Effects of reprogrammed splenic CD8+ T-cells in vitro and in mice with spontaneous metastatic Lewis lung carcinoma

Table 3 Effect of cell therapy of reprogrammed CD8⁺ T-cells of the spleen on tumor and metastases in C57BL/6 mice under conditions of spontaneous metastasis LLC on the 10th day of the experiment (M ± m)

Characteristics	Intact control	LLC	Naive CD8⁺ T-cells	Reprogrammed CD8⁺T-cells
Body weight, g	20.44 ± 0.12	22.73 ± 0.71	22.58 ± 0,59	22.30 ± 0.25
Tumor weight, mg	-	89.25 ± 19.21 ^*	100.50 ± 18.84 ^*	52.50 ± 13.52 ^*●+
Tumor weight ratio, mg/g	-	3.95 ± 0.87 ^*	4.41 ± 0.75 ^*	2.36 ± 0.61 ^*
% of the tumor by body weight	-	0.40 ± 0.09 ^*	0.44 ± 0.08 ^*	0.24 ± 0.06 ^*
Tumor volume, mm³	-	130.05 ± 35.32 ^*	109.38 ± 28.50 ^*	93.81 ± 28.97
The frequency of metastasis, %	-	100.00 ± 1.00 ^*	100.00 ± 1.00 ^*	0 ⁺
The degree of lung metastasis	-	1.00 ± 0.01 ^*	1.00 ± 0.01 ^*	0 ^●+
Average number of metastases	-	2.75 ± 0.25 ^*	2.25 ± 0.48 ^*	0 ^●+
Lung weight, mg	109.6 ± 2.14	80.00 ± 8.61	131.00 ± 9.28 ^*●	108.8 ± 26.90

*– for comparison with intact control, ●– for comparison with LLC, +– for comparison with naive T-cells (Mann–Whitney test, p-value < 0.05)

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