Skip to main content

Articles

Page 112 of 335

  1. The preoperative peripheral blood neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR) and monocyte-lymphocyte ratio (MLR) have been reported to be associated with the prognosis of various cancer...

    Authors: Rong Cong, Fanfei Kong, Jian Ma, Qing Li, Qijun Wu and Xiaoxin Ma
    Citation: BMC Cancer 2020 20:464
    Content type: Research article Published on:

  2. Venous thromboembolism (VTE) is highly prevalent in cancer patients and can cause severe morbidity. VTE treatment is essential, but anticoagulation increases the risk of major bleeding. The purpose was to eval...

    Authors: Jennifer Howlett, Eric Benzenine, Jonathan Cottenet, Pascal Foucher, Philippe Fagnoni and Catherine Quantin
    Citation: BMC Cancer 2020 20:461
    Content type: Research article Published on:

  3. Individuals with pathogenic germline variants in DNA mismatch repair (MMR) genes are at increased risk of developing colorectal, endometrial and other cancers (Lynch syndrome, LS). While previous studies have ...

    Authors: Karolin Bucksch, Silke Zachariae, Stefan Aretz, Reinhard Büttner, Elke Holinski-Feder, Stefanie Holzapfel, Robert Hüneburg, Matthias Kloor, Magnus von Knebel Doeberitz, Monika Morak, Gabriela Möslein, Jacob Nattermann, Claudia Perne, Nils Rahner, Wolff Schmiegel, Karsten Schulmann…
    Citation: BMC Cancer 2020 20:460
    Content type: Research article Published on:

  4. Leucine-rich repeats and immunoglobulin-like domains 1 (LRIG1) copy number alterations and unbalanced gene recombination events have been reported to occur in breast cancer. Importantly, LRIG1 loss was recently s...

    Authors: Mahmood Faraz, Andreas Tellström, Christina Edwinsdotter Ardnor, Kjell Grankvist, Lukasz Huminiecki, Björn Tavelin, Roger Henriksson, Håkan Hedman and Ingrid Ljuslinder
    Citation: BMC Cancer 2020 20:459
    Content type: Research article Published on:

  5. Despite the embedding of bladder cancer management in European guidelines, large variation in clinical practice exists for applied diagnostics and treatments. This variation may affect patients’ outcomes inclu...

    Authors: T. M. Ripping, L. A. Kiemeney, L. M. C. van Hoogstraten, J. A. Witjes and K. K. H. Aben
    Citation: BMC Cancer 2020 20:455
    Content type: Study protocol Published on:

  6. Activated eosinophils have been deemed to affect carcinogenesis and tumor progression via various mechanisms in tumor microenvironment. However, the prognostic role of tumor-associated tissue eosinophilia (TAT...

    Authors: Guoming Hu, Shimin Wang, Kefang Zhong, Feng Xu, Liming Huang, Wei Chen and Pu Cheng
    Citation: BMC Cancer 2020 20:454
    Content type: Research article Published on:

  7. As aging is the most significant risk factor for cancer development, long-term prostate cancer (PCa) survivors have an evident risk of developing subsequent primary cancers (SPCs). Radiotherapy itself is an ad...

    Authors: Kristiina Vuolukka, Päivi Auvinen, Jan-Erik Palmgren, Sirpa Aaltomaa and Vesa Kataja
    Citation: BMC Cancer 2020 20:453
    Content type: Research article Published on:

  8. UK national guidelines suggest women at high-risk of breast cancer should be offered more frequent screening or preventative medications. Currently, only 1 in 6 high-risk women are identified. One route to ide...

    Authors: Victoria G. Woof, Helen Ruane, David P. French, Fiona Ulph, Nadeem Qureshi, Nasaim Khan, D. Gareth Evans and Louise S. Donnelly
    Citation: BMC Cancer 2020 20:452
    Content type: Research article Published on:

  9. The aim of the current study was to report a single-institution experience using breast-conserving surgery after neoadjuvant chemotherapy (NACT), focusing on the association between microscopic resection margi...

