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  1. To investigate the implications of prophylactic intraoperative Hyperthermic Intraperitoneal Chemotherapy (HIPEC) with D2 radical gastrectomy for locally advanced Gastric Cancer (AGC) in a randomized case contr...

    Authors: Maneesh Kumarsing Beeharry, Zheng-Lun Zhu, Wen-Tao Liu, Xue-Xin Yao, Min Yan and Zheng-Gang Zhu
    Citation: BMC Cancer 2019 19:932
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1256

  2. The Foxo3 gene, belonging to the forkhead family, is one of the classes of transcription factors characterized by a forkhead DNA-binding domain, which usually considered being a cancer suppressor gene. Circ-Foxo3

    Authors: Jiao Zhou, Ling-Yu Zhou, Xi Tang, Jing Zhang, Ling-Ling Zhai, Yun Yun Yi, Jing Yi, Jiang Lin, Jun Qian and Zhao-Qun Deng
    Citation: BMC Cancer 2019 19:930
    Content type: Research article Published on:

  3. Preoperative 5-FU-based chemoradiation is currently a standard treatment for advanced rectal cancer, particularly in Western countries. Although it reduced the local recurrence, it could not necessarily improv...

    Authors: Tsunekazu Mizushima, Masataka Ikeda, Takeshi Kato, Atsuyo Ikeda, Junichi Nishimura, Taishi Hata, Chu Matsuda, Taroh Satoh, Masaki Mori and Yuichiro Doki
    Citation: BMC Cancer 2019 19:929
    Content type: Research article Published on:

  4. Ovarian cancer is the main cause of gynecological cancer-associated death. However, 5-year survival rates differ dramatically between the five main ovarian carcinoma histotypes. Therefore, we need to have a be...

    Authors: Hanna Engqvist, Toshima Z. Parris, Anikó Kovács, Szilárd Nemes, Elisabeth Werner Rönnerman, Shahin De Lara, Jana Biermann, Karin Sundfeldt, Per Karlsson and Khalil Helou
    Citation: BMC Cancer 2019 19:928
    Content type: Research article Published on:

  5. The clinical target volume (CTV) for postoperative radiotherapy for thoracic esophageal squamous cell carcinoma (TESCC) needs to be defined. The study aim was to map metastatic lymph nodes (LNMs) in a computed...

    Authors: Jing Yu, Wen Ouyang, Chunyang Li, Jiuling Shen, Yu Xu, Junhong Zhang and Conghua Xie
    Citation: BMC Cancer 2019 19:927
    Content type: Research article Published on:

  6. Reproductive characteristics are well-established risk factors for breast cancer, but the underlying mechanisms are not fully resolved. We hypothesized that altered DNA methylation, measured in tumor tissue, c...

    Authors: Lauren E. McCullough, Lindsay J. Collin, Kathleen Conway, Alexandra J. White, Yoon Hee Cho, Sumitra Shantakumar, Mary Beth Terry, Susan L. Teitelbaum, Alfred I. Neugut, Regina M. Santella, Jia Chen and Marilie D. Gammon
    Citation: BMC Cancer 2019 19:926
    Content type: Research article Published on:

  7. Gingival metastasis from primary hepatocellular cancer (HCC) is rare, highly malignant, and generally has no distinct symptoms. Not performing a biopsy can lead to misdiagnosis. This article reports an 87-year...

    Authors: Yating Hou, Weiping Deng, Gang Deng, Linhui Hu, Chao Liu and Lishu Xu
    Citation: BMC Cancer 2019 19:925
    Content type: Case report Published on:

  8. Current therapies fail to cure over a third of osteosarcoma patients and around three quarters of those with metastatic disease. “Smac mimetics” (also known as “IAP antagonists”) are a new class of anti-cancer...

    Authors: Tanmay M. Shekhar, Ingrid J. G. Burvenich, Michael A. Harris, Angela Rigopoulos, Damien Zanker, Alex Spurling, Belinda S. Parker, Carl R. Walkley, Andrew M. Scott and Christine J. Hawkins
    Citation: BMC Cancer 2019 19:924
    Content type: Research article Published on:

  9. Glioblastoma (GB) is considered one of the most lethal tumors. Extensive research at the molecular level may enable to gain more profound insight into its biology and thus, facilitate development and testing o...

