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  1. Intraventricular neuroepithelial tumors (IVT) are rare lesions and comprise different pathological entities such as ependymomas, subependymomas and central neurocytomas. The treatment of choice is neurosurgica...

    Authors: A. Kaywan Aftahy, Melanie Barz, Philipp Krauss, Friederike Liesche, Benedikt Wiestler, Stephanie E. Combs, Christoph Straube, Bernhard Meyer and Jens Gempt
    Citation: BMC Cancer 2020 20:1060
    Content type: Research article Published on:

  4. Hypoxic tumors are known to be highly resistant to radiotherapy and cause poor prognosis in non-small cell lung cancer (NSCLC) patients. CKD-516, a novel vascular disrupting agent (VDA), mainly affects blood v...

    Authors: Min-Young Kim, Jung-Young Shin, Jeong-Oh Kim, Kyoung-Hwa Son, Yeon Sil Kim, Chan Kwon Jung and Jin-Hyoung Kang
    Citation: BMC Cancer 2020 20:1057
    Content type: Research article Published on:

  5. In general, human papillomavirus (HPV) vaccines have demonstrated efficacy in young women worldwide, but there is limited evidence on the efficacy of the quadrivalent HPV6/11/16/18 vaccine in adult women and n...

    Authors: Tetsuji Kurokawa, Makoto Yamamoto, Toshimichi Onuma, Hideaki Tsuyoshi, Akiko Shinagawa, Yoko Chino and Yoshio Yoshida
    Citation: BMC Cancer 2020 20:1056
    Content type: Study protocol Published on:

  6. Chondrosarcoma (CS) most commonly involves the pelvis. This study aimed to analyze differences in clinical characteristics and prognostic factors between primary and secondary conventional pelvic CS, and provi...

    Authors: Jie Zang, Wei Guo, Rongli Yang, Xiaodong Tang and Haijie Liang
    Citation: BMC Cancer 2020 20:1054
    Content type: Research article Published on:

  7. Germline TP53 mutations are associated with Li-Fraumeni syndrome, a severe and rare hereditary cancer syndrome. Despite the rarity of germline TP53 mutations, the clinical implication for mutation carriers and th...

    Authors: Ava Kwong, Vivian Yvonne Shin, Cecilia Y. S. Ho, Chun Hang Au, Thomas P. Slavin, Jeffrey N. Weitzel, Tsun-Leung Chan and Edmond S. K. Ma
    Citation: BMC Cancer 2020 20:1053
    Content type: Research article Published on:

  8. Triple-Negative Breast Cancer (TNBC) is an aggressive and complex subtype of breast cancer. The current biomarkers used in the context of breast cancer treatment are highly dependent on the targeting of oestro...

    Authors: Gyeong Back Lim, Young-Ae Kim, Jeong-Han Seo, Hee Jin Lee, Gyungyub Gong and Sung Hee Park
    Citation: BMC Cancer 2020 20:1052
    Content type: Research article Published on:

  10. This analysis aims to evaluate health-related quality of life (HrQoL) (primary outcome for this analysis), nausea and vomiting, and pain in patients with inoperable malignant bowel obstruction (IMBO) due to ca...

    Authors: Nikki McCaffrey, Tegan Asser, Belinda Fazekas, Wendy Muircroft, Meera Agar, Katherine Clark, Simon Eckermann, Jessica Lee, Rohit Joshi, Peter Allcroft, Caitlin Sheehan and David C. Currow
    Citation: BMC Cancer 2020 20:1050
    Content type: Research article Published on:

  11. Measurement of serum human epidermal growth factor receptor-2 (HER-2/neu) levels might play an essential role as a diagnostic/screening marker for the early selection of therapeutic approaches and predict prognos...

    Authors: Amir Shamshirian, Amir Reza Aref, George W. Yip, Majid Ebrahimi Warkiani, Keyvan Heydari, Sajad Razavi Bazaz, Zeinab Hamzehgardeshi, Danial Shamshirian, Mahmood Moosazadeh and Reza Alizadeh-Navaei
    Citation: BMC Cancer 2020 20:1049
    Content type: Research article Published on:

  13. This study explored the diagnostic power of preoperative circulating tumor cells (CTCs) for the presence of microvascular invasion (MVI) and the relationship between dynamic changes in postoperative CTCs and p...

