Table 1 Patient demographics and clinical characteristics

Age at index date (years), mean ± SD [median]

58.1 ± 11.8 [58.0]

58.8 ± 12.7 [61.0]

57.8 ± 11.3 [57.0]

0.42

58.0 ± 12.2 [57.5]

57.8 ± 11.6 [58.0]

58.7 ± 10.5 [59.0]

0.84

Male sex, n (%)

284 (56.0)

85 (50.6)

199 (58.7)

0.10

195 (54.2)

22 (48.9)

67 (65.7)

0.07

Race, n (%)^a

 White

386 (76.1)

135 (80.4)

251 (74.0)

0.14

281 (78.1)

30 (66.7)

75 (73.5)

0.19

 Black or African American

55 (10.8)

13 (7.7)

42 (12.4)

0.15

35 (9.7)

6 (13.3)

14 (13.7)

0.44

 Asian

54 (10.7)

18 (10.7)

36 (10.6)

1.00

38 (10.6)

7 (15.6)

9 (8.8)

0.47

 Other

13 (2.6)

2 (1.2)

11 (3.2)

0.24

7 (1.9)

2 (4.4)

4 (3.9)

0.27

Hispanic ethnicity, n (%)

54 (10.7)

11 (6.5)

43 (12.7)

0.05

31 (8.6)

8 (17.8)

15 (14.7)

0.06

Insurance type, n (%)^a

0.28

 < 0.01 *

 Commercial/private insurance

299 (59.0)

98 (58.3)

201 (59.3)

299 (59.0)

220 (61.1)

31 (68.9)

 Medicare

131 (25.8)

48 (28.6)

83 (24.5)

131 (25.8)

97 (26.9)

10 (22.2)

 Medicaid/No insurance

67 (13.2)

17 (10.1)

50 (14.7)

67 (13.2)

37 (10.3)

4 (8.9)

  Other

10 (2.0)

5 (3.0)

5 (1.5)

10 (2.0)

6 (1.7)

0 (0.0)

Disease substage at resection date, n (%)

 < 0.001 *

 < 0.01 *

 IIIA

168 (33.1)

168 (100.0)

0 (0.0)

112 (31.1)

16 (35.6)

40 (39.2)

 IIIB

188 (37.1)

0 (0.0)

188 (55.5)

133 (36.9)

11 (24.4)

44 (43.1)

 IIIC

118 (23.3)

0 (0.0)

118 (34.8)

92 (25.6)

10 (22.2)

16 (15.7)

 IIID

33 (6.5)

0 (0.0)

33 (9.7)

23 (6.4)

8 (17.8)

2 (2.0)

Main comorbidities at resection date, n (%)^a

 Any comorbidity

363 (71.6)

117 (69.6)

246 (72.6)

0.56

256 (71.1)

32 (71.1)

75 (73.5)

0.89

 Hypertension

196 (38.7)

60 (35.7)

136 (40.1)

0.39

135 (37.5)

16 (35.6)

45 (44.1)

0.43

 Coronary artery disease/myocardial infarction

60 (11.8)

12 (7.1)

48 (14.2)

 < 0.05 *

31 (8.6)

7 (15.6)

22 (21.6)

 < 0.01 *

 Asthma

48 (9.5)

17 (10.1)

31 (9.1)

0.85

35 (9.7)

7 (15.6)

6 (5.9)

0.17

 Anxiety disorder

41 (8.1)

15 (8.9)

26 (7.7)

0.75

29 (8.1)

4 (8.9)

8 (7.8)

0.96

 Depression

38 (7.5)

11 (6.5)

27 (8.0)

0.70

31 (8.6)

1 (2.2)

6 (5.9)

0.32

Performance status after resection, n (%)

 ECOG-PS after resection

 < 0.01 *

 < 0.001 *

 0

167 (32.9)

66 (39.3)

101 (29.8)

135 (37.5)

9 (20.0)

23 (22.5)

 1

249 (49.1)

70 (41.7)

179 (52.8)

176 (48.9)

32 (71.1)

41 (40.2)

 2

61 (12.0)

16 (9.5)

45 (13.3)

32 (8.9)

3 (6.7)

26 (25.5)

 3

9 (1.8)

2 (1.2)

7 (2.1)

4 (1.1)

0 (0.0)

5 (4.9)

 Unknown/not sure

21 (4.1)

14 (8.3)

7 (2.1)

13 (3.6)

1 (2.2)

7 (6.9)

Baseline LDH level on resection date or in the preceding 6 months (N = 370), n (%)

 < 0.001 *

0.45

 Normal range

231 (62.4)

96 (78.7)

135 (54.4)

172 (64.4)

20 (57.1)

39 (57.4)

 Above upper limit of normal

139 (37.6)

26 (21.3)

113 (45.6)

95 (35.6)

15 (42.9)

29 (42.6)

BRAF mutated/positive, n (%)

157 (31.0)

59 (35.1)

98 (28.9)

0.19

90 (25.0)

36 (80.0)

31 (30.4)

 < 0.001 *

Pathological characteristics, n (%)

 Ulceration

268 (52.9)

75 (44.6)

193 (56.9)

 < 0.05 *

195 (54.2)

26 (57.8)

47 (46.1)

0.51

 Deep margin status

 < 0.001 *

0.48

 Positive

113 (22.3)

24 (14.3)

89 (26.3)

76 (21.1)

11 (24.4)

26 (25.5)

 Negative

368 (72.6)

139 (82.7)

229 (67.6)

267 (74.2)

30 (66.7)

71 (69.6)

 Transected

19 (3.7)

2 (1.2)

17 (5.0)

12 (3.3)

4 (8.9)

3 (2.9)

 Unknown/not reported

7 (1.4)

3 (1.8)

4 (1.2)

5 (1.4)

0 (0.0)

2 (2.0)

 Lymphovascular/ angiolymphatic invasion

211 (41.6)

56 (33.3)

155 (45.7)

 < 0.05 *

152 (42.2)

21 (46.7)

38 (37.3)

0.47