    Authors: Karolina Janik, Cezary Treda, Aneta Wlodarczyk, Joanna Peciak, Kamila Rosiak, Jolanta Zieba, Dagmara Grot, Adrianna Rutkowska, Roza Pawlowska, Waldemar Och, Piotr Rieske and Ewelina Stoczynska-Fidelus
    Citation: BMC Cancer 2019 19:923
    Content type: Research article Published on:

  10. Pancreatic adenocarcinoma is a high-mortality neoplasm with a documented 5-years-overall survival around 5%. In the last decades, a real breakthrough in the treatment of the disease has not been achieved. Here...

    Authors: Viviana Vitolo, Lorenzo Cobianchi, Silvia Brugnatelli, Amelia Barcellini, Andrea Peloso, Angelica Facoetti, Alessandro Vanoli, Sara Delfanti, Lorenzo Preda, Silvia Molinelli, Catherine Klersy, Piero Fossati, Roberto Orecchia and Francesca Valvo
    Citation: BMC Cancer 2019 19:922
    Content type: Study protocol Published on:

  11. Free flap-mediated gene therapy in the tumor bed following surgical resection is a promising approach in cancer targeted treatment of residual disease. We investigated the selective killing efficacy of a lenti...

    Authors: Jianhua Zhang, Yuanbo Liu, Mengqing Zang, Shan Zhu, Bo Chen, Shanshan Li, Bingjian Xue and Li Yan
    Citation: BMC Cancer 2019 19:921
    Content type: Research article Published on:

  12. Tumor-infiltrating immune cells are present in various malignant tumors, but their clinical significance in gastric cancer (GC) remains unclear. This study aimed to investigate the prognostic significance of t...

    Authors: Jun Lu, Yu Xu, Yuan Wu, Xiao-yan Huang, Jian-wei Xie, Jia-bin Wang, Jian-xian Lin, Ping Li, Chao-hui Zheng, Ai-min Huang and Chang-ming Huang
    Citation: BMC Cancer 2019 19:920
    Content type: Research article Published on:

  13. Single nucleotide polymorphisms (SNPs) in genes encoding mitotic kinases could influence development and progression of gastric cancer (GC).

    Authors: Aner Mesic, Marija Rogar, Petra Hudler, Nurija Bilalovic, Izet Eminovic and Radovan Komel
    Citation: BMC Cancer 2019 19:919
    Content type: Research article Published on:

  14. A number of circular RNAs (circRNAs) have been identified in various cancer including F-box and WD repeat domain containing 7 (FBXW7) circular RNA (circ-FBXW7), which can suppress glioma cell growth. However, ...

    Authors: Haoran Lu, Baofu Yao, Xinyuan Wen and Baoqing Jia
    Citation: BMC Cancer 2019 19:918
    Content type: Research article Published on:

  15. Renal cell carcinomas (RCC) harboring a TFE3 gene fusion (TfRCC) represent an aggressive subset of kidney tumors. Key signaling pathways of TfRCC are unknown and preclinical in vivo data are lacking. We investiga...

    Authors: Eric C. Kauffman, Martin Lang, Soroush Rais-Bahrami, Gopal N. Gupta, Darmood Wei, Youfeng Yang, Carole Sourbier and Ramaprasad Srinivasan
    Citation: BMC Cancer 2019 19:917
    Content type: Research article Published on:

  16. Fibrin-associated diffuse large B-cell lymphoma (FA-DLBCL) is a rare Epstein-Barr virus (EBV) positive lymphoproliferative disorder included in the current World Health Organization (WHO) classification. It ar...

    Authors: Magda Zanelli, Maurizio Zizzo, Marco Montanaro, Vito Gomes, Giovanni Martino, Loredana De Marco, Giulio Fraternali Orcioni, Maria Paola Martelli and Stefano Ascani
    Citation: BMC Cancer 2019 19:916
    Content type: Case report Published on:

  18. NY-BR-1 has been described as a breast cancer associated differentiation antigen with intrinsic immunogenicity giving rise to endogenous T and B cell responses. The current study presents the first murine tumo...

