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  1. Clear cell renal cell carcinoma (ccRCC) is the most common form of adult kidney cancer. Ubiquitin-specific protease (USP)44 has been reported to be involved in various cancers. We investigated the function, ro...

    Authors: Jiangqiao Zhou, Tianyu Wang, Tao Qiu, Zhongbao Chen, Xiaoxiong Ma, Long Zhang and Jilin Zou
    Citation: BMC Cancer 2020 20:214
    Content type: Research article Published on:

  2. Tumor mutational burden (TMB) is a potential biomarker for immune checkpoint therapy and prognosis. The impact of TMB on clinical outcomes and the correlation coefficient between exome sequencing and targeted ...

    Authors: Lihong Wang, Jia Ge, Yang Lan, Yu Shi, Ying Luo, Yuhuan Tan, Mei Liang, Song Deng, Xia Zhang, Wenying Wang, Yaoyao Tan, Yuanyuan Xu and Tao Luo
    Citation: BMC Cancer 2020 20:213
    Content type: Research article Published on:

  3. The incidence of breast cancer among young women (aged ≤40 years) has increased in North America and Europe. Fewer than 10% of cases among young women are attributable to inherited BRCA1 or BRCA2 mutations, sugge...

    Authors: Nicole E. Mealey, Dylan E. O’Sullivan, Joy Pader, Yibing Ruan, Edwin Wang, May Lynn Quan and Darren R. Brenner
    Citation: BMC Cancer 2020 20:212
    Content type: Research article Published on:

  4. Acute lymphoblastic leukemia (ALL), the most common childhood malignancy, is characterized by recurring structural chromosomal alterations and genetic alterations, whose detection is critical in diagnosis, ris...

    Authors: Honghong Zhang, Hongsheng Wang, Xiaowen Qian, Shuai Gao, Jieqi Xia, Junwen Liu, Yanqin Cheng, Jie Man and Xiaowen Zhai
    Citation: BMC Cancer 2020 20:211
    Content type: Research article Published on:

  5. Tumor budding (TB) is used as an indicator of poor prognosis in various cancers. However, studies on TB in perihilar cholangiocarcinoma are still limited. We examined the significance of TB in resected perihil...

    Authors: Takahiro Ito, Naohisa Kuriyama, Yuji Kozuka, Haruna Komatsubara, Ken Ichikawa, Daisuke Noguchi, Aoi Hayasaki, Tekehiro Fujii, Yusuke Iizawa, Hiroyuki Kato, Akihiro Tanemura, Yasuhiro Murata, Masashi Kishiwada, Shugo Mizuno, Masanobu Usui, Hiroyuki Sakurai…
    Citation: BMC Cancer 2020 20:209
    Content type: Research article Published on:

  6. Inflammation-related parameters have been revealed to have prognostic value in multiple caners. However, the significance of some inflammation-related parameters, including the peripheral blood neutrophil-to-l...

    Authors: Li-jian Xia, Wen Li, Jian-cheng Zhai, Chuan-wang Yan, Jing-bo Chen and Hui Yang
    Citation: BMC Cancer 2020 20:208
    Content type: Research article Published on:

  7. Dissociated responses (DR) are phenomena in which some tumors shrink, whereas others progress during treatment of patients with cancer. The purpose of the present study was to evaluate the frequency and progno...

    Authors: Takehiro Tozuka, Satoru Kitazono, Hiroaki Sakamoto, Hiroshi Yoshida, Yoshiaki Amino, Shinya Uematsu, Takahiro Yoshizawa, Tsukasa Hasegawa, Ken Uchibori, Noriko Yanagitani, Atsushi Horiike, Takeshi Horai, Masahiro Seike, Akihiko Gemma and Makoto Nishio
    Citation: BMC Cancer 2020 20:207
    Content type: Research article Published on:

  9. Classical MPNs including ET and PMF have a chronic course and potential for leukaemic transformation. Timely diagnosis is obligatory to ensure appropriate management and positive outcomes. The aim of this stud...

