Fig. 7From: Homoharringtonine enhances cytarabine-induced apoptosis in acute myeloid leukaemia by regulating the p38 MAPK/H2AX/Mcl-1 axisProposed mechanism of HHT in combination with Ara-C. HHT downregulated Mcl-1 and induced DNA damage and apoptosis through the activation of p38 MAPK. HHT accelerated the Ara-C-induced increase in p38 phosphorylation and the decrease in Mcl-1 in AML cells. Response of Mcl-1 to DNA repair and DNA damageBack to article page