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Fig. 3 | BMC Cancer

Fig. 3

From: 25-hydroxycholesterol promotes proliferation and metastasis of lung adenocarcinoma cells by regulating ERβ/TNFRSF17 axis

Fig. 3

ERβ knockdown inhibited 25-HC-induced cell migration and invasion. (A) A549 and SPC-A1 cells were transfected with the lentivirus carrying ctrl-sgRNA or ESR2-sgRNA, followed by treatment with 0, 0.013 and 0.085 µM 25-HC for 48 h. Wound healing assay was performed to determine the effect of 25-HC on cell migration. (B) After ERβ knockdown, the cells were exposed to 0, 0.013 and 0.085 µM 25-HC for 48 h. Transwell assay was performed to determine the effect of 25-HC on cell invasion. Data were shown as mean ± SD of at least three independent experiments.*, p < 0.05; **, p < 0.01;*** p < 0.0001

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BMC Cancer

ISSN: 1471-2407

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