    Authors: Joseph Lin, Kuo-Juei Lin, Yu-Fen Wang, Ling-Hui Huang, Sam Li-Sheng Chen and Dar-Ren Chen
    Citation: BMC Cancer 2020 20:451
    Content type: Research article Published on:

  10. The T2-FLAIR mismatch sign is an imaging finding highly suggestive of isocitrate dehydrogenase mutated (IDH-mut) 1p19q non-codeleted (non-codel) gliomas (astrocytomas). In previous studies, it has shown excellent...

    Authors: Alba Corell, Sandra Ferreyra Vega, Nickoleta Hoefling, Louise Carstam, Anja Smits, Thomas Olsson Bontell, Isabella M. Björkman-Burtscher, Helena Carén and Asgeir Store Jakola
    Citation: BMC Cancer 2020 20:450
    Content type: Research article Published on:

  11. There is no established second-line treatment after failure of gemcitabine plus nab-paclitaxel (GnP) therapy for metastatic pancreatic cancer (MPC). The purpose of this study was to evaluate the efficacy and t...

    Authors: Masashi Sawada, Akiyoshi Kasuga, Takafumi Mie, Takaaki Furukawa, Takanobu Taniguchi, Koshiro Fukuda, Yuto Yamada, Tsuyoshi Takeda, Ryo Kanata, Masato Matsuyama, Takashi Sasaki, Masato Ozaka and Naoki Sasahira
    Citation: BMC Cancer 2020 20:449
    Content type: Research article Published on:

  13. Sex is recognized as a significant determinant of outcome among glioblastoma patients, but the relative prognostic importance of glioblastoma features has not been thoroughly explored for sex differences.

    Authors: Paula Whitmire, Cassandra R. Rickertsen, Andrea Hawkins-Daarud, Eduardo Carrasco Jr, Julia Lorence, Gustavo De Leon, Lee Curtin, Spencer Bayless, Kamala Clark-Swanson, Noah C. Peeri, Christina Corpuz, Christine Paula Lewis-de los Angeles, Bernard R. Bendok, Luis Gonzalez-Cuyar, Sujay Vora, Maciej M. Mrugala…
    Citation: BMC Cancer 2020 20:447
    Content type: Research article Published on:

  14. Several physiological (fertilization, placentation, wound healing) and pathophysiological processes (infection with enveloped viruses, cancer) depend on cell fusion. In cancer it was postulated that the fusion...

    Authors: Sera Selina Fahlbusch, Silvia Keil, Jörg T. Epplen, Kurt S. Zänker and Thomas Dittmar
    Citation: BMC Cancer 2020 20:446
    Content type: Research article Published on:

  15. While combinations of immune checkpoint (ICP) inhibitors and neo-adjuvant chemotherapy (NAC) have begun testing in patients with breast cancer (BC), the effects of chemotherapy on ICP expression in circulating...

    Authors: Robert Wesolowski, Andrew Stiff, Dionisia Quiroga, Christopher McQuinn, Zaibo Li, Hiroaki Nitta, Himanshu Savardekar, Brooke Benner, Bhuvaneswari Ramaswamy, Maryam Lustberg, Rachel M. Layman, Erin Macrae, Mahmoud Kassem, Nicole Williams, Sagar Sardesai, Jeffrey VanDeusen…
    Citation: BMC Cancer 2020 20:445
    Content type: Research article Published on:

  17. Human papillomavirus (HPV) testing is more sensitive than cytology for detecting cervical cancer and its precursors. This study aimed to analyze the prevalence of high-risk HPV genotypes and evaluate the role ...

