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Fig. 6 | BMC Cancer

Fig. 6

From: Homoharringtonine enhances cytarabine-induced apoptosis in acute myeloid leukaemia by regulating the p38 MAPK/H2AX/Mcl-1 axis

Fig. 6

HHT in combination with Ara-C improved the survival of THP-1 xenografts. A, B, Tumour images and weights of 20 NOD-SCID mice subcutaneously inoculated with THP-1 cells and treated with Ara-C, HHT, or the combination treatment for 7 days. **, P < 0.01, ***, P < 0.001 compared with the control group. ##, P < 0.01 compared with the Ara-C group. $, P < 0.05 compared with the HHT group. C, Protein analysis of tumour tissue. D, Survival curves of THP-1 xenografted mice inoculated through the tail vein and treated with 1 mg/kg HHT for 14 d and 50 mg/kg Ara-C for 7 d. E, Median survival and ILS of these drugs were calculated. ILS, an increase in lifespan over the control

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BMC Cancer

ISSN: 1471-2407

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