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  1. Mouse and human studies support the promise of dry beans to improve metabolic health and to lower cancer risk. In overweight/obese patients with a history of colorectal polyps or cancer, the Beans to Enrich th...

    Authors: Xiaotao Zhang, Gladys Browman, Wesley Siu, Karen M. Basen-Engquist, Samir M. Hanash, Kristi L. Hoffman, Pablo C. Okhuysen, Paul Scheet, Joseph F. Petrosino, Scott Kopetz and Carrie R. Daniel
    Citation: BMC Cancer 2019 19:1233
    Content type: Study protocol Published on:

  2. We sought to assess the prognostic significance of lymph node ratio (LNR) and N stage in patients undergoing D2 gastrectomy and adjuvant chemotherapy, S-1, and XELOX and to compare the efficacy of them accordi...

    Authors: Kabsoo Shin, Se Jun Park, Jinsoo Lee, Cho Hyun Park, Kyo Young Song, Han Hong Lee, Ho Seok Seo, Yoon Ju Jung, Jae Myung Park, Sung Hak Lee, Sang Young Roh and In-Ho Kim
    Citation: BMC Cancer 2019 19:1232
    Content type: Research article Published on:

  3. Retrospective studies show improved outcomes in colorectal cancer patients if taking statins, including overall survival, pathological response of rectal cancer to preoperative chemoradiotherapy (pCRT), and re...

    Authors: Michael B. Jameson, Kirsten Gormly, David Espinoza, Wendy Hague, Gholamreza Asghari, Grahame Mark Jeffery, Timothy Jay Price, Christos Stelios Karapetis, Michael Arendse, James Armstrong, John Childs, Frank A. Frizelle, Sam Ngan, Andrew Stevenson, Martinus Oostendorp and Stephen P. Ackland
    Citation: BMC Cancer 2019 19:1229
    Content type: Study protocol Published on:

  4. To explain the association between adjuvant radiation therapy after breast conserving surgery (BCS RT) and overall survival (OS) by quantifying bias due to confounding in a sample of elderly breast cancer bene...

    Authors: Fabian Camacho, Roger Anderson and Gretchen Kimmick
    Citation: BMC Cancer 2019 19:1228
    Content type: Research article Published on:

  5. Following publication of the original article [1], the authors reported an error in Figure 2, where the color code of the text boxes is reversed. Figure 2-amended shows the correct color association between the t...

    Authors: Ainara Ruiz de Sabando, Edurne Urrutia Lafuente, Fermín García-Amigot, Angel Alonso Sánchez, Lourdes Morales Garofalo, Sira Moreno, Eva Ardanaz and Maria A. Ramos-Arroyo
    Citation: BMC Cancer 2019 19:1227
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2019 19:1145

  6. Neuroendocrine tumours (NETs) are rare malignancies characterised by its capacity to synthesise and secrete monoamines, due to its neuroendocrine origin. Its varied locations and symptoms have traditionally be...

    Authors: Josep Darbà and Alicia Marsà
    Citation: BMC Cancer 2019 19:1226
    Content type: Research article Published on:

  8. Mitochondria are considered a primary intracellular site of reactive oxygen species (ROS) generation. Generally, cancer cells with mitochondrial genetic abnormalities (copy number change and mutations) have es...

    Authors: Tarek Zaidieh, James R. Smith, Karen E. Ball and Qian An
    Citation: BMC Cancer 2019 19:1224
    Content type: Research article Published on:

  9. Texture analysis of medical images has been reported to be a reliable method for differential diagnosis of neoplasms. This study was to investigate the performance of textural features and the combined perform...

    Authors: Jing Yang, Xinli Guo, Hao Zhang, Weiwei Zhang, Jinen Song, Hui Xu and Xuelei Ma
    Citation: BMC Cancer 2019 19:1223
    Content type: Research article Published on:

  10. Neoadjuvant chemoradiotherapy is regarded as the standard of treatment for locally advanced lower rectal cancer, although some of these cases are systemic, and distant control may be inadequate. Neoadjuvant ch...

