer types and in some cases...

    Authors: Madeleine Sassenberg, Johanna Droop, Wolfgang A. Schulz, Dimo Dietrich, Sophia Marie Loick, Constanze Wiek, Kathrin Scheckenbach, Nadine T. Gaisa and Michèle J. Hoffmann
    Citation: BMC Cancer 2019 19:806
    Content type: Research article Published on:

  27. Clinical features of Asian melanoma patients are distinct from those of Western patients. This study was designed to determine the molecular and clinical characteristics of Asian melanoma patients treated with...

    Authors: Jiyun Lee, Su Jin Lee, Kyung Kim, Seung Tae Kim, Kee-Taek Jang and Jeeyun Lee
    Citation: BMC Cancer 2019 19:805
    Content type: Research article Published on:

  28. Protein kinase C iota (PKCι) and protein kinase C zeta (PKCζ) are two atypical protein kinase (aPKC) enzymes that contribute to cell proliferation and cancer development. The Hippo/YAP pathway is commonly disr...

    Authors: Kyung-Hee Kim, Chaeuk Chung, Jin-Man Kim, Dahye Lee, Sang Yeon Cho, Tae Hee Lee, Hyun Jin Cho and Min-Kyung Yeo
    Citation: BMC Cancer 2019 19:804
    Content type: Research article Published on:

  29. The risk of lymph node positivity in early-stage colon cancer is a parameter that impacts therapeutic recommendations. However, little is known about the effect of age on lymph node positivity in colon cancer ...

    Authors: Xin Xie, Jianhao Yin, Zhangjian Zhou, Chengxue Dang, Hao Zhang and Yong Zhang
    Citation: BMC Cancer 2019 19:803
    Content type: Research article Published on:

  30. To validate the utility of the chemokine ligand 12 (CXCL12) as prognostic marker in patients with localized and metastatic germ cell tumors (GCT).

    Authors: Christian Daniel Fankhauser, Lisa Roth, Nico Christian Grossmann, Benedikt Kranzbühler, Daniel Eberli, Tullio Sulser, Holger Moch, Peter-Karl Bode, Joerg Beyer and Thomas Hermanns
    Citation: BMC Cancer 2019 19:802
    Content type: Research article Published on:

  31. Plasma cell disorders are a rare group of hematological malignancies that accounts for 10% of all hematological neoplasms. Solitary plasmacytomas are rarer entities accounting for less than 5% of all the plasm...

    Authors: Sridevi Hanaganahalli Basavaiah, Flora D. Lobo, Cheryl Sarah Philipose, Pooja K. Suresh, Saraswathy Sreeram, Hema Kini, Kausalya K. Sahu and Krishna Prasad
    Citation: BMC Cancer 2019 19:801
    Content type: Research article Published on:

  32. Alcohol consumption is associated with increased risk of breast cancer; however, its association with subsequent risk of breast cancer death is unclear.

    Authors: Huiyan Ma, Kathleen E. Malone, Jill A. McDonald, Polly A. Marchbanks, Giske Ursin, Brian L. Strom, Michael S. Simon, Jane Sullivan-Halley, Leslie Bernstein and Yani Lu
    Citation: BMC Cancer 2019 19:800
    Content type: Research article Published on:

  34. We report an extremely rare case of vaginal clear cell carcinoma, which originated from the malignant transformation of vaginal adenosis without prenatal diethylstilbestrol (DES) exposure.

    Authors: Lihong Pang, Lei Li, Lan Zhu, Jinghe Lang and Yalan Bi
    Citation: BMC Cancer 2019 19:798
    Content type: Case report Published on:

  35. To demonstrate that post-therapy pathological tumor volume (ypTV) should be considered as an independent prognostic factor in advanced gastric cancer (GC) patients who underwent neoadjuvant chemotherapy (NAC) ...

    Authors: Xiaolong Tang, Qingsi He, Hui Qu, Guorui Sun, Jia Liu, Lei Gao, Jingbo Shi, Jianhong Ye and Yahang Liang
    Citation: BMC Cancer 2019 19:797
    Content type: Research article Published on:

  36. Histology is a traditional way to classify subtypes of thymoma, because of low cost and convenience. Yet, due to the diverse morphology of thymoma, this method increases the complexity of histopathologic class...

    Authors: Liang-Chuan Lai, Qiang-Ling Sun, Yu-An Chen, Yi-Wen Hsiao, Tzu-Pin Lu, Mong-Hsun Tsai, Lei Zhu, Eric Y. Chuang and Wentao Fang
    Citation: BMC Cancer 2019 19:796
    Content type: Research article Published on:

  37. The real-world incidence of chronic liver damage after transarterial chemoembolization (TACE) is unclear. LiverT, a retrospective, observational study, assessed liver function deterioration after a single TACE...

    Authors: Rebecca A. Miksad, Sadahisa Ogasawara, Fang Xia, Marc Fellous and Fabio Piscaglia
    Citation: BMC Cancer 2019 19:795
    Content type: Research article Published on:

  38. PALETTE is a phase 3 trial that demonstrated single-agent activity of pazopanib in advanced soft tissue sarcomas (aSTS). We performed retrospective subgroup analyses to explore potential relationships between ...

    Authors: Axel Le Cesne, Sebastian Bauer, George D. Demetri, Guangyang Han, Luca Dezzani, Qasim Ahmad, Jean-Yves Blay, Ian Judson, Patrick Schöffski, Massimo Aglietta, Peter Hohenberger and Hans Gelderblom
    Citation: BMC Cancer 2019 19:794
    Content type: Research article Published on:

  39. The treatment strategy for brain metastasis (BM) in patients with epidermal growth factor receptor (EGFR) -mutant lung adenocarcinoma (LAC) remains controversial. In the present study, we compared the efficacy...

