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  1. Soluble Fms-like tyrosine kinase-1 (sFLT1) as an anti-angiogenic factor is abundantly expressed in placental trophoblasts. Choriocarcinoma, a malignant tumor derived from trophoblasts, is known to be highly an...

    Authors: Tadashi Sasagawa, Atsushi Jinno-Oue, Takeshi Nagamatsu, Kazuki Morita, Tetsushi Tsuruga, Mayuyo Mori-Uchino, Tomoyuki Fujii and Masabumi Shibuya
    Citation: BMC Cancer 2020 20:112
    Content type: Research article Published on:

  2. TP53 mutations occur in only about 3% of primary and 10–20% of relapse B-cell precursor acute lymphoblastic leukaemia (BCP-ALL). However, alternative mechanisms may contribute to functionally impairing the p53 pa...

    Authors: Lixian Oh, Pierre Hainaut, Sandrine Blanchet and Hany Ariffin
    Citation: BMC Cancer 2020 20:110
    Content type: Research article Published on:

  3. This study aims to understand the factors that influence whether patients receive potentially curative treatment for early stage lung cancer. A key question was whether indigenous Māori patients were less like...

    Authors: Ross Lawrenson, Chunhuan Lao, Leonie Brown, Lucia Moosa, Lynne Chepulis, Rawiri Keenan, Jacquie Kidd, Karen Middleton, Paul Conaglen, Charles de Groot, Denise Aitken and Janice Wong
    Citation: BMC Cancer 2020 20:109
    Content type: Research article Published on:

  4. Colorectal cancer (CRC) in patients aged under 55 years is on the rise, constituting approximately 10% of cases. Our aim was to determine the survival and clinico-pathological details of young-onset CRC (yCRC)...

    Authors: Sarah Perrott, Kirsten Laurie, Kirsten Laws, Annie Johnes, Zosia Miedzybrodzka and Leslie Samuel
    Citation: BMC Cancer 2020 20:108
    Content type: Research article Published on:

  5. Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is used in the palliative treatment of peritoneal metastasis. The combination of intraperitoneal and systemic chemotherapy seems rational, and the aim o...

    Authors: Magnus Ploug, Martin Graversen, Per Pfeiffer and Michael Bau Mortensen
    Citation: BMC Cancer 2020 20:105
    Content type: Research article Published on:

  6. Recent studies indicate the benefit of treatment with osimertinib over that with conventional epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKI) for untreated EGFR-mutated non-small cell lun...

    Authors: Mariko Kogo, Daichi Fujimoto, Kazutaka Hosoya, Kazuma Nagata, Atsushi Nakagawa, Ryo Tachikawa, Daisuke Yamashita, Yuka Kitamura, Yukihiro Imai and Keisuke Tomii
    Citation: BMC Cancer 2020 20:104
    Content type: Research article Published on:

  7. Epidermal growth factor receptor (EGFR)-sensitizing mutation, exon 19 deletion consists of several molecular variants. Influences of these variants on clinical response to EGFR tyrosine kinase inhibitors remain e...

    Authors: Nahomi Tokudome, Yasuhiro Koh, Hiroaki Akamatsu, Daichi Fujimoto, Isamu Okamoto, Kazuhiko Nakagawa, Toyoaki Hida, Fumio Imamura, Satoshi Morita and Nobuyuki Yamamoto
    Citation: BMC Cancer 2020 20:103
    Content type: Research article Published on:

  8. Neuroblastoma is the most common extracranial solid tumor of childhood. The high rate of recurrence is associated with a low survival rate for patients with high-risk neuroblastoma. There is thus an urgent nee...

    Authors: Yan Su, Lijun Wang, Chiyi Jiang, Zhixia Yue, Hongjun Fan, Huimin Hong, Chao Duan, Mei Jin, Dawei Zhang, Lihua Qiu, Xianfeng Cheng, Zhong Xu and Xiaoli Ma
    Citation: BMC Cancer 2020 20:102
    Content type: Research article Published on:

  9. Epidemiological studies on the association between coffee intake and cancer risk have yielded inconsistent results. To summarize and appraise the quality of the current evidence, we conducted an umbrella revie...

