The radiological characteristics, tertiary lymphoid structures, and survival status associated with EGFR mutation in patients with subsolid nodules like stage I-II LUAD.

Table 3 Logistic regression model analysis for EGFR mutation in the cohort of 325 patients

Features	Status	Univariate analysis			Multivariate analysis
Features	Status	Odds ratio	95%CI	P value	Odds ratio	95%CI	P value
Gender	Female	1.995	1.342 ∼ 2.965	0.001	1.944	1.136 ∼ 3.329	0.015
Age	≥ 70	2.257	0.977 ∼ 5.213	0.057	NA
Smoking history	negative	2.043	1.297 ∼ 3.218	0.002	1.607	0.869 ∼ 2.973	0.131
Category of nodule	mGGN	2.887	1.944 ∼ 4.287	< 0.001	2.071	1.278 ∼ 3.357	0.003
Lobulation	positive	1.709	1.159 ∼ 2.521	0.007	1.423	0.924 ∼ 2.191	0.110
Spiculation	positive	1.185	0.767 ∼ 1.832	0.444	NA
Vascular changes	positive	0.852	0.580 ∼ 1.250	0.412	NA
Air-bronchogram	positive	1.598	1.078 ∼ 2.368	0.020	0.969	0.615 ∼ 1.528	0.892
Bubble-like lucency	positive	1.846	1.254 ∼ 2.717	0.002	1.991	1.268 ∼ 3.126	0.003
Pleural retraction	positive	2.329	1.568 ∼ 3.458	< 0.001	1.477	0.931 ∼ 2.343	0.097

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