    Authors: Jiangmin Zhou, Zhiwei Zhang, Honghao Zhou, Chao Leng, Bingwu Hou, Chenyang Zhou, Xinsheng Hu, Jinlin Wang and Xiaoping Chen
    Citation: BMC Cancer 2020 20:1047
    Content type: Research article Published on:

  14. Lung adenocarcinoma (LUAD) remains a crucial factor endangering human health. Gene-based clinical predictions could be of great help for cancer intervention strategies. Here, we tried to build a gene-based sur...

    Authors: Yanlu Xiong, Jie Lei, Jinbo Zhao, Qiang Lu, Yangbo Feng, Tianyun Qiao, Shaowei Xin, Yong Han and Tao Jiang
    Citation: BMC Cancer 2020 20:1046
    Content type: Research article Published on:

  15. Recent evidence supports hippocampal avoidance with whole brain radiotherapy (HA-WBRT) as the recommended treatment option in patients with good prognosis and multiple brain metastases as this results in bette...

    Authors: Brendan Seng Hup Chia, Jing Yun Leong, Ashley Li Kuan Ong, Cindy Lim, Shi Hui Poon, Melvin Lee Kiang Chua, Kevin Lee Min Chua, Grace Kusumawidjaja, Eu Tiong Chua, Fuh Yong Wong and Tih Shih Lee
    Citation: BMC Cancer 2020 20:1045
    Content type: Study protocol Published on:

  16. The effect of tumor size on account of long-term survival results in perihilar cholangiocarcinoma (PCCA) patients has remained a controversial debate. It is urgent necessary to identify the optimal cutoff valu...

    Authors: Yaodong Zhang, Zhengshan Wu, Xing Wang, Changxian Li, Jiang Chang, Wangjie Jiang, Hongwei Wang, Yirui Wang and Xiangcheng Li
    Citation: BMC Cancer 2020 20:1044
    Content type: Research article Published on:

  17. The incidence and mortality rates of colorectal cancer (CRC) continue to increase worldwide. Therefore, new preventive strategies are needed to lower the burden of this disease. Previous studies reported that ...

    Authors: Takuma Higurashi, Jun Arimoto, Keiichi Ashikari, Tomohiro Takatsu, Noboru Misawa, Tsutomu Yoshihara, Tetsuya Matsuura, Akiko Fuyuki, Hidenori Ohkubo and Atsushi Nakajima
    Citation: BMC Cancer 2020 20:1043
    Content type: Study protocol Published on:

  18. Breast cancer (BC) can be divided into five subtypes: Lumina1A, Lumina1B, HER-2 overexpression, Basal-like and Normal breast-like subtype, based on the differently expressed genes in breast cancer tissue. The ...

    Authors: Changran Wei and Xiangqi Li
    Citation: BMC Cancer 2020 20:1042
    Content type: Research article Published on:

  19. OCT-1 gene is a member of the POU-homeodomain family of transcriptional regulators of B-lymphocyte differentiation by controlling expression of B-cell specific genes. BCL-2 gene is a potent inhibitor of apoptosis...

    Authors: Gisele R. Gouveia, Suzete C. Ferreira, Sheila A. C. Siqueira, Luis Alberto de Pádua Covas Lage, Abrahão E. Hallack Neto, Renata de Oliveira Costa and Juliana Pereira
    Citation: BMC Cancer 2020 20:1041
    Content type: Research article Published on:

  20. The COVID-19 pandemic is predicted to significantly affect patients with lung cancer, owing to its rapid progression and high mortality. Studies on lung cancer diagnosis and treatment during an epidemic are la...

    Authors: Ji Young Park, Ye Jin Lee, Taehee Kim, Chang Youl Lee, Hwan Il Kim, Joo-Hee Kim, Sunghoon Park, Yong Il Hwang, Ki-Suck Jung and Seung Hun Jang
    Citation: BMC Cancer 2020 20:1040
    Content type: Research article Published on:

  21. Gastric cancer is the fifth most frequently diagnosed cancer and the third leading cause of cancer death worldwide. The molecular mechanisms of action for anti-HER-family drugs in gastric cancer cells are inco...

    Authors: Karolin Ebert, Gwen Zwingenberger, Elena Barbaria, Simone Keller, Corinna Heck, Rouven Arnold, Vanessa Hollerieth, Julian Mattes, Robert Geffers, Elba Raimúndez, Jan Hasenauer and Birgit Luber
    Citation: BMC Cancer 2020 20:1039
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:1127

  22. β-catenin activation plays a crucial role for tumourigenesis in the large intestine but except for Lynch syndrome (LS) associated cancers stabilizing mutations of β-catenin gene (CTNNB1) are rare in colorectal ca...