    Authors: Long-Gang Zhao, Zhuo-Ying Li, Guo-Shan Feng, Xiao-Wei Ji, Yu-Ting Tan, Hong-Lan Li, Marc J. Gunter and Yong-Bing Xiang
    Citation: BMC Cancer 2020 20:101
    Content type: Research article Published on:

  10. The purpose of this study was to investigate the value of wavelet-transformed radiomic MRI in predicting the pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) for patients with locally adv...

    Authors: Jiali Zhou, Jinghui Lu, Chen Gao, Jingjing Zeng, Changyu Zhou, Xiaobo Lai, Wenli Cai and Maosheng Xu
    Citation: BMC Cancer 2020 20:100
    Content type: Research article Published on:

  11. Gastrointestinal stromal tumor (GIST) initiation and evolution is commonly framed by KIT/PDGFRA oncogenic activation, and in later stages by the polyclonal expansion of resistant subpopulations harboring KIT s...

    Authors: César Serrano, Ana Vivancos, Antonio López-Pousa, Judit Matito, Francesco M. Mancuso, Claudia Valverde, Sergi Quiroga, Stefania Landolfi, Sandra Castro, Cristina Dopazo, Ana Sebio, Anna C. Virgili, María M. Menso, Javier Martín-Broto, Miriam Sansó, Alfonso García-Valverde…
    Citation: BMC Cancer 2020 20:99
    Content type: Research article Published on:

  12. Men who have sex with men (MSM) living with HIV are at increased risk for anal cancer. We evaluated satisfaction with first-time anal cancer screening using high resolution anoscopy (HRA) as a cross sectional ...

    Authors: Rebecca G. Nowak, Chinedu H. Nnaji, Wuese Dauda, Andrew Mitchell, Oluwole Olaomi, Paul Jibrin, Trevor A. Crowell, Stefan D. Baral, Nicaise Ndembi, Manhattan E. Charurat, Joel M. Palefsky, Søren M. Bentzen and Kevin J. Cullen
    Citation: BMC Cancer 2020 20:98
    Content type: Research article Published on:

  13. For selected locally advanced prostate cancer (PCa) patients, radical prostatectomy (RP) is one of the first-line treatments. We aimed to develop a preoperative nomogram to identify what kinds of patients can ...

    Authors: Xianghong Zhou, Qingyang Ning, Kun Jin, Tao Zhang and Xuelei Ma
    Citation: BMC Cancer 2020 20:97
    Content type: Research article Published on:

  14. A decrease in thermogenesis is suspected to be implicated in the energy expenditure reduction during breast cancer treatment. This study aimed to investigate the impact of chemotherapy on the metabolic activit...

    Authors: Angeline Ginzac, Bertrand Barres, Marion Chanchou, Emilie Gadéa, Ioana Molnar, Charles Merlin, Bruno Coudert, Emilie Thivat and Xavier Durando
    Citation: BMC Cancer 2020 20:96
    Content type: Research article Published on:

  15. Neuromedin U (NMU) is a neuropeptide belonging to the neuromedin family. Recently, significant associations between NMU and several cancers have been reported. However, no studies have examined the association...

    Authors: Qiao Li, Lingyu Han, Shengnan Ruan, Shunli Shen, Qinghua Cao, Xiuqin Cai, Yuan Yan, Baogang Peng and Yunpeng Hua
    Citation: BMC Cancer 2020 20:95
    Content type: Research article Published on:

  16. Lymphovascular invasion (LVI) is a vital risk factor for prognosis across cancers. We aimed to develop a scoring system for stratifying LVI risk in patients with breast cancer.

