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  1. Multiple myeloma (MM) remains incurable despite recent therapeutic advances. RAS mutations are frequently associated with relapsed/refractory disease. Efforts to target the mitogen-activated protein kinase (MA...

    Authors: Priya Sriskandarajah, Alexis De Haven Brandon, Kenneth MacLeod, Neil O. Carragher, Vladimir Kirkin, Martin Kaiser and Steven R. Whittaker
    Citation: BMC Cancer 2020 20:269
    Content type: Research article Published on:

  2. Clinical outcomes of patients with osteosarcoma remain unsatisfactory, with little improvement in a 5-year overall survival over the past three decades. There is a substantial need for further research and dev...

    Authors: Nut Koonrungsesomboon, Nuttapong Ngamphaiboon, Natavudh Townamchai, Pimpisa Teeyakasem, Chaiyut Charoentum, Pimlak Charoenkwan, Rungrote Natesirinilkul, Lalita Sathitsamitphong, Touch Ativitavas, Parunya Chaiyawat, Jeerawan Klangjorhor, Suradej Hongeng and Dumnoensun Pruksakorn
    Citation: BMC Cancer 2020 20:268
    Content type: Study protocol Published on:

  3. Lymphovascular invasion (LOI), a key pathological feature of head and neck squamous cell carcinoma (HNSCC), is predictive of poor survival; however, the associated clinical characteristics and underlying molec...

    Authors: Jian Zhang, Huaming Lin, Huali Jiang, Hualong Jiang, Tao Xie, Baiyao Wang, Xiaoting Huang, Jie Lin, Anan Xu, Rong Li, Jiexia Zhang and Yawei Yuan
    Citation: BMC Cancer 2020 20:266
    Content type: Research article Published on:

  4. Cancer survivors and their caregivers may have various unmet needs that are medically difficult to solve. Previous studies have suggested the relations between individuals’ backgrounds and their unmet needs. W...

    Authors: Kaname Watanabe, Kayoko Katayama, Takashi Yoshioka and Hiroto Narimatsu
    Citation: BMC Cancer 2020 20:263
    Content type: Research article Published on:

  5. The efficacy and safety of lapatinib plus capecitabine (LC or LX) versus trastuzumab plus chemotherapy in patients with HER-positive metastatic breast cancer who are resistant to trastuzumab is unknown.

    Authors: Fan Yang, Xiang Huang, Chunxiao Sun, Jianbin Li, Biyun Wang, Min Yan, Feng Jin, Haibo Wang, Jin Zhang, Peifen Fu, Tianyu Zeng, Jian Wang, Wei Li, Yongfei Li, Mengzhu Yang, Jun Li…
    Citation: BMC Cancer 2020 20:255
    Content type: Research article Published on:

  6. In high-income countries (HICs), increased rates of survival among pediatric cancer patients are achieved through the use of protocol-driven treatment. Compared to HICs, differences in infrastructure, supporti...

    Authors: Lavanya Vasudevan, Kristin Schroeder, Yadurshini Raveendran, Kunal Goel, Christina Makarushka, Nestory Masalu and Leah L. Zullig
    Citation: BMC Cancer 2020 20:254
    Content type: Study protocol Published on:

  7. Various tumor characteristics might lead to inaccurate local MRI-defined stage of rectal cancer and the purpose of this study was to explore the clinicopathological factors that impact on the precision pre-tre...

    Authors: Zerong Cai, Xiaoyu Xie, Yufeng Chen, Zexian Chen, Wuteng Cao, Khamis Salem Saeed Saad, Yifeng Zou, Ping Lan and Xiaojian Wu
    Citation: BMC Cancer 2020 20:253
    Content type: Research article Published on:

  8. Colorectal cancer (CRC) cases are detected late in Malaysia similar to most Asian countries. The Be Cancer Alert Campaign (BCAC) was a culturally adapted mass media campaign designed to improve CRC awareness and ...

    Authors: Désirée Schliemann, Darishiani Paramasivam, Maznah Dahlui, Christopher R. Cardwell, Saunthari Somasundaram, Nor Saleha Binti Ibrahim Tamin, Conan Donnelly, Tin Tin Su and Michael Donnelly
    Citation: BMC Cancer 2020 20:252
    Content type: Research article Published on:

  9. Invasive urothelial carcinoma (iUC) is highly similar between dogs and humans in terms of pathologic presentation, molecular subtypes, response to treatment and age at onset. Thus, the dog is an established an...

