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Fig. 1 | BMC Cancer

Fig. 1

From: Creatine supplementation and resistance training to preserve muscle mass and attenuate cancer progression (CREATINE-52): a protocol for a double-blind randomized controlled trial

Fig. 1

Creatine’s Role in Energy Metabolism. Creatine (Cr) combines with free inorganic phosphate to form phosphocreatine (Cr-P). When adenosine triphosphate (ATP) undergoes degradation into adenosine diphosphate (ADP) and inorganic phosphate (P) to supply free energy for activities, such as exercise, phosphocreatine serves as a buffer for the regeneration of ATP. The generated ATP then undergoes degradation to provide energy and the cycle continues. Additionally, creatine enters the cytosol through a creatine transporter. In the cytosol, creatine, along with its related cytosolic and glycolytic creatine kinase (CK-c and CK-g, respectively) isoforms, plays a pivotal role in preserving glycolytic ATP levels, regulating the cytosolic ATP/ADP ratio, and facilitating cytosolic ATP consumption for glycolysis

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BMC Cancer

ISSN: 1471-2407

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