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  1. Suffering from cancer confronts both the patient and their partner with a number of psychosocial challenges in various aspects of their life. These challenges may differentially impact on quality of life, copi...

    Authors: Inga Lorenz, Daniela Bodschwinna, Nina Hallensleben, Hartmut Döhner, Dietger Niederwieser, Tanja Zimmermann, Anja Mehnert, Harald Gündel, Jochen Ernst and Klaus Hoenig
    Citation: BMC Cancer 2019 19:885
    Content type: Study protocol Published on:

  2. Population-based studies suggest that emergency department visits and hospitalizations are common among patients receiving chemotherapy and that rates in routine practice are higher than expected from clinical...

    Authors: Monika K. Krzyzanowska, Jim A. Julian, Melanie Powis, Doris Howell, Craig C. Earle, Katherine A. Enright, Nicole Mittmann, Maureen E. Trudeau and Eva Grunfeld
    Citation: BMC Cancer 2019 19:884
    Content type: Study protocol Published on:

  3. Bispecific T-cell engaging antibodies (BiTES), comprising dual anti-CD3 and anti-tumor antigen scFv fragments, are important therapeutic agents for the treatment of cancer. The dual scFv construct for BiTES re...

    Authors: Maciej Kujawski, Lin Li, Supriyo Bhattacharya, Patty Wong, Wen-Hui Lee, Lindsay Williams, Harry Li, Junie Chea, Kofi Poku, Nicole Bowles, Nagarajan Vaidehi, Paul Yazaki and John E. Shively
    Citation: BMC Cancer 2019 19:882
    Content type: Technical advance Published on:

  4. Gene expression profiling of rare cancers has proven challenging due to limited access to patient materials and requirement of intact, non-degraded RNA for next-generation sequencing. We customized a gene expr...

    Authors: Jasmine A. McQuerry, David F. Jenkins, Susan E. Yost, Yuqing Zhang, Daniel Schmolze, W. Evan Johnson, Yuan Yuan and Andrea H. Bild
    Citation: BMC Cancer 2019 19:881
    Content type: Research article Published on:

  6. Bone metastases represent an important source of morbidity in cancer patients, mostly due to severe pain. Radiotherapy is an established symptomatic treatment for painful bone metastases, however, when convent...

    Authors: Carole Mercier, Piet Dirix, Piet Ost, Charlotte Billiet, Ines Joye, Peter Vermeulen, Yolande Lievens and Dirk Verellen
    Citation: BMC Cancer 2019 19:876
    Content type: Study protocol Published on:

  7. Esophageal squamous cell carcinoma (ESCC) is one of the most frequent malignant digestive tumors around the world. We previously demonstrated that eIF3b could promote the progression of ESCC. The exact mechani...

    Authors: Fengkai Xu, Shu Zhang, Zhonghe Liu, Jie Gu, Yin Li, Lin Wang, Wei Mao, Qiaoliang Zhu, Huankai Shou, Di Ge and Chunlai Lu
    Citation: BMC Cancer 2019 19:875
    Content type: Research article Published on:

  8. The ubiquitous expressed transcript (UXT) plays a key role in various tumors by regulating transcriptional activity of multiple transcription factors, including androgen receptor (AR). However, the role of UXT...

    Authors: Jin Zeng, Wei Xiang, Yucong Zhang, Chunhua Huang, Ke Chen and Zhiqiang Chen
    Citation: BMC Cancer 2019 19:874
    Content type: Research article Published on:

  9. This study investigated a large number of patients to develop a predictive nomogram for survival and a web-based survival rate calculator that can dynamically predict the long-term survival of patients with pr...

    Authors: Ju-Li Lin, Jian-Xian Lin, Ping Li, Jian-Wei Xie, Jia-bin Wang, Jun Lu, Qi-Yue Chen, Long-long Cao, Chang-Ming Huang and Chao-Hui Zheng
    Citation: BMC Cancer 2019 19:873
    Content type: Research article Published on:

  10. Pseudomyogenic hemangioendothelioma (PMHE) is a rare endothelial neoplasm that involves the bones in only 14% of all cases. The optimal treatment strategy has not been established. We herein report a case of p...

    Authors: Shinya Otani, Robert Nakayama, Tetsuya Sekita, Toru Hirozane, Naofumi Asano, Kazumasa Nishimoto, Aya Sasaki, Hajime Okita, Hideo Morioka, Masaya Nakamura and Morio Matsumoto
    Citation: BMC Cancer 2019 19:872
    Content type: Case report Published on:

  11. Metastasis of gastric cancer commonly manifests as a malignant effusion, which presents an alternative cell source for human epidermal growth factor receptor 2 (HER2) status identification. This study aimed to...