    Authors: Jing Zhang, Deyu Zhang, Zhuo Yang, Xiaobin Wang and Danbo Wang
    Citation: BMC Cancer 2020 20:443
    Content type: Research article Published on:

  18. The present study aims to evaluate long-term side-effects and outcomes and confirm prognostic factors after stereotactic body radiotherapy (SBRT) of pulmonary lesions. This is the first work that combines the ...

    Authors: Kerstin A. Kessel, Rebekka C. E. Grosser, Kim Melanie Kraus, Hans Hoffmann, Markus Oechsner and Stephanie E. Combs
    Citation: BMC Cancer 2020 20:442
    Content type: Research article Published on:

  19. For cervical cancer patients whose tumors display a combination of intermediate risk factors, postoperative radiation with or without adjuvant chemotherapy is suggested for them. However, who should be adminis...

    Authors: Hong-tao Guo, Xue-han Bi, Ting Lei, Xiao Lv, Guang Yao, Yao Chen and Chang Liu
    Citation: BMC Cancer 2020 20:441
    Content type: Research article Published on:

  20. After neoadjuvant chemotherapy of breast cancer pathologic complete response (pCR) indicates a favorable prognosis. Among non-selected patients, pCR is, however, achieved in only 10–30%. Early evaluation of tu...

    Authors: Bernhard Tribukait
    Citation: BMC Cancer 2020 20:440
    Content type: Research article Published on:

  21. Systemic inflammation and cachexia are associated with adverse clinical outcomes in diffuse large B-cell lymphoma (DLBCL). The Geriatric Nutritional Risk Index (GNRI) is one of the main parameters used to asse...

    Authors: Se-Il Go, Hoon-Gu Kim, Myoung Hee Kang, Sungwoo Park and Gyeong-Won Lee
    Citation: BMC Cancer 2020 20:439
    Content type: Research article Published on:

  22. Evidence suggests that physical activity (PA) is beneficial for reducing fatigue in colorectal cancer (CRC) survivors. However, little is known regarding long-term effects of PA on fatigue and whether pre-diag...

    Authors: Ruth Elisa Eyl, Melissa S. Y. Thong, Prudence R. Carr, Lina Jansen, Lena Koch-Gallenkamp, Michael Hoffmeister, Jenny Chang-Claude, Hermann Brenner and Volker Arndt
    Citation: BMC Cancer 2020 20:438
    Content type: Research article Published on:

  23. Prostate cancer (PC) can display very heterogeneous phenotypes ranging from indolent asymptomatic to aggressive lethal forms. Understanding how these PC subtypes vary in their striving for energy and anabolic ...

    Authors: Ilona Dudka, Elin Thysell, Kristina Lundquist, Henrik Antti, Diego Iglesias-Gato, Amilcar Flores-Morales, Anders Bergh, Pernilla Wikström and Gerhard Gröbner
    Citation: BMC Cancer 2020 20:437
    Content type: Research article Published on:

  24. Dihydropyrimidine dehydrogenase (DPD) status is an indicator of a marked risk for toxicity following fluoropyrimidine (FP)-based chemotherapy. This notion is well-established for low DPD status but little is k...

    Authors: Emmanuel Chamorey, Eric Francois, Marie-Christine Etienne, Jean-Marc Ferrero, Frederic Peyrade, Emmanuel Barranger, Alexandre Bozec, Rémy Largillier, Ophelie Cassuto, Julien Viotti, Renaud Schiappa and Gérard Milano
    Citation: BMC Cancer 2020 20:436
    Content type: Research article Published on:

  25. Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow which results in hematopoietic failure. Despite various e...

    Authors: Paulina Gil-Kulik, Ewa Dudzińska, Elżbieta Radzikowska-Büchner, Joanna Wawer, Mariusz Jojczuk, Adam Nogalski, Genowefa Anna Wawer, Marcin Feldo, Wojciech Kocki, Maria Cioch, Anna Bogucka-Kocka, Mansur Rahnama and Janusz Kocki
    Citation: BMC Cancer 2020 20:435
    Content type: Research article Published on:

  27. Langerhans Cell Histiocytosis (LCH) is a rare disease puzzling both children and adults, however outcome of adult patients is unfavorable. This prospective interventional trial aims to test the efficacy and sa...

