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  1. The classification of Breast Imaging Reporting and Data System 4A (BI-RADS 4A) lesions is mostly based on the personal experience of doctors and lacks specific and clear classification standards. The developme...

    Authors: Sihua Niu, Jianhua Huang, Jia Li, Xueling Liu, Dan Wang, Ruifang Zhang, Yingyan Wang, Huiming Shen, Min Qi, Yi Xiao, Mengyao Guan, Haiyan Liu, Diancheng Li, Feifei Liu, Xiuming Wang, Yu Xiong…
    Citation: BMC Cancer 2020 20:959
    Content type: Research article Published on:

  2. It is well acknowledged that cancer-related pathways play pivotal roles in the progression of pancreatic cancer (PC). Employing Integrated analysis, we aim to identify the pathway-related ceRNA network associa...

    Authors: Fuqiang Zu, Peng Liu, Huaitao Wang, Ting Zhu, Jian Sun, Weiwei Sheng and Xiaodong Tan
    Citation: BMC Cancer 2020 20:958
    Content type: Research article Published on:

  3. Chromosome mis-segregation caused by spindle assembly checkpoint (SAC) dysfunction during mitosis is an important pathogenic factor in cancer, and modulating SAC function has emerged as a potential novel thera...

    Authors: Han Lei, Kun Wang, Tongying Jiang, Jingjing Lu, Xue Dong, Feilong Wang, Qiang Li and Liming Zhao
    Citation: BMC Cancer 2020 20:957
    Content type: Research article Published on:

  4. L-asparaginase (L-ASP) is a key component of acute lymphoblastic leukemia (ALL) treatment, but its use in clinical practice raises challenges to clinicians due to a relatively high incidence of drug-related ad...

    Authors: Federico Lussana, Paola Minetto, Felicetto Ferrara, Sabina Chiaretti, Giorgina Specchia and Renato Bassan
    Citation: BMC Cancer 2020 20:956
    Content type: Research article Published on:

  5. For patients with any kind of atypical squamous intraepithelial lesion of the uterine cervix or vagina, colposcopy and punch biopsy are common procedures for histological determination following cytology. Howe...

    Authors: Shoko Ono, Ayako Nozaki, Kana Matsuda, Emi Takakuwa, Naoya Sakamoto and Hidemichi Watari
    Citation: BMC Cancer 2020 20:955
    Content type: Research article Published on:

  6. Proctitis is an inflammation of the rectum and may be induced by radiation treatment for cancer. The genetic heritability of developing radiotoxicity and prior role of genetic variants as being associated with...

    Authors: Gita A. Pathak, Renato Polimanti, Talisa K. Silzer, Frank R. Wendt, Ranajit Chakraborty and Nicole R. Phillips
    Citation: BMC Cancer 2020 20:954
    Content type: Research article Published on:

  7. Early treatment of patients at risk for developing aggressive prostate cancer is able to delay metastasis and reduce mortality; as such, up-front identification of these patients is critical. Several risk clas...

    Authors: Shivani Kamdar, Neil E. Fleshner and Bharati Bapat
    Citation: BMC Cancer 2020 20:953
    Content type: Research article Published on:

  8. Colorectal cancer (CRC) is the second most common cause of cancer-related mortality worldwide with one in every five patients diagnosed with metastatic CRC (mCRC). In mCRC cases, the 5-year survival rate remai...

    Authors: Susan A. Kennedy, Maria E. Morrissey, Margaret R. Dunne, Fiona O’Connell, Clare T. Butler, Mary-Clare Cathcart, Amy M. Buckley, Brian J. Mehigan, John O. Larkin, Paul McCormick, Breandán N. Kennedy and Jacintha O’Sullivan
    Citation: BMC Cancer 2020 20:952
    Content type: Research article Published on:

  9. Osimertinib, a third-generation epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI), can be used as second-line treatment for lung cancer patients harboring the T790M substitution. Although...

    Authors: Yuichiro Takeda, Go Naka, Yoh Yamaguchi, Masao Hashimoto, Manabu Suzuki, Shinyu Izumi and Haruhito Sugiyama
    Citation: BMC Cancer 2020 20:951
    Content type: Research article Published on:

  10. In recent years treatment options for advanced pancreatic cancer have markedly improved, and a combination regimen of gemcitabine and nab-paclitaxel is now considered standard of care in Sweden and elsewhere. ...

    Authors: Hakon Blomstrand, Henrik Green, Mats Fredrikson, Emma Gränsmark, Bergthor Björnsson and Nils O. Elander
    Citation: BMC Cancer 2020 20:950
    Content type: Research article Published on:

  11. Breast cancer is the leading cause of cancer mortality in women worldwide. Therefore, it is of great significance to identify the biological mechanism of tumorigenesis and explore the development of breast can...