    Authors: Heidi G. Parker, Deepika Dhawan, Alex C. Harris, Jose A. Ramos-Vara, Brian W. Davis, Deborah W. Knapp and Elaine A. Ostrander
    Citation: BMC Cancer 2020 20:251
    Content type: Research article Published on:

  10. It is evident that comorbidity exacerbate the complexity of the management of lung cancer, however, limited research has been conducted to investigate the impact of comorbidity on health service utilization an...

    Authors: Ruoxi Ding, Dawei Zhu, Ping He, Yong Ma, Zhishui Chen and Xuefeng Shi
    Citation: BMC Cancer 2020 20:250
    Content type: Research article Published on:

  11. No study has evaluated C-reactive protein (CRP) and plasma albumin (PA) levels longitudinally in patients with acute myeloid leukaemia (AML).

    Authors: Kim Oren Gradel, Pedro Póvoa, Olav Sivertsen Garvik, Pernille Just Vinholt, Stig Lønberg Nielsen, Thøger Gorm Jensen, Ming Chen, Ram Benny Dessau, Jens Kjølseth Møller, John Eugenio Coia, Pernille Sanberg Ljungdalh, Annmarie Touborg Lassen and Henrik Frederiksen
    Citation: BMC Cancer 2020 20:249
    Content type: Research article Published on:

  12. This study was designed to investigate the clinicopathologic features of pulmonary blastomatoid carcinosarcoma and explore the genomic profiles of epithelial and mesenchymal components in this tumor.

    Authors: Jikai Zhao, Chan Xiang, Ruiying Zhao, Ping Guo, Jingjing Zheng, Han Han-Zhang, Keke Yu, Jie Zhang and Yuchen Han
    Citation: BMC Cancer 2020 20:248
    Content type: Research article Published on:

  13. Increased knowledge of breast cancer risk factors has meant that we are currently exploring risk-based screening, i.e. determining screening strategies based on women’s varying levels of risk. This also enable...

    Authors: Linda Rainey, Daniëlle van der Waal, Anna Jervaeus, Louise S. Donnelly, D. Gareth Evans, Mattias Hammarström, Per Hall, Yvonne Wengström and Mireille J. M. Broeders
    Citation: BMC Cancer 2020 20:247
    Content type: Research article Published on:

  14. Approximately one third of all patients with CRC present with, or subsequently develop, colorectal liver metastases (CRLM). The objective of this population-based analysis was to assess the impact of resection...

    Authors: Alexander R. Siebenhüner, Ulrich Güller and Rene Warschkow
    Citation: BMC Cancer 2020 20:246
    Content type: Research article Published on:

  15. Patients with multiple myeloma report more problems with quality of life (QoL) than other haematological malignancies over the course of their incurable illness. The patient-centred Myeloma Patient Outcome Sca...

    Authors: Christina Gerlach, Katherine Taylor, Marion Ferner, Markus Munder, Martin Weber and Christina Ramsenthaler
    Citation: BMC Cancer 2020 20:245
    Content type: Research article Published on:

  16. Pregnancy-associated breast cancer (PABC) is an aggressive disease, and since Chinese authority began to encourage childbearing in 2015, the incidence of PABC has increased. This study investigated the charact...

    Authors: Bo-yue Han, Xiao-guang Li, Hai-yun Zhao, Xin Hu and Hong Ling
    Citation: BMC Cancer 2020 20:244
    Content type: Research article Published on:

  18. Colorectal cancer (CRC) ranks the third among the most common malignancies globally. It is well known that microRNAs (miRNAs) play vital roles in destabilizing mRNAs and repressing their translations in this d...

    Authors: Fangbin Zhou, Donge Tang, Yong Xu, Huiyan He, Yan Wu, Liewen Lin, Jun Dong, Wenyong Tan and Yong Dai
    Citation: BMC Cancer 2020 20:242
    Content type: Research article Published on:

  20. Locally advanced nasopharyngeal carcinoma (LA-NPC) is a relatively rare disease in the west but more common in East Asia and areas of the Middle East like Saudi Arabia. Despite the advances in radiation therap...