    Authors: Takuya Shiraishi, Takeshi Sasaki, Koji Ikeda, Yuichiro Tsukada, Yuji Nishizawa and Masaaki Ito
    Citation: BMC Cancer 2019 19:1222
    Content type: Research article Published on:

  11. Cervical cancer is a cancer of uterine cervix caused mostly by sexually-acquired infection called Human papillomavirus (HPV. In developing region of the globe, fewer than 50% of women with cervical malignancy ...

    Authors: Mulugeta Wassie, Zeleke Argaw, Yosief Tsige, Mesfin Abebe and Sezer Kisa
    Citation: BMC Cancer 2019 19:1221
    Content type: Research article Published on:

  12. Nivolumab is an immune checkpoint inhibitor (ICI) and is used for the treatment of advanced non-small cell lung cancer (NSCLC). Several immune-mediated neurological adverse events associated with ICIs have bee...

    Authors: Takashi Sakoh, Mami Kanzaki, Atsushi Miyamoto, Sayaka Mochizuki, Toshiyuki Kakumoto, Kenichiro Sato, Yoshikazu Uesaka and Kazuma Kishi
    Citation: BMC Cancer 2019 19:1220
    Content type: Case report Published on:

  13. The posterior-inferior border of symphysis (PIBS) point system is a novel vaginal dose-reporting method and is a simple and reliable method proposed by the Medical University of Vienna proposed for both extern...

    Authors: Juan Wang, Kai-shuo Zhang, Tao Wang, Zi Liu, Rui-hua Wang, Fu-quan Zhang, Lang Yu, Li Ran, Jian-li He, Ya-li Wang, Li-chun Wei, Mei Shi, Guo-qing Wang, Chao-qun Wu, Qi-jun Kang, Jie Yang…
    Citation: BMC Cancer 2019 19:1219
    Content type: Research article Published on:

  14. Consumption of moldy food has previously been identified as a risk factor for esophageal squamous cell carcinoma (ESCC) in high-risk countries; however, what contributing roles these dietary carcinogenic mycot...

    Authors: Kathy S. Xue, Lili Tang, Guiju Sun, Shaokang Wang, Xu Hu and Jia-Sheng Wang
    Citation: BMC Cancer 2019 19:1218
    Content type: Research article Published on:

  15. Granulocyte-colony stimulating factor (G-CSF) is increasingly been used to prevent febrile neutropenia (FN) associated with the administration of chemotherapy for various cancers. The most common adverse effec...

    Authors: Hideko Hoshina and Hiroyuki Takei
    Citation: BMC Cancer 2019 19:1217
    Content type: Case report Published on:

  16. Little is known about the relationship between the metabolite profile of plasma from pre-operative prostate cancer (PCa) patients and the risk of PCa progression. In this study we investigated the association ...

    Authors: Eugenio Zoni, Martina Minoli, Cédric Bovet, Anne Wehrhan, Salvatore Piscuoglio, Charlotte K. Y. Ng, Peter C. Gray, Martin Spahn, George N. Thalmann and Marianna Kruithof-de Julio
    Citation: BMC Cancer 2019 19:1216
    Content type: Research article Published on:

  17. The optimal timing of surgery in relation to chemoradiation is still controversial. Retrospective analysis has demonstrated in the recent decades that the regression of adenocarcinoma can be slow and not compl...

    Authors: Igor Monsellato, Filippo Alongi, Elisa Bertocchi, Stefania Gori, Giacomo Ruffo, Elisa Cassinotti, Ludovica Baldarti, Luigi Boni, Graziano Pernazza, Fabio Pulighe, Carlo De Nisco, Roberto Perinotti, Emilio Morpurgo, Tania Contardo, Enzo Mammano, Ugo Elmore…
    Citation: BMC Cancer 2019 19:1215
    Content type: Study protocol Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:128

  18. Monocytes are a major component of the tumor microenvironment (TME) in pancreatic ductal adenocarcinoma (PDAC). However, the complex interactions between tumor cells and monocytes and their role in tumor invas...