    Authors: Hongsik Kim, Seung-Myoung Son, Chang Gok Woo, Ok-Jun Lee, Dae Hoon Kim, Hyo Yung Yun, Jieun Yun, Hee Kyung Kim, Yaewon Yang and Hye Sook Han
    Citation: BMC Cancer 2019 19:834
    Content type: Research article Published on:

  12. The relationship between first-degree family history of female breast cancer and prostate cancer risk in the general population remains unclear. We performed a meta-analysis to determine the association betwee...

    Authors: Zheng-Ju Ren, De-Hong Cao, Qin Zhang, Peng-Wei Ren, Liang-Ren Liu, Qiang Wei, Wu-Ran Wei and Qiang Dong
    Citation: BMC Cancer 2019 19:871
    Content type: Research article Published on:

  13. Trauma- and stressor-related disorders pose an important threat for patients with medical conditions by negatively affecting the outcomes of the underlying somatic disease. Nevertheless, research on distress i...

    Authors: Peter Esser, Katharina Kuba, Jochen Ernst and Anja Mehnert-Theuerkauf
    Citation: BMC Cancer 2019 19:870
    Content type: Study protocol Published on:

  14. Few studies compared cancer incidence among migrants both to their host countries and to their population of origin. We aimed to compare cancer incidence of ethnic Germans who migrated from the former Soviet U...

    Authors: Philipp Jaehn, Simone Kaucher, Lidia V. Pikalova, Sofia Mazeina, Hiltraud Kajüter, Heiko Becher, Mikhail Valkov and Volker Winkler
    Citation: BMC Cancer 2019 19:869
    Content type: Research article Published on:

  17. Cancer is a genetic and epigenetic disease that involves inactivation of tumor suppressor genes and activation of proto-oncogenes. All-trans retinoic acid (ATRA) is an isomer of retinoic acid involved in the o...

    Authors: Lara Lima, Thaísa Cristina Tavares de Melo, Diego Marques, Jéssica Nayara Góes de Araújo, Isabela Samária Fernandes Leite, Camila Xavier Alves, Julieta Genre and Vivian Nogueira Silbiger
    Citation: BMC Cancer 2019 19:866
    Content type: Research article Published on:

  18. This study aims to investigate the expression of thioredoxin 1, peroxiredoxin 1 and peroxiredoxin 2 in bulky cervical squamous carcinoma and its predictive role in cisplatin-based neoadjuvant chemotherapy.

    Authors: Haiyan Zhu, Xuejiao Tao, Lulu Zhou, Bo Sheng, Xuejie Zhu and Xueqiong Zhu
    Citation: BMC Cancer 2019 19:865
    Content type: Research article Published on:

  19. Bronchial carcinoids are neuroendocrine tumors that present as typical (TC) and atypical (AC) variants, the latter being more aggressive, invasive and metastatic. Studies of tumor initiating cell (TIC) biology...

    Authors: Reza Bayat Mokhtari, Narges Baluch, Evgeniya Morgatskaya, Sushil Kumar, Angelo Sparaneo, Lucia Anna Muscarella, Sheyun Zhao, Hai-Ling Cheng, Bikul Das and Herman Yeger
    Citation: BMC Cancer 2019 19:864
    Content type: Research article Published on:

  20. Most clinical trials on colorectal cancer (CRC) exclude cases who have history of a prior malignancy. However, no prior research studied this history’s actual impact on the survival of CRC. In the paper, we st...

    Authors: Muneer J. Al-Husseini, Anas M. Saad, Hadeer H. Mohamed, Mohamad A. Alkhayat, Mohamad Bassam Sonbol and Omar Abdel-Rahman
    Citation: BMC Cancer 2019 19:863
    Content type: Research article Published on:

  21. Metformin is proven to improve the prognosis of various cancers, but it is unknown if metformin could ameliorate hypopharyngeal cancer in diabetes mellitus patients. This was a retrospective cohort study, and ...

    Authors: Yung-An Tsou, Wen-Dien Chang, Jian-Ji Lu, Tsu-Fang Wu, Hsiao-Ling Chen, Chuan-Mu Chen and Ming Hsui Tsai
    Citation: BMC Cancer 2019 19:862
    Content type: Research article Published on:

  22. Our purpose was to examine the outcomes of patients who underwent extensive resection of periacetabular tumors involving the sacroiliac joint and joint reconstruction with a hemipelvic endoprosthesis.