    Authors: Ma-yi-di-li Ni-jia-ti, Di-li-a-re-mu Ai-hai-ti, Ai-si-ka-er-jiang Huo-jia, Pa-li-dan-mu Wu-mai-er, A-bu-du-ke-you-mu-jiang A-bu-li-zi, Yu Shi, Nu-er-a-mi-na Rou-zi, Wen-jing Su, Guo-zhao Dai and Mai-he-mi-ti-jiang Da-mo-la
    Citation: BMC Cancer 2020 20:94
    Content type: Research article Published on:

  17. Pembrolizumab is effective as first-line therapy against advanced non-small cell lung cancer (NSCLC) in patients with programmed death ligand-1 (PD-L1) expression levels ≥50% [1]. However, it is not effective ...

    Authors: Mitsunori Morita, Motohiro Tamiya, Daichi Fujimoto, Akihiro Tamiya, Hidekazu Suzuki, Katsuya Hirano, Yasushi Fukuda, Toshihide Yokoyama, Ryota Kominami, Masaki Kanazu, Junji Uchida, Satoshi Hara, Shuji Yamashita and Hiromi Tomioka
    Citation: BMC Cancer 2020 20:93
    Content type: Research article Published on:

  18. Colorectal cancer (CRC) is a major killer. Host immunity is important in tumorigenesis. Direct comparison among IL-36α, IL-36β and IL-36γ in the prognosis of CRC is unclear.

    Authors: Feier Chen, Meng Qu, Feng Zhang, Zhenyu Tan, Qinghua Xia, Brett D. Hambly, Shisan Bao and Kun Tao
    Citation: BMC Cancer 2020 20:92
    Content type: Research article Published on:

  19. The standard first- and second- line chemotherapy backbone regimens for metastatic colorectal cancer (mCRC) are 5-fluorouracil (5-FU)/capecitabine-based with addition of irinotecan or oxaliplatin. Until recent...

    Authors: Timothy Iveson, Angela M. Carter, Kai-Keen Shiu, Clare Spooner, Daniel Stevens and Saifee Mullamitha
    Citation: BMC Cancer 2020 20:91
    Content type: Research article Published on:

  20. It has been hypothesized that radiotherapy (RT) techniques delivering radiations to larger volumes (IMRT, VMAT) are potentially associated with a higher risk of second primary tumors. The aim of this study was...

    Authors: Milly BUWENGE, Erica SCIROCCO, Francesco DEODATO, Gabriella MACCHIA, Maria NTRETA, Silvia BISELLO, Giambattista SIEPE, Savino CILLA, Anna Rita ALITTO, Vincenzo VALENTINI, Lidia STRIGARI, Alessio G. MORGANTI and Silvia CAMMELLI
    Citation: BMC Cancer 2020 20:90
    Content type: Research article Published on:

  21. We compared the efficacy and toxicity of three IC regimens (TPF: taxanes, cisplatin, and 5-fluorouracil; TP: taxanes and cisplatin; and PF: cisplatin and 5-fluorouracil) followed by CCRT in locoregionally adva...

    Authors: Sai-Lan Liu, Xue-Song Sun, Hao-Jun Xie, Qiu-Yan Chen, Huan-Xin Lin, Hu Liang, Yu-Jing Liang, Xiao-Yun Li, Jin-Jie Yan, Chao Lin, Zhen-Chong Yang, Shan-Shan Guo, Li-Ting Liu, Qing-Nan Tang, Yu-Yun Du, Lin-Quan Tang…
    Citation: BMC Cancer 2020 20:89
    Content type: Research article Published on:

  22. This planning study compares different radiotherapy techniques for patients with pituitary adenoma, including flatness filter free mode (FFF), concerning plan quality and secondary malignancies for potentially...