    Authors: Christian Benzing, Hoyin Lam, Chi Man Tsang, Alexander Rimmer, Yoana Arroyo-Berdugo, Yolanda Calle and Claire M. Wells
    Citation: BMC Cancer 2019 19:1214
    Content type: Research article Published on:

  19. Cranial radiotherapy (cRT) can induce hormonal deficiencies as a consequence of significant doses to the hypothalamic-pituitary (HP) axis. In contrast to profound endocrinological follow-up data from survivors...

    Authors: P. Mehta, F. B. Fahlbusch, D. Rades, S. M. Schmid, J. Gebauer and S. Janssen
    Citation: BMC Cancer 2019 19:1213
    Content type: Research article Published on:

  20. As biomarkers, DNA methylation is used to detect colorectal cancer (CRC) and make assessment of CRC prognosis. The published findings showed the association between the methylation of SFRP1, SFRP2, and WIF1, loca...

    Authors: Xinyan Liu, Jinming Fu, Haoran Bi, Anqi Ge, Tingting Xia, Yupeng Liu, Hongru Sun, Dapeng Li and Yashuang Zhao
    Citation: BMC Cancer 2019 19:1212
    Content type: Research article Published on:

  21. Increasing evidence indicates an etiological role of human papillomavirus (HPV) in head and neck cancers, particularly oropharyngeal squamous cell carcinoma (OPSCC). However, the association between HPV and ot...

    Authors: Siaw Shi Boon, Zigui Chen, Jintao Li, Karen Y. C. Lee, Liuyang Cai, Rugang Zhong and Paul K. S. Chan
    Citation: BMC Cancer 2019 19:1211
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2019 19:1255

  22. It was reported that tumor-expressed dickkopf-related (DKK) proteins affect micro-environment. However, the influence of DKK1 on colorectal cancer (CRC) liver oligometastases (CRCLOM) remains unclear.

    Authors: Qiaoqi Sui, Jian Zheng, Dingxin Liu, Jianhong Peng, Qingjian Ou, Jinghua Tang, Yuan Li, Lingheng Kong, Wu Jiang, Binyi Xiao, Xue Chao, Zhizhong Pan, Huizhong Zhang and Pei-Rong Ding
    Citation: BMC Cancer 2019 19:1210
    Content type: Research article Published on:

  23. Treatment with radioactive iodine is effective for many patients with progressive, locally advanced or metastatic, differentiated thyroid cancer. However, some patients become refractory to treatment. These ty...

    Authors: Nigel Fleeman, Rachel Houten, Marty Chaplin, Sophie Beale, Angela Boland, Yenal Dundar, Janette Greenhalgh, Rui Duarte and Aditya Shenoy
    Citation: BMC Cancer 2019 19:1209
    Content type: Research article Published on:

  24. Radical radiotherapy is the standard treatment for patients with locally advanced cervix uteri carcinoma (FIGO stage IB2–IVA). Worldwide, incidence and mortality rates vary among regions because of differences...

    Authors: Alparslan Serarslan, Bilge Gursel, Deniz Meydan and Nilgun Ozbek Okumus
    Citation: BMC Cancer 2019 19:1208
    Content type: Research article Published on:

  25. We aimed to estimate the stage-specific impact of lymph node dissection (LND) on survival for upper urinary tract urothelial carcinoma (UTUC) patients treated with nephroureterectomy (NU).

    Authors: Ting-Shuai Zhai, Liang Jin, Zhen Zhou, Xiang Liu, Huan Liu, Wei Chen, Jing-Yi Lu, Xu-Dong Yao, Li-Ming Feng and Lin Ye
    Citation: BMC Cancer 2019 19:1207
    Content type: Research article Published on:

  26. Stereotactic ablative radiotherapy (SABR) has become an established treatment option for medically-inoperable early-stage (Stage I-IIA) non-small cell lung cancer (ES-NSCLC). SABR is able to obtain high rates ...

