Association of DOK3 and infiltrated tumor-associated macrophages with risk for the prognosis of Porphyromonas gingivalis-infected oral cancer: a 12-year data analysis of 200 patients from a tertiary teaching hospital, Urumqi, China

Table 1 Immunohistochemical expression of P. gingivalis in 200 patients with oral squamous cell carcinoma according to the clinical data and follow-up

Variable	P. gingivalis		P value
Variable	Weak (%)	Strong (%)	P value
Sex			0.282
Male	27 (44.3)	73 (52.5)
Female	34 (55.7)	66 (47.5)
Age (yr)			0.580
< 60	24 (39.3)	49 (35.3)
≥ 60	37 (60.7)	90 (64.7)
Survival status			0.002^**
Alive	50 (82.0)	83 (59.7)
Dead	11 (18.0)	56 (40.3)
Tobacco smoking			0.000^***
No	31 (50.8)	37 (26.6)
Yes	30 (49.2)	102 (73.4)
Alcohol consumption			0.160
No	32 (52.5)	58 (41.7)
Yes	29 (47.5)	81 (58.3)
Baseline severe dysphagia (Gr.3–6)^a			0.905
No	50 (82.0)	79 (56.8)
Yes	11 (18.0)	60 (43.2)
Diet			0.181
Vegetarian	12 (19.7)	7 (5.0)
Non-vegetarian	49 (80.3)	132 (95.0)
Milk & dairy products			0.026
Never	0	2 (1.4)
Less than once a week	7 (11.5)	22 (15.8)
More than once a week	54 (88.5)	115 (82.8)
T stage^b			0.000^***
T1 ~ T2	47 (77.0)	72 (51.8)
T3 ~ T4	14 (23.0)	67 (48.2)
N stage^b			0.025^*
N0	48 (78.7)	87 (62.6)
N ( +)	13 (21.3)	52 (37.4)
Clinical stage^b			0.000^***
I ~ II	44 (72.1)	56 (40.3)
III ~ IV	17 (27.9)	83 (59.7)
Recurrence			0.298
Yes	7 (11.5)	24 (17.3)
No	54 (88.5)	115 (82.7)
Tumor size (cm)			0.014^*
< 3	36 (59.0)	55 (39.6)
≥ 3	25 (41.0)	84 (60.4)
Differentiation			0.003^**
Well	49 (80.33)	80 (57.6)
Moderate	11 (18.03)	38 (27.3)
Poor	1 (1.64)	21 (15.1)
Periodontal condition			0.000^***
Well	28 (45.9)	28 (20.1)
Poor	33 (54.1)	111 (79.9)
Oral hygiene habits^c			0.019^*
Good	16 (26.2)	51 (36.7)
Average	41 (67.2)	69 (49.6)
Bad	4 (6.6)	19 (13.7)
Treatment			0.351
Surgery	16 (26.2)	47 (33.8)
Radiotherapy	22 (36.1)	37 (26.6)
Chemoradiation/comprehensive	23 (37.7)	55 (39.6)

Abbreviations: cm centimeter, Gr Grade, yr year
Statistically significant (^*P < 0.05, ^**P < 0.01, ^***P < 0.001)
^aGrade of dysphagia according to the standard symptom scale (10.4103/0973–1482.63563). In subjective dysphagia, evaluation score ranges from 0 to 6. Score 0 suggests no dysphagia and score 6 suggests ‘nothing by mouth’
^bAccording to the 8th edition of the American Joint Committee on Cancer/ the International Union Against Cancer staging system
^cThe composite oral hygiene score [23], ranging from 0 to 6 (with a score of 4 or more indicating poor oral hygiene; 2 to 3, reasonable; 1 or less indicating good hygiene), aimed to capture oral hygiene habits and intra-oral examination findings for each study participant by summing up the following states: bleeding gums (no = 0, yes = 1); frequency of cleaning teeth (> 2 times a day = 0, ≤ once a day = 1); instrument used for cleaning (toothbrush = 0, finger or other = 1); substance used for cleaning (toothpaste/toothpowder = 0, other = 1); wearing dentures (no = 0, yes = 1); dental check-ups (rare = 0, only when in pain = 1); missing teeth (≤ 5 = 0, > 5 = 1)

ISSN: 1471-2407