    Authors: Bo Wang, Changye Zou, Xiaokun Hu, Jian Tu, Hao Yao, Junqiang Yin, Gang Huang, Xianbiao Xie and Jingnan Shen
    Citation: BMC Cancer 2019 19:861
    Content type: Research article Published on:

  23. CA19–9 decrease during treatment has been associated with superior survival of pancreatic cancer in several studies. The evidence to show the correlation of high platelet level with inferior survival is insuff...

    Authors: Y. Chen, Y. R. Wang, G. C. Deng and G. H. Dai
    Citation: BMC Cancer 2019 19:860
    Content type: Research article Published on:

  24. We report on our experience of ultrasound (US)-guided dual-localization for axillary nodes before and after neoadjuvant chemotherapy (NAC) with clip and activated charcoal to guide axillary surgery in breast c...

    Authors: Won Hwa Kim, Hye Jung Kim, See Hyung Kim, Jin Hyang Jung, Ho Yong Park, Jeeyeon Lee, Wan Wook Kim, Ji Young Park, Yee Soo Chae and Soo Jung Lee
    Citation: BMC Cancer 2019 19:859
    Content type: Research article Published on:

  25. Nested case-control studies examining the association between serum markers of chronic inflammation, focused on three specific biomarkers (CRP, IL-8 and TNF-α), and risk of pancreatic cancer have reported no a...

    Authors: Sam Sollie, Dominique S. Michaud, Debashis Sarker, Sophia N. Karagiannis, Debra H. Josephs, Niklas Hammar, Aida Santaolalla, Goran Walldius, Hans Garmo, Lars Holmberg, Ingmar Jungner and Mieke Van Hemelrijck
    Citation: BMC Cancer 2019 19:858
    Content type: Research article Published on:

  26. Selecting the appropriate patients to receive immunotherapy (IO) remains a challenge due to the lack of optimal biomarkers. The presence of liver metastases has been implicated as a poor prognostic factor in p...

    Authors: Mehmet Asim Bilen, Julie M. Shabto, Dylan J. Martini, Yuan Liu, Colleen Lewis, Hannah Collins, Mehmet Akce, Haydn Kissick, Bradley C. Carthon, Walid L. Shaib, Olatunji B. Alese, Conor E. Steuer, Christina Wu, David H. Lawson, Ragini Kudchadkar, Viraj A. Master…
    Citation: BMC Cancer 2019 19:857
    Content type: Research article Published on:

  27. To investigate the association between pre-diagnostic colonoscopy and colorectal cancer mortality in South Australia.

    Authors: Ming Li, Ian Olver, Dorothy Keefe, Carol Holden, Dan Worthley, Timothy Price, Christos Karapetis, Caroline Miller, Kate Powell, Dianne Buranyi-Trevarton, Kellie Fusco and David Roder
    Citation: BMC Cancer 2019 19:856
    Content type: Research article Published on:

  28. Despite recent advances in the treatment of multiple myeloma, the disease constantly relapses and is still considered as incurable. The current knowledge about the biological mechanisms underlying resistance t...

    Authors: Lina Benaniba, Benoit Tessoulin, Sabrina Trudel, Catherine Pellat-Deceunynck, Martine Amiot, Stéphane Minvielle, Pierre Antoine Gourraud, Sophie de Visme, Hervé Maisonneuve, Anne Lok, Steven Le Gouill, Philippe Moreau and Cyrille Touzeau
    Citation: BMC Cancer 2019 19:855
    Content type: Study protocol Published on:

  29. Lung cancer is the leading cause of cancer-related deaths worldwide. This study focuses on its most common form, Non-Small-Cell Lung Cancer (NSCLC). No cure exists for advanced NSCLC, and patient prognosis is ...

    Authors: Dania Movia, Despina Bazou and Adriele Prina-Mello
    Citation: BMC Cancer 2019 19:854
    Content type: Research article Published on:

  30. Following publication of the original article [1], the authors reported the family name of the second author was incorrectly published.

    Authors: V. Doma, S. Kárpáti, E. Rásó, T. Barbai and J. Tímár
    Citation: BMC Cancer 2019 19:853
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2019 19:786

  31. Recently, evidence has emerged that palliative gastrectomy in patients with stage IV gastric cancer may offer some survival benefits. However, the decision whether to perform primary tumor surgery remains chal...