    Authors: Uzma Zaidi, Gul Sufaida, Munazza Rashid, Bushra Kaleem, Sidra Maqsood, Samina Naz Mukry, Rifat Zubair Ahmed Khan, Saima Munzir, Munira Borhany and Tahir Sultan Shamsi
    Citation: BMC Cancer 2020 20:205
    Content type: Research article Published on:

  10. Poly (ADP-ribose) polymerase inhibitors targeting BRCA1/2 mutations are available for treating patients with high-grade serous ovarian cancer. These treatments may be more appropriately directed to patients who m...

    Authors: Kyung Jin Eoh, Hye Min Kim, Jung-Yun Lee, Sunghoon Kim, Sang Wun Kim, Young Tae Kim and Eun Ji Nam
    Citation: BMC Cancer 2020 20:204
    Content type: Research article Published on:

  11. Na+/H+ exchanger regulatory factor 1 (NHERF1) is an important scaffold protein participates in the modulation of a variety of intracellular signal pathways. NHERF1 was able to enhance the effects of chemo-drugs i...

    Authors: Fenglian Yang, Mu Hu, Siyuan Chang, Jing Huang, Yang Si, Jinghui Wang, Shan Cheng and Wen G. Jiang
    Citation: BMC Cancer 2020 20:202
    Content type: Research article Published on:

  12. The fine-needle aspiration (FNA) biopsy was broadly applied to clinical diagnostics evaluation for thyroid carcinomas nodule, while companioning with higher uncertainty rate (15~30%) to identify malignancy for...

    Authors: Dandan Wu, Shudong Hu, Yongzhong Hou, Yingying He and Shubai Liu
    Citation: BMC Cancer 2020 20:199
    Content type: Research article Published on:

  13. Median survival for patients with glioblastoma is less than a year. Standard treatment consists of surgical debulking if feasible followed by temozolomide chemo-radiotherapy. The immune checkpoint inhibitor ip...

    Authors: Nicholas F. Brown, Stasya M. Ng, Claire Brooks, Tim Coutts, Jane Holmes, Corran Roberts, Leena Elhussein, Peter Hoskin, Tim Maughan, Sarah Blagden and Paul Mulholland
    Citation: BMC Cancer 2020 20:198
    Content type: Study protocol Published on:

  14. BRCA1/2 germline mutation related cancers are candidates for new immune therapeutic interventions. This study was a hypothesis generating exploration of genomic data collected at diagnosis for 19 patients. The...

    Authors: Ewa Przybytkowski, Thomas Davis, Abdelrahman Hosny, Julia Eismann, Ursula A. Matulonis, Gerburg M. Wulf and Sheida Nabavi
    Citation: BMC Cancer 2020 20:197
    Content type: Research article Published on:

  15. The expression of vascular endothelial growth factor (VEGF)-A/ VAGF receptors (VEGFRs) signaling plays a pivotal role in the tumor angiogenesis and the development of the immunosuppressive tumor microenvironme...

    Authors: Ryota Tamura, Yukina Morimoto, Kenzo Kosugi, Mizuto Sato, Yumiko Oishi, Ryo Ueda, Ryogo Kikuchi, Hideaki Nagashima, Tetsuro Hikichi, Shinobu Noji, Yutaka Kawakami, Hikaru Sasaki, Kazunari Yoshida and Masahiro Toda
    Citation: BMC Cancer 2020 20:196
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:301

  16. Donor acute lymphoblastic leukemia with recipient intact is a rare condition. We report a case of donor developing acute lymphoblastic leukemia 8 yrs after donating both bone marrow and peripheral blood hemato...

