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  1. The prognosis is very poor for lung cancer patients with bone metastasis. Unfortunately, a suitable method has yet to become available for the early diagnosis of bone metastasis in lung cancer patients. The pr...

    Authors: Xiaoyan Teng, Lirong Wei, Liming Han, Daliu Min and Yuzhen Du
    Citation: BMC Cancer 2020 20:562
    Content type: Research article Published on:

  2. Racial disparities are well-documented in preventive cancer care, but they have not been fully explored in the context of lung cancer screening. We sought to explore racial differences in lung cancer screening...

    Authors: Michael Lake, Christine S. Shusted, Hee-Soon Juon, Russell K. McIntire, Charnita Zeigler-Johnson, Nathaniel R. Evans, Gregory C. Kane and Julie A. Barta
    Citation: BMC Cancer 2020 20:561
    Content type: Research article Published on:

  3. Pain self-management support interventions were effective in controlled clinical trials and meta analyses. However, implementation of these complex interventions may not translate into identical effects. This ...

    Authors: Silvia Raphaelis, Florian Frommlet, Hanna Mayer and Antje Koller
    Citation: BMC Cancer 2020 20:559
    Content type: Research article Published on:

  4. About 50% of non-small cell lung cancer (NSCLC) patients have metastatic disease at initial diagnosis, which limits their treatment options and, consequently, the 5-year survival rate (15%). Immune checkpoint ...

    Authors: Relinde I. Y. Lieverse, Evert J. Van Limbergen, Cary J. G. Oberije, Esther G. C. Troost, Sine R. Hadrup, Anne-Marie C. Dingemans, Lizza E. L. Hendriks, Franziska Eckert, Crispin Hiley, Christophe Dooms, Yolande Lievens, Monique C. de Jong, Johan Bussink, Xavier Geets, Vincenzo Valentini, Giuliano Elia…
    Citation: BMC Cancer 2020 20:557
    Content type: Study protocol Published on:

  5. Liver fibrosis or cirrhosis is associated with the dismal prognosis of hepatocellular carcinoma (HCC), and it might also be involved in intrahepatic cholangiocarcinoma (ICC). The effect of hepatic fibrosis on ...

    Authors: Jian Xi Zhang, Peipei Li, Zhibin Chen, Huogui Lin, Zhezhen Cai, Weijia Liao and Zirong Pan
    Citation: BMC Cancer 2020 20:556
    Content type: Research article Published on:

  6. Prostate cancer (PC), a common malignant tumor, is the second-leading cause of cancer death among American men. Its successful treatment greatly relies on the early diagnose. Engrailed-2 (EN2) has been confirm...

    Authors: Qi Li, Yibo Shi, Rigai Sa, Jun Hao, Jinhao Hu, Mulun Xiao, Chaoliang Wang, Liang Yan, Baoping Qiao and Guoxun Chen
    Citation: BMC Cancer 2020 20:555
    Content type: Research article Published on:

  7. Metastatic medulloblastoma (MB) portends a poor prognosis. Amongst the 4 molecular subtypes, Group 3 and Group 4 patients have a higher incidence of metastatic disease, especially involving the neuroaxis. At p...

    Authors: Sharon Y. Y. Low, Nurfahanah Bte Syed Sulaiman, Enrica E. K. Tan, Lee Ping Ng, Chik Hong Kuick, Kenneth T. E. Chang, Phua Hwee Tang, Ru Xin Wong, Wen Shen Looi, David C. Y. Low and Wan Tew Seow
    Citation: BMC Cancer 2020 20:554
    Content type: Research article Published on:

  8. Pediatric acute myeloid leukemia (AML) with t(8;21) (q22;q22) is classified as a low-risk group. However, relapse is still the main factor affecting survival. We aimed to investigate the effect of allogeneic h...