    Authors: Alexander Arnold, Moritz Tronser, Christine Sers, Aysel Ahadova, Volker Endris, Soulafa Mamlouk, David Horst, Markus Möbs, Philip Bischoff, Matthias Kloor and Hendrik Bläker
    Citation: BMC Cancer 2020 20:1038
    Content type: Research article Published on:

    The Correction to this article has been published in BMC Cancer 2020 20:1151

  24. To develop a nomogram for predicting the International Study Group of Liver Surgery (ISGLS) grade B/C posthepatectomy liver failure (PHLF) in hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) pati...

    Authors: Jia-zhou Ye, Rong-yun Mai, Wei-xing Guo, Yan-yan Wang, Liang Ma, Bang-de Xiang, Shu-qun Cheng and Le-qun Li
    Citation: BMC Cancer 2020 20:1036
    Content type: Research article Published on:

  25. Treating patients with advanced sarcomas is challenging due to great histologic diversity among its subtypes. Leiomyosarcoma (LMS) and de-differentiated liposarcoma (DDLPS) are two common and aggressive subtyp...

    Authors: Wenshuai Liu, Hanxing Tong, Chenlu Zhang, Rongyuan Zhuang, He Guo, Chentao Lv, Hua Yang, Qiaowei Lin, Xi Guo, Zhiming Wang, Yan Wang, Feng Shen, Shengzhou Wang, Chun Dai, Guan Wang, Jun Liu…
    Citation: BMC Cancer 2020 20:1035
    Content type: Research article Published on:

  26. The feasibility of submandibular gland (SMG) preservation in oral squamous cell carcinoma (SCC) has occasionally been analyzed, but the differences in survival associated with the presence or absence of SMG pr...

    Authors: Bo Gu, Qigen Fang, Yao Wu, Wei Du, Xu Zhang and Defeng Chen
    Citation: BMC Cancer 2020 20:1034
    Content type: Research article Published on:

  27. The distress thermometer (DT) is an effective tool for identifying distress among cancer patients worldwide. However, DT has not been studied in Egyptian patients. We aimed to study the prevalence of distress ...

    Authors: Nashwa Abd El-Aziz, Salah Khallaf, Waleed Abozaid, Ghada Elgohary, Ola Abd El-Fattah, Mai Alhawari, Safaa Khaled, Azza AbdelHaffez, Ehab Kamel and Sherif Mohamed
    Citation: BMC Cancer 2020 20:1033
    Content type: Research article Published on:

  28. High-grade serous ovarian cancer (HGSOC) is a fatal form of ovarian cancer. Previous studies indicated some potential biomarkers for clinical evaluation of HGSOC prognosis. However, there is a lack of systemat...

    Authors: Min Li, Xue Cheng, Rong Rong, Yan Gao, Xiuwu Tang and Youguo Chen
    Citation: BMC Cancer 2020 20:1032
    Content type: Research article Published on:

  29. Studies evaluating health information needs in colorectal cancer (CRC) lack specificity in terms of study samples involving patients. We assessed how health information needs of individuals with CRC are met ac...

    Authors: Hallie Dau, Abdollah Safari, Khalid Saad El Din, Helen McTaggart-Cowan, Jonathan M. Loree, Sharlene Gill and Mary A. De Vera
    Citation: BMC Cancer 2020 20:1031
    Content type: Research article Published on:

  30. Globally, endometrial cancer is the fourth most common malignant tumor in women and the number of women being diagnosed is increasing. Tumor progression is strongly related to the cell survival-promoting funct...

    Authors: Jun Zhang, Ziwei Wang, Rong Zhao, Lanfen An, Xing Zhou, Yingchao Zhao and Hongbo Wang
    Citation: BMC Cancer 2020 20:1030
    Content type: Research article Published on:

  31. Cervical cancer is the leading cause of cancer-related death in women worldwide. However, the mechanisms mediating the development and progression of cervical cancer are unclear. In this study, we aimed to elu...

    Authors: Jianbing Liu, Yunfeng Li, Xihua Chen, Xiangbo Xu, Haoqi Zhao, Shufang Wang, Jianqing Hao, Bin He, Shuyan Liu and Jiedong Wang
    Citation: BMC Cancer 2020 20:1029
    Content type: Research article Published on:

  32. Prostate cancer (PCa) is one of the most common types of cancer in men. In the course of the development and progression of this disease, abnormal expression of miR-203 is usually accompanied. However, its rol...