    Authors: Tai Ma, Zhi-jun Wu, Hui Xu, Chang-hao Wu, Jing Xu, Wan-ren Peng, Lu-lu Fan and Guo-ping Sun
    Citation: BMC Cancer 2019 19:852
    Content type: Research article Published on:

  32. Gradual loss of terminal differentiation markers and gain of stem cell-like properties is a major hall mark of cancer malignant progression. The stem cell pluripotent transcriptional factor SOX family play cri...

    Authors: Mei-Mei Li, Yun-Qiang Tang, Yuan-Feng Gong, Wei Cheng, Hao-Long Li, Fan-En Kong, Wen-Jie Zhu, Shan-Shan Liu, Li Huang, Xin-Yuan Guan, Ning-Fang Ma and Ming Liu
    Citation: BMC Cancer 2019 19:851
    Content type: Research article Published on:

  33. In 2017, the New South Wales Cancer Registry (NSWCR) participated in a project, supported by Cancer Australia, aiming to provide national stage data for melanoma, prostate, colorectal, breast, and lung cancers...

    Authors: Sheena Lawrance, Chau Bui, Vidur Mahindra, Maria Arcorace and Claire Cooke-Yarborough
    Citation: BMC Cancer 2019 19:850
    Content type: Research article Published on:

  34. Recent years have witnessed the rapid evolution of therapies in chronic-phase chronic myeloid leukemia (CP-CML). To assess the efficacy and tolerability of all reported front-line treatments for patients with ...

    Authors: Lu Tang, Huan Zhang, Yi-zhong Peng, Cheng-gong Li, Hui-wen Jiang, Min Xu, Heng Mei and Yu Hu
    Citation: BMC Cancer 2019 19:849
    Content type: Research article Published on:

  35. Atypical teratoid/rhabdoid tumors (AT/RTs) are highly malignant brain tumors with inactivation of the SMARCB1 gene, which play a critical role in genomic transcriptional control. In this study, we analyzed the ge...

    Authors: Ji Hoon Phi, Choong-Hyun Sun, Se-Hoon Lee, Seungmook Lee, Inho Park, Seung Ah Choi, Sung-Hye Park, Ji Yeoun Lee, Kyu-Chang Wang, Seung-Ki Kim, Hongseok Yun and Chul-Kee Park
    Citation: BMC Cancer 2019 19:848
    Content type: Research article Published on:

  36. Studies over the past 10 years strongly support an association between skeletal muscle mass (SMM) depletion and outcome in metastatic colorectal cancer (mCRC). Factors influencing SMM changes over time are, ho...

    Authors: Sami Antoun, Mohamed Amine Bayar, Valérie Dyevre, Emilie Lanoy, Cristina Smolenschi and Michel Ducreux
    Citation: BMC Cancer 2019 19:847
    Content type: Research article Published on:

  37. To explore the association between biologically effective dose (BED) and survival rates in Child-Pugh A classification (CP-A) small hepatocellular carcinoma (HCC) patients treated with stereotactic body radiat...

    Authors: Jing Sun, Tao Zhang, Jia Wang, Wengang Li, Aimin Zhang, Weiping He, Dan Zhang, Dong Li, Junqiang Ding and Xuezhang Duan
    Citation: BMC Cancer 2019 19:846
    Content type: Research article Published on:

  38. The rise in cervical cancer trends in the past two decades has coincided with the human immunodeficiency virus (HIV) epidemic especially in the sub-Saharan African region. Young people (15 to 24 years old) are...

    Authors: Witness Mapanga, Brendan Girdler-Brown and Elvira Singh
    Citation: BMC Cancer 2019 19:845
    Content type: Research article Published on:

  39. The prognosis of ductal carcinoma in situ (DCIS) is reportedly well. Extremely rare patients with DCIS develop distant breast cancer metastasis without locoregional or contralateral recurrence. This is the fir...

    Authors: Qiuting You, Yichao Fang, Chenchen Li, Yujie Tan, Jianli Zhao, Cui Tan, Ying Wang, Herui Yao and Fengxi Su
    Citation: BMC Cancer 2019 19:844
    Content type: Case report Published on:

  40. Recent studies reported that blood-based microRNAs (miRNAs) could detect cancers and predict prognosis have opened a new field of utilizing circulating miRNAs as cancer biomarkers. In this pilot study, we cond...