    Authors: Nasser Al-Rajhi, Hussein Soudy, Shoaib A. Ahmed, Tusneem Elhassan, Shamayel F. Mohammed, Hatim A. Khoja and Hazem Ghebeh
    Citation: BMC Cancer 2020 20:240
    Content type: Research article Published on:

  21. The identification of neck lymph node (LN) metastases represents a very important issue in the management of patients with differentiated thyroid carcinoma (DTC). To this purpose, in the present study, we used...

    Authors: Angela Spanu, Susanna Nuvoli, Andrea Marongiu, Ilaria Gelo, Luciana Mele, Bastiana Piras and Giuseppe Madeddu
    Citation: BMC Cancer 2020 20:239
    Content type: Research article Published on:

  22. Many studies have reported the prognostic significance of the bone scan index (BSI) for metastatic castration-resistant prostate cancer (mCRPC); however, these reports are controversial. This study investigate...

    Authors: Hualin Song, Song Jin, Peng Xiang, Shuai Hu and Jie Jin
    Citation: BMC Cancer 2020 20:238
    Content type: Research article Published on:

  23. Treatment resistance is a major clinical challenge of diffuse large B-cell lymphoma (DLBCL) where approximately 40% of the patients have refractory disease or relapse. Since DLBCL is characterized by great cli...

    Authors: Hanne Due, Rasmus Froberg Brøndum, Ken H. Young, Martin Bøgsted and Karen Dybkær
    Citation: BMC Cancer 2020 20:237
    Content type: Research article Published on:

  25. The relationship of neutrophil/lymphocyte ratio (NLR) to prognosis of HER2-positive breast cancer (BC) is not well studied. We aimed to assess the prognostic role of NLR in HER2-positive BC patients treated wi...

    Authors: Nianhua Ding, Juan Huang, Ningsha Li, Jiaqi Yuan, Shouman Wang and Zhi Xiao
    Citation: BMC Cancer 2020 20:235
    Content type: Research article Published on:

  26. Despite conflicting results, considerable evidence suggests the association between single nucleotide polymorphisms in MTHFR, XRCC1 and OGG1 genes and, risk of developing breast cancer. Here a case-control study ...

    Authors: Matteo Floris, Daria Sanna, Paolo Castiglia, Carlo Putzu, Valeria Sanna, Antonio Pazzola, Maria Rosaria De Miglio, Francesca Sanges, Giovanna Pira, Antonio Azara, Emanuele Lampis, Antonello Serra, Ciriaco Carru, Maristella Steri, Flavia Costanza, Marco Bisail…
    Citation: BMC Cancer 2020 20:234
    Content type: Research article Published on:

  28. NEPA is an oral fixed-dose combination of netupitant, a new highly selective neurokinin-1 receptor antagonist, and palonosetron. This study was conducted to evaluate whether the efficacy of NEPA against chemot...

    Authors: Roberta Caputo, Marina Elena Cazzaniga, Andrea Sbrana, Rosalba Torrisi, Ida Paris, Monica Giordano, Vincenzo Montesarchio, Valentina Guarneri, Laura Amaducci, Domenico Bilancia, Giuseppina Cilenti, Alessandra Fabi, Elena Collovà, Alessio Schirone, Erminio Bonizzoni, Luigi Celio…
    Citation: BMC Cancer 2020 20:232
    Content type: Research article Published on:

  29. Prophylactic cranial irradiation (PCI) is a current standard of care after confirmed response to radical chemoradiotherapy for limited disease small cell lung cancer (LD-SCLC). This standard is mostly based on...

    Authors: Sergiusz Nawrocki and Anna Sugajska
    Citation: BMC Cancer 2020 20:231
    Content type: Study protocol Published on:

  30. Immune checkpoint inhibitors (ICI) are an integral part of bladder cancer therapy, however, the relevance of ICI treatment for mixed and pure squamous cell carcinoma of the bladder remains poorly studied. Ther...

    Authors: Ronja Morsch, Michael Rose, Angela Maurer, Maria Angela Cassataro, Till Braunschweig, Ruth Knüchel, Thomas-Alexander Vögeli, Thorsten Ecke, Markus Eckstein, Veronika Weyerer, Irene Esposito, Maximilian Ackermann, Günter Niegisch and Nadine T. Gaisa
    Citation: BMC Cancer 2020 20:230
    Content type: Research article Published on:

  31. Although checkpoint blockades have become widely used, the immunological impact in cancer patients, especially those with oral cavity squamous cell carcinoma (OCSCC), has not been well studied.