    Authors: Liqin Xia, Feng Li, Jun Qiu, Zhongming Feng, Zihan Xu, Zhengtang Chen and Jianguo Sun
    Citation: BMC Cancer 2020 20:949
    Content type: Research article Published on:

  12. Breast cancer care today involves state-of-the-art biomedical treatment but can fail to address the broader psychosocial and quality-of-life (QoL) issues associated with the transition to breast cancer survivo...

    Authors: Michael G. Culbertson, Kathleen Bennett, Catherine M. Kelly, Linda Sharp and Caitriona Cahir
    Citation: BMC Cancer 2020 20:948
    Content type: Research article Published on:

  13. Radiotherapy is known to improve local tumor control in locally advanced pancreatic cancer (LAPC), although there is a lack of convincing data on a potential overall survival benefit of chemoradiotherapy over ...

    Authors: Jakob Liermann, Patrick Naumann, Adriane Hommertgen, Moritz Pohl, Meinhard Kieser, Juergen Debus and Klaus Herfarth
    Citation: BMC Cancer 2020 20:947
    Content type: Study protocol Published on:

  14. Undifferentiated carcinoma (UC) of the pancreas is a rare subtype of pancreatic cancer. Although UC has been considered a highly aggressive malignancy, no clinical studies have addressed the efficacy of chemot...

    Authors: Hiroshi Imaoka, Masafumi Ikeda, Kosuke Maehara, Kumiko Umemoto, Masato Ozaka, Satoshi Kobayashi, Takeshi Terashima, Hiroto Inoue, Chihiro Sakaguchi, Kunihiro Tsuji, Kazuhiko Shioji, Keiya Okamura, Yasuyuki Kawamoto, Rei Suzuki, Hirofumi Shirakawa, Hiroaki Nagano…
    Citation: BMC Cancer 2020 20:946
    Content type: Research article Published on:

  15. Circulating tumor (ct) DNA assays performed in clinical laboratories provide tumor biomarker testing support for biopharmaceutical clinical trials. Yet it is neither practical nor economically feasible for man...

    Authors: Suman Verma, Mathew W. Moore, Rebecca Ringler, Abhisek Ghosal, Kyle Horvath, Theodore Naef, Sheri Anvari, Philip D. Cotter and Shelly Gunn
    Citation: BMC Cancer 2020 20:945
    Content type: Technical advance Published on:

  16. Next-generation sequencing (NGS) has shown that recurrent/metastatic breast cancer lesions may have additional genetic changes compared with the primary tumor. These additional changes may be related to tumor ...

    Authors: Toshiaki Akahane, Naoki Kanomata, Oi Harada, Tetsumasa Yamashita, Junichi Kurebayashi, Akihide Tanimoto and Takuya Moriya
    Citation: BMC Cancer 2020 20:944
    Content type: Research article Published on:

  17. Several studies have demonstrated autophagy was involved in the process of esophageal adenocarcinoma (EAC). The aim of this study was to explore autophagy-related genes (ARGs) correlated with overall survival ...

    Authors: Lei Zhu, Lin Dong, Minghao Feng, Fugui Yang, Wenhao Jiang, Zhiyuan Huang, Fabing Liu, Lingwei Wang, Guangxue Wang and Qinchuan Li
    Citation: BMC Cancer 2020 20:943
    Content type: Research article Published on:

  18. Despite detailed instruction for full bladder, patients are unable to maintain consistent bladder filling during a 5-week pelvic radiation therapy (RT) course. We investigated the best bladder volume estimatio...

    Authors: Nalee Kim, Hong In Yoon, Jin Sung Kim, Woong Sub Koom, Jee Suk Chang and Yoonsun Chung
    Citation: BMC Cancer 2020 20:942
    Content type: Research article Published on:

  19. Quiescent tumor cells pose a major clinical challenge due to their ability to resist conventional chemotherapies and to drive tumor recurrence. Understanding the molecular mechanisms that promote quiescence of...

    Authors: Ethan P. Metz, Erin L. Wuebben, Phillip J. Wilder, Jesse L. Cox, Kaustubh Datta, Donald Coulter and Angie Rizzino
    Citation: BMC Cancer 2020 20:941
    Content type: Research article Published on:

  20. After High-Dose Methotrexate (HD-MTX), folinic acid rescue therapy (Leucovorin) is administered to reduce side effects in pediatric acute lymphoblastic leukemia (ALL) patients. Leucovorin and MTX are structura...