    Authors: Xiao Han, Mingqi Ouyang, Minghui Duan, Wei Zhang, Tienan Zhu, Jian Li, Shujie Wang and Daobin Zhou
    Citation: BMC Cancer 2020 20:433
    Content type: Research article Published on:

  28. The prevalence and correlates of job and insurance problems were examined among a cohort of young U.S. breast cancer survivors during the first 18-months following diagnosis.

    Authors: Michelle J. Naughton, Chloe M. Beverly Hery, Sarah A. Janse, Elizabeth Z. Naftalis, Electra D. Paskett and Kimberly J. Van Zee
    Citation: BMC Cancer 2020 20:432
    Content type: Research article Published on:

  29. Identification of patient-related factors associated with Health-Related Quality of Life (HRQoL) and Quality of Life (QoL) at the start of treatment may identify patients who are prone to a decrease in HRQoL a...

    Authors: Mark de Mol, Sabine Visser, Joachim Aerts, Paul Lodder, Nico van Walree, Huub Belderbos and Brenda den Oudsten
    Citation: BMC Cancer 2020 20:431
    Content type: Research article Published on:

  30. The purpose of this study was to determine the prognostic role of hormone receptor (HR) on inflammatory breast cancer (IBC) to elucidate its aggressive biological behavior.

    Authors: Toshiaki Iwase, Kenichi Harano, Hiroko Masuda, Kumiko Kida, Kenneth R. Hess, Ying Wang, Luc Dirix, Steven J. Van Laere, Anthony Lucci, Savitri Krishnamurthy, Wendy A. Woodward, Rachel M. Layman, François Bertucci and Naoto T. Ueno
    Citation: BMC Cancer 2020 20:430
    Content type: Research article Published on:

  31. Adenosquamous carcinoma (ASC) is an uncommon histological subtype of lung cancer. The purpose of this study was to assess the cumulative incidences of lung cancer-specific mortality (LC-SM) and other cause-spe...

    Authors: Xiao Wu, Wenfeng Yu, R. H. Petersen, Hongxu Sheng, Yiqing Wang, Wang Lv and Jian Hu
    Citation: BMC Cancer 2020 20:429
    Content type: Research article Published on:

  32. α-tocopherol (AT) and γ-tocotrienol (GT3) are vitamin E isoforms considered to have potential chemopreventive properties. AT has been widely studied in vitro and in clinical trials with mixed results. The late...

    Authors: Christine Moore, Victoria E. Palau, Rashid Mahboob, Janet Lightner, William Stone and Koyamangalath Krishnan
    Citation: BMC Cancer 2020 20:428
    Content type: Research article Published on:

  33. Enhancer of zeste homolog 2 (EZH2) is considered an important driver of tumor development and progression by its histone modifying capabilities. Inhibition of EZH2 activity is thought to be a potent treatment ...

    Authors: Chidimma Agatha Akpa, Karsten Kleo, Elisabeth Oker, Nancy Tomaszewski, Clemens Messerschmidt, Cristina López, Rabea Wagener, Kathrin Oehl-Huber, Katja Dettmer, Anne Schoeler, Dido Lenze, Peter J. Oefner, Dieter Beule, Reiner Siebert, David Capper, Lora Dimitrova…
    Citation: BMC Cancer 2020 20:427
    Content type: Research article Published on:

  34. Colon cancer is one of the most commonly diagnosed types of cancer with surgical resection of the tumor being the primary choice of treatment. However, the surgical stress response induced during treatment may...