    Authors: Ying Xiong, David M. Neskey, Joshua D. Horton, Chrystal M. Paulos, Hannah M. Knochelmann, Kent E. Armeson and M. Rita I. Young
    Citation: BMC Cancer 2020 20:229
    Content type: Research article Published on:

  32. We assessed breast cancer mortality in older versus younger women according to race/ethnicity, neighborhood socioeconomic status (nSES), and health insurance status.

    Authors: Yazmin San Miguel, Scarlett Lin Gomez, James D. Murphy, Richard B. Schwab, Corinne McDaniels-Davidson, Alison J. Canchola, Alfredo A. Molinolo, Jesse N. Nodora and Maria Elena Martinez
    Citation: BMC Cancer 2020 20:228
    Content type: Research article Published on:

  33. As the number of PET/CT scanners increases and FDG PET/CT becomes a common imaging modality for oncology, the demands for automated detection systems on artificial intelligence (AI) to prevent human oversight ...

    Authors: Keisuke Kawauchi, Sho Furuya, Kenji Hirata, Chietsugu Katoh, Osamu Manabe, Kentaro Kobayashi, Shiro Watanabe and Tohru Shiga
    Citation: BMC Cancer 2020 20:227
    Content type: Research article Published on:

  34. Simeoni and colleagues introduced a compartmental model for tumor growth that has proved quite successful in modeling experimental therapeutic regimens in oncology. The model is based on a system of ordinary d...

    Authors: James A. Koziol, Theresa J. Falls and Jan E. Schnitzer
    Citation: BMC Cancer 2020 20:226
    Content type: Technical advance Published on:

  35. Considering the potential of p16 as a marker for diagnosis, prognosis and therapeutic response, the aim of this study was to assess its presence, via immunocytochemistry, in metastatic carcinoma of different p...

    Authors: Fabiana Pirani Carneiro, Rivadávio Fernandes Amorim, Marcos de Vasconcelos Carneiro, Tercia Maria Mendes Lousa de Castro, Leonora Maciel de Souza Vianna, Gustavo Henrique Soares Takano, Andersen Charles Daros, Isabela Peres, Selma Aparecida Souza Kuckelhaus and Andrea Barretto Motoyama
    Citation: BMC Cancer 2020 20:225
    Content type: Research article Published on:

  36. Even though treatment modalities such as adjuvant systemic radio-chemotherapy and neoadjuvant chemotherapy (NAC) have individually have improved overall survival (OS) and progression-free survival (PFS) rates ...

    Authors: Maneesh Kumarsing Beeharry, Zhen-Tian Ni, Zhong Yin Yang, Ya Nan Zheng, Run Hua Feng, Wen-Tao Liu, Chao Yan, Xue Xin Yao, Chen Li, Min Yan and Zheng-Gang Zhu
    Citation: BMC Cancer 2020 20:224
    Content type: Study protocol Published on:

  37. The burden of disease due to cancer remains substantial. Since the value of real-world evidence has also been recognised by regulatory agencies, we established a Research Ethics Committee (REC) approved resear...

    Authors: C. Moss, A. Haire, F. Cahill, D. Enting, S. Hughes, D. Smith, E. Sawyer, A. Davies, J. Zylstra, K. Haire, A. Rigg and M. Van Hemelrijck
    Citation: BMC Cancer 2020 20:187
    Content type: Database Published on:

  38. Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet del...

    Authors: Johanne Dam Lyhne, Allan ‘ Ben’ Smith, Lisbeth Frostholm, Per Fink and Lars Henrik Jensen
    Citation: BMC Cancer 2020 20:223
    Content type: Study protocol Published on:

  40. Following publication of the original article [1], the authors reported that they had misspelt the name of a cell line and supplied the incorrect Fig. 7 for publication.

    Authors: Minhua Rong, Gang Chen and Yiwu Dang
    Citation: BMC Cancer 2020 20:221
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2013 13:21

  41. To retrospectively investigate the clinical characteristics, initial treatment, relapse, therapy outcome, and prognosis of Chinese patients with primary testicular lymphoma (PTL) through analysis of the cases ...