    Authors: Krishna Das, David Eisel, Mathias Vormehr, Karin Müller-Decker, Adriane Hommertgen, Dirk Jäger, Inka Zörnig, Markus Feuerer, Annette Kopp-Schneider, Wolfram Osen and Stefan B. Eichmüller
    Citation: BMC Cancer 2019 19:914
    Content type: Research article Published on:

  19. Gastrointestinal stromal tumor (GIST) is the most common primary mesenchymal neoplasm of the gastrointestinal tract. Mutations of KIT and platelet-derived growth factor receptor alpha have been well characteri...

    Authors: Li Li, Marian Khalili, Gregg Johannes, Praneeth Baratam, William F. Morano, Michael Styler, Wilbur B. Bowne and J. Steve Hou
    Citation: BMC Cancer 2019 19:913
    Content type: Case report Published on:

  20. Interaction between cancer cells and fibroblasts mediated by extracellular matrix metalloproteinase inducer (emmprin, CD147) is important in the invasion and proliferation of cancer cells. However, the exact m...

    Authors: M. Aoki, K. Koga, M. Miyazaki, M. Hamasaki, N. Koshikawa, M. Oyama, H. Kozuka-Hata, M. Seiki, B. P. Toole and K. Nabeshima
    Citation: BMC Cancer 2019 19:912
    Content type: Research article Published on:

  21. Gliomas account for the majority of primary human brain tumors and remain a challenging neoplasm for cure due to limited therapeutic options. Cell adhesion molecules play pivotal roles in the growth and progre...

    Authors: Qiong Jiang, Qing Xie, Chengliang Hu, Zhai Yang, Peizhi Huang, Huifan Shen, Melitta Schachner and Weijiang Zhao
    Citation: BMC Cancer 2019 19:911
    Content type: Research article Published on:

  22. Oligosaccharides of glycoprotein, particularly negatively-charged sialylated N-glycans, on the surface of lymphomas play important roles in cell–cell interactions and bind immunoglobulin-like lectins, causing inf...

    Authors: Yasuo Takashima, Takeshi Yoshimura, Yuichiro Kano, Azusa Hayano, Hiroaki Hondoh, Kazuhiro Ikenaka and Ryuya Yamanaka
    Citation: BMC Cancer 2019 19:910
    Content type: Research article Published on:

  23. Older patients with HER2-positive metastatic breast (HER2 + MBC) cancer are underrepresented in clinical trials. We aim to describe the treatment patterns and overall survival (OS) for older women receiving tr...

    Authors: Benjamin Daniels, Belinda E. Kiely, Monica Tang, Hanna Tervonen and Sallie-Anne Pearson
    Citation: BMC Cancer 2019 19:909
    Content type: Research article Published on:

  24. This study aimed to evaluate the prognostic value of maximal standard uptake values (SUVmax) of 18F-fluoro-2-deoxy-D-glucose positron emission tomography (PET) comparing with Epstein-Barr virus (EBV) DNA levels i...

    Authors: Xue-Song Sun, Yu-Jing Liang, Sai-Lan Liu, Qiu-Yan Chen, Shan-Shan Guo, Yue-Feng Wen, Li-Ting Liu, Hao-Jun Xie, Qing-Nan Tang, Xiao-Yun Li, Jin-Jie Yan, Lin-Quan Tang and Hai-Qiang Mai
    Citation: BMC Cancer 2019 19:908
    Content type: Research article Published on:

  25. Oncoplastic surgery techniques lead to a rearrangement of the breast tissue and impede target definition during adjuvant radiotherapy (RT). The aim of this study was to assess local control rates after immedia...

    Authors: Kai Joachim Borm, Christine Schönknecht, Andrea Nestler, Markus Oechsner, Birgit Waschulzik, Stephanie Elisabeth Combs, Stefan Münch, Markus Niemeyer and Marciana Nona Duma
    Citation: BMC Cancer 2019 19:907
    Content type: Research article Published on:

  26. Following definitive chemoradiation for anal squamous cell carcinoma (ASCC), patients face a variety of chronic issues including: bowel dysfunction, accelerated bone loss, sexual dysfunction, and psychosocial ...