    Authors: Guan-hua Hu, Yi-fei Cheng, Ai-dong Lu, Yu Wang, Ying-xi Zuo, Chen-hua Yan, Jun Wu, Yu-qian Sun, Pan Suo, Yu-hong Chen, Huan Chen, Yue-ping Jia, Kai-yan Liu, Wei Han, Lan-ping Xu, Le-ping Zhang…
    Citation: BMC Cancer 2020 20:553
    Content type: Research article Published on:

  9. Prostate cancer (PCa) and type 2 diabetes mellitus (T2DM) are prevalent conditions that often occur concomitantly. However, many aspects of the impact of T2DM, particularly the duration of T2DM and antidiabeti...

    Authors: E. Lin, Hans Garmo, Mieke Van Hemelrijck, Jan Adolfsson, Pär Stattin, Björn Zethelius and Danielle Crawley
    Citation: BMC Cancer 2020 20:551
    Content type: Research article Published on:

  10. Regarding the longer-term recurrence rate the optimal activity for the remnant thyroid ablation in patients with differentiated thyroid cancer (DTC) is discussed controversially. For the short-term ablation su...

    Authors: I. Vardarli, F. Weidemann, M. Aboukoura, K. Herrmann, I. Binse and R. Görges
    Citation: BMC Cancer 2020 20:550
    Content type: Research article Published on:

  11. Glioma is the most common primary brain tumor, occurring due to the carcinogenesis of glial cells in the brain and spinal cord. Many aspects of the mechanism of its tumorigenesis remain unknown. The relationsh...

    Authors: Zehao Cai, Shoubo Yang, Xiaoyan Li, Feng Chen and Wenbin Li
    Citation: BMC Cancer 2020 20:549
    Content type: Research article Published on:

  12. Ramucirumab (RAM) with weekly paclitaxel (wPTX) is a standard second-line therapy for advanced or recurrent gastric cancer. Nanoparticle albumin-bound paclitaxel (nab-PTX), an albumin-bound form of PTX, was de...

    Authors: Kenro Hirata, Yasuo Hamamoto, Masahiko Ando, Chiyo K. Imamura, Kenichi Yoshimura, Kentaro Yamazaki, Shuichi Hironaka and Kei Muro
    Citation: BMC Cancer 2020 20:548
    Content type: Study protocol Published on:

  13. To explore the correlation of flash dual source computed tomography perfusion imaging (CTPI) and regional lymph node metastasis of non-small cell lung cancer (NSCLC), and to evaluate the value of CT perfusion ...

    Authors: Tingting Huang, Hui Sun, Xianli Luo, Xuemei Zhang, Kaiyuan Jin, Feng Wang, Lv Sun, Nianlan Cheng, Shuo Wu, Qin Lou and Bangguo Li
    Citation: BMC Cancer 2020 20:547
    Content type: Research article Published on:

  14. Multiple Myeloma (MM) is a cancer characterised by the proliferation of malignant plasma cells in the bone marrow. This study examined the treatment preferences of people living with MM compared to the treatme...

    Authors: Simon J. Fifer, Kerrie-Anne Ho, Sean Lybrand, Laurie J. Axford and Steve Roach
    Citation: BMC Cancer 2020 20:546
    Content type: Research article Published on:

  15. Unresectable esophageal cancer harbors high mortality despite chemoradiotherapy. Better patient selection for more personalized management may result in better treatment outcomes. We presume the ratio of maxim...

    Authors: Po-Jui Chen, Wing-Keen Yap, Yu-Chuan Chang, Chen-Kan Tseng, Yin-Kai Chao, Jason Chia-Hsun Hsieh, Ping-Ching Pai, Ching-Hsin Lee, Chan-Keng Yang, Albert Tsung-Ying Ho and Tsung-Min Hung
    Citation: BMC Cancer 2020 20:545
    Content type: Research article Published on:

  16. We conducted this study to combine the mean standardized uptake value (SUVmean) and neutrophil to lymphocyte ratio (NLR) to establish a strong predictive model for patients with esophageal squamous cell carcin...

    Authors: Chunsheng Wang, Kewei Zhao, Shanliang Hu, Yong Huang, Li Ma, Yipeng Song and Minghuan Li
    Citation: BMC Cancer 2020 20:544
    Content type: Research article Published on:

  17. Advances in peri-operative care of surgical oncology patients result in shorter hospital stays. Earlier discharge may bring benefits, but complications can occur while patients are recovering at home. Electron...