    Authors: David A. Palma, Hanbo Chen, Houda Bahig, Stewart Gaede, Stephen Harrow, Joanna M. Laba, X. Melody Qu, George B. Rodrigues, Brian P. Yaremko, Edward Yu, Alexander V. Louie, Inderdeep Dhaliwal and Christopher J. Ryerson
    Citation: BMC Cancer 2019 19:1206
    Content type: Study protocol Published on:

  27. Cervical cancer is the second cause leading of malignancy-related death among Mexican women. The present study determined the population-based prevalence of high risk Human Papillomavirus (HR-HPV) infection an...

    Authors: K. Torres-Poveda, I. Ruiz-Fraga, V. Madrid-Marina, M. Chavez and V. Richardson
    Citation: BMC Cancer 2019 19:1205
    Content type: Research article Published on:

  28. Malignant pleural mesothelioma (MPM) is a debilitating disease of the pleural cavity. It is primarily associated with previous inhalation of asbestos fibers. These fibers initiate an oxidant coupled inflammato...

    Authors: Takumi Kishimoto, Nobukazu Fujimoto, Takeshi Ebara, Toyonori Omori, Tetsuya Oguri, Akio Niimi, Takako Yokoyama, Munehiro Kato, Ikuji Usami, Masayuki Nishio, Kosho Yoshikawa, Takeshi Tokuyama, Mouka Tamura, Yoshifumi Yokoyama, Ken Tsuboi, Yoichi Matsuo…
    Citation: BMC Cancer 2019 19:1204
    Content type: Research article Published on:

  30. Transcription factors forkhead box protein O1 (FOXO1) and paired box 3 (PAX3) have been reported to play important roles in various cancers. However, their role in epithelial ovarian cancer (EOC) has not been ...

    Authors: Gwan Hee Han, Doo Byung Chay, Sanghee Nam, Hanbyoul Cho, Joon-Yong Chung and Jae-Hoon Kim
    Citation: BMC Cancer 2019 19:1202
    Content type: Research article Published on:

  31. In patients diagnosed with ductal carcinoma in situ (DCIS) with needle biopsy before surgery, invasive component (IC) is often found in the postoperative tissue, which results in altered post-surgical care. Ho...

    Authors: Kwan Ho Lee, Jeong Woo Han, Eun Young Kim, Ji Sup Yun, Yong Lai Park and Chan Heun Park
    Citation: BMC Cancer 2019 19:1201
    Content type: Research article Published on:

  32. On the basis of some significant clinical parameters, we had an intent to establish nomograms for estimating the prognosis of patients with squamous cell carcinoma of the urinary bladder (SCCB), including over...

    Authors: Guanghao Zhang, Zhiwei Li, Daoqing Song and Zhiqing Fang
    Citation: BMC Cancer 2019 19:1200
    Content type: Research article Published on:

  33. Hormone replacement therapy (HRT) use has shown to be associated with a reduced risk of colorectal cancer, however, its impact on survival among women with colorectal cancer remains uncertain. This meta-analys...

    Authors: Yeu-Chai Jang, Hsi-Lan Huang and Chi Yan Leung
    Citation: BMC Cancer 2019 19:1199
    Content type: Research article Published on:

  34. Māori, Pacific and Asian women in New Zealand have lower cervical-cancer screening rates than European women, and there are persistent inequities in cervical cancer outcomes for Māori and Pacific women. Innova...

    Authors: Naomi Brewer, Karen Bartholomew, Anna Maxwell, Jane Grant, Helen Wihongi, Collette Bromhead, Nina Scott, Sue Crengle, Chris Cunningham, Jeroen Douwes and John D. Potter
    Citation: BMC Cancer 2019 19:1198
    Content type: Study protocol Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:163

  35. Glioblastoma multiform (GBM), a malignant brain tumour, has a very often poor prognosis. The therapeutic approach is represented by surgery followed by radiotherapy and chemotherapy. Hypoxia is a factor that c...

