Variable |  | Training cohort(n = 721, image = 1638) | Validation cohort (n = 82, image = 194) | Internal-test cohort (n = 89, image = 192) | External-test cohort(n = 88, image = 187) | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Benign (n = 506, Image = 1155) | Malignant (n = 215, Image = 483) | p-value | Benign (n = 57, Image = 136) | Malignant (n = 25, Image = 58) | p-value | Benign (n = 64, Image = 139) | Malignant (n = 25, Image = 53) | p-value | Benign (n = 79, Image = 165) | Malignant (n = 9, Image = 22) | p-value | ||
Age (years) | Â | 56.00(44.00,64.00) | 59.00(49.00,69.00) | 0.001 | 57.00(41.00,69.00) | 52.00(37.00,65.50) | 0.372 | 56.50(43.75,63.00) | 59.00(52.00,71.50) | 0.203 | 65.00(54.00,75.00) | 72.00(59.00,77.50) | 0.380 |
Max-diameter (mm) | Â | 23.00(17.00,32.00) | 24.00(18.00,32.00) | 0.401 | 24.00(16.00,34.00) | 22.50(15.00,27.20) | 0.126 | 22.95(16.75,28.25) | 26.00(17.00,38.70) | 0.172 | 24.00(18.00,31.00) | 24.00(16.00,76.00) | 0.634 |
Sex | Female | 186 (40.5%) | 78 (38.6%) | 0.644 | 24 (43.6%) | 9 (36.0%) | 0.520 | 20 (37.0%) | 5 (20.8%) | 0.157 | 41 (51.9%) | 4 (44.4%) | 0.736 |
 | Male | 273 (59.5%) | 124 (61.4%) |  | 31 (56.4%) | 16 (64.0%) |  | 34 (63.0%) | 19 (79.2%) |  | 38 (48.1%) | 5 (55.6%) |  |
Location | Superficial | 289 (63.0%) | 113 (55.9%) | 0.183 | 30 (54.5%) | 17 (68.0%) | 0.257 | 36 (66.7%) | 16 (66.7%) | 1.000 | 67 (84.8%) | 8 (88.9%) | 1.000 |
 | Deep | 166 (36.2%) | 88 (43.6%) |  | 25 (45.5%) | 8 (32.0%) |  | 18 (33.3%) | 8 (33.3%) |  | 12 (15.2%) | 1 (11.1%) |  |
 | Both | 4 (0.9%) | 1 (0.5%) |  | 0 (0%) | 0 (0%) |  | 0 (0.0%) | 0 (0.0%) |  | 0 (0.0%) | 0 (0.0%) |  |
Shape | Regular | 365 (72.1%) | 87 (40.5%) | <0.001 | 41 (71.9%) | 12 (48.0%) | 0.037 | 48 (75.0%) | 8 (32.0%) | 0.004 | 77 (97.5%) | 2 (33.3%) | <0.001 |
 | Irregular | 141 (27.9%) | 128 (59.5%) |  | 16 (28.1%) | 13 (52.0%) |  | 16 (25.0%) | 17 (68.0%) |  | 2 (2.5%) | 6 (66.7%) |  |
Margin | Clear | 491 (97.0%) | 102 (47.4%) | <0.001 | 53 (93.0%) | 9 (36.0%) | <0.001 | 64 (100.0%) | 4 (16.0%) | <0.001 | 79 (100.0%) | 6 (66.7%) | 0.001 |
 | Unclear | 15 (3.0%) | 113 (52.6%) |  | 4 (7.0%) | 16 (64.0%) |  | 0 (0.0%) | 21 (84.0%) |  | 0 (0.0%) | 3 (33.3%) |  |
Echo | Homogeneous | 103 (20.4%) | 42 (19.5%) | 0.801 | 11 (19.3%) | 5 (20.0%) | 1.000 | 10 (15.6%) | 1 (4.0%) | 0.171 | 38 (48.1%) | 2 (22.2%) | 0.174 |
 | Heterogeneous | 403 (79.6%) | 173 (80.5%) |  | 46 (80.7%) | 20 (80.0%) |  | 54 (84.4%) | 24 (96.0%) |  | 41 (51.9%) | 7 (77.8%) |  |
Cystic areas | Absent | 424 (83.8%) | 177 (82.3%) | 0.628 | 51 (89.5%) | 20 (80.0%) | 0.297 | 61 (95.3%) | 23 (92.0%) | 0.617 | 60 (79.5%) | 5 (55.6%) | 0.058 |
 | Present | 82 (16.2%) | 38 (17.7%) |  | 6 (10.5%) | 5 (20.0%) |  | 3 (4.7%) | 2 (8.0%) |  | 19 (24.1%) | 4 (44.4%) |  |
Posterior acoustic enhancement | Absent | 55 (10.9%) | 114 (53.0%) | <0.001 | 10 (17.5%) | 11 (44.0%) | 0.012 | 6 (9.4%) | 20 (80.0%) | <0.001 | 3 (3.8%) | 5 (55.6%) | <0.001 |
Present | 451 (89.1%) | 101 (47.0%) | Â | 47 (82.5%) | 14 (56.0%) | Â | 58 (90.6%) | 5 (20.0%) | Â | 76 (96.2%) | 4 (44.4%) | Â | |
Calcification | Absent | 486 (96.0%) | 189 (87.9%) | <0.001 | 54 (94.7%) | 22 (88.0%) | 0.363 | 61 (95.3%) | 19 (76.0%) | 0.013 | 77 (97.5%) | 5 (55.6%) | 0.001 |
 | Present | 20 (4.0%) | 26 (12.1%) |  | 3 (5.3%) | 3 (12.0%) |  | 3 (4.7%) | 6 (24.0%) |  | 2 (2.5%) | 4 (44.4%) |  |