    Authors: H. S. Richards, J. M. Blazeby, A. Portal, R. Harding, T. Reed, T. Lander, K. A. Chalmers, R. Carter, R. Singhal, K. Absolom, G. Velikova and K. N. L. Avery
    Citation: BMC Cancer 2020 20:543
    Content type: Research article Published on:

  18. Novel biomarkers are required to discern between breast tumors that should be targeted for treatment from those that would never become clinically apparent and/or life threatening for patients. Moreover, thera...

    Authors: Catharina Hagerling, Mark Owyong, Vaishnavi Sitarama, Chih-Yang Wang, Charlene Lin, Renske J. E. van den Bijgaart, Charlotte D. Koopman, Audrey Brenot, Ankitha Nanjaraj, Fredrik Wärnberg, Karin Jirström, Ophir D. Klein, Zena Werb and Vicki Plaks
    Citation: BMC Cancer 2020 20:542
    Content type: Research article Published on:

  19. Recent evidence suggests that albumin-to-Alkaline Phosphatase Ratio (AAPR) functions as a novel prognostic marker in several malignancies. However, whether it can predict the prognosis of unresectable pancreat...

    Authors: Ke Zhang, Shu Dong, Yan-Hua Jing, Hui-Feng Gao, Lian-Yu Chen, Yong-Qiang Hua, Hao Chen and Zhen Chen
    Citation: BMC Cancer 2020 20:541
    Content type: Research article Published on:

  20. Abdominal/pelvic lymph node (LN) oligometastasis, a pattern of treatment failure, is observed occasionally, and radiotherapy may work as salvage therapy. The optimal prescription dose, however, is yet to be de...

    Authors: Makoto Ito, Takeshi Kodaira, Yutaro Koide, Takahito Okuda, Shinichiro Mizumatsu, Yukihiko Oshima, Arisa Takeuchi, Toshie Mori, Souichirou Abe, Ayumi Asai and Kojiro Suzuki
    Citation: BMC Cancer 2020 20:540
    Content type: Research article Published on:

  21. Cervical cancer is caused by Human Papilloma viruses (HPV) and is preceded by precursor stages: Cervical Intraepithelial Neoplasia (CIN). CIN is mostly found in women in their reproductive age and treated with...

    Authors: R. L. O. van de Laar, W. Hofhuis, R. G. Duijnhoven, S. Polinder, W. J. G. Melchers, F. J. van Kemenade, R. L. M. Bekkers and H. J. Van Beekhuizen
    Citation: BMC Cancer 2020 20:539
    Content type: Study protocol Published on:

  22. Immunotherapy has become an essential part of cancer treatment after showing great efficacy in various malignancies. However, its effectiveness in pancreatic ductal adenocarcinoma (PDAC), especially in resecta...

    Authors: Saber Amin, Michael Baine, Jane Meza and Chi Lin
    Citation: BMC Cancer 2020 20:538
    Content type: Research article Published on:

  24. Adrenal gland metastases are a common diagnostic finding in various tumor diseases. Due to the increased use of imaging methods, they are diagnosed more frequently, especially in asymptomatic patients. SBRT ha...

    Authors: Theresa Voglhuber, Kerstin A. Kessel, Markus Oechsner, Marco M. E. Vogel, Jürgen E. Gschwend and Stephanie E. Combs
    Citation: BMC Cancer 2020 20:536
    Content type: Research article Published on:

  25. Expression of forkhead box P3 (FOXP3), a key regulator of T-cell function, in the tumor immune microenvironment is related to survival in classic Hodgkin lymphoma (CHL). Vitamin D receptor (VDR), a transcripti...

    Authors: Gaurav K. Gupta, Tanupriya Agrawal and Monika Pilichowska
    Citation: BMC Cancer 2020 20:535
    Content type: Research article Published on:

  26. The aim of this study was to establish a comprehensive nomogram for the cancer-specific survival (CSS) of patients with upper-tract urothelial carcinoma (UTUC) and compare it with the traditional American Join...

