Corticosteroids | Antihistamines | Antipyretics | |||
---|---|---|---|---|---|
Cycle 1 | 1st epcoritamab administration (priming dose) | Day 1* | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | Chlorphenamine 10 mg PO/IV (or equivalent) | Paracetamol 1000 mg PO (or equivalent) |
Day 2 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
Day 3 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
Day 4 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
2nd epcoritamab administration (first intermediate dose) | Day 8* | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | Chlorphenamine 10 mg PO/IV (or equivalent) | Paracetamol 1000 mg PO (or equivalent) | |
Day 9 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
Day 10 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
Day 11 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
3rd epcoritamab administration (second intermediate dose) | Day 15* | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | Chlorphenamine 10 mg IV (or equivalent) | Paracetamol 1000 mg PO (or equivalent) | |
Day 16 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
Day 17 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
Day 18 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
4th epcoritamab administration (full dose) | Day 22* | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | Chlorphenamine 10 mg PO/IV (or equivalent) | Paracetamol 1000 mg PO (or equivalent) | |
Day 23 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
Day 24 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
Day 25 | Dexamethasone 16 mg or Prednisolone 100 mg IV (or equivalent) | ||||
Cycle 2 | 5th epcoritamab administration (full dose) | Day 1* | If CRS > grade 1 occurs following the 4th epcoritamab administration, 4-day consecutive corticosteroid administration is continued in from Cycle 2 onwards as required | Optional | Optional |