    Authors: Yanxin Chen, Jianping Wei, Jing Cai and Anwen Liu
    Citation: BMC Cancer 2019 19:793
    Content type: Research article Published on:

  40. Febrile neutropenia (FN) is a serious complication of myelosuppressive chemotherapy. Clinical practice guidelines recommend routine prophylactic coverage with granulocyte colony-stimulating factor (G-CSF)—such...

    Authors: Derek Weycker, Robin Doroff, Ahuva Hanau, Charles Bowers, Rajesh Belani, David Chandler, Alexander Lonshteyn, Mark Bensink and Gary H. Lyman
    Citation: BMC Cancer 2019 19:792
    Content type: Research article Published on:

  41. Roles of cancer stem cells and early growth response gene 1 (Egr1) in carcinogenesis have been extensively studied in lung cancer. However, the role of Egr1 in the metastasis of lung cancer remains undetermine...

    Authors: Yin-Hsun Feng, Yu-Chu Su, Shuo-Fu Lin, Pey-Ru Lin, Chao-Liang Wu, Chao-Ling Tung, Chien-Feng Li, Gia-Shing Shieh and Ai-Li Shiau
    Citation: BMC Cancer 2019 19:791
    Content type: Research article Published on:

  42. This study aimed to investigate the prognostic value of volumetric parameters on 18F- fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) in gastric-cancer patients, accor...

    Authors: Guobing Liu, Yan Hu, Xi Cheng, Yan Wang, Yushen Gu, Tianshu Liu and Hongcheng Shi
    Citation: BMC Cancer 2019 19:790
    Content type: Research article Published on:

  43. Hepatitis B virus (HBV) is the major risk factor for hepatocellular carcinoma (HCC). The molecular mechanisms underlying HBV-associated HCC pathogenesis is still unclear. Genetic alterations in cancer-related ...

    Authors: Fung-Yu Huang, Danny Ka-Ho Wong, Vivien Wai-Man Tsui, Wai-Kay Seto, Lung-Yi Mak, Tan-To Cheung, Keane K.-Y. Lai and Man-Fung Yuen
    Citation: BMC Cancer 2019 19:789
    Content type: Research article Published on:

  44. NETTER-1 trial demonstrated high efficacy and low toxicity of four cycles of Peptide Receptor Radionuclide Therapy (PRRT) in patients with metastasized NET. The present study evaluates the outcome of further P...

    Authors: S. Rudisile, A. Gosewisch, V. Wenter, M. Unterrainer, G. Böning, F. J. Gildehaus, W. P. Fendler, C. J. Auernhammer, C. Spitzweg, P. Bartenstein, A. Todica and H. Ilhan
    Citation: BMC Cancer 2019 19:788
    Content type: Research article Published on:

  45. Inherited pathogenic variants in BRCA1 and BRCA2 are the most common causes of hereditary breast and ovarian cancer (HBOC). The risk of developing breast cancer by age 80 in women carrying a BRCA1 pathogenic vari...

    Authors: Ilnaz Sepahi, Ulrike Faust, Marc Sturm, Kristin Bosse, Martin Kehrer, Tilman Heinrich, Kathrin Grundman-Hauser, Peter Bauer, Stephan Ossowski, Hana Susak, Raymonda Varon, Evelin Schröck, Dieter Niederacher, Bernd Auber, Christian Sutter, Norbert Arnold…
    Citation: BMC Cancer 2019 19:787
    Content type: Research article Published on:

  46. Data indicate that primary cutaneous melanomas are characterized by clonal heterogeneity associated with oncogenic drivers. Less data are available on the clonal changes occurring during melanoma progression. ...

    Authors: V. Doma, S. Kárpáti, E. Rásó, T. Barbai and J. Tímár
    Citation: BMC Cancer 2019 19:786
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:853

  47. The prognostic role of serum alkaline phosphatase (ALP) has been found in several kinds of solid malignant tumor, but has never been extensively discussed in pancreatic cancer, especially through the applicati...

    Authors: Yuanyuan Xiao, Jian Lu, Wei Chang, Ying Chen, Xiaomei Li, Dehui Li, Chuanzhi Xu and Haijun Yang
    Citation: BMC Cancer 2019 19:785
    Content type: Research article Published on:

  48. The aim of this study was to compare the oncological outcomes and clinical efficacy of laparoscopic pancreaticoduodenectomy (LPD) and open pancreaticoduodenectomy (OPD) in patients with pancreatic ductal adeno...

    Authors: Yu-Li Jiang, Ren-Chao Zhang and Yu-Cheng Zhou
    Citation: BMC Cancer 2019 19:781
    Content type: Research article Published on:

    The Correspondence to this article has been published in BMC Cancer 2020 20:327

  50. Adjunct testosterone therapy improves lean body mass, quality of life, and physical activity in patients with advanced cancers; however, the effects of testosterone on cardiac morphology and function are unkno...

    Authors: Jessica M. Scott, E. Lichar Dillon, Michael Kinsky, Albert Chamberlain, Susan McCammon, Daniel Jupiter, Maurice Willis, Sandra Hatch, Gwyn Richardson, Christopher Danesi, Kathleen Randolph, William Durham, Traver Wright, Randall Urban and Melinda Sheffield-Moore
    Citation: BMC Cancer 2019 19:778
    Content type: Research article Published on:

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