    Authors: Chengzhuo Li, Jin Yang, Fengshuo Xu, Didi Han, Shuai Zheng, Rahel Elishilia Kaaya, Shengpeng Wang and Jun Lyu
    Citation: BMC Cancer 2020 20:534
    Content type: Research article Published on:

  27. Accurate diagnosis of early lung cancer from small pulmonary nodules (SPN) is challenging in clinical setting. We aimed to develop a radiomic nomogram to differentiate lung adenocarcinoma from benign SPN.

    Authors: Qin Liu, Yan Huang, Huai Chen, Yanwen Liu, Ruihong Liang and Qingsi Zeng
    Citation: BMC Cancer 2020 20:533
    Content type: Research article Published on:

  28. Whole brain radiation therapy (WBRT) is the standard therapy for multiple brain metastases. However, WBRT has a poor local tumor control and is associated with a decline in neurocognitive function (NCF). Aim o...

    Authors: Anca-Ligia Grosu, Lars Frings, Iryna Bentsalo, Oliver Oehlke, Franziska Brenner, Angelika Bilger, Jamina Tara Fennell, Thomas Rothe, Sabine Schneider-Fuchs, Erika Graf, Claudia Schmoor, Jürgen Beck, Gerhild Becker, Michael Bock, Karl Egger, Horst Urbach…
    Citation: BMC Cancer 2020 20:532
    Content type: Study protocol Published on:

  29. Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge re...

    Authors: Tomer Boldes, Keren Merenbakh-Lamin, Shani Journo, Eliya Shachar, Doron Lipson, Adva Yeheskel, Metsada Pasmanik-Chor, Tami Rubinek and Ido Wolf
    Citation: BMC Cancer 2020 20:531
    Content type: Research article Published on:

  30. Formulae of estimated glomerular filtration rate (eGFR) based on serum creatinine (Scr) are routinely used in oncology patients, however, they are inaccurate in some populations. Our aim was to assess the agre...

    Authors: Yichun Cheng, Liu Huang, Yunfeng Han, Chummun Vanisha, Shuwang Ge and Gang Xu
    Citation: BMC Cancer 2020 20:530
    Content type: Research article Published on:

  31. Financial toxicity of cancer has so far been discussed primarily in the US health care system and is associated with higher morbidity and mortality. In European health care systems, the socio-economic impact o...

    Authors: Katja Mehlis, Julian Witte, Bastian Surmann, Matthias Kudlich, Leonidas Apostolidis, Jürgen Walther, Dirk Jäger, Wolfgang Greiner and Eva C. Winkler
    Citation: BMC Cancer 2020 20:529
    Content type: Research article Published on:

  33. Sarcomas constitute a heterogeneous group of tumors with different clinical behaviors and variable responses to systemic therapies. Recent immunotherapy studies with PD1 inhibitors (PD1i) show promising result...

    Authors: Dionisia Quiroga, David A. Liebner, Jennifer S. Philippon, Sarah Hoffman, Yubo Tan, James L. Chen, Scott Lenobel, Paul E. Wakely Jr, Raphael Pollock and Gabriel Tinoco
    Citation: BMC Cancer 2020 20:527
    Content type: Research article Published on:

  34. Effectiveness of L-asparaginase administration in acute lymphoblastic leukemia treatment is mirrored in the overall outcome of patients. Generally, leukemia patients differ in their sensitivity to L-asparagina...

    Authors: Katerina Hlozkova, Alena Pecinova, Natividad Alquezar-Artieda, David Pajuelo-Reguera, Marketa Simcikova, Lenka Hovorkova, Katerina Rejlova, Marketa Zaliova, Tomas Mracek, Alexandra Kolenova, Jan Stary, Jan Trka and Julia Starkova
    Citation: BMC Cancer 2020 20:526
    Content type: Research article Published on:

  35. Previous researches have reported that tripartite motif-containing 44 (TRIM44) is related to the prognosis of multiple human tumors. This study was designed to systematically assess the prognostic value of TRI...

