Fig. 8From: High expression of RTEL1 predicates worse progression in gliomas and promotes tumorigenesis through JNK/ELK1 cascadeSchematic model of RTEL1/JNK/ELK-1 signaling-induced tumorigenesis of glioma. Accumulation of ROS caused by short telomere or RTEL1 Konckdown will suppress the JNK/ELK1 signaling pathway in glioma cells. RTEL1 cooperated with TERT maintains telomere elongation. The long telomere or ROS scavenger will decrease the ROS level and re-active the JNK caspase to promote TERT transcription. In conclusion, RTEL1 might promote glioma tumorigenesis through JNK/ELK1 cascade and ROS signalingBack to article page