    Authors: Marissa B. Savoie, Angela Laffan, Cristina Brickman, Bevin Daniels, Anna Levin, Tami Rowen, James Smith, Erin L. Van Blarigan, Thomas A. Hope, J. Michael Berry-Lawhorn, Mekhail Anwar and Katherine Van Loon
    Citation: BMC Cancer 2019 19:906
    Content type: Review Published on:

  27. As splenectomy and spleen-preserving lymphadenectomy are performed only in some proximal gastric cancer patients, it is difficult to identify patients who have undergone radical gastrectomy with or without spl...

    Authors: Peng Ding, Ziming Gao, Chen Zheng, Junqing Chen, Kai Li and Shan Gao
    Citation: BMC Cancer 2019 19:905
    Content type: Research article Published on:

  28. Appropriate assessment is essential for the management of chemotherapy-induced peripheral neuropathy (CIPN), an intractable symptom that cannot yet be palliated, which is high on the list of causes of distress...

    Authors: K. Kanda, K. Fujimoto, R. Mochizuki, K. Ishida and B. Lee
    Citation: BMC Cancer 2019 19:904
    Content type: Research article Published on:

  29. Prostate cancer (PCa) is the second most common cancer among men. New imaging-modalities have increased the diagnosed patients with limited number of metastasis after primary curative therapy, introducing so-c...

    Authors: Giulia Marvaso, Delia Ciardo, Giulia Corrao, Sara Gandini, Cristiana Fodor, Dario Zerini, Damaris Patricia Rojas, Matteo Augugliaro, Giuseppina Bonizzi, Salvatore Pece, Federica Cattani, Ketti Mazzocco, Francesco Alessandro Mistretta, Gennaro Musi, Sarah Alessi, Giuseppe Petralia…
    Citation: BMC Cancer 2019 19:903
    Content type: Study protocol Published on:

  30. The impact of HER2-targeted therapy alone followed by the addition of chemotherapy at disease progression (PD) versus upfront combination was investigated by the SAKK 22/99 trial. The aim of this exploratory a...

    Authors: Sabine Schmid, Dirk Klingbiel, Stefan Aebi, Aron Goldhirsch, Christoph Mamot, Elisabetta Munzone, Franco Nolè, Christian Oehlschlegel, Olivia Pagani, Bernhard Pestalozzi, Christoph Rochlitz, Beat Thürlimann, Roger von Moos, Patrik Weder, Khalil Zaman and Thomas Ruhstaller
    Citation: BMC Cancer 2019 19:902
    Content type: Research article Published on:

  31. Poly (ADP-ribose) Polymerase (PARP) inhibitors are promising novel radiosensitisers. Pre-clinical models have demonstrated potent and tumour-specific radiosensitisation by PARP inhibitors. Olaparib is a PARP i...

    Authors: R. de Haan, E. van Werkhoven, M.M. van den Heuvel, H. M. U. Peulen, G. S. Sonke, P. Elkhuizen, M. W. M. van den Brekel, M. E. T. Tesselaar, C. Vens, J. H. M. Schellens, B. van Triest and M. Verheij
    Citation: BMC Cancer 2019 19:901
    Content type: Study protocol Published on:

  32. The sensitivity of endoscopic ultrasound (EUS) in staging gastro-oesophageal cancers (GOCs) has been widely studied. However, the economic evidence of EUS staging in the management of patients with GOCs is sca...

    Authors: Seow Tien Yeo, Nathan Bray, Hasan Haboubi, Zoe Hoare and Rhiannon Tudor Edwards
    Citation: BMC Cancer 2019 19:900
    Content type: Research article Published on:

  33. Combination of chemotherapies (fluoropirimidines, oxaliplatin and irinotecan) with biologic drugs (bevacizumab, panitumumab, cetuximab) have improved clinical responses and survival of metastatic colorectal ca...