    Authors: Guoliang Xiao, Qiuxi Yang, Ziwei Bao, Haixia Mao, Yi Zhang and Shibu Lin
    Citation: BMC Cancer 2020 20:525
    Content type: Research article Published on:

  36. Xenograft mouse tumor models are used to study mechanisms of tumor growth and metastasis formation and to investigate the efficacy of different therapeutic interventions. After injection the engrafted cells fo...

    Authors: Bertin Hoffmann, Tobias Lange, Vera Labitzky, Kristoffer Riecken, Andreas Wree, Udo Schumacher and Gero Wedemann
    Citation: BMC Cancer 2020 20:524
    Content type: Research article Published on:

  37. Pediatric patients with relapsed or refractory disease represent a population with a desperate medical need. The aim of the INFORM (INdividualized Therapy FOr Relapsed Malignancies in Childhood) program is to ...

    Authors: Cornelis M. van Tilburg, Ruth Witt, Melanie Heiss, Kristian W. Pajtler, Christoph Plass, Isabel Poschke, Michael Platten, Inga Harting, Oliver Sedlaczek, Angelika Freitag, David Meyrath, Lenka Taylor, Gnana Prakash Balasubramanian, Natalie Jäger, Elke Pfaff, Barbara C. Jones…
    Citation: BMC Cancer 2020 20:523
    Content type: Study protocol Published on:

  38. microRNAs (miRNAs) play essential roles in the development and progression of gastric cancer (GC). Although aberrant miR-874 expression has been reported in various human cancers, its role in GC remains obscure.

    Authors: Qin Hui Sun, Zong Xiu Yin, Zhi Li, Shu Bo Tian, Hong Chang Wang, Fang Xu Zhang, Le Ping Li, Chun Ning Zheng and Shuai Kong
    Citation: BMC Cancer 2020 20:522
    Content type: Research article Published on:

  39. Octamer-binding transcription factor 4A (OCT4A) is essential for cell pluripotency and reprogramming both in humans and mice. To date, however, the function of human OCT4 in somatic and/or tumour tissues is la...

    Authors: Seijiro Koshimune, Mitsuko Kosaka, Nobuhiko Mizuno, Hiromasa Yamamoto, Tomoyuki Miyamoto, Kohta Ebisui, Shinichi Toyooka and Aiji Ohtsuka
    Citation: BMC Cancer 2020 20:521
    Content type: Research article Published on:

  40. According to the proportion of glandular and squamous pathological components, adenosquamous carcinoma (ASC) could be divided into adenocarcinoma (AC) and squamous cell carcinoma (SCC) predominant subtypes. Du...

    Authors: Yangli Liu, Ying Zhu, Lihong Bai, Fengjia Chen, Jue Wang and Yubiao Guo
    Citation: BMC Cancer 2020 20:520
    Content type: Research article Published on:

  41. Treatment options for advanced head and neck adenoid cystic carcinoma (AdCC) are limited. Prostate-Specific Membrane Antigen (PSMA), a transmembrane protein that is known for its use in diagnostics and targete...

    Authors: Thomas J. W. Klein Nulent, Matthijs H. Valstar, Laura A. Smit, Ludwig E. Smeele, Nicolaas P. A. Zuithoff, Bart de Keizer, Remco de Bree, Robert J. J. van Es and Stefan M. Willems
    Citation: BMC Cancer 2020 20:519
    Content type: Research article Published on:

  42. Chemoradiotherapy (CRT) with high cumulative doses (CDs) of cisplatin has been considered the standard of care for non-metastatic nasopharyngeal carcinoma (NPC). However, given most patients’ inability to tole...