    Authors: N. Oosterom, M. Fiocco, R. Q. H. Kloos, I. M. van der Sluis, R. Pieters, B. D. van Zelst, D. E. C. Smith, M. M. van den Heuvel-Eibrink, R. de Jonge and S. G. Heil
    Citation: BMC Cancer 2020 20:940
    Content type: Research article Published on:

  21. Cervical cancer is the most common cancer among women in Sub-Saharan countries, including Tanzania. While early detection and diagnosis are available in some parts of this large country, radiotherapy has been ...

    Authors: Mariah P. Gesink, Robert M. Chamberlain, Julius Mwaiselage, Crispin Kahesa, Kahima Jackson, William Mueller, Jane L. Meza and Amr S. Soliman
    Citation: BMC Cancer 2020 20:939
    Content type: Research article Published on:

  22. As we all know, patients with epithelial ovarian carcinoma have poor prognosis and high recurrence rate. It is critical and challenging to screen out the patients with high risk of recurrence. At present, ther...

    Authors: Jun Hu, Xiaobing Jiao, Lirong Zhu, Hongyan Guo and Yumei Wu
    Citation: BMC Cancer 2020 20:938
    Content type: Research article Published on:

  23. Hepatocellular carcinoma (HCC) is an inflammation-related cancer, where nonresolving inflammation contributes to its development and progression. Peripheral inflammatory cells have been shown to be associated ...

    Authors: Young Mi Hong, Ki Tae Yoon, Tae Ho Hwang and Mong Cho
    Citation: BMC Cancer 2020 20:937
    Content type: Research article Published on:

  25. Lung squamous cell carcinoma (LSCC) remains a challenging disease to treat, and further improvements in prognosis are dependent upon the identification of LSCC-specific therapeutic biomarkers and/or targets. W...

    Authors: Erkhem-Ochir Bilguun, Kyoichi Kaira, Reika Kawabata-Iwakawa, Susumu Rokudai, Kimihiro Shimizu, Takehiko Yokobori, Tetsunari Oyama, Ken Shirabe and Masahiko Nishiyama
    Citation: BMC Cancer 2020 20:935
    Content type: Research article Published on:

  26. Preoperative breast magnetic resonance imaging (MRI) provides more information than mammography and ultrasonography for determining the surgical plan for patients with breast cancer. This study aimed to determ...

    Authors: Jeeyeon Lee, Jin Hyang Jung, Wan Wook Kim, Chan Sub Park, Ryu Kyung Lee, Hye Jung Kim, Won Hwa Kim and Ho Yong Park
    Citation: BMC Cancer 2020 20:934
    Content type: Research article Published on:

  27. Head and neck squamous cell cancer (HNSCC) frequently causes severe symptoms that may be reduced, when the tumor is successfully treated. The SOCCER trial studied the association of treatment response with pat...

    Authors: Markus Hecht, Dennis Hahn, Philipp Wolber, Matthias G. Hautmann, Dietmar Reichert, Steffi Weniger, Claus Belka, Tobias Bergmann, Thomas Göhler, Manfred Welslau, Christina Große-Thie, Orlando Guntinas-Lichius, Jens von der Grün, Panagiotis Balermpas, Katrin Orlowski, Diethelm Messinger…
    Citation: BMC Cancer 2020 20:933
    Content type: Research article Published on:

  28. Internal mammary and/or supraclavicular (IM–SC) lymph node (LN) recurrence without distant metastasis (DM) in patients with breast cancer is rare, and there have been few reports on its clinical outcomes.

    Authors: Hitoshi Inari, Natsuki Teruya, Miki Kishi, Rie Horii, Futoshi Akiyama, Shunji Takahashi, Yoshinori Ito, Takayuki Ueno, Takuji Iwase and Shinji Ohno
    Citation: BMC Cancer 2020 20:932
    Content type: Research article Published on:

  29. Glioma is a deadly and immunosuppressive brain tumour. Complement C1r subcomponent like (C1RL), a prognostic biomarker in several kinds of tumours, has attracted increasing attention from oncologists. However, th...

    Authors: Junyou Wang, Luqing Tong, Gaojun Lin, Hui Wang, Liang Zhang and Xuejun Yang
    Citation: BMC Cancer 2020 20:931
    Content type: Research article Published on:

  30. Elastography is a promising way to evaluate tissue differences regarding stiffness, and the stiffness of the malignant breast lesions increased at the lesion margin. However, there is a lack of data on the val...

    Authors: Hui Yang, Yongyuan Xu, Yanan Zhao, Jing Yin, Zhiyi Chen and Pintong Huang
    Citation: BMC Cancer 2020 20:930
    Content type: Research article Published on:

  31. Metabolic reprogramming is being recognized as a fundamental hallmark of cancer, and efforts to identify drugs that can target cancer metabolism are underway. In this study, we used human breast cancer (BC) ce...