    Authors: Johanne Davidsen, Stine Bull Jessen, Sara Kehlet Watt, Sylvester Larsen, Katja Dahlgaard, Tove Kirkegaard, Ismail Gögenur and Jesper T. Troelsen
    Citation: BMC Cancer 2020 20:426
    Content type: Research article Published on:

  35. PPFIA1 is an important regulator of cell migration and invasion, regulating focal adhesion signalling and disassembly. PPFIA1 is frequently amplified in breast cancer, and recent functional studies indicate th...

    Authors: Lutfi H. Alfarsi, Rokaya El Ansari, Madeleine L. Craze, Brendah K. Masisi, Ian O. Ellis, Emad A. Rakha and Andrew R. Green
    Citation: BMC Cancer 2020 20:425
    Content type: Research article Published on:

  36. The CSC (cancer stem cell) markers often indicate poor prognosis and more cell invasion or migration of cancer patients. Podoplanin was assumed as a candidate CSC marker and predict poor prognosis among squamo...

    Authors: Liya Hu, Peng Zhang, Qi Mei, Wei Sun, Lei Zhou and Tiejun Yin
    Citation: BMC Cancer 2020 20:424
    Content type: Research article Published on:

  37. Our aim was to investigate the value of serum squamous cell carcinoma (SCC) antigen levels in predicting chemosensitivity, lymph node metastasis, as well as prognosis in patients with cervical squamous cell ca...

    Authors: Peng Chen, Liang Jiao, Fang Ren and Dan-Bo Wang
    Citation: BMC Cancer 2020 20:423
    Content type: Research article Published on:

  38. Chemotherapy with gemcitabine and cisplatin has been the standard of care in first-line chemotherapy for advanced biliary tract cancer (BTC) since the trial ABC-02 was published in 2010. We aimed to investigat...

    Authors: Chiao-En Wu, Wen-Chi Chou, Chia-Hsun Hsieh, John Wen-Cheng Chang, Cheng-Yu Lin, Chun-Nan Yeh and Jen-Shi Chen
    Citation: BMC Cancer 2020 20:422
    Content type: Research article Published on:

  39. We aimed to assess whether disease-free survival (DFS) could serve as a reliable surrogate endpoint for overall survival (OS) in adjuvant trials of pancreatic cancer.

    Authors: Run-Cong Nie, Xue-Bin Zou, Shu-Qiang Yuan, Ying-Bo Chen, Shi Chen, Yong-Ming Chen, Guo-Ming Chen, Xiao-Jiang Chen, Tian-Qi Luo, Shu-Man Li, Jin-Ling Duan, Yun Wang and Yuan-Fang Li
    Citation: BMC Cancer 2020 20:421
    Content type: Research article Published on:

  40. It is generally accepted that microRNA-20a (miR-20a) is aberrantly expressed in gastrointestinal cancer (GIC), and may be associated with the prognosis of GIC patients. Nevertheless, the clinical prognostic va...

    Authors: Qiliang Peng, Peifeng Zhao, Yi Shen, Ming Cheng, Yongyou Wu and Yaqun Zhu
    Citation: BMC Cancer 2020 20:420
    Content type: Research article Published on:

  41. To obtain high-yield histological samples by targeted prostate cancer (PCa) biopsy is the current trend compared with transrectal ultrasound (TRUS)-guided systematic histological biopsy, which is regarded as t...

    Authors: Chen Qiu, Yuanyuan Bai, Tinghui Yin, Xiaoyan Miao, Rongkang Gao, Huichao Zhou, Jie Ren, Liang Song, Chengbo Liu, Hairong Zheng and Rongqin Zheng
    Citation: BMC Cancer 2020 20:419
    Content type: Research article Published on:

  42. Elderly patients are underrepresented in clinical study where combined endocrine strategies were compared to endocrine therapy (ET) in hormone receptors positive, HER2 negative, metastatic breast cancer. The r...