    Authors: Yang Meng, Xiaoyan Hu, Shasha Li, Xinyi Zeng, Lei Qiu, Mingtian Wei, Ziqing Wang and Junhong Han
    Citation: BMC Cancer 2020 20:1028
    Content type: Research article Published on:

  33. An amendment to this paper has been published and can be accessed via the original article.

    Authors: Linghua Kong, Xiaoping Xiao, Huiping Lou, Pengfei Liu, Shuhui Song, Moudu Liu, Tao Xu, Ying Zhang, Caijuan Li, Ruoli Guan, Yan Li, Xin Yu, Haiyuan Liu, Qingbo Fan, Honghui Shi and Lan Zhu
    Citation: BMC Cancer 2020 20:1027
    Content type: Correction Published on:

    The original article was published in BMC Cancer 2020 20:999

  34. Circular RNAs (circRNAs) have emerged as a novel category of non-coding RNA, which exhibit a pivotal effect on regulating gene expression and biological functions, yet how circRNAs function in osteosarcoma (OS...

    Authors: Houkun Li, Limin He, Yuan Tuo, Yansheng Huang and Bing Qian
    Citation: BMC Cancer 2020 20:1026
    Content type: Research article Published on:

  35. During 2013 and 2016 the region of Skåne, Sweden started to analyse human papillomavirus (HPV) and cytology in postmenopausal women 60–65 years of age. Our aim was to evaluate high-risk (HR) HPV mRNA testing f...

    Authors: Katrin Christine Asciutto, Christer Borgfeldt and Ola Forslund
    Citation: BMC Cancer 2020 20:1025
    Content type: Research article Published on:

  36. For most patients, pancreatic adenocarcinoma responds poorly to treatment, and novel therapeutic approaches are needed. Standard-of-care paclitaxel (PTX), combined with birinapant (BRP), a bivalent mimetic of ...

    Authors: Jin Niu, Xue Wang, Jun Qu, Donald E. Mager and Robert M. Straubinger
    Citation: BMC Cancer 2020 20:1024
    Content type: Research article Published on:

  37. This study proposes a prediction model for the automatic assessment of lung cancer risk based on an artificial neural network (ANN) with a data-driven approach to the low-dose computed tomography (LDCT) standa...

    Authors: Yin-Chen Hsu, Yuan-Hsiung Tsai, Hsu-Huei Weng, Li-Sheng Hsu, Ying-Huang Tsai, Yu-Ching Lin, Ming-Szu Hung, Yu-Hung Fang and Chien-Wei Chen
    Citation: BMC Cancer 2020 20:1023
    Content type: Research article Published on:

  39. Both intermittent intravenous (IIV) infusion and continuous intravenous (CIV) infusion of Endostar are widely used for NSCLC in China. We aimed to compare the efficacy and safety of CIV of Endostar versus IIV ...

    Authors: Bo Wang, Lu Xu, Qihuan Li, Sailimai Man, Cheng Jin, Lian Liu, Siyan Zhan and Yi Ning
    Citation: BMC Cancer 2020 20:1021
    Content type: Research article Published on:

  40. Loss of the genomic stability jeopardize genome stability and promote malignancies. A fraction of ovarian cancer (OvCa) arises from pathological mutations of DNA repair genes that result in highly mutagenic ge...

    Authors: Liang Song, Zizhi Tang, Changsheng Peng, Yueming Yang, Chang Guo, Danqing Wang, Liandi Guo, Jie Chen and Cong Liu
    Citation: BMC Cancer 2020 20:1020
    Content type: Research article Published on:

  41. The downregulation of microRNA (miR)-451a has been reported in bladder cancer (BCa) tissues. Herein, we elucidated the role of miR-451a in BCa with the involvement of DNA methyltransferase 3B (DNMT3B).

    Authors: Beibei Liu, Wei Sun, Wuyue Gao, Liqiang Li, Zhenxue Cao, Xiaohuai Yang, Jianmin Liu and Yuanyuan Guo
    Citation: BMC Cancer 2020 20:1019
    Content type: Research article Published on:

  42. The association between immune-related adverse events (irAEs) and survival outcomes in patients with advanced melanoma receiving therapy with immune checkpoint inhibitors (ICIs) has not been well established, ...

