Fig. 5
From: CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis
Overexpression of PKM2 or inhibit miR-122-5p reversed PTC cells proliferaion and migration after silence circPHGDH. (A-F) RT-qPCR detection showing the expression of circPHGDH, miR-122-5p and PKM2 in both HGC-27 and AGS cells. Data are presented as mean ± SD; ***P < 0.001 vs. NC; ###P < 0.001, #P < 0.05 vs. si-circPHGDH. (G and H) CCK8 detection show the proliferation ability of SW579 and TPC-1 cells. The data are expressed as the mean ± SD. ***p < 0.001 vs. NC. (I-K) EdU detection show the proliferation ability of SW579 and TPC-1 cells. The data are expressed as the mean ± SD. ***p < 0.001 vs. NC. ###P < 0.001 vs. si-circPHGDH. Scale bar, 50 μm. (L-N) Transwell detection show the invasion and migration of SW579 and TPC-1 cells. The data are expressed as the mean ± SD. ***p < 0.001 vs. NC. ###P < 0.001 vs. si-circPHGDH. Scale bar, 50 μm