Table 2 CT and pathological features according to EGFR mutation status
Characteristics | EGFR mutation (n = 173) | EGFR wild-type (n = 152) | P-values |
|---|---|---|---|
Location | Â | Â | Â |
right upper lobe | 56(32.4%) | 66(43.4%) | Â |
right middle lobe | 12(6.9%) | 8(5.3%) | Â |
right lower lobe | 34(19.7%) | 20(13.2%) | Â |
left upper lobe | 42(24.3%) | 26(17.1%) | Â |
left lower lobe | 29(16.8%) | 32(21.1%) | 0.098 |
Tumor size (cm) | 1.60 ± 0.50 | 1.24 ± 0.41 | <0.01 |
Category of nodule | Â | Â | Â |
pGGN | 48(27.7%) | 81(53.3%) | Â |
mGGN | 125(72.3%) | 71(46.7%) | <0.01 |
Lobulation | Â | Â | Â |
positive | 90(52.0%) | 59(38.8%) | Â |
negative | 83(48.0%) | 93(61.2%) | 0.012 |
Spiculation | Â | Â | Â |
positive | 49(28.3%) | 38(25.0%) | Â |
negative | 124(71.7%) | 114(75.0%) | 0.497 |
Vascular changes | Â | Â | Â |
positive | 91(52.6%) | 86(56.6%) | Â |
negative | 82(47.4%) | 66(43.4%) | 0.470 |
Air-bronchogram | Â | Â | Â |
positive | 81(46.8%) | 54(35.5%) | Â |
negative | 92(53.2%) | 98(64.5%) | 0.034 |
Bubblelike lucency | Â | Â | Â |
positive | 98(56.6%) | 63(41.4%) | Â |
negative | 75(43.4%) | 89(58.6%) | <0.01 |
Pleural retraction | Â | Â | Â |
positive | 96(55.5%) | 53(34.9%) | Â |
negative | 77(44.5%) | 99(65.1%) | 0.010 |
Histopathologic subtype | Â | Â | Â |
precursor glandular lesions | 5(2.9%) | 6(3.9%) | Â |
adenocarcinomas | 168(97.1%) | 146(96.1%) | 0.597 |
TLS | Â | Â | Â |
positive | 76(43.9%) | 92(68.4%) | Â |
negative | 97(56.1%) | 60(31.6%) | <0.01 |