Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral cancer: a 12-year data analysis of 200 patients from a tertiary teaching hospital, Urumqi, China

Li, Chenxi; Li, Muqiu; Wei, Wei; Wang, Zhengye; Yu, Jingwen; Gong, Zhongcheng

doi:10.1186/s12885-024-12300-y

Table 4 Univariate analysis of the Cox proportional-hazards regression model for patients with oral squamous cell carcinoma

From: Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral cancer: a 12-year data analysis of 200 patients from a tertiary teaching hospital, Urumqi, China

Variable		Total no. = 200	Survival rate (%)	HR value	95% CI	P value
Sex	Male	100	50.0	Ref	Ref	Ref
Sex	Female	100	50.0	0.824	0.436–1.618	0.847
Age (yr)	≥ 60	127	63.5	Ref	Ref	Ref
Age (yr)	< 60	73	36.5	0.662	0.296–0.963	0.028*
Survival status	Alive	133	66.5	Ref	Ref	Ref
Survival status	Dead	67	33.5	0.982	0.216–2.052	0.729
Tobacco smoking	No	68	34.0	Ref	Ref	Ref
Tobacco smoking	Yes	132	66.0	1.046	0.612–1.894	0.853
Alcohol consumption	No	90	45.0	Ref	Ref	Ref
Alcohol consumption	Yes	110	55.0	0.516	0.213–1.021	0.092
Diet	Vegetarian	19	9.5	Ref	Ref	Ref
Diet	Non-vegetarian	181	90.5	0.626	0.240–1.117	1.701
Milk & dairy products	Never	2	1.0	Ref	Ref	Ref
	Less than once a week	29	14.5	0.552	0.295–0.997	1.692
	More than once a week	169	84.5	0.755	0.262–1.229	0.183
BMI	< 22.5	132	66.0	Ref	Ref	Ref
BMI	≥ 22.5	68	34.0	0.646	0.313–0.947	0.032^*
Baseline severe dysphagia (Gr.3–6)	No	129	64.5	Ref	Ref	Ref
Baseline severe dysphagia (Gr.3–6)	Yes	71	35.5	1.579	1.002–1.859	0.677
T stage	T1 ~ T2	119	59.5	Ref	Ref	Ref
T stage	T3 ~ T4	81	40.5	1.441	0.522–1.619	0.002^**
N stage	N0	135	67.5	Ref	Ref	Ref
N stage	N ( +)	65	32.5	0.968	0.248–1.635	0.818
Clinical stage	I ~ II	100	50.0	Ref	Ref	Ref
Clinical stage	III ~ IV	100	50.0	1.395	0.573–1.726	0.016^*
Recurrence	Yes	31	15.5	Ref	Ref	Ref
Recurrence	No	169	84.5	0.813	0.546–1.024	0.005^**
Tumor size (cm)	< 3	91	45.5	Ref	Ref	Ref
Tumor size (cm)	≥ 3	109	54.5	0.822	0.072–1.098	0.022^*
Differentiation	Well	129	64.5	Ref	Ref	Ref
	Moderate	49	24.5	1.025	0.717–1.446	0.000^***
	Poor	22	11.0	1.806	0.428–2.352	0.017^*
Neck dissection	No	137	68.5	Ref	Ref	Ref
Neck dissection	Yes	63	31.5	0.923	0.625–2.163	0.027^*
Oral hygiene habits	Good	67	33.5	Ref	Ref	Ref
	Average	110	55.0	0.995	0.026–1.655	0.066
	Bad	23	11.5	1.229	0.183–1.975	0.018^*
Periodontal condition	Well	56	28.0	Ref	Ref	Ref
Periodontal condition	Poor	144	72.0	1.437	0.846–1.895	0.043^*
*P. gingivalis*	Weak	61	30.5	Ref	Ref	Ref
*P. gingivalis*	Strong	139	69.5	1.137	0.135–1.503	0.026^*
DOK3^a	Weak	47	33.8	Ref	Ref	Ref
DOK3^a	Strong	92	66.2	1.085	0.156–1.514	0.018^*
M2-TAM^b	Weak	61	43.9	Ref	Ref	Ref
M2-TAM^b	Strong	78	56.1	1.419	0.283–1.862	0.013^*

Abbreviations: BMI body mass index, CI confidence interval, cm centimeter, Gr Grade, HR hazard ratios, P. gingivalis Porphyromonas gingivalis, Ref reference, TAM tumor-associated macrophage, yr year
Statistically significant (^*P < 0.05, ^**P < 0.01, ^***P < 0.001)
^aThe sample size for DOK3 detection was 139 OSCC patients with strong immunostaining for P. gingivalis (Table 2)
^bThe sample size for M2-TAM detection was 139 OSCC patients with strong immunostaining for P. gingivalis (Table 2)

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