Fig. 1

Signatures of genetic variation of m¹A regulators in hepatocellular carcinoma (HCC) cells. (A) Comparative analysis of m¹A-related genes expressed in tumor and normal liver tissues from The Cancer Genome Atlas-Liver Hepatocellular Carcinoma (TCGA-LIHC); (B) Frequency of CNV variation in TCGA-LIHC regulators. Column height represents CNV alteration frequency. Deletion frequency is indicated by green dots, and the amplification frequency is indicated by red dots; (C) Location of alterations in copy number variation (CNV) of m¹A regulators on 23 chromosomes using the TCGA-LIHC cohort; (D) Analysis of 10 m¹A regulator expression profiles in the TCGA-LIHC cohort by principal component analysis (PCA). On the basis of m¹A regulator expression profiles, we identified two subgroups without intersection, indicating excellent differentiation between tumor samples and normal samples. Tumors are labeled in blue and normal samples in yellow; (E–N) Overall survival of subgroups of low m¹A regulator expression and high m¹A regulator expression, including TRMT6 (E), TRMT61A (F), TRMT61B (G), TRMT10C (H), ALKBH1 (I), ALKBH3 (J), YTHDF1 (K), YTHDF2 (L), YTHDF3 (M), and YTHDC1 (N) *p < 0.05, **p < 0.01, ***p < 0.001 compared with the control group; ns, not significant