    Authors: Di Zhou, Ting Xie, Suning Chen, Yipeng Ling, Yueyi Xu, Bing Chen, Jian Ouyang and Yonggong Yang
    Citation: BMC Cancer 2020 20:195
    Content type: Case report Published on:

  17. After neoadjuvant chemoradiotherapy (nCRT) for esophageal cancer, high pathologically complete response (pCR) rates are being achieved especially in patients with squamous cell carcinoma (SCC). An active surve...

    Authors: Xiaobin Zhang, Ben M. Eyck, Yang Yang, Jun Liu, Yin-Kai Chao, Ming-Mo Hou, Tsung-Min Hung, Qingsong Pang, Zhen-Tao Yu, Hongjing Jiang, Simon Law, Ian Wong, Ka-On Lam, Berend J. van der Wilk, Ate van der Gaast, Manon C. W. Spaander…
    Citation: BMC Cancer 2020 20:194
    Content type: Study protocol Published on:

  18. To determine the optimal timing of the first Magnetic Resonance Imaging (MRI) scan after curative-intent radiotherapy (RT) for nasopharyngeal carcinoma (NPC), and evaluate the role of MRI in surveillance for l...

    Authors: Katherine Meng, Jeremy Tey, Francis Cho Hao Ho, Hira Asim and Timothy Cheo
    Citation: BMC Cancer 2020 20:193
    Content type: Research article Published on:

  19. Altered glycosylation associated with hepatocellular carcinoma (HCC) is well documented. However, few reports have investigated the association between dedifferentiation and glycosylation. Therefore, the aim o...

    Authors: Hiroomi Takayama, Masayuki Ohta, Yukio Iwashita, Hiroki Uchida, Yuki Shitomi, Kazuhiro Yada and Masafumi Inomata
    Citation: BMC Cancer 2020 20:192
    Content type: Research article Published on:

  20. This case represents the first report of malignant primary cardiac tumour in a patient with Lynch Syndrome associated with MSH2 pathogenic variant.

    Authors: Pasquale Paolisso, Giulia Saturi, Alberto Foà, Maristella Saponara, Margherita Nannini, Maria Abbondanza Pantaleo, Ornella Leone, Daniela Turchetti, Daniele Calistri, Carlo Savini, Davide Pacini, Carmine Pizzi and Nazzareno Galiè
    Citation: BMC Cancer 2020 20:191
    Content type: Case report Published on:

  21. The exhaustive collection of new sarcoma cases and their second histologic review offer a unique opportunity to study their incidence and time trends in France according to the major subtypes.

    Authors: Brice Amadeo, Nicolas Penel, Jean-Michel Coindre, Isabelle Ray-Coquard, Karine Ligier, Patricia Delafosse, Anne-Marie Bouvier, Sandrine Plouvier, Justine Gallet, Aude Lacourt, Gaëlle Coureau, Alain Monnereau, Simone Mathoulin-Pélissier and Emmanuel Desandes
    Citation: BMC Cancer 2020 20:190
    Content type: Research article Published on:

  22. This study aimed to compare the survival outcomes of radio-chemotherapy (R-CT) and radical hysterectomy with postoperative standard therapy (RH) in stage IB1-IIA2 cervical cancer patients.

    Authors: Ping Liu, Lihong Lin, Yanxiang Kong, Zhifeng Huo, Lin Zhu, Xiaonong Bin, Jinghe Lang and Chunlin Chen
    Citation: BMC Cancer 2020 20:189
    Content type: Research article Published on:

  23. The American Joint Committee on Cancer (AJCC) and the European Neuroendocrine Tumor Society (ENETS) staging classifications are two broadly used systems for pancreatic neuroendocrine tumors. This study aims to...

    Authors: Haihong Wang, Zhenyu Lin, Guiling Li, Dejun Zhang, Dandan Yu, Qili Lin, Jing Wang, Ye Zhao, Guoliang Pi and Tao Zhang
    Citation: BMC Cancer 2020 20:188
    Content type: Research article Published on:

  24. CYP2A6 is an enzyme involved in oxidation of a number of environmental chemicals, including nicotine, pro-carcinogenic nitrosamines and polycyclic aromatic hydrocarbons (PAHs). The whole gene deletion of CYP2A...