    Authors: Alessandro Ottaiano, Stefania Scala, Nicola Normanno, Maria Napolitano, Monica Capozzi, Anna Maria Rachiglio, Cristin Roma, Anna Maria Trotta, Crescenzo D’Alterio, Luigi Portella, Carmela Romano, Antonino Cassata, Rossana Casaretti, Lucrezia Silvestro, Anna Nappi, Salvatore Tafuto…
    Citation: BMC Cancer 2019 19:899
    Content type: Study protocol Published on:

  34. Although the leucine zipper-EF-hand-containing transmembrane protein 1 (LETM1) is one of the mitochondrial inner membrane proteins that is involved in cancer prognosis in various tumors, LETM1 as a biomarker f...

    Authors: Longzhen Piao, Zhaoting Yang, Ying Feng, Chengye Zhang, Chunai Cui and Yanhua Xuan
    Citation: BMC Cancer 2019 19:898
    Content type: Research article Published on:

  35. We evaluated the clinical efficacy and prognosis of muscle-invasive bladder cancer according to the basal/squamous-like (BASQ) classification system based on immunohistochemical staining [CK5/6(+), CK14(+), GA...

    Authors: Hyeong Dong Yuk, Chang Wook Jeong, Cheol Kwak, Hyeon Hoe Kim, Kyung Chul Moon and Ja Hyeon Ku
    Citation: BMC Cancer 2019 19:897
    Content type: Research article Published on:

  36. This study aimed to evaluate the efficacy, side-effects and resistance mechanisms of first-line afatinib in a real-world setting.

    Authors: Gwo-Fuang Ho, Chee-Shee Chai, Adlinda Alip, Mohd Ibrahim A. Wahid, Matin Mellor Abdullah, Yoke-Ching Foo, Soon-Hin How, Adel Zaatar, Kai-Seng Lam, Kin-Wah Leong, John-Seng-Hooi Low, Mastura Md Yusof, Erica Chai-Yong Lee, Yok-Yong Toh and Chong-Kin Liam
    Citation: BMC Cancer 2019 19:896
    Content type: Research article Published on:

  37. Chimeric antigen receptor (CAR)-based T cell therapy is in early clinical trials to target the neuroectodermal tumor, neuroblastoma. No preclinical or clinical efficacy data are available for retinoblastoma to...

    Authors: Lena Andersch, Josefine Radke, Anika Klaus, Silke Schwiebert, Annika Winkler, Elisa Schumann, Laura Grunewald, Felix Zirngibl, Carina Flemmig, Michael C. Jensen, Claudia Rossig, Antonia Joussen, Anton Henssen, Angelika Eggert, Johannes H. Schulte and Annette Künkele
    Citation: BMC Cancer 2019 19:895
    Content type: Research article Published on:

  38. Heterogeneous ribonucleoproteins (hnRNPs) are involved in the metastasis-related network. Our previous study demonstrated that hnRNP K is associated with epithelial-to-mesenchymal transition (EMT) in A549 cell...

    Authors: Liping Li, Songxin Yan, Hua Zhang, Min Zhang, Guofu Huang and Miaojuan Chen
    Citation: BMC Cancer 2019 19:894
    Content type: Research article Published on:

  39. To evaluate the short- and long-term outcomes of 3 different endoscopic dissection techniques for upper gastrointestinal (GI) submucosal tumours (SMTs).

    Authors: Xi-Feng Jin, Wei Gai, Rong-Lian Du, Tong-Hai Chai, Ling Li and Christoph J. Auernhammer
    Citation: BMC Cancer 2019 19:893
    Content type: Research article Published on:

  40. Cancer is a leading burden of disease in Australia and worldwide, with incidence rates varying with age, sex and geographic location. As part of the Ageing, Chronic Disease and Injury study, we aimed to map th...