    Authors: Bo Chen, De-Hong Cao, Li Lai, Jian-Bing Guo, Ze-Yu Chen, Yin Huang, Shi Qiu, Tian-Hai Lin, Yue Gou, Na Ma, Lu Yang, Liang-Ren Liu and Qiang Wei
    Citation: BMC Cancer 2020 20:220
    Content type: Research article Published on:

  42. We performed a pooled analysis of the COMPARZ study assessing efficacy and safety of pazopanib versus sunitinib in treatment-naïve Chinese patients with locally advanced and/or metastatic renal cell carcinoma ...

    Authors: Xinan Sheng, Jie Jin, Zhisong He, Yiran Huang, Aiping Zhou, Jinwan Wang, Xiubao Ren, Dingwei Ye, Xu Zhang, Shukui Qin, Fangjian Zhou, Binhui Wang and Jun Guo
    Citation: BMC Cancer 2020 20:219
    Content type: Research article Published on:

  43. Oral squamous cell carcinoma (OSCC) is an aggressive human malignancy. Because of late diagnosis and recurrence of OSCC, the treatment of patients with OSCC is often ineffective. Thus, finding novel biomarkers...

    Authors: Ratakorn Srisuttee, Areeya Arayataweegool, Patnarin Mahattanasakul, Napadon Tangjaturonrasme, Virachai Kerekhanjanarong, Somboon Keelawat, Apiwat Mutirangura and Nakarin Kitkumthorn
    Citation: BMC Cancer 2020 20:218
    Content type: Research article Published on:

  44. Colorectal cancer (CRC) is the most common cancer and a leading cause of death worldwide. Extracellular matrix (ECM) proteins regulate tumor growth and development in CRC. Elastin (ELN) is a component of ECM p...

    Authors: Jinzhi Li, Xiaoyue Xu, Yanyan Jiang, Nicole G. Hansbro, Philip M. Hansbro, Jincheng Xu and Gang Liu
    Citation: BMC Cancer 2020 20:217
    Content type: Research article Published on:

  45. Periampullary cancers (PAC) including pancreatic, ampulla of Vater (AOV), and common bile duct (CBD) cancers are highly aggressive with a lack of useful prognostic markers beyond T stage. However, T staging ca...

    Authors: Yosep Chong, Nishant Thakur, Kwang Yeol Paik, Eun Jung Lee and Chang Suk Kang
    Citation: BMC Cancer 2020 20:216
    Content type: Research article Published on:

  46. Poly (ADP-ribose) polymerase (PARP) inhibitors are approved for the treatment of breast cancer susceptibility genes 1 and 2 (BRCA1/2) mutant ovarian and breast cancers, and are now being evaluated in metastatic c...

    Authors: Andrew D. Simmons, Minh Nguyen and Elias Pintus
    Citation: BMC Cancer 2020 20:215
    Content type: Case report Published on:

  47. Following publication of the original article [1], the authors reported an error in Fig. 1f.

    Authors: Chaoyang Sun, Ensong Guo, Bo Zhou, Wanying Shan, Jia Huang, Danhui Weng, Peng Wu, Changyu Wang, Shixuan Wang, Wei Zhang, Qinglei Gao, Xiaoyan Xu, Beibei Wang, Junbo Hu, Ding Ma and Gang Chen
    Citation: BMC Cancer 2020 20:210
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2019 19:1061

  48. The current study aimed to evaluate the outcomes of patients with unresectable non-metastatic locally advanced pancreatic adenocarcinoma (LAPA) who did not benefit from resection considering the treatment stra...

    Authors: Jonathan Garnier, Jacques Ewald, Ugo Marchese, Marine Gilabert, Simon Launay, Laurence Moureau-Zabotto, Flora Poizat, Marc Giovannini, Jean-Robert Delpero and Olivier Turrini
    Citation: BMC Cancer 2020 20:203
    Content type: Research article Published on:

  50. Existing data from several reports on the association between lipid profile and ovarian tumour (OT) suggests divergent conclusions. Our aim was to examine whether circulating lipid profile: total cholesterol (...

    Authors: Justina Ucheojor Onwuka, Akinkunmi Paul Okekunle, Olaniyi Matthew Olutola, Onoja Matthew Akpa and Rennan Feng
    Citation: BMC Cancer 2020 20:200
    Content type: Research article Published on:

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