    Authors: Vincenzo Gangemi, Chiara Mignogna, Giusy Guzzi, Angelo Lavano, Salvatore Bongarzone, Giuseppe Lucio Cascini and Umberto Sabatini
    Citation: BMC Cancer 2019 19:1197
    Content type: Case report Published on:

  36. NF1(Neurofibromatosis type 1) is an autosomal dominant genetic disorder. Patients with NF1 have an increased risk of developing benign or malignant tumours, such as gastrointestinal stromal tumours (GISTs). Ho...

    Authors: Liang Shang, Zhen Fang, Jin Liu, Fengying Du, Haiyan Jing, Yali Xu, Kangdi Dong, Xiaoman Zhang, Hao Wu, Changqing Jing and Leping Li
    Citation: BMC Cancer 2019 19:1196
    Content type: Case report Published on:

  37. To discover biomarker panels that could distinguish cancers (BC and RCC) from healthy controls (HCs) and bladder cancers (BC) from renal cell carcinoma (RCC), regardless of whether the patients have haematuria...

    Authors: Zhan Wang, Xiaoyan Liu, Xiang Liu, Haidan Sun, Zhengguang Guo, Guoyang Zheng, Yushi Zhang and Wei Sun
    Citation: BMC Cancer 2019 19:1195
    Content type: Research article Published on:

  38. Brain metastasis (BM) is a rare event in ovarian cancer patients. The current prognostic scores that have been used for other tumors do not account for specific characteristics of ovarian cancer, such as plati...

    Authors: Alexandre André Balieiro Anastácio da Costa, Elizabeth Santana dos Santos, Deborah Porto Cotrim, Natasha Carvalho Pandolfi, Marcelle Goldner Cesca, Henrique Mantoan, Solange Moraes Sanches, Adriana Regina Gonçalves Ribeiro, Louise de Brot, Graziele Bonvolim, Paulo Issamu Sanematsu, Ronaldo Pereira de Souza, Joyce Maria Lisboa Maya, Fabrício de Souza Castro, João Paulo da Nogueira Silveira Lima, Michael Jenwel Chen…
    Citation: BMC Cancer 2019 19:1194
    Content type: Research article Published on:

  39. Immune checkpoint inhibitors (ICIs) have achieved unprecedented success in cancer treatment over the past decade. The application of ICIs hasled to the discovery of various types of immune-related adverse even...

    Authors: Yuan Liu, Zhi Liu, Xuejun Zeng, Chunmei Bai, Lin Chen, Songbai Lin and Xinlun Tian
    Citation: BMC Cancer 2019 19:1193
    Content type: Case report Published on:

  40. Hepatic stellate cells (HSCs) have a key role in fibrogenesis and in the filtrates of the hepatocellular carcinoma (HCC) stroma, in which they are remodeled and play a critical role in HCC progression. However...

    Authors: Xia Liao, Yang Bu, Fan Chang, Fengan Jia, Ge Song, Xuelian Xiao, Mei Zhang, Pengbo Ning and Qingan Jia
    Citation: BMC Cancer 2019 19:1192
    Content type: Research article Published on:

  41. Cholangiocarcinoma is a rapidly fatal cancer entity with a median survival of less than one year. In contrast to many other malignancies, no substantial therapeutic breakthrough has been made in the past few d...

    Authors: Thomas Albrecht, Melina Rausch, Stephanie Rössler, Michael Albrecht, Jana Dorothea Braun, Veronika Geissler, Arianeb Mehrabi, Monika Nadja Vogel, Anita Pathil-Warth, Gunhild Mechtersheimer, Marcus Renner, Christian Rupp, Karl Heinz Weiss, Elena Busch, Bruno Köhler, Christoph Springfeld…
    Citation: BMC Cancer 2019 19:1191
    Content type: Research article Published on:

  42. Hepatocellular carcinoma (HCC) is an aggressive solid tumor. HCC occurred at younger and elder ages were considered driven by different oncogenic mechanisms, and they demonstrated distinct clinical courses.