    Authors: Stephanie P. Cowdery, Muhammad A. Sajjad, Kara L. Holloway-Kew, Mohammadreza Mohebbi, Lana J. Williams, Mark A. Kotowicz, Patricia M. Livingston, Mustafa Khasraw, Sharon Hakkennes, Trisha L. Dunning, Susan Brumby, Richard S. Page, Alasdair G Sutherland, Sharon L. Brennan-Olsen, Michael Berk, David Campbell…
    Citation: BMC Cancer 2019 19:892
    Content type: Research article Published on:

  41. Glutamate metabotropic receptors (GRM) play a variety of roles in neuronal cells. However, their clinical significance and biological functions in breast cancer remain unknown.

    Authors: Bin Xiao, Daxiang Chen, Quan Zhou, Jianfeng Hang, Weiyun Zhang, Zhenzhan Kuang, Zhaohui Sun and Linhai Li
    Citation: BMC Cancer 2019 19:891
    Content type: Research article Published on:

  42. Soft-tissue sarcomas (STS) are rare malignant tumors those are resistant to chemotherapy. We have previously reported the 3-year follow-up result on the efficacy of perioperative chemotherapy with doxorubicin ...

    Authors: Kazuhiro Tanaka, Junki Mizusawa, Norifumi Naka, Akira Kawai, Hirohisa Katagiri, Toru Hiruma, Yoshihiro Matsumoto, Hiroyuki Tsuchiya, Robert Nakayama, Hiroshi Hatano, Makoto Emori, Munenori Watanuki, Yukihiro Yoshida, Takeshi Okamoto, Satoshi Abe, Kunihiro Asanuma…
    Citation: BMC Cancer 2019 19:890
    Content type: Research article Published on:

  43. Capacitive-resistive electric transfer (CRET) is a non-invasive therapeutic strategy that applies radiofrequency electric currents within the 400–600 kHz range to tissue repair and regeneration. Previous studi...

    Authors: María Luisa Hernández-Bule, Enrique Medel, Clara Colastra, Raquel Roldán and Alejandro Úbeda
    Citation: BMC Cancer 2019 19:889
    Content type: Research article Published on:

  45. Hepatocellular carcinoma (HCC) is the most prevalent primary liver cancer, accounting for 80–90% of cases. Mutations are commonly found in the signaling regulating the PI3K/Akt pathway, leading to oncogenic ce...

    Authors: Miao Lu, Daniel Hartmann, Rickmer Braren, Aayush Gupta, Baocai Wang, Yang Wang, Carolin Mogler, Zhangjun Cheng, Thomas Wirth, Helmut Friess, Jörg Kleeff, Norbert Hüser and Yoshiaki Sunami
    Citation: BMC Cancer 2019 19:887
    Content type: Research article Published on:

  47. Evidences support social inequalities in cancer survival. Studies on hematological malignancies, and more specifically Acute Myeloid Leukemia (AML), are sparser. Our study assessed: 1/ the influence of patient...

    Authors: Eloïse Berger, Cyrille Delpierre, Fabien Despas, Sarah Bertoli, Emilie Bérard, Oriane Bombarde, Pierre Bories, Audrey Sarry, Guy Laurent, Christian Récher and Sébastien Lamy
    Citation: BMC Cancer 2019 19:883
    Content type: Research article Published on:

  48. Abrogation of growth factor-dependent signaling represents an effective therapeutic strategy for patients with colorectal cancer (CRC). Here we evaluated the effectiveness of targeting the epidermal growth fac...

    Authors: Lena-Christin Conradi, Melanie Spitzner, Anna-Lena Metzger, Merle Kisly, Peter Middel, Hanibal Bohnenberger, Jochen Gaedcke, Michael B. Ghadimi, Torsten Liersch, Joseph Rüschoff, Tim Beißbarth, Alexander König and Marian Grade
    Citation: BMC Cancer 2019 19:880
    Content type: Research article Published on:

  50. Breast cancer is the most common malignancy in women, and neoadjuvant chemotherapy has been recommended to the patients with locally advanced breast cancer as the initial treatments. Long non-coding RNA (lncRN...

    Authors: Battseren Bayarmaa, Ziping Wu, Jing Peng, Yan Wang, Shuguang Xu, Tingting Yan, Wenjin Yin, Jinsong Lu and Liheng Zhou
    Citation: BMC Cancer 2019 19:877
    Content type: Research article Published on:

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