    Authors: Mayumi Fujita, Kaori Imadome, Veena Somasundaram, Miki Kawanishi, Kumiko Karasawa and David A. Wink
    Citation: BMC Cancer 2020 20:929
    Content type: Research article Published on:

  32. Role of biomarkers for promotion of tumor proliferation (BPTPs) and for promotion of apoptosis (BPAs) in thymic malignant tumors is still unclear. The purpose of this study was to evaluate the relationship bet...

    Authors: Huilan Zeng, Weilin Yang, Bo Xu, Jianyong Zou, Chunhua Su, Beilong Zhong, Haoshuai Zhu and Zhenguang Chen
    Citation: BMC Cancer 2020 20:928
    Content type: Research article Published on:

  33. Human skin cutaneous melanoma is the most common and dangerous skin tumour, but its pathogenesis is still unclear. Although some progress has been made in genetic research, no molecular indicators related to t...

    Authors: Junyou Zhu, Jin Deng, Lijun Zhang, Jingling Zhao, Fei Zhou, Ning Liu, Ruizhao Cai, Jun Wu, Bin Shu and Shaohai Qi
    Citation: BMC Cancer 2020 20:927
    Content type: Research article Published on:

  35. Helicobacter pylori (H. pylori) and Epstein - Barr virus (EBV) plays a significant role in aggressive gastric cancer (GC). The investigation of genes associated with these pathogens and host kinases may be essent...

    Authors: Charu Sonkar, Tarun Verma, Debi Chatterji, Ajay Kumar Jain and Hem Chandra Jha
    Citation: BMC Cancer 2020 20:925
    Content type: Research article Published on:

  36. Long non-coding RNAs (LncRNAs) are dysregulated in multiple human cancers and they are highly involved in tumor progression. Previous studies have identified the oncogenic lncRNA HOXD cluster antisense RNA 1 (...

    Authors: Shaozheng Chen and Kejun Li
    Citation: BMC Cancer 2020 20:924
    Content type: Research article Published on:

  37. Supportive care Prioritization, Assessment and Recommendations for Kids (SPARK) is a web-based application that facilitates symptom screening and access to supportive care clinical practice guidelines (CPGs) f...

    Authors: Cody Z. Watling, Clodagh McCarthy, Alexandra Theodorakidis, Sadie Cook, Emily Vettese, Tal Schechter, Hanan Abubeker, L. Lee Dupuis and Lillian Sung
    Citation: BMC Cancer 2020 20:923
    Content type: Research article Published on:

  38. A large number of patients suffer recurrence after curative resection, and mortality from colon cancer remains high. The role of systemic inflammatory response, as reflected by neutrophil-to-lymphocyte ratio (...

    Authors: Junichi Mazaki, Kenji Katsumata, Kenta Kasahara, Tomoya Tago, Takahiro Wada, Hiroshi Kuwabara, Masanobu Enomoto, Tetsuo Ishizaki, Yuichi Nagakawa and Akihiko Tsuchida
    Citation: BMC Cancer 2020 20:922
    Content type: Research article Published on:

  39. It is a well-known fact show that the risk of developing endometrial cancer (type 1 EC) is strongly associated with obesity. In this study, selected markers, such as obesity, insulin resistance, angiogenesis a...

    Authors: Katarzyna M. Terlikowska, Bozena Dobrzycka, Robert Terlikowski, Anna Sienkiewicz, Maciej Kinalski and Slawomir J. Terlikowski
    Citation: BMC Cancer 2020 20:921
    Content type: Research article Published on:

  40. Bladder cancer (BC) is the 9th most common cancer worldwide, but little progress has been made in improving patient outcomes over the last 25 years. The King’s Health Partners (KHP) BC biobank was established ...

    Authors: Pinky Kotecha, Charlotte L. Moss, Deborah Enting, Cheryl Gillett, Magdalene Joseph, Debra Josephs, Sarah Rudman, Simon Hughes, Fidelma Cahill, Harriet Wylie, Anna Haire, James Rosekilly, Muhammad Shamin Khan, Rajesh Nair, Ramesh Thurairaja, Sachin Malde…
    Citation: BMC Cancer 2020 20:920
    Content type: Database Published on:

  41. Inflammatory cytokine markers, including the neutrophil-to-lymphocyte ratio (NLR), monocyte-lymphocyte ratio, and platelet-to-lymphocyte ratio, play important roles as prognostic markers in several solid malig...