    Authors: Nuttapong Ngamphaiboon, Arunee Dechaphunkul, Jiraporn Setakornnukul, Tanadech Dechaphunkul, Rungarun Jiratrachu, Bhoom Suktitipat, Chuleeporn Jiarpinitnun, Poompis Pattaranutaporn and Pongwut Danchaivijitr
    Citation: BMC Cancer 2020 20:518
    Content type: Research article Published on:

  43. Although many studies have identified several inflammation-based and/or nutritional markers with prognostic value for patients with various types of cancer, the optimal markers and cut-off values for these mar...

    Authors: Takahiro Toyokawa, Kazuya Muguruma, Mami Yoshii, Tatsuro Tamura, Katsunobu Sakurai, Naoshi Kubo, Hiroaki Tanaka, Shigeru Lee, Masakazu Yashiro and Masaichi Ohira
    Citation: BMC Cancer 2020 20:517
    Content type: Research article Published on:

  44. Trichilemmal carcinoma (TC) is an extremely rare hair follicle tumor. We aimed to explore the genetic abnormalities involved in TC to gain insight into its molecular pathogenesis.

    Authors: Jeong Hyun Ha, Cheol Lee, Kyu Sang Lee, Chang-sik Pak, Choong-Hyun Sun, Youngil Koh and Hak Chang
    Citation: BMC Cancer 2020 20:516
    Content type: Research article Published on:

  45. FOLFIRINOX is a pillar first-line regimen in the treatment of pancreatic cancer. Historically, biliary tract cancer (BTC) and pancreatic cancer have been treated similarly with gemcitabine alone or combined wi...

    Authors: Ayhan Ulusakarya, Abdoulaye Karaboué, Oriana Ciacio, Gabriella Pittau, Mazen Haydar, Pamela Biondani, Yusuf Gumus, Amale Chebib, Wathek Almohamad and Pasquale F. Innominato
    Citation: BMC Cancer 2020 20:515
    Content type: Research article Published on:

  46. Morcellation may lead to intraperitoneal spread of tumor cells, thus making prognosis of undiagnosed uterine leiomyosarcoma (ULMS) worse. However, preoperative diagnosis of ULMS remains challenging. This study...

    Authors: Guorui Zhang, Xin Yu, Lan Zhu, Qingbo Fan, Honghui Shi and Jinghe Lang
    Citation: BMC Cancer 2020 20:514
    Content type: Research article Published on:

  47. 18 F-FDG is a glucose analogue whose metabolic index SUV can effectively reflect the metabolic level of tumor microenvironment. Aspirin can affect the uptake of 18F-FDG by cancer cells, reducing the SUVmax val...

    Authors: Jinghua Chen, Junxian Xia, Jiacheng Huang and Ruilian Xu
    Citation: BMC Cancer 2020 20:510
    Content type: Research article Published on:

  48. Whilst epidemiological studies have provided evidence of associations between certain risk factors and glioma onset, inferring causality has proven challenging. Using Mendelian randomization (MR), we assessed ...

    Authors: A. E. Howell, J. W. Robinson, R. E. Wootton, A. McAleenan, S. Tsavachidis, Q. T. Ostrom, M. Bondy, G. Armstrong, C. Relton, P. Haycock, R. M. Martin, J. Zheng and K. M. Kurian
    Citation: BMC Cancer 2020 20:508
    Content type: Research article Published on:

  49. PARP inhibitors (PARPi) have recently been approved for various malignancies based on the results of several clinical trials. However, these trials have mostly recruited patients with germline BRCA mutations, ...

    Authors: Ghulam Rehman Mohyuddin, Muhammad Aziz, Alec Britt, Lee Wade, Weijing Sun, Joaquina Baranda, Raed Al-Rajabi, Anwaar Saeed and Anup Kasi
    Citation: BMC Cancer 2020 20:507
    Content type: Research article Published on:

  50. Recent studies have extensively investigated the roles of miR-106 in colorectal cancer (CRC). However, the associations and molecular mechanism underlying the roles of miR-106 in CRC remain unclear. We aimed t...

    Authors: Qiliang Peng, Yi Shen, Peifeng Zhao, Ming Cheng, Yaqun Zhu and Bo Xu
    Citation: BMC Cancer 2020 20:506
    Content type: Research article Published on:

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