    Authors: Chiao-En Wu, Chan-Keng Yang, Meng-Ting Peng, Pei-Wei Huang, Ching-Fu Chang, Kun-Yun Yeh, Chun-Bing Chen, Chih-Liang Wang, Chao-Wei Hsu, I-Wen Chen, Cheng-Tao Lin, Shir-Hwa Ueng, Gigin Lin, Yu-Fen Lin, Chi-Yuan Cheng and John Wen-Cheng Chang
    Citation: BMC Cancer 2020 20:1018
    Content type: Research article Published on:

  43. Thirty to forty percent of patients with Diffuse Large B-cell Lymphoma (DLBCL) have an adverse clinical evolution. The increased understanding of DLBCL biology has shed light on the clinical evolution of this ...

    Authors: Adrián Mosquera Orgueira, José Ángel Díaz Arias, Miguel Cid López, Andrés Peleteiro Raíndo, Beatriz Antelo Rodríguez, Carlos Aliste Santos, Natalia Alonso Vence, Ángeles Bendaña López, Aitor Abuín Blanco, Laura Bao Pérez, Marta Sonia González Pérez, Manuel Mateo Pérez Encinas, Máximo Francisco Fraga Rodríguez and José Luis Bello López
    Citation: BMC Cancer 2020 20:1017
    Content type: Research article Published on:

  44. Inhibition of DNA-binding of proteins by small-molecule chemicals holds immense potential in manipulating the activities of DNA-binding proteins. Such a chemical inhibition of DNA-binding of proteins can be us...

    Authors: Manthan Patel, Divyesh Patel, Subhamoy Datta and Umashankar Singh
    Citation: BMC Cancer 2020 20:1016
    Content type: Technical advance Published on:

  45. Immune-related genes is closely related to the occurrence and prognosis of head and neck squamous cell carcinoma (HNSCC). At the same time, immune-related genes have great potential as prognostic markers in ma...

    Authors: Fujun Zhang, Yu Liu, Yixin Yang and Kai Yang
    Citation: BMC Cancer 2020 20:1015
    Content type: Research article Published on:

  46. Peritoneal metastasis (PM) in gastric cancer (GC) is characterized by diffusely infiltrating and proliferating cancer cells accompanied by extensive stromal fibrosis in the peritoneal space. The prognosis of G...

    Authors: Daisuke Fujimori, Jun Kinoshita, Takahisa Yamaguchi, Yusuke Nakamura, Katsuya Gunjigake, Takashi Ohama, Koichi Sato, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Tetsuo Ohta and Sachio Fushida
    Citation: BMC Cancer 2020 20:1014
    Content type: Research article Published on:

  47. In recent years, the differences between left-sided colon cancer (LCC) and right-sided colon cancer (RCC) have received increasing attention due to the clinicopathological variation between them. However, some...

    Authors: Yimei Jiang, Xiaowei Yan, Kun Liu, Yiqing Shi, Changgang Wang, Jiele Hu, You Li, Qinghua Wu, Ming Xiang and Ren Zhao
    Citation: BMC Cancer 2020 20:1012
    Content type: Research article Published on:

  48. About 85% of breast cancer patients attending Komfo Anokye Teaching Hospital (KATH), Ghana, present with stage III/IV disease. In spite of great investments into the early diagnosis and management of breast ca...

    Authors: Anita Eseenam Agbeko, Joshua Arthur, Jonathan Bayuo, Basil Benduri Kaburi and Ishmael Kyei
    Citation: BMC Cancer 2020 20:1011
    Content type: Research article Published on:

  49. Dynapenia is defined as an age-related loss of muscle strength. There is little information on dynapenia in cancer patients and on how it relates to anthropometric variables. The aim of this study was to analy...

    Authors: Ana Beatriz Rechinelli, Isabele Lessa Marques, Eduarda Cristina Rodrigues de Morais Viana, Isadora da Silva Oliveira, Vanusa Felício de Souza, Glenda Blaser Petarli, Jose Luiz Marques Rocha and Valdete Regina Guandalini
    Citation: BMC Cancer 2020 20:1010
    Content type: Research article Published on:

  50. Epithelial ovarian cancer (EOC) is rare in women of reproductive age and fertility-sparing surgery (FSS) may be applied in early stages. The purpose of this study was to investigate the safety and efficacy of ...

    Authors: Gry Johansen, Pernilla Dahm-Kähler, Christian Staf, Angelique Flöter Rådestad and Kenny A. Rodriguez-Wallberg
    Citation: BMC Cancer 2020 20:1009
    Content type: Research article Published on:

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