From: Pathogenic variants in human DNA damage repair genes mostly arose in recent human history
Gene | PVs | Gene | PVs |
---|---|---|---|
ATM | 147 | RAD51 | 5 |
BRCA2 | 122 | XPA | 5 |
BRCA1 | 116 | ATR | 4 |
FANCA | 67 | DCLRE1C | 4 |
MLH1 | 66 | ERCC4 | 4 |
MSH2 | 59 | LIG4 | 4 |
TP53 | 50 | NHEJ1 | 4 |
PALB2 | 48 | RAD54L | 4 |
MSH6 | 46 | RNASEH2C | 4 |
RAD50 | 38 | SLX4 | 4 |
MUTYH | 33 | SSBP1 | 4 |
BRIP1 | 33 | XRCC4 | 4 |
PMS2 | 32 | ERCC1 | 3 |
ERCC6 | 30 | FAN1 | 3 |
BARD1 | 28 | RNASEH1 | 3 |
CHEK2 | 28 | TELO2 | 3 |
NBN | 24 | FANCF | 2 |
BLM | 21 | GTF2H5 | 2 |
FANCC | 17 | LIG1 | 2 |
RAD51D | 16 | LIG3 | 2 |
MSH3 | 15 | MCM2 | 2 |
FANCD2 | 12 | RBBP8 | 2 |
RAD51C | 12 | XRCC2 | 2 |
XPC | 12 | MCM7 | 2 |
ERCC2 | 11 | RAD51B | 1 |
FANCI | 11 | DDB2 | 1 |
FANCG | 10 | DNA2 | 1 |
MRE11 | 10 | FANCL | 1 |
ERCC3 | 9 | MCM5 | 1 |
ERCC8 | 8 | POLD1 | 1 |
RNASEH2B | 8 | TOP3A | 1 |
ERCC5 | 7 | UBE2T | 1 |
RNASEH2A | 7 | UIMC1 | 1 |
FANCE | 6 | UNG | 1 |
FANCM | 6 | XRCC1 | 1 |
NTHL1 | 6 | MCM4 | 1 |
POLH | 5 | Â | Â |