Carbon-ion radiotherapy for hepatocellular carcinoma with major vascular invasion: a retrospective cohort study

BMC Cancer

Table 3 Univariate analysis of influencing factors of OS

Factor	n	p-value	2-year OS rate (%)
Age (years)		0.596
< 71	37		69.5
≥ 71	39		70.3
Sex		0.056
Male	58		65.1
Female	18		83.3
Performance status		0.530
0	55		74.0
1 or 2	21		60.7
Child–Pugh grade		0.107
A	68		73.3
B	8		42.9
ALBI grade:		0.065
1	47		79.3
2a or 2b	29		54.4
AFP (ng/mL)		0.885
< 400.0	51		71.8
≥ 400.0	25		66.8
DCP (mAU/mL)		0.059
= < 100.0	35		80.9
≥ 100.0	41		61.2
Tumor status		0.016
Naïve	40		81.4
Reginal or local recurrence	36		56.6
Number of lesions		0.018
1	64		74.2
≥ 2	12		50.0
Maximum tumor diameter (cm)		0.200
< 4.6	37		80.5
≥ 4.6	39		59.7
Vp4 or Vv3		0.297
Yes	17		62.3
No	59		71.8
Protocol dose		0.030
45.0–48.0 Gy/2 fractions	32		77.5
52.8–60.0 Gy/4 fractions	44		65.1
Start date of C-ion RT		0.133
First half (1995–2007)	35		68.6
Second half (2008–2020)	41		72.7

Abbreviations: OS Overall survival, ALBI grade Albumin-bilirubin grade, AFP Alpha-fetoprotein, DCP Des-gamma carboxyprothrombin, C-ion RT Carbon-ion radiotherapy

ISSN: 1471-2407