    Authors: Maidina Abudushataer, Noriko Sato, Makiko Mieno, Motoji Sawabe, Masaaki Muramatsu and Tomio Arai
    Citation: BMC Cancer 2020 20:186
    Content type: Research article Published on:

  25. To analyze the effects of BRCA1/2 mutations on chemotherapy response scores (CRS) and survival in a cohort of patients with advanced-stage ovarian cancer who were treated with neoadjuvant chemotherapy (NAC) follo...

    Authors: Yong Jae Lee, Hyun-Soo Kim, John Hoon Rim, Jung-Yun Lee, Eun Ji Nam, Sang Wun Kim, Sunghoon Kim and Young Tae Kim
    Citation: BMC Cancer 2020 20:185
    Content type: Research article Published on:

  26. Casein kinase II (CK2) is involved in multiple tumor-relevant signaling pathways affecting proliferation and apoptosis. CK2 is frequently upregulated in acute B-lymphoblastic leukemia (B-ALL) and can be target...

    Authors: Anna Richter, Sina Sender, Annemarie Lenz, Rico Schwarz, Burkhard Hinz, Gudrun Knuebel, Anett Sekora, Hugo Murua Escobar, Christian Junghanss and Catrin Roolf
    Citation: BMC Cancer 2020 20:184
    Content type: Research article Published on:

  27. Serum miRNA was once found as potential disease survival index,thus we investigated the role of miRNA in predicting prognosis in loco-regionally advanced NPC patients treated with CCRT.

    Authors: Zhimin Zhang, Jiangbiao Huang, Ge Wang, Feng Jin, Jijun Zheng, He Xiao, Lin Lei, Jia Luo and Chuan Chen
    Citation: BMC Cancer 2020 20:183
    Content type: Research article Published on:

  28. Aspiration pneumonia is one of the most important side effects of chemoradiotherapy (CRT) and bio-radiotherapy (BRT) in patients with head and neck cancer (HNC). Aspiration pneumonia can lead to cancer-related...

    Authors: Hiromichi Shirasu, Tomoya Yokota, Satoshi Hamauchi, Yusuke Onozawa, Hirofumi Ogawa, Tsuyoshi Onoe, Tetsuro Onitsuka, Takashi Yurikusa, Keita Mori and Hirofumi Yasui
    Citation: BMC Cancer 2020 20:182
    Content type: Research article Published on:

  29. Lymph node metastasis (LNM) occurs frequently in young papillary thyroid carcinoma (PTC) patients, though the mortality rates are low. We aimed to analyze the relationship between age at diagnosis and LNM in P...

    Authors: Yuanchao Liu, Yizeng Wang, Ke Zhao, Dongyang Li, Zuoyu Chen, Ruoyu Jiang, Xiaoning Wang and Xianghui He
    Citation: BMC Cancer 2020 20:181
    Content type: Database Published on:

  30. It is not known what combination of bevacizumab and chemotherapy agents is the best therapeutic regimen. Comparative study results among the efficacies of bevacizumab plus chemotherapy remain controversial in ...

    Authors: Zhengwu Sun, Xiaoyan Lan, Shizhao Xu, Shen Li and Yalin Xi
    Citation: BMC Cancer 2020 20:180
    Content type: Research article Published on:

  31. The objective of this systematic review and meta-analysis was to determine the prognostic value of total tumor-infiltrating lymphocytes (TILs) and subtypes of TILs (CD4+, CD8+, and FOXP3+) in triple-negative brea...

    Authors: Guoxuan Gao, Zihan Wang, Xiang Qu and Zhongtao Zhang
    Citation: BMC Cancer 2020 20:179
    Content type: Research article Published on:

  33. Dabrafenib and trametinib combination therapy is approved for the treatment of patients with BRAF V600E positive tumors including melanoma and lung cancer. The effect of BRAF and MEK inhibitors on the immune syst...