    Authors: Marius Treutwein, Felix Steger, Rainer Loeschel, Oliver Koelbl and Barbara Dobler
    Citation: BMC Cancer 2020 20:88
    Content type: Research article Published on:

  23. Following publication of the original article [1], an error was reported in the author group. The correct author group should read as follows:

    Authors: Anita Feller, Katarina L. Matthes, Andrea Bordoni, Christine Bouchardy, Jean-Luc Bulliard, Christian Herrmann, Isabelle Konzelmann, Manuela Maspoli, Mohsen Mousavi, Sabine Rohrmann, Katharina Staehelin and Volker Arndt
    Citation: BMC Cancer 2020 20:87
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:51

  25. Interrogation of site-specific CpG methylation in circulating tumor DNAs (ctDNAs) has been employed in a number of studies for early detection of breast cancer (BrCa). In many of these studies, the markers wer...

    Authors: Manny D. Bacolod, Jianmin Huang, Sarah F. Giardina, Philip B. Feinberg, Aashiq H. Mirza, Alexander Swistel, Steven A. Soper and Francis Barany
    Citation: BMC Cancer 2020 20:85
    Content type: Research article Published on:

  26. Cancer subtyping has mainly relied on pathological and molecular means. Massively parallel sequencing-enabled subtyping requires genomic markers to be developed based on global features rather than individual ...

    Authors: Zhenggang Wu, Xi Long, Shui Ying Tsang, Taobo Hu, Jian-Feng Yang, Wai Kin Mat, Hongyang Wang and Hong Xue
    Citation: BMC Cancer 2020 20:84
    Content type: Research article Published on:

  27. Gene expression profiling has consistently identified three molecular subtypes of lung adenocarcinoma that have prognostic implications. To facilitate stratification of patients with this disease into similar ...

    Authors: Roberto Ruiz-Cordero, Junsheng Ma, Abha Khanna, Genevieve Lyons, Waree Rinsurongkawong, Roland Bassett, Ming Guo, Mark J. Routbort, Jianjun Zhang, Ferdinandos Skoulidis, John Heymach, Emily B. Roarty, Zhenya Tang, L. Jeffrey Medeiros, Keyur P. Patel, Rajyalakshmi Luthra…
    Citation: BMC Cancer 2020 20:83
    Content type: Research article Published on:

  28. Although the pancreatic ductal adenocarcinoma (PDAC) presents high mortality and metastatic potential, there is a lack of effective therapies and a low survival rate for this disease. This PDAC scenario urges ...

    Authors: Palloma Porto Almeida, Cristina Padre Cardoso and Leandro Martins de Freitas
    Citation: BMC Cancer 2020 20:82
    Content type: Software Published on:

  29. Increased usage of genomic risk assessment assays suggests increased reliance on data provided by these assays to guide therapy decisions. The current study aimed to assess the change in treatment decision and...

    Authors: Hatem Soliman, Varsha Shah, Gordan Srkalovic, Reshma Mahtani, Ellis Levine, Blanche Mavromatis, Jayanthi Srinivasiah, Mohamad Kassar, Robert Gabordi, Rubina Qamar, Sarah Untch, Heather M. Kling, Tina Treece and William Audeh
    Citation: BMC Cancer 2020 20:81
    Content type: Research article Published on:

  31. Gliomas consist of a heterogeneous group of tumors. This study aimed to report the incidences of O6-methylguanine-DNA-methyltransferase (MGMT) promoter methylation, 1p19q co-deletion, isocitrate dehydrogenase (ID...

    Authors: Samantha Ya Lyn Ang, Lester Lee, Angela An Qi See, Ting Yao Ang, Beng Ti Ang and Nicolas Kon Kam King
    Citation: BMC Cancer 2020 20:79
    Content type: Research article Published on:

  32. Although immediate breast reconstruction has been reported to be oncologically safe, no affirmative study comparing the two reconstruction methods exists. We investigated breast cancer recurrence rates in two ...

    Authors: Jeong Hyun Ha, Ki Yong Hong, Han-Byoel Lee, Hyeong-Gon Moon, Wonshik Han, Dong-Young Noh, Joonho Lim, Sehoon Yoon, Hak Chang and Ung Sik Jin
    Citation: BMC Cancer 2020 20:78
    Content type: Research article Published on:

  33. Recently, accumulating evidence has suggested that the aberrant expression of SNHG6 exists in a variety of tumors and has a correlation with poor clinical outcomes across cancer patients. Considering the incon...

