Table 5 Multivariate analysis of the Cox proportional-hazards regression model for 200 patients with oral squamous cell carcinoma

Age (yr)

≥ 60

Ref

Ref

Ref

Ref

Ref

< 60

0.053

0.031

3.162

0.723 (0.311–1.261)

0.283

BMI

< 22.5

Ref

Ref

Ref

Ref

Ref

≥ 22.5

-0.653

0.271

5.358

0.554 (0.302–0.985)

0.034^*

T stage

T1 ~ T2

Ref

Ref

Ref

Ref

Ref

T3 ~ T4

0.061

0.041

3.862

1.524 (0.471–2.128)

0.052

Clinical stage

I ~ II

Ref

Ref

Ref

Ref

Ref

III ~ IV

0.264

0.209

6.764

1.628 (0.831–2.315)

0.021^*

Recurrence

Yes

Ref

Ref

Ref

Ref

Ref

No

0.864

0.294

12.683

0.897 (0.629–1.246)

0.003^**

Tumor size (cm)

< 3

Ref

Ref

Ref

Ref

Ref

≥ 3

0.648

0.273

2.081

0.914 (0.127–1.874)

0.648

Differentiation

Well

Ref

Ref

Ref

Ref

Ref

Moderate

0.527

0.341

13.057

1.016 (0.702–1.336)

0.000^***

Poor

0.954

0.527

3.152

1.811 (0.849–2.717)

0.381

Neck dissection

No

Ref

Ref

Ref

Ref

Ref

Yes

0.421

0.137

4.689

1.624 (0.348–2.526)

0.757

Periodontal condition

Well

Ref

Ref

Ref

Ref

Ref

Poor

0.682

0.426

1.025

1.841 (1.569–3.437)

0.946

Oral hygiene habits

Good

Ref

Ref

Ref

Ref

Ref

Average

0.417

0.603

3.152

1.006 (0.477–1.895)

0.058

Bad

0.530

0.916

5.158

1.915 (1.002–2.216)

0.055

P. gingivalis

Weak

Ref

Ref

Ref

Ref

Ref

Strong

0.746

0.319

6.319

1.674 (1.216–4.142)

0.012^*

DOK3

Weak

Ref

Ref

Ref

Ref

Ref

Strong

0.547

0.307

5.527

1.881 (1.433–3.457)

0.042^*

M2-TAM

Weak

Ref

Ref

Ref

Ref

Ref

Strong

0.316

0.208

5.942

1.649 (0.824–3.082)

0.034^*