    Authors: Puo-Hsien Le, Chia-Jung Kuo, Yi-Chung Hsieh, Tsung-Hsing Chen, Chih-Lang Lin, Chau-Ting Yeh and Kung-Hao Liang
    Citation: BMC Cancer 2019 19:1190
    Content type: Research article Published on:

  43. Utilization of RNA sequencing methods to measure gene expression from archival formalin-fixed paraffin-embedded (FFPE) tumor samples in translational research and clinical trials requires reliable interpretati...

    Authors: Michal Marczyk, Chunxiao Fu, Rosanna Lau, Lili Du, Alexander J. Trevarton, Bruno V. Sinn, Rebekah E. Gould, Lajos Pusztai, Christos Hatzis and W. Fraser Symmans
    Citation: BMC Cancer 2019 19:1189
    Content type: Research article Published on:

  44. An extremely rare condition, radiation-induced angiosarcoma is characterized by a poor prognosis, high recurrence rate and lack of effective treatment. Herein, we present a case report of a 48-year-old female ...

    Authors: Jieshan Guan, Zhijie Luo, Zhiwei Xiao, Yubin Xie and Lizhu Lin
    Citation: BMC Cancer 2019 19:1188
    Content type: Case report Published on:

  45. Precise staging is indispensable to select the appropriate treatment strategy for gastric cancer (GC); however, the diagnostic accuracy of conventional modalities needs to be improved. This study investigated ...

    Authors: Toshiyuki Kosuga, Tomoki Konishi, Takeshi Kubota, Katsutoshi Shoda, Hirotaka Konishi, Atsushi Shiozaki, Kazuma Okamoto, Hitoshi Fujiwara, Michihiro Kudou, Tomohiro Arita, Ryo Morimura, Yasutoshi Murayama, Yoshiaki Kuriu, Hisashi Ikoma, Masayoshi Nakanishi and Eigo Otsuji
    Citation: BMC Cancer 2019 19:1187
    Content type: Research article Published on:

  46. Currently, clinical studies on the prognosis of prostate cancer (PC) taking aspirin were developing, but the precise mechanism of aspirin on tumor cells was still unclear. In addition, the conclusion that aspi...

    Authors: Jiatong Zhou, Shuai Xia, Tao Li and Ranlu Liu
    Citation: BMC Cancer 2019 19:1186
    Content type: Research article Published on:

  47. Several multicenter randomized controlled trials comparing laparoscopy and conventional open surgery for colon cancer have demonstrated that laparoscopic approach achieved the same oncological results while im...

    Authors: Gilles Manceau, Antoine Brouquet, Pascal Chaibi, Guillaume Passot, Olivier Bouché, Murielle Mathonnet, Jean-Marc Regimbeau, Rea Lo Dico, Jérémie H. Lefèvre, Frédérique Peschaud, Olivier Facy, Enrico Volpin, Elie Chouillard, Laura Beyert-Berjot, Marc Verny, Mehdi Karoui…
    Citation: BMC Cancer 2019 19:1185
    Content type: Study protocol Published on:

  49. The metabolic consequences of preoperative carbohydrate load in breast cancer patients are not known. The present explorative study investigated the systemic and tumor metabolic changes after preoperative per-...

    Authors: Tone Hoel Lende, Marie Austdal, Tone Frost Bathen, Anne Elin Varhaugvik, Ivar Skaland, Einar Gudlaugsson, Nina G. Egeland, Siri Lunde, Lars A. Akslen, Kristin Jonsdottir, Emiel A. M. Janssen, Håvard Søiland and Jan P. A. Baak
    Citation: BMC Cancer 2019 19:1183
    Content type: Research article Published on:

  50. Excess body weight and sub-optimal lifestyle are modifiable causes of breast cancer and other diseases. There is little evidence that behaviour change is possible within screening programmes and whether this i...

    Authors: Michelle Harvie, Mary Pegington, David French, Grace Cooper, Sarah McDiarmid, Anthony Howell, Louise Donnelly, Helen Ruane, Katharine Sellers, Philip Foden and D. Gareth Evans
    Citation: BMC Cancer 2019 19:1089
    Content type: Research article Published on:

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