    Authors: Si Zhao, Hanlong Zhu, Ruonan Jiao, Xueru Wu, Guozhong Ji and Xiuhua Zhang
    Citation: BMC Cancer 2020 20:77
    Content type: Research article Published on:

  34. The prognosis of non-small-cell lung cancer (NSCLC) with brain metastases is very poor. Currently, therapeutic methods for this patient population include whole-brain radiation therapy (WBRT), surgery, radiosu...

    Authors: Kejun Liu, Guanming Jiang, Ailing Zhang, Zhuanghua Li and Jun Jia
    Citation: BMC Cancer 2020 20:76
    Content type: Research article Published on:

  35. Carbon ion Radiotherapy for prostate cancer is widely used, however reports are limited from single institute or short follow up. We performed a prospective observational study (GUNMA0702) to evaluate the feas...

    Authors: Hidemasa Kawamura, Nobuteru Kubo, Hiro Sato, Tatsuji Mizukami, Hiroyuki Katoh, Hitoshi Ishikawa, Tatsuya Ohno, Hiroshi Matsui, Kazuto Ito, Kazuhiro Suzuki and Takashi Nakano
    Citation: BMC Cancer 2020 20:75
    Content type: Research article Published on:

  36. Approximately 40% of colorectal cancer patients will develop colorectal liver metastases (CRLM). The most effective approach to increase long-term survival is CRLM complete resection. Unfortunately, only 10–15...

    Authors: Alice Boilève, Aline Maillard, Mathilde Wagner, Clarisse Dromain, Christophe Laurent, Eric Dupont Bierre, Samuel Le Sourd, Franck Audemar, Ayhan Ulusakarya, Veronique Guerin-Meyer, Denis Smisth, Veronica Pezzella, Thierry De Baere, Diane Goere, Maximiliano Gelli, Julien Taieb…
    Citation: BMC Cancer 2020 20:74
    Content type: Study protocol Published on:

  37. This study aimed to compare clinical outcomes following placement of fully covered self-expanding metallic stents (FCSEMS) vs partially covered self-expanding metallic stents (PCSEMS) for palliative treatment ...

    Authors: Chunmei Wang, Hua Wei and Yuxia Li
    Citation: BMC Cancer 2020 20:73
    Content type: Research article Published on:

  38. Breast cancer (BC) is known to be the most common malignancy in females whereas colorectal cancer (CRC) incidence also higher in both genders in Sri Lanka. TP53 is an important tumour suppressor gene and its soma...

    Authors: Vahinipriya Manoharan, Eric Hamilton Karunanayake, Kamani Hemamala Tennekoon, Sumadee De Silva, Ahamed Ilyas Ahamed Imthikab, Kanishka De Silva, Preethika Angunawela, Sameera Vishwakula and John Lunec
    Citation: BMC Cancer 2020 20:72
    Content type: Research article Published on:

  39. Kaposi’s sarcoma (KS) is one of the most common HIV-associated malignancies in sub-Saharan Africa. Worldwide, the availability of antiretroviral therapy (ART) has improved KS survival. In resource-rich setting...

    Authors: Esther E. Freeman, Naftali Busakhala, Susan Regan, Fredrick Chite Asirwa, Megan Wenger, Divya Seth, Khatiya Chelidze Moon, Aggrey Semeere, Toby Maurer, Kara Wools-Kaloustian, Ingrid Bassett and Jeffrey Martin
    Citation: BMC Cancer 2020 20:71
    Content type: Research article Published on:

  41. Second primary cancer of the esophagus is frequent in head and neck patients, especially in high-risk populations, and has a great impact on the prognosis. Although Positron emission tomography (PET)/computed ...