    Authors: Claudia Omarini, Federico Piacentini, Isabella Sperduti, Monica Barbolini, Chrystel Isca, Angela Toss, Laura Cortesi, Elena Barbieri, Massimo Dominici and Luca Moscetti
    Citation: BMC Cancer 2020 20:418
    Content type: Research article Published on:

  43. Pancreatic cancer remains a fatal disease. Experimental systems are needed for personalized treatment strategies, drug testing and to further understand tumor biology. Cell cultures can serve as an excellent p...

    Authors: L. Ehlen, J. Arndt, D. Treue, P. Bischoff, F. N. Loch, E. M. Hahn, K. Kotsch, F. Klauschen, K. Beyer, G. A. Margonis, M. E. Kreis and C. Kamphues
    Citation: BMC Cancer 2020 20:417
    Content type: Research article Published on:

  44. KRAS mutations have been characterized as the major predictive biomarkers for resistance to cetuximab treatment. However, studies indicate that not all KRAS mutations are associated with equivalent treatment o...

    Authors: Hangyu Zhang, Liyun Yuan, Lulu Liu, Cong Yan, Jinming Cheng, Qihan Fu, Zhou Tong, Weiqin Jiang, Yi Zheng, Peng Zhao, Guoqing Zhang and Weijia Fang
    Citation: BMC Cancer 2020 20:416
    Content type: Research article Published on:

  45. Curative treatment for upper gastrointestinal (UGI) and hepatopancreaticobiliary (HPB) cancers, involves complex surgical resection often in combination with neoadjuvant/adjuvant chemo/chemoradiotherapy. With ...

    Authors: Linda O’Neill, Emer Guinan, Suzanne Doyle, Deirdre Connolly, Jacintha O’Sullivan, Annemarie Bennett, Grainne Sheill, Ricardo Segurado, Peter Knapp, Ciaran Fairman, Charles Normand, Justin Geoghegan, Kevin Conlon, John V. Reynolds and Juliette Hussey
    Citation: BMC Cancer 2020 20:415
    Content type: Study protocol Published on:

  46. Anaemia is highly prevalent in gastric cancer (GC) patients. The role of initial haemoglobin levels in predicting the prognosis of GC patients treated by chemotherapy has not been well determined. Our present ...

    Authors: Wen-Huan Li, Ji-Yu Zhang, Wen-Hui Liu and Xian-Xian Chen
    Citation: BMC Cancer 2020 20:414
    Content type: Research article Published on:

  47. A major impediment in the treatment of ovarian cancer is the relapse of chemotherapy-resistant tumors, which occurs in approximately 25% of patients. A better understanding of the biological mechanisms underly...

    Authors: Jihoon Choi, Danai G. Topouza, Anastasiya Tarnouskaya, Sean Nesdoly, Madhuri Koti and Qing Ling Duan
    Citation: BMC Cancer 2020 20:413
    Content type: Research article Published on:

  49. Single nucleotide polymorphisms (SNPs) in DNA repair genes have a potential clinical value in predicting treatment outcomes. In the current study, we examined the association of SNPs in the genes XRCC1-rs25487...

    Authors: Hamideh Salimzadeh, Elinor Bexe Lindskog, Bengt Gustavsson, Yvonne Wettergren and David Ljungman
    Citation: BMC Cancer 2020 20:409
    Content type: Research article Published on:

  50. Thyroid Hurthle cell carcinoma (HCC) is a rare disease with high risk of invasion and metastasis and poor prognosis. The clinical characteristics, prognosis and treatment of HCC are still controversial, and cl...

    Authors: Xingtong Zhou, Zhibo Zheng, Chuyan Chen, Bangbo Zhao, Hongtao Cao, Tianhao Li, Xudong Liu, Weibin Wang and Yongning Li
    Citation: BMC Cancer 2020 20:407
    Content type: Research article Published on:

Featured videos

View featured videos from across the BMC-series journals

Submit manuscript

Follow

BMC Cancer

ISSN: 1471-2407

Contact us