    Authors: Takashi Kawahara, Masashi Kato, Kenichi Tabata, Ippei Kojima, Hiroshi Yamada, Osamu Kamihira, Hideyasu Tsumura, Masatsugu Iwamura, Hiroji Uemura and Yasuhide Miyoshi
    Citation: BMC Cancer 2020 20:919
    Content type: Research article Published on:

  42. Results from a phase III, randomized, double-blind, active comparator-controlled, parallel-group trial evaluating fosaprepitant for the prevention of chemotherapy-induced nausea and vomiting (CINV) found that ...

    Authors: Cindy Weinstein, Karin Jordan, Stuart Green, Saleem Khanani, Elizabeth Beckford-Brathwaite, Waldimir Vallejos, Annpey Pong, Stephen J. Noga and Bernardo L. Rapoport
    Citation: BMC Cancer 2020 20:918
    Content type: Research article Published on:

  43. Identification of effective diagnostic and prognostic biomarkers of cancer is necessary for improving precision medicine. Long non-coding RNAs (lncRNAs) play an important regulatory role in tumor initiation an...

    Authors: Chunmei Fan, Jinpeng Wang, Yanyan Tang, Shanshan Zhang, Fang Xiong, Can Guo, Yanhong Zhou, Zheng Li, Xiaoling Li, Yong Li, Guiyuan Li, Zhaoyang Zeng and Wei Xiong
    Citation: BMC Cancer 2020 20:917
    Content type: Research article Published on:

  44. Lung cancer is a leading cause of cancer morbidity and mortality worldwide. Several studies have suggested that Human papillomavirus (HPV) infection is an important risk factor in the development of lung cance...

    Authors: Marzieh Rezaei, Shayan Mostafaei, Amir Aghaei, Nayyerehalsadat Hosseini, Hassan Darabi, Majid Nouri, Ashkan Etemadi, Andrew O’. Neill, Javid Sadri Nahand, Hamed Mirzaei, Seamas C. Donnelly, Mohammad Doroudian and Mohsen Moghoofei
    Citation: BMC Cancer 2020 20:916
    Content type: Research article Published on:

  46. In the management of operable hilar cholangiocarcinoma (HC) patients with hyperbilirubinemia, preoperative biliary drainage is a measure to bring down the bilirubin to a certain level so as to avoid adverse po...

    Authors: Wong Hoi She, Tan To Cheung, Ka Wing Ma, Simon H. Y. Tsang, Wing Chiu Dai, Albert C. Y. Chan and Chung Mau Lo
    Citation: BMC Cancer 2020 20:914
    Content type: Research article Published on:

  47. Adjuvant gemcitabine for pancreatic cancer has limited efficacy in the clinical setting. Impaired drug metabolism is associated with treatment resistance. We aimed to evaluate the chemosensitising effect of in...

    Authors: Amber Blaauboer, Stephanie Booy, Peter M. van Koetsveld, Bas Karels, Fadime Dogan, Suzanne van Zwienen, Casper H. J. van Eijck and Leo J. Hofland
    Citation: BMC Cancer 2020 20:913
    Content type: Research article Published on:

  48. The incidence of oropharyngeal squamous cell carcinoma (OPSCC) in the US is rapidly increasing, driven largely by the epidemic of human papillomavirus (HPV)-mediated OPSCC. Although survival for patients with ...

    Authors: Hesham Elhalawani, Abdallah S. R. Mohamed, Baher Elgohari, Timothy A. Lin, Andrew G. Sikora, Stephen Y. Lai, Abdelrahman Abusaif, Jack Phan, William H. Morrison, G. Brandon Gunn, David I. Rosenthal, Adam S. Garden, Clifton D. Fuller and Vlad C. Sandulache
    Citation: BMC Cancer 2020 20:912
    Content type: Research article Published on:

  49. Various parameters have been considered for predicting survival in pancreatic ductal adenocarcinoma. Information about western population is missing. The aim of this study is to assess the association between ...

    Authors: Mar Achalandabaso Boira, Marcello Di Martino, Carlos Gordillo, Magdalena Adrados and Elena Martín-Pérez
    Citation: BMC Cancer 2020 20:909
    Content type: Research article Published on:

  50. Several systemic inflammatory response (SIR) markers, including platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR), lymphocyte-to-monocyte ratio (LMR), and albumin-to-globulin ratio (AGR)...

    Authors: Gunn Huh, Ji Kon Ryu, Jung Won Chun, Joo Seong Kim, Namyoung Park, In Rae Cho, Woo Hyun Paik, Sang Hyub Lee and Yong-Tae Kim
    Citation: BMC Cancer 2020 20:907
    Content type: Research article Published on:

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