    Authors: Hsuan-An Su, Shun-Wen Hsiao, Yu-Chun Hsu, Lien-Yen Wang and Hsu-Heng Yen
    Citation: BMC Cancer 2020 20:69
    Content type: Research article Published on:

  42. The antibody targeting platelet-derived growth factor receptor alpha (PDGFRA), olaratumab, was approved in 2016 for metastatic soft tissue sarcoma (STS) in combination with doxorubicin based on promising resul...

    Authors: Jana Käthe Striefler, Franziska Brandes, Alexander Baur, Berit Maria Pfitzner, David Kaul, Daniel Rau, Anne Dörr, Maren Schmiester, Georgios Koulaxouzidis, Lars Bullinger, Sven Märdian and Anne Flörcken
    Citation: BMC Cancer 2020 20:68
    Content type: Research article Published on:

  43. We previously reported that tamoxifen (TAM)-induced ovarian hyperstimulation (OHS) is associated with high serum concentrations of estradiol in premenopausal women with breast cancer. To investigate risk facto...

    Authors: Rena Yamazaki, Masafumi Inokuchi, Satoko Ishikawa, Takuya Ayabe, Hiromitsu Jinno, Takashi Iizuka, Masanori Ono, Subaru Myojo, Soko Uchida, Toshiya Matsuzaki, Akira Tangoku, Masato Kita, Tomoharu Sugie and Hiroshi Fujiwara
    Citation: BMC Cancer 2020 20:67
    Content type: Research article Published on:

  44. We sought to construct the optimal neurocognitive function (NCF) change criteria sensitive to health-related quality of life (HR-QOL) in patients who have undergone whole-brain radiation therapy (WBRT) for bra...

    Authors: Toshimichi Nakano, Hidefumi Aoyama, Hirotake Saito, Satoshi Tanabe, Kensuke Tanaka, Katsuya Maruyama, Tomoya Oshikane, Atsushi Ohta, Eisuke Abe and Motoki Kaidu
    Citation: BMC Cancer 2020 20:66
    Content type: Research article Published on:

  45. Osteosarcoma is a primary malignant tumor originating from mesenchymal tissue, with a poor distant metastasis prognosis. The molecular mechanisms of osteosarcoma metastasis are extremely complicated.

    Authors: Mi Li, Xin Jin, Hao Li, Gang Wu, Shanshan Wang, Caihong Yang and Sisi Deng
    Citation: BMC Cancer 2020 20:65
    Content type: Research article Published on:

  46. It is still difficult to detect and diagnose early adenocarcinoma of the esophagogastric junction (EGJ) using conventional endoscopy or image-enhanced endoscopy. A glutamylprolyl hydroxymethyl rhodamine green ...

    Authors: Keiko Yamamoto, Shunsuke Ohnishi, Takeshi Mizushima, Junichi Kodaira, Masayoshi Ono, Yutaka Hatanaka, Kanako C. Hatanaka, Yugo Kuriki, Mako Kamiya, Nobuyuki Ehira, Keisuke Shinada, Hiroaki Takahashi, Yuichi Shimizu, Yasuteru Urano and Naoya Sakamoto
    Citation: BMC Cancer 2020 20:64
    Content type: Research article Published on:

  47. The value of the CT features and quantitative analysis of lung subsolid nodules (SSNs) in the prediction of the pathological grading of lung adenocarcinoma is discussed.

    Authors: Xiaohu Li, Wei Zhang, Yongqiang Yu, Guihong Zhang, Lifen Zhou, Zongshan Wu and Bin Liu
    Citation: BMC Cancer 2020 20:60
    Content type: Research article Published on:

  50. This study aimed to evaluate the safety and feasibility of self-expanding metallic stent (SEMS) followed by neoadjuvant chemotherapy prior to elective surgery for obstructing left-sided colon cancer.

    Authors: Jia Gang Han, Zhen Jun Wang, Wei Gen Zeng, Yan Bin Wang, Guang Hui Wei, Zhi Wei Zhai, Bao Cheng Zhao and Bing Qiang Yi
    Citation: BMC Cancer 2020 20:57
    Content type: Research article Published on:

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