    Authors: Lirong Wu, Kexiao Zheng, Cheng Yan, Xuan Pan, Yatian Liu, Juying Liu, Feijiang Wang, Wenjie Guo, Xia He, Jiong Li and Ye Shen
    Citation: BMC Cancer 2019 19:843
    Content type: Research article Published on:

  41. Helicobacter pylori (H. pylori) is thought to have an oncogenic effect on the development of gastric malignancies. However, the effect of H. pylori status on the prognosis of gastric diffuse large B-cell lymphoma...

    Authors: Yuan Cheng, Yinan Xiao, Ruofan Zhou, Yi Liao, Jing Zhou and Xuelei Ma
    Citation: BMC Cancer 2019 19:842
    Content type: Research article Published on:

  42. Blood counting and the liver function tests, as the routine examinations, can reflect the immune and nutritional status of the body, our aim is to assess the prognostic significance of serum gamma-glutamyltran...

    Authors: Li-xiang Zhang, Yang Lv, A-Man Xu and Huan-zhong Wang
    Citation: BMC Cancer 2019 19:841
    Content type: Research article Published on:

  43. Advanced stage laryngeal squamous cell carcinoma (LSCC) presents a poor prognosis; thus, there is a great need to identify novel prognostic molecular markers. Procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2...

    Authors: Xiaoli Sheng, Yunxian Li, Yixuan Li, Wenlin Liu, Zhongming Lu, Jiandong Zhan, Mimi Xu, Liangsi Chen, Xiaoning Luo, Gang Cai and Siyi Zhang
    Citation: BMC Cancer 2019 19:840
    Content type: Research article Published on:

  44. Identification of specific needs in patients with cancer is very important for the provision of patient-centered medical service. The aim of this study was to investigate the unmet needs and related factors of...

    Authors: Byung Joo Chae, Jihyoun Lee, Se Kyung Lee, Hyuk-Jae Shin, So-Youn Jung, Jong Won Lee, Zisun Kim, Min Hyuk Lee, Juhyung Lee and Hyun Jo Youn
    Citation: BMC Cancer 2019 19:839
    Content type: Research article Published on:

  45. Adrenal tumors in patients with previous/synchronous extra-adrenal malignancy are diverse and are a dilemma in clinical practice. This study investigated the differentiation of adrenal malignant and benign tum...

    Authors: Lei Tan, Yunlin Ye, Kanghua Xiao, Xuelian Xu, Haitao Liang, Fufu Zheng and Zike Qin
    Citation: BMC Cancer 2019 19:838
    Content type: Research article Published on:

  46. The activity of MP1, a pyrrolomycin, was studied in MYCN amplified neuroblastoma (NB) alone and combined with temsirolimus (TEM).

    Authors: Timothy R. McGuire, Don W. Coulter, Dachang Bai, Jason A. Sughroue, Jerry Li, Zunhua Yang, Zhen Qiao, Yan Liu, Daryl J. Murry, Yashpal S. Chhonker, Erin M. McIntyre, Gracey Alexander, John G. Sharp and Rongshi Li
    Citation: BMC Cancer 2019 19:837
    Content type: Research article Published on:

  47. Depression is a common co-morbid, disabling disorder that affects 10–25% of cancer patients. It causes substantial functional impairment and lowers survival rate of breast cancer patients. Therefore, the aim o...

    Authors: Abigiya Wondimagegnehu, Workeabeba Abebe, Aynalem Abraha and Solomon Teferra
    Citation: BMC Cancer 2019 19:836
    Content type: Research article Published on:

  48. In the U.S., lung cancer accounts for 14% of cancer diagnoses and 28% of cancer deaths annually. Since no cure exists for advanced lung cancer, the main treatment goal is to prolong survival. Chemotherapy regi...

    Authors: K. M. Islam, T. Anggondowati, P. E. Deviany, J. E. Ryan, A. Fetrick, D. Bagenda, M. S. Copur, A. Tolentino, I. Vaziri, H. A. McKean, S. Dunder, J. E. Gray, C. Huang and A. K. Ganti
    Citation: BMC Cancer 2019 19:835
    Content type: Research article Published on:

  50. Metastasis is responsible for the majority of deaths in a variety of cancer types, including breast cancer. Although several factors or biomarkers have been identified to predict the outcome of patients with b...

    Authors: Liang Zeng, Xiyun Deng, Jingmin Zhong, Li Yuan, Xiaojun Tao, Sai Zhang, Yong Zeng, Guangchun He, Pingping Tan and Yongguang Tao
    Citation: BMC Cancer 2019 19:831
    Content type: Research article Published on:

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