    Authors: Anastasios Dimou, Gregory Barron, Daniel T. Merrick, Jason Kolfenbach and Robert C. Doebele
    Citation: BMC Cancer 2020 20:177
    Content type: Case report Published on:

  34. The development of tumor cells inside the lymphatics or blood vessels is known as lymphovascular invasion (LVI). The correlation between LVI, lymph node metastasis (LNM), and the diagnosis of superficial esoph...

    Authors: Jinxin Yang, Zhouyi Lu, Lintao Li, Yong Li, Yulong Tan, Dekang Zhang and An Wang
    Citation: BMC Cancer 2020 20:176
    Content type: Research article Published on:

  35. Programmed cell death 1 (PD-1) is one of the immune checkpoint molecules that negatively regulate the function of T cells. Although recent studies indicate that PD-1 is also expressed on other immune cells bes...

    Authors: Yusuke Kono, Hiroaki Saito, Wataru Miyauchi, Shota Shimizu, Yuki Murakami, Yuji Shishido, Kozo Miyatani, Tomoyuki Matsunaga, Yoji Fukumoto, Yuji Nakayama, Chiye Sakurai, Kiyotaka Hatsuzawa and Yoshiyuki Fujiwara
    Citation: BMC Cancer 2020 20:175
    Content type: Research article Published on:

  36. The European Guidelines for breast cancer screening suggest that the impact of population-based mammography screening programmes (MSP) may be assessed using the relative reduction in the incidence of advanced ...

    Authors: Laura Khil, Jan Heidrich, Ina Wellmann, Vanessa Kääb-Sanyal, Stefanie Weigel, Walter Heindel, Hans-Werner Hense and Oliver Heidinger
    Citation: BMC Cancer 2020 20:174
    Content type: Research article Published on:

  37. Alterations in peripheral blood lymphocytes in cervical cancer have been reported, although conflicting views exist. The present study investigated the distributions of lymphocyte subsets in tumor tissue and p...

    Authors: Yutuan Wu, Shuang Ye, Shyamal Goswami, Xuan Pei, Libing Xiang, Xiaoming Zhang and Huijuan Yang
    Citation: BMC Cancer 2020 20:173
    Content type: Research article Published on:

  38. Breast cancer is the most commonly diagnosed cancer and the leading cause of cancer death in women worldwide. Recently, studies have been published with inconsistent findings regarding whether sarcopenia is a ...

    Authors: Xiao-Ming Zhang, Qing-Li Dou, Yingchun Zeng, Yunzhi Yang, Andy S. K. Cheng and Wen-Wu Zhang
    Citation: BMC Cancer 2020 20:172
    Content type: Research article Published on:

  39. Silica and asbestos are recognized lung carcinogens. However, their role in carcinogenesis at other organs is less clear. Clearance of inhaled silica particles and asbestos fibers from the lungs may lead to tr...

    Authors: Lidija Latifovic, Paul J. Villeneuve, Marie-Élise Parent, Linda Kachuri and Shelley A. Harris
    Citation: BMC Cancer 2020 20:171
    Content type: Research article Published on:

  40. Bone complications (pathologic fracture, spinal cord compression, surgery to bone and radiation to bone) are a common problem in patients with multiple myeloma (MM). We set out to provide insights into the rea...

    Authors: María-Victoria Mateos, Leah Fink, Niranchana Koneswaran, Michele Intorcia, Christina Giannopoulou, Daniela Niepel and Michele Cavo
    Citation: BMC Cancer 2020 20:170
    Content type: Research article Published on:

  41. Multiple myeloma is a cancer in the bone marrow causing bone destruction. Patients experience various symptoms related to the disease and/or treatment, such as pain and fatigue, leading to poorer quality of li...

    Authors: Rikke Faebo Larsen, Mary Jarden, Lisbeth Rosenbek Minet, Ulf Christian Frølund, Sören Möller and Niels Abildgaard
    Citation: BMC Cancer 2020 20:169
    Content type: Research article Published on:

  42. Following publication of the original article [1], the authors reported an error in the “Samples size calculation and statistical considerations” section.

    Authors: Lilian Schwarz, Dewi Vernerey, Jean-Baptiste Bachet, Jean-Jacques Tuech, Fabienne Portales, Pierre Michel and Antonio Sa Cunha
    Citation: BMC Cancer 2020 20:168
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2018 18:762

  43. Although combination chemotherapy (CC) is generally recommended in recurrent or primary metastatic gastric cancer (RPMGC), the results of randomized trials are conflicting.

    Authors: Jin-Hyuk Choi, Yong Won Choi, Seok Yun Kang, Geum Sook Jeong, Hyun Woo Lee, Seong Hyun Jeong, Joon Seong Park, Mi Sun Ahn and Seung Soo Sheen
    Citation: BMC Cancer 2020 20:167
    Content type: Research article Published on:

  44. High rates of venous thromboembolic events (VTEs), mainly in advanced disease, are reported for patients with cancer of the upper gastrointestinal tract (stomach, pancreas) and for treatment with cisplatin.

    Authors: Martin Fehr, Hanne Hawle, Stefanie Hayoz, Peter Thuss-Patience, Sabina Schacher, Jorge Riera Knorrenschild, Donat Dürr, Wolfram T. Knoefel, Holger Rumpold, Michael Bitzer, Martin Zweifel, Panagiotis Samaras, Ulrich Mey, Marc Küng, Ralph Winterhalder, Wolfgang Eisterer…
    Citation: BMC Cancer 2020 20:166
    Content type: Research article Published on:

  45. Hepatocellular carcinoma (HCC) is the second most common cause of cancer-related death in the world. N6-methyladenosine (m6A) RNA methylation is dynamically regulated by m6A RNA methylation modulators (“writer,” ...

    Authors: Nanfang Qu, Sanyu Qin, Xuemei Zhang, Xiaotong Bo, Zhengchun Liu, Chao Tan, Guiqiong Wen and Haixing Jiang
    Citation: BMC Cancer 2020 20:165
    Content type: Research article Published on:

  46. Following publication of the original article [1], an error was reported in the tagging of Joël Fokom Domgue in the author group. The tagging in this correction article has been fixed.

    Authors: Hong Lou, Eduardo Gharzouzi, Sarita Polo Guerra, Joël Fokom Domgue, Julie Sawitzke, Guillermo Villagran, Lisa Garland, Joseph F. Boland, Sarah Wagner, Héctor Rosas, Jami Troxler, Heidi McMillen, Bailey Kessing, Enrique Alvirez, Miriam Castillo, Hesler Morales…
    Citation: BMC Cancer 2020 20:164
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2018 18:562

  47. Following publication of the original article [1], the authors reported an error in the authorship list associated with the paper. Georgina McPherson has therefore been added.

    Authors: Naomi Brewer, Karen Bartholomew, Anna Maxwell, Jane Grant, Georgina McPherson, Helen Wihongi, Collette Bromhead, Nina Scott, Sue Crengle, Chris Cunningham, Jeroen Douwes and John D. Potter
    Citation: BMC Cancer 2020 20:163
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2019 19:1198

  50. Rash is one of the most common severe adverse events associated with use of vemurafenib for the treatment of melanoma, either as monotherapy or in combination with cobimetinib. The study aimed to identify pre-...

    Authors: Ashley M. Hopkins, Akash D. Rathod, Andrew Rowland, Ganessan Kichenadasse and Michael J. Sorich
    Citation: BMC Cancer 2020